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Mar 29 28 tweets 12 min read Read on X
🚨 Indoor AIRBORNE Risk Assessment in the context of SARS-CoV-2 from the World Health Organisation (@WHO)

For clean air advocates, this is HUGE!

The WHO are finally saying, loud & proud: COVID IS AIRBORNE.

Let’s take a closer look at the details…🧵

🔗 iris.who.int/handle/10665/3…
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Foreword:

“We live immersed in an ocean of air, yet we hardly ever notice its presence. However, without air we would simply not be able to survive.”

“We must reshape & redesign the building environment, while focusing on optimizing indoor ventilation and the air we breathe.” Image
Introduction:

This purpose of this document is to introduce “an innovative method to quantify the risk of SARS-CoV-2 airborne transmission in indoor settings, thereby providing an alternative approach to developing ventilation requirements that lower the risk of infection.” Image
The document outlines the following major modes of transmission:

▪️Airborne: long-range (>2m)

▪️ Airborne: short-range (<2m)

▪️Direct deposition

▪️Contact (direct or indirect transfer) Image
This is another graphic from the document which depicts the mechanisms of transmission:

▪️Airborne: long-range (>2m)

▪️ Airborne: short-range (<2m)

▪️Direct deposition

▪️Contact (direct or indirect transfer) Image
Important Note:

While SARS-CoV-2 can spread through multiple routes of transmission, the model outlined in this document only considers short- and long-range AIRBORNE transmission (with short-range limited to particle inhalation and not direct deposition). Image
There’s also a handy explanation of “Airborne or Inhalation transmission”:

▪️“The process whereby aerosolized infectious respiratory particles are inhaled & enter the respiratory tract of a susceptible person.”

“Aerosolised” is the important word here - ie. NOT droplets. Image
To better understand the difference between droplet & aerosol transmission and why it’s so critically important to recognise the importance of aerosol spread, this 45 second video from ABC News Australia does an excellent job of explaining it ⬇️
“Long-range transmission can occur in indoor, enclosed settings when infectious particles accumulate over time in a given volume, at room scale, where the viral concentration is sufficient enough to cause infection once infectious particles are inhaled by a susceptible host.” Image
The previous SARS/MERS outbreaks & the current Covid pandemic “have given a new impetus to researching airborne transmission”

In turn, this has “raised awareness of the importance of ventilation strategies for public health purposes - in both healthcare & other public settings”. Image
“Currently, the recommended minimum ventilation rate for hospital rooms under airborne precautions is 12 ACH or 160 L/s per patient in most guidelines.”

Increasing the ventilation rate decreases the risk of transmission of infectious aerosols to those present. Image
Based on the Wells-Riley equation, in situations of high quanta emission (assuming 5 quanta/min & a minute volume of 6 litres/min), in a room of ~85m3, the probability of infection for a 15-minute exposure in a room would be:

▪️3ACH ➡️ 10%

▪️6 ACH ➡️ 5%

▪️12 ACH ➡️ 3% Image
The document points out that scientific expertise has evolved significantly since the Wells-Riley equation was developed in the 20th century.

The Covid pandemic has highlighted the urgent need for improved methods of determining risk of airborne transmission in indoor spaces. Image
This newly published WHO manual therefore aims to define a new & improved model, with a standard method to quantify the risk of SARS-CoV-2 airborne transmission in indoor settings according to the current evidence available at the time of this publication. Image
The WHO Technical Advisory Group have agreed to describe the airborne (inhalation) transmission mechanism as a 5 step process:

▪️1: Emission rate
▪️2: Removal rate
▪️3: Exposure
▪️4: Cumulative (absorbed) dose
▪️5: Probability of infection (transmission/risk profile) Image
Here’s a closer look at those 5 components of the new WHO airborne transmission risk assessment model…

There’s a significant amount of detail on each of these components within the full document so it’s worth having a read to better understand it.

