☞ Put on more fat
☞ Lose muscle
☞ Produce less energy
☞ Do so in a more stressful manner
The primary stress hormone, cortisol, actually predicts your perceived age.
In other words, the lower your stress, the younger you appear to other people, and the younger you likely are biologically!
Stress directly promotes the breakdown of
☞ Skin
☞ Hair
☞ Muscle
while promoting the creation of fat mass.
Pregnenolone INHIBITS the release of CRH, the hypothalamic precursor of cortisol.
Prengnolone’s ability to inhibit the release of CRH/CRF is unique, targeting stress at the most basic biological root cause.
Pregnenolone also functionally inhibits the receptor for cortisol.
The "pregnenolone facelift" phenomenon is real.
The production of pregnenolone and its metabolites like DHEA, declines in aging, while the production of stress steroids like cortisol continue to rise.
The ratio of DHEA/Cortisol is one of the best predictors of disease and mortality, and declines with aging.
Pregnenolone also gets metabolized in large quantities to progesterone, which also inhibits CRH release and is a direct antagonist on the cortisol receptors.
Progesterone has GABAnergic effects, which is the key relaxing signaling molecule in the body.
Another compound which pregnenolone largely gets converted into is allopregnanolone, our body’s primary endogenous GABAnergic steroid.
2. Pregnenolone is anti-inflammatory
CRH, independently of cortisol production, also contributes to stress, disease and aging, by initiating inflammation.
Inflammation is uniformly seen in all chronic diseases and in the aging process, as it
☞ Breaks down our tissue
☞ Dampens energy production
☞ Generally makes us feel crappy
Pregnenolone actually degrades the toll like receptors (TLRs) that initiate inflammation in conditions from Alzheimer's disease to IBS.
3. Pregnenolone increases energy
As we age, our mitochondria become:
☞ More susceptible to damage
☞ More fragmented
☞ Smaller
☞ Less effective at producing energy,
☞ More prone to generate free radicals
but pregnenolone allows them to
☞ Produce more energy,
☞ Produce less with oxidative stress
☞ Undergo fusion, when mitochondria come together and become more robust.
The pro-energy effects of pregnenolone have been observed for nearly a century.
Some early studies showed that workers, especially those under stress, subjectively felt better when doing so with pregnenolone.
This anti-fatigue effect was also demonstrated in arthritic patients.
100-500 mg of pregnenolone taken orally has consistently shown an anti-fatigue, cognitive enhancing and anti-stress/anxiety effect.
I'll link the pregnenolone we use ourselves and with clients below.
Perhaps the most noteworthy testimonial:
" 'I didn't have my usual summer recovery from "winter sickness,' during a two week trip I felt perfectly well, but except for that short time I kept getting sicker and sicker (with inflammation of arteries, dental abscesses, asthma, migraines, and colitis).
Lying in bed one day trying to understand what had happened during that two week trip, I remembered that I had used the vitamin E containing a residue of pregnenolone on the trip, but used pure vitamin E after I got home.
I immediately got out of bed and took a pinch of pregnenolone. In about an hour, all of my
symptoms had stopped, and for over a week I was healthy and energetic.
But then I got sick again, and was so distracted by the pain that it was several days before I remembered the pregnenolone. Another pinch had the same dramatic sudden effect.