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Analyze & Optimize Profile picture
@Outdoctrination
Apr 9, 2024 • 1 tweets • 1 min read • Read on X
Vitamin B1 is a PED.

Megadosing this nutrient (as TTFD) in animals:

• QUADRUPLED endurance
• Enhances cellular ATP content
• Lowered lactic acid
• Improved glycogen (stored sugar)

>1 gram human dose, wouldn't go that high, but the effect is potent even at lower doses.Image

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More from @Outdoctrination

Analyze & Optimize Profile picture
Dec 3
NAC can prevent grey hair, as shown in a recent groundbreaking study that reveals the true causes behind the greying process.

(🧵1/8)Image
Image
This study came out earlier this year in Cell Regeneration.

They used a system to assess the impact of mitochondrial function on melanocytes and their stem cells, which are the cells that produce colored pigment.

They did this by genetically deleting an enzyme called deoxyguanosine kinase - which is needed for mitochondria to synthesize their DNA.

Without it, mitochondria don't get the proteins they need and don't work properly.Image
What we see here is melanocytes dying in the hair follicles.

The red portion is a label for melanocytes.

See how there is little to no red in the right picture? That is because those cells are not there without that mitochondrial enzyme.

This shows the importance of proper mitochondrial function for maintaining these cells.Image
Read 10 tweets
Analyze & Optimize Profile picture
Dec 1
Your face can reveal a TON about your internal health.

Here are 5 signs it's giving you (🧵1/6):

#1 Dark circles under the eyes

This is from poor vitamin C status + impaired collagen production, oxidative stress.

The skin underneath the eyes is very thin - making it more susceptible to collagen loss.

The dark color is caused by blood vessel congestion and damage.Image
Vitamin C reduces dark circles under the eyes.

10% mix applied for 6 months achieved this by:

➝ Stimulating collagen synthesis
➝ Inhibiting excessive skin pigmentation / coloring
➝ Preventing oxidative stress (causes colorization via hemoglobin)

Orally it acts on the same pathways.Image
#2 Thinning eyebrows

This is a classic sign of hypothyroidism.

Thyroid hormones are vital to hair follicle growth.

This is especially true in the eyebrows which are much more sensitive to their deprivation.

Classic sign: outer 1/3 of the eyebrow thins (Queen Anne’s sign). Image
Read 8 tweets
Analyze & Optimize Profile picture
Dec 1
Vitamin D at high doses diverts calories away from fat and into muscle and height growth, demonstrated in a recent new study.

(🧵1/9)Image
They supplemented 3 levels of vitamin D in the diet:

0 IU/kg - low
2,000 IU/kg - normal
10,000 IU/kg - high

For human equivalents, the normal and high doses would be ~1,800 IU and 9,000 IU per day.

corresponding to serum 25(OH)D of:

<5 ng/mL - low
20-30 ng/mL - normal
>30 ng/mL - highImage
After 12 weeks, the vitamin D showed some incredible effects.

➠ Improved strength (high amounts best)
➠ Increased muscle mass
➠ Decreased fat mass in the high amount

No change in body weight. Image
Read 9 tweets
Analyze & Optimize Profile picture
Nov 20
TESTOSTERONE - the foundation is your DIET.

Problem is, most "health" diets are a recipe for low T.

Here are the KEYS to optimizing it (🧵1/12):

#1 ZINC

The first study in humans (1977) showed that 100 mg of zinc daily could massively improve testosterone by >400 ng/dLImage
Later studies showed that zinc in infertile men:

‣ More than DOUBLED sperm count
‣ Increased testosterone by over 50%
‣ Increased DHT by over 30%

9/22 men got their wives pregnant, when none could for 5 years prior.

Full zinc x T thread below: Image
#2 Saturated fat > seed oils

Seed oils lower testosterone.

Compared to coconut or olive oil, they:

➜ Lower test producing enzymes
➜ Lower cholesterol in the testicles
➜ Cause testicular oxidative damage

cholesterol in the testicles directly fuels T production. Image
Read 13 tweets
Analyze & Optimize Profile picture
Nov 19
Your hormones are getting assaulted from all angles.

Here are 7 sources of endocrine disrupting chemicals you didn't even know about, and what to use instead (🧵1/8):

#1 CLOTHES

Female dogs wearing polyester pants become infertile and have lower progesterone levels.

This was not true for cotton.Image
Image
Polyester on the scrotum destroys male fertility.

By creating an electrostatic field around the testicle, polyester:

- Completely depleted men of ALL sperm
- Decreased testicle volume
- Did not effect hormone levels

Protect your jewels boys. Image
Image
#2 COOKING UTENSILS & NON-STICK PANS

Hormonal disruptors:

➤ PFAS (PFOA, PFOS, GenX) - interfere with thyroid & reproductive hormone synthesis, receptor binding, metabolism

Alternative: Use stainless steel, cast iron, copper or ceramic cookware. Image
Read 9 tweets
Analyze & Optimize Profile picture
Nov 19
Protein can cause insulin resistance and even fat gain.

I didn't believe it either, until I started looking at the research (🧵1/9)Image
I recently covered a study demonstrating LOW protein diets in weight loss, metabolism and insulin sensitivity.

But there's more to the story.

In fact, there's a ton of research showing high protein diets can worsen metabolism.

A high protein diet worsens glucose metabolism. [study]

0.7 g protein / kg bodyweight vs 1.8 g / kg.

Those on the high protein diet had:

➠ Higher glucagon / glucose production
➠ Worsened insulin sensitivity
➠ Lower glucose oxidation

than those on the normal protein diet. Image
Image
Image
Read 12 tweets

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