🔗 iris.who.int/handle/10665/3…
Image
The WHO Technical Advisory Group also agreed that the new model should use a multi-box approach accounting separately for the long- and short-range contributions to airborne transmission:

🟡 Box 1 : Long-range (>2m)
🟠 Box 2: Short-range (<2m)

Box 1 + Box 2 = Overall risk Image
Having determined the components & parameters of the new model for assessing the risk of airborne transmission, this work has culminated in the development of an online tool which puts the principles into action:

▪️ARIA: AIRBORNE RISK INDOOR ASSESSMENT

partnersplatform.who.int/tools/aria/
Image
The ARIA tool guides the user through a series of 14 sections to provide the input components to the risk assessment calculation, including:

▪️space dimension
▪️duration
▪️occupancy
▪️short range interactions
▪️masks
▪️ventilation
▪️air filtration

(This is not the full list). Image
Once the questionnaire is completed, the tool then delivers a simple risk assessment summary.

In the example I used (30 kids in a 200m3 classroom for 2 hrs; 1 infected child; no windows open or air filters), the model estimated:

▪️32% risk per child
▪️9 kids would be infected Image
The results page also provides some simple suggestions for how you can reduce your risk, including:

▪️wearing a well-fitting mask
▪️reducing close interaction frequency & duration with others
▪️increasing ventilation
▪️using air cleaning devices
▪️limiting time spent indoors Image
There’s even a handy diagram for the ‘Hierarchy of Controls’ which explains the relative effectiveness of different risk reduction strategies.

Elimination (physically removing the hazard) is the MOST effective strategy.

This is why sick people should be encouraged to stay home. Image
The ARIA tool is really easy to use.

There are lots of parameters which you can tweak (eg. Time spent silently breathing vs talking or shouting, the number & duration of close interactions etc).

Here’s the link so you can try it out for yourself!

🔗 partnersplatform.who.int/tools/aria/
Image
My hope is that the publication of this document acts as a tipping point for a clean indoor air revolution.

No longer can our governments ignore this critical issue.

We MUST start optimising indoor ventilation.

The return on investment will be enormous for generations to come. Image
In tandem with the release of this new WHO document, an important new paper has also just been published in ‘Science’ which puts forward a compelling argument on the pressing need to mandate indoor air quality in public buildings.

Image
Image
Image
The list of co-authors of the Science article is an impressive who’s who of indoor air quality scientists & experts from around the world (43 in total!).

One of the authors, @jljcolorado, has put together a thread summarising the key points 🧵⬇️
The short video below features Prof Lidia Morawska explaining the importance of regulating the quality of the indoor air that we breathe.

Prof Morawska co-chaired the WHO ARIA Technical Advisory Group & is also one of the authors of the Science paper.


Two more of the experts who co-authored the Science paper (@j_g_allen & @linseymarr) featured in a CBS News show which tackled the topic of indoor air quality.

Below is one clip, but I’ve also pulled together a thread of multiple clips from the show ⬇️


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More from @_CatintheHat

Mar 28
🚨NEW Report presents findings from a review of Long Covid to guide New Zealand’s Public Health response.

Report concludes that “preventative action is urgently needed”.

Let’s dive into the details as the findings are relevant for ALL countries.

🔗

/1 phcc.org.nz/briefing/long-…
Image
Below are some of the key findings of the report:

▪️Changes in health status following SARS-CoV-2 infection are common and can occur at any age.

▪️Symptoms are frequently experienced for months or years and can increase over time.

/2 • Several recent and well-designed cohort studies have reported central estimates ranging from 4 – 14% for ongoing symptoms per infection. • Long Covid includes a full spectrum of severity from hidden effects through mild and transient symptoms to life-changing and life-limiting conditions such as heart attacks and strokes, diabetes, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and neurological disorders. Commonly experienced symptoms such as fatigue and cognitive dysfunction have a high impact on quality of life. • Both SARS-CoV-2 infection and Long Covid are under-counted ...
▪️Future health impacts can be expected in addition to the effects that are already observed.

▪️ Some people who are currently well post-Covid are already expressing biomarkers of risk for cardiovascular disease, neurodegenerative disorders, autoimmune diseases & cancers.

/3 Future health impacts can be expected in addition to the effects that are already known and observed.  • Some people who are currently well post-Covid are already expressing biomarkers of risk for cardiovascular disease, neurodegenerative disorders, a range of autoimmune diseases, and cancers: conditions that typically have latency periods lasting years or decades. • Early-life exposure to infections can have lasting impacts on developing tissues and organ systems. Already, several adverse effects of perinatal Covid-19 exposure have been described. • Pre-pandemic evidence shows the adverse ...
Read 20 tweets
Mar 7
MEASLES, a thread🧵

Having successfully eliminated measles in the UK back in 2017, it’s now back with a vengeance.

