Saloni & Vera's Dad 🙈📈🇵🇸 Profile picture
Mar 27 25 tweets 4 min read Read on X
My immune system appears to have recovered

No more lymphopenia or neutropenia

CD8s and CD4s up around 50% from nadir

Image
Image
In the past 5-6 months:

I'm not catching *everything* our kids bring home

Of the 1 or 2 things I've caught, recovery has been relatively quick

Cuts/wounds (from gardening, etc) are healing normally like they used to

Almost no skin reactions/issues

No bacterial infections
No inflammation related fatigue

I've even noticed lately the overgrowth on tongue is disappearing

(I highly suspect BLIS K12 / oral probiotics are helping here)
The initial improvements coincided with experimentation with maraviroc

5 weeks after I'd started, the pain in thymus area abated

Then the lymphocyte levels started to increase
It *felt* different

Thymus pain was tempered. Other illnesses didn't feel quite as prolonged

I'm near certain maraviroc (+atorvastatin) was key. I stopped treatment once and the pain returned. After restarting treatment, the pain/inflammation started to subside again
Not only is my immune system functioning like it used to, but I've had a great run this month with the chest inflammation

At one stage a box of 100 ibuprofen would last me a month

This month I've maybe taken anti-inflammatories twice
CRP, fibrinogen, cholesterol, iron, ALTs are all normal again

All of these inflammatory markers, I've frequently had abnormal results after covid infection in March 2022
I'd still not consider myself 100% normal. But it feels like 90-95%. I'm not going to stop antivirals anytime soon, I'm going to continue to experiment, as much as it seems maraviroc has helped, it doesn't seem like a panacea

Aim is to find a PrEP/TaP, HAART (HAACT?) regime
Anyway, 2 years on from infection, it feels like I'm close to normal again

All I had to do was get a few tests:

FBC
EUC
LFT
CMP
LDH
Uric Acid
D-Dimer
Coagulation profile
Troponin
CK
CRP
Fasting BSL and Cholesterol
Iron Studies
Vitamin D, B12, Folate, Selenium, Zinc
TSH
EBV and CMV serology and quantitative PCR
Hepatitis B and C serology
Complement system
Thyroid
Testosterone
Lymphocyte subset panels
Cytokine panel
HIV antibodies
Celiacs antibodies
SARS-CoV-2 antibody levels
And experiment with a few different supplements:

Vitamins C, D, Zinc, Magnesium, Iron, B complex
Tollovid
Nattokinase/Serrapeptase
Lactoferrin
Quercetin
EGCG
EPA
AHCC
PEA
Curcumin
RYR
Melatonin
NAC
Resveratrol
Taurine
Berberine
And try out a few drugs:

Antihistamines
Fluvoxamine
Aspirin
Tenofovir Disoproxil Fumarate/Emtricitabine
Nirmatrelvir/Ritonavir
Sofosbuvir
Maraviroc
Pravastatin
Atorvastatin
Valacyclovir
Daclatasvir
And probiotics (did I mention BLIS K12?)
And somehow not get reinfected
(I still have no idea how I haven't been reinfected)
And I had to learn immunology/virology
And read 100s of science papers
And see a lot of doctors
And get very lucky
And read and converse with 1000s of people on here (thanks everyone you all are awesome)
So yeahhhh
Anyway

HIV/Hep C drugs rock! ✊🤘✌️
I've written a little bit about maraviroc before for those unfamiliar

Dr Patterson looks to be taking his treatment protocol through formal approval with the FDA

Maraviroc is the main treatment agent

biospace.com/article/releas…
Didn't realise this would blow up! For anyone wondering, current stack is:

Maraviroc/Atorvastatin (heavy lifting)
Sofosbuvir

Nattokinase+Serrapeptase
Lactoferrin

Gut probiotics (l. sakei, l. plantarum)
Oral probiotics (BLIS K12)
Now foods Candida support

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More from @TristanVeness

Mar 12
Ordered 3 months worth of Sofosbuvir+Daclatasvir after learning about the powers of exonuclease inhibitors when combined with RdRp inhibitors

10-500x (in-vitro) reduction in viral units?!?! Yes please! Image
Hats off to @sun_in_winter12 for finding and sharing this study

ncbi.nlm.nih.gov/pmc/articles/P…
What I can't believe is how much literature there is on how effective these drugs are, in-vivo as well!

sciencedirect.com/science/articl…
Read 8 tweets
Mar 2
Acyclovir (valacyclovir, famciclovir, valganciclovir) is effective against all of these little guys

Most of these have been implicated as root causes of ME/CFS Image
Once infected, these viruses stay with you for life

Virtually everyone has been infected by multiple of these viruses, often as a child

This family of viruses enjoy living inside nerve and immune cells
For most people, they lay dormant (technical term is 'latent')

The immune system keeps the viruses in check, but is unable to ever 'clear' the virus
Read 11 tweets
Feb 11
Maraviroc

Developed by Pfizer, is a CCR5 antagonist, the first and only approved drug of its class

It was approved in 2007 to treat HIV

en.m.wikipedia.org/wiki/Maraviroc
"CCR5 is the main coreceptor used by macrophage (M)-tropic strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2, which are responsible for viral transmission."

pubmed.ncbi.nlm.nih.gov/12402506/
The mechanism of action against HIV is maraviroc's ability to block the CCR5 receptor and thus prevent HIV from entering into our immune cells, including macrophages and T Cells Image
Read 25 tweets
Dec 14, 2023
I have been wanting to do a big SARS-CoV-2 antiviral mega-thread, as I've been mentally collecting all the information and anecdotes I've found over the past 1.5 years, as well as trying out many antivirals myself

But time has been escaping me

So I'll do a quick mini-thread
The obtainable antivirals:

Paxlovid (3CL inhibitor)
Tollovid (3CL inhibitor)
Tenofovir Disoproxil Fumarate (RdRp inhibitor)
Sofosbuvir (RdRp inhibitor)
Maraviroc (CCR5 antagonist)

The OMG-just-approve-them-already list:

Ensitrelvir (3CL inhibitor)
Azvudine (RdRp inhibitor)
Plenty of evidence of antiviral activity behind all of these. I've tried all of the obtainables myself and I've had a marked improvement in symptoms to practically all of them

I suspect my reservoir(s) (heart, maybe thymus), are much easier for antivirals to reach, lucky me
Read 19 tweets
Sep 18, 2023
Some have been asking how I obtained Paxlovid after my recent thread

I know there are a lot of people suffering who want to join the antiviral experimentation club, so for the greater good, I'm going to share how you can do this


A picture of my stash, containing several SARS-COV-2 antivirals
Firstly, a word of warning

Any drug you wish to experiment with, you should do so under supervision and guidance of a good doctor

Paxlovid in particular has an enormous list of contraindications and drug interactions

The list is 10 pages long

mayoclinic.org/drugs-suppleme…
If you have any underlying medical problems, Paxlovid in particular, carries heightened risks

So please, discuss with your doctor first A list of health conditions that Ritonavir can be problematic with
Read 22 tweets
Mar 14, 2023
Azvudine

I have pain where my thymus is located, where T Cells go to workout

My CD8s and CD3s are deteriorating

I'm certain viral persistence is the root cause

Looking for new options after current treatment regime hasn't helped

Then I lookup Azvudine and lo and behold 🤯
"Oral administration of FNC in rats revealed a substantial thymus-homing feature, with FNC triphosphate (the active form) concentrated in the thymus and peripheral blood mononuclear cells (PBMC)."
"Treating SARS-CoV-2 infected rhesus macaques with FNC (0.07 mg/kg, qd, orally) reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray."
Read 6 tweets

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