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Dalton (Analyze & Optimize) Profile picture
@Outdoctrination
Apr 9, 2024 • 1 tweets • 1 min read • Read on X
Vitamin B1 is a PED.

Megadosing this nutrient (as TTFD) in animals:

• QUADRUPLED endurance
• Enhances cellular ATP content
• Lowered lactic acid
• Improved glycogen (stored sugar)

>1 gram human dose, wouldn't go that high, but the effect is potent even at lower doses.Image

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More from @Outdoctrination

Dalton (Analyze & Optimize) Profile picture
Feb 12
Iron can actually SHORTEN your lifespan and age you on a cellular level.

(🧵1/10)Image
This study was published in 2024, investigating the effects of iron chelation on age related parameters.

They used a common aging animal model - a Klotho knockout animal.

Animals are known to have shorter lifespans without this gene, and longer lifespans with more of it.

They gave them a drug called deferiprone, which binds up free iron and gets rid of it.Image
What exactly does klotho do?

Well it's main function is a co-receptor for FGF proteins, which govern various metabolic functions (fat burning, glucose uptake, etc.) as well as vitamin D synthesis.

But it also shows a number of other anti-aging effects:

◈ Reduced oxidative stress
◈ Senescence resistance
◈ Anti-inflammatory effectsImage
Read 11 tweets
Dalton (Analyze & Optimize) Profile picture
Feb 12
Put your finger on your wrist like this right now.

I can tell you more about your health on this alone than with $100s in lab tests.

Ready? This is what it means (🧵1/8):Image
What you are feeling is your radial artery in your wrist area.

This tells you your:

◇ Heart rate (duh)
◇ Pulse amplitude

Both of these give you a ton of information on your health - in real time.

Let's talk about your heart rate first Image
A LOW heart rate is often associated with hypothyroidism.

This is not always true, for instance athletes have lower pulse rates due to adaptation,

but in many people, a low HR indicates thyroid function.

A few functional thyroid doctors like to see this number at 70-85 BPM, and that pretty much aligns with our experience with our clients.Image
Read 8 tweets
Dalton (Analyze & Optimize) Profile picture
Feb 10
Aged garlic was shown to shrink arterial plaques in a landmark clinical trial.

(🧵1/7)Image
Image
This study was published in 2019, examining people with diabetes with plaque in the coronary artery.

This is the primary place where if plaque forms, you're susceptible to a heart attack. Image
They also used what is now considered the best tool for predicting heart disease - Coronary Computed Tomography Angiography (CCTA).

This is an imaging technique used to visualize the plaques.

For this reason, it's incredibly accurate at seeing active disease. Image
Read 8 tweets
Dalton (Analyze & Optimize) Profile picture
Feb 8
N-acetylcysteine (NAC) was shown to reverse brain damage from aluminum in a critical study.

(🧵1/8)Image
Animals were put into 6 groups - either getting aluminum or NAC or both.

The aluminum was administered as aluminum chloride, and it was done so orally.

This is important because roughly only 0.5% of oral aluminum chloride is absorbed, so the real effective doses the animals received were far less than than the 100 mg / kg.

This is still a high dose, but aluminum is known to accumulate in tissues.Image
Animals had severely impaired memory performance with the aluminum, but this was improved with NAC.

The morris water test trains rats to find a hidden platform in pool.

The latencies (times) is how long it takes to find it on a given day.

Less time = better memory.

As you can see, the high dose NAC almost completely reversed the memory impairment from aluminum.Image
Read 11 tweets
Dalton (Analyze & Optimize) Profile picture
Feb 5
Vinegar drastically reduces blood sugar and insulin levels, according to multiple clinical trials.

(🧵1/7)Image
This first paper is a review article from 2017.

They looked at studies giving people vinegar alongside meals and monitored their blood sugar and insulin responses.

Having high levels of these post meal is highly indicative of insulin resistance and is a risk for heart disease.

Apologies, I do not have the official PDF so I'm working with the raw file here.Image
Here were the included studies.

Most are looking at roughly one tablespoon of vinegar alongside a meal with carbs. Image
Image
Image
Read 10 tweets
Dalton (Analyze & Optimize) Profile picture
Feb 5
Why you SHOULDN'T be hysterical about vitamin C causing kidney stones, and what to do to prevent them (🧵1/10):Image
The idea that vitamin C supplementation can cause kidney stones is not completely baseless, but it does lack context.

Ascorbic acid, or vitamin C, can get metabolized in our cells to create oxalate.

Oxalate is what binds to calcium to form kidney stones in most people.

Seems pretty straightforward, BUT...Image
Ascorbic acid mainly gets converted to oxalate under conditions of high oxidative stress.

That is when ascorbic acid (AA) turns into dehydroascorbate (DHA).

But we have glutathione to help regenerate ascorbic acid from dehydroascorbate.

This depends on your entire antioxidant network.Image
Read 12 tweets

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