Cases have risen to a 10-year high & a National Health Emergency has been declared.

Here’s a whistlestop tour of everything you need to know about measles. Image
MEASLES CASES IN ENGLAND

▪️In the 5 months since 1 Oct 2023, 733 measles cases have been reported, a 10-year high.

▪️239 new cases have been reported in Feb so far (data still incomplete).

▪️The majority (63%) of cases are in children under 10 yrs.

🔗 gov.uk/government/pub…
Image
INFECTIOUSNESS

Measles is one of the world’s MOST infectious diseases.

It transmits very easily from person to person (the infected person is infectious from 4 days BEFORE the rash appears).

On average, each person with measles will infect 15 other (unvaxxed) people. Image
Read 24 tweets
Mar 2
COVID + THE BRAIN 🧠

There’s been a flurry of new studies published in recent weeks about Covid’s detrimental impact on the brain.

This is the aspect of Covid which concerns me most, but which many people seem to be blissfully unaware of.

So let’s dig into what we know… 🧵 Image
It’s important to note that this is not new news… we’ve known about Covid’s impact on the brain for a long time.

1. This article from Dr @zalaly provides an excellent summary of the mounting evidence about how Covid leaves its mark on the brain.

🔗 theconversation.com/mounting-resea…
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2. This is one of the new studies published this week (29 Feb 2024).

Researchers found that those with Long Covid had measurable memory & cognitive deficits equivalent to a difference of 6 IQ points which lasted for a year or more after infection.

🔗 amp.theguardian.com/society/2024/f…
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Read 34 tweets
Feb 28
It’s incredibly disappointing to read @LibDems policy motion for tackling persistent absence in schools.

It completely FAILS to address the primary cause of persistent absence…

You can read the policy here (p32): 🔗

@EdwardJDavey @munirawilson

🧵 libdems.org.uk/fileadmin/grou…
Image
So what is the primary cause of persistent absence?

Let’s look at the government’s own data from the last academic year (2022/23).

It’s right there in black & white:

‘Both overall absence & persistent absence rates have been driven by ILLNESS during the 2022/23 academic year.’ Image
In case you’re wondering, this is *not* normal.

Pupil absences due to illness alone increased to an average of 3.9% across the 2022/23 academic year, compared with a pre-pandemic average of 2.6%.

That’s a 50% rise!

Children never used to be sick nearly as much as this. Image
Read 26 tweets
Feb 28
Does anyone know of a medical reason why the recently updated guidance for measles infection control in healthcare settings states that:

“FFP3 respirators must NEVER be worn by an infectious patient”

Guidance is here:
🔗 england.nhs.uk/long-read/guid…
Image
I can understand powered respirator hoods not being allowed since the air exiting the PAPR hoods is not filtered & therefore doesn’t provide any ‘outbound’ protection.

Similarly with valved FFP3 masks.

But, as long as the FFP3 mask isn’t valved, why would it not be allowed?
If they mean that *valved* respirators are not allowed (as per guidance below), why don’t they clearly specify that?

To put a blanket ban on ALL FFP3 respirators for patients known to be infected with an extremely contagious airborne disease seems v odd.

england.nhs.uk/wp-content/upl…
Image
Read 4 tweets
Feb 22
Rishi Sunak met King Charles at Buckingham Palace yesterday afternoon for the first time since his cancer diagnosis.

🔗

Now, do you see what I see?! 👀

It’s a HEPA air filter, prominently positioned in the background of many of the photos!

1/ bbc.co.uk/news/uk-683632…
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It’s BRILLIANT to see a HEPA air filter so prominently positioned.

I wonder if it was a coincidence or intentionally placed within camera shot?

I’d like to think it was intentional and that the King is subtly sending us a message of support for clean indoor air!

2/ Image
I don’t know what cancer treatments the King is undertaking but it’s possible he is on immunosuppression drugs leaving him clinically vulnerable.

It would have been good to see him wearing a mask too - but even without a mask, clean air can help reduce his risk.

3/
Read 29 tweets

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