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Naomi Harvey PhD #WearAMask Profile picture
@Naomi_D_Harvey
Mar 25 • 7 tweets • 2 min read • Read on X
Check your choline intake: are you getting enough? #MEcfs #LongCovid

In people who have a variation of the PEMT -744 gene with one change from G-->C (rs12325817) 78% developed organ dysfunction when fed a low choline diet

pubmed.ncbi.nlm.nih.gov/16816108/
Choline deficiency is more likely in those with folate or B12 deficiency since choline is utilised more for methylation in the absence of those B vits.

Lack of choline leads the body to cannibalise it’s own cell membranes to keep blood levels above 50% ods.od.nih.gov/factsheets/Cho…
Choline levels have been found to be depleted in #pwME
Depleted choline can cause problems with:
- energy metabolism
- cellular membrane quality
- mitochondrial health
- myelin sheaths
- cognition
- organ damage
- and may even be a risk for autonomic dysfunction
Post menopausal women need more choline to avoid deficiency
Yes, you can get too much choline also (just as too much of anything is bad) but the daily tolerable upper limits for safety are quite high 3.5grams).

In short: choline is a critical nutrient in many systems, make sure you get enough of it especially if you’re chronically ill.
If you want to read more on possible links between choline and #LongCovid #MEcfs etc

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More from @Naomi_D_Harvey

Naomi Harvey PhD #WearAMask Profile picture
Mar 22
Revisiting this in depth metabolomics paper on ME/CFS.

Of the 6 such studies “common threads in the results from all these studies are decreased levels of phospholipids and metabolic dysregulation”
ncbi.nlm.nih.gov/pmc/articles/P…
“we observed decreased levels of phospholipids, especially plasmalogens and phospholipid ethers”

My takeaway: Phospholipids may be crucial for pwME to supplement, even if they don’t touch symptom levels, but for basic cellular support.
“Plasmalogens are abundant phospholipid ethers that protect phospholipids and lipoprotein particles from oxidative stress and associated damage”

As @chydorina has highlighted, plasmalogens may be an important target in ME/CFS supplemental therapy. Really need to be cheaper tho!
Read 16 tweets
Naomi Harvey PhD #WearAMask Profile picture
Mar 14
@cstroeckw I think it could. I’ve just started a trial on myself. But there are good reasons why some pwME could react v badly also. It carries a risk of metabolic acidosis via pushing mitochondria into anearobic activity. Many of our mitochondria already do this too much anyway.
@cstroeckw The main risks for a bad outcome on Metformin are 1) hypoxia and 2) poor renal clearance of lactate. We know from #TheAcidTest some pwME have poor lactate clearance as standard, and may have chronic hypoxia from poor blood flow.
@cstroeckw So imho as a biologist not a medic, I think to trial it safely it’s best to address clotting and blood flow first. Then check for renal clearance and resting lactate levels. For me, I’ve done all this, my lactate clearance is good, resting lactate is mildly elevated but ‘normal’
Read 4 tweets
Naomi Harvey PhD #WearAMask Profile picture
Feb 8
Every now and then I find something about research on #MyalgicEncephalomyelitis that I didn’t know.

This one is particularly astonishing in terms of remmision events such as @remissionbiome are creating.



Has relevance for #LongCovid toome-pedia.org/wiki/Interfero…
This research also shows that most of those with ME who ‘recover’ are in fact not recovered but remain at high risk of relapse. Which may prove the same for Long Covid.

So, highlights pasted in below:
“Interferon therapy appears to be temporarily very effective for treating enterovirus-associated ME/CFS, with severe bedbound patients being able to return to work after treatment,but Dr John Chia discovered that most patients relapse several months later.”
Read 17 tweets
Naomi Harvey PhD #WearAMask Profile picture
Jan 23
I don’t think I mention this often enough as I see people describe this quite often:

If you get night sweats and adrenaline dumps at night, it’s very possibly caused by hypoglycaemia (low blood sugar).

When suga drops, adrenaline is released to compensate.

#MEcfs #LongCovid
Blood sugar regulation is commonly messed up in #MEcfs #LongCovid #Fibromyalgia and #POTS

🚨**You can have sugar problems in these conditions even if your GP has done a HbA1c test and says you’re fine**

You need to use a continuous glucose monitor for a week or two to check.
Having problems at night is not the only sugar related issues people can have with these conditions, so watch out also for things like Impaired Fasting Glycemia .diabetes.co.uk/impaired-fasti…
Read 5 tweets
Naomi Harvey PhD #WearAMask Profile picture
Jan 17
Very interesting study here on the metabolic and muscle consequences of extreme bed rest.

For 60 days the participants weren’t even allow to sit up, or use a pillow to prop up, did they develop ME/CFS?

Of course they didn’t!!
““a 60-day strict 6° head-down bed rest. No pillows were allowed except for a thin cushion when participants lay on their side; one shoulder always had to touch the mattress, and all daily activities including personal hygiene were done in the −6° position”
They did show evidence of metabolic changes we do sometimes see in ME/CFS such as evidence of mitochondrial dysfunction and inflammation. But when we see that in ME/CFS it’s in patients who are still moderately active & able to take part in research, not those trapped in bed 🛌
Read 5 tweets
Naomi Harvey PhD #WearAMask Profile picture
Oct 9, 2023
This disease is like when someone is help captive & deprived of so much that when their captor eventually gives them just a grain of kindness & gives them back the smallest of privileges, like being able to clean themselves, or use a toilet, the captive is so grateful for it…
that they become subservient & accept their situation.

It takes so much, repeatedly, that we lower and lower what standards we’d accept as ‘good’ & be grateful for them as though if we aren’t grateful, those small privileges will be taken away again #MyalgicEncephalomyelitis
*held
Read 6 tweets

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