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Dalton (Analyze & Optimize) Profile picture
Dalton (Analyze & Optimize)
@Outdoctrination
Biomolecular Engineer. Helping people virtually worldwide with a personalized approach. Book a free call here to work with us: https://t.co/zanpmphTQB
Jun 15 ā€¢ 9 tweets ā€¢ 5 min read
Taurine is one of the most important nutrients for the brain, serving a number of protective roles in cognitive aging and stroke.

(šŸ§µ1/7)Image
Image I was surprised to find out that taurine is actually the second most abundant amino acid in the central nervous system, behind glutamate.

Taurine levels in both the cerebrospinal fluid and certain brain regions are lower in people with Alzheimer's disease.

This has important consequences.Image
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Jun 13 ā€¢ 9 tweets ā€¢ 5 min read
Low dose naltrexone is legitimately a life changing drug for many - its anti-inflammatory benefits are able to help in a multitude of conditions. Let's talk about it. (šŸ§µ1/8)Image Naltrexone is classically an opioid antagonist.

At its normal doses (50-100 mg) it's used to block opioid signaling in conditions like addiction, which reduces dopamine output from drugs.

This makes it easier to get off the drugs.

However, when used at lower doses it has some amazing other actions.Image
Jun 12 ā€¢ 9 tweets ā€¢ 5 min read
Vinegar at ~1 tbsp reduces insulin response by up to 50% across multiple trials, a review article concluded.

(šŸ§µ1/8)Image This first paper is a review article from 2017.

They looked at studies giving people vinegar alongside meals and monitored their blood sugar and insulin responses.

Having high levels of these post meal is highly indicative of insulin resistance and is a risk for heart disease.

Apologies, I do not have the official PDF so I'm working with the raw file here.Image
Jun 11 ā€¢ 14 tweets ā€¢ 5 min read
The vitamin that NEVER gets talked about has more benefits than you can even count.

Mental health, boosting metabolism, gut health and even increasing testosterone.

Let's talk about the marvelous VITAMIN K