Of the 1 or 2 things I've caught, recovery has been relatively quick
Cuts/wounds (from gardening, etc) are healing normally like they used to
Almost no skin reactions/issues
No bacterial infections
No inflammation related fatigue
I've even noticed lately the overgrowth on tongue is disappearing
(I highly suspect BLIS K12 / oral probiotics are helping here)
The initial improvements coincided with experimentation with maraviroc
5 weeks after I'd started, the pain in thymus area abated
Then the lymphocyte levels started to increase
It *felt* different
Thymus pain was tempered. Other illnesses didn't feel quite as prolonged
I'm near certain maraviroc (+atorvastatin) was key. I stopped treatment once and the pain returned. After restarting treatment, the pain/inflammation started to subside again
Not only is my immune system functioning like it used to, but I've had a great run this month with the chest inflammation
At one stage a box of 100 ibuprofen would last me a month
This month I've maybe taken anti-inflammatories twice
CRP, fibrinogen, cholesterol, iron, ALTs are all normal again
All of these inflammatory markers, I've frequently had abnormal results after covid infection in March 2022
I'd still not consider myself 100% normal. But it feels like 90-95%. I'm not going to stop antivirals anytime soon, I'm going to continue to experiment, as much as it seems maraviroc has helped, it doesn't seem like a panacea
Aim is to find a PrEP/TaP, HAART (HAACT?) regime
Anyway, 2 years on from infection, it feels like I'm close to normal again
All I had to do was get a few tests:
FBC
EUC
LFT
CMP
LDH
Uric Acid
D-Dimer
Coagulation profile
Troponin
CK
CRP
Fasting BSL and Cholesterol
Iron Studies
Vitamin D, B12, Folate, Selenium, Zinc
TSH
EBV and CMV serology and quantitative PCR
Hepatitis B and C serology
Complement system
Thyroid
Testosterone
Lymphocyte subset panels
Cytokine panel
HIV antibodies
Celiacs antibodies
SARS-CoV-2 antibody levels
"CCR5 is the main coreceptor used by macrophage (M)-tropic strains of human immunodeficiency virus type 1 (HIV-1) and HIV-2, which are responsible for viral transmission."
The mechanism of action against HIV is maraviroc's ability to block the CCR5 receptor and thus prevent HIV from entering into our immune cells, including macrophages and T Cells
I have been wanting to do a big SARS-CoV-2 antiviral mega-thread, as I've been mentally collecting all the information and anecdotes I've found over the past 1.5 years, as well as trying out many antivirals myself
Plenty of evidence of antiviral activity behind all of these. I've tried all of the obtainables myself and I've had a marked improvement in symptoms to practically all of them
I suspect my reservoir(s) (heart, maybe thymus), are much easier for antivirals to reach, lucky me
Some have been asking how I obtained Paxlovid after my recent thread
I know there are a lot of people suffering who want to join the antiviral experimentation club, so for the greater good, I'm going to share how you can do this
I have pain where my thymus is located, where T Cells go to workout
My CD8s and CD3s are deteriorating
I'm certain viral persistence is the root cause
Looking for new options after current treatment regime hasn't helped
Then I lookup Azvudine and lo and behold 🤯
"Oral administration of FNC in rats revealed a substantial thymus-homing feature, with FNC triphosphate (the active form) concentrated in the thymus and peripheral blood mononuclear cells (PBMC)."
"Treating SARS-CoV-2 infected rhesus macaques with FNC (0.07 mg/kg, qd, orally) reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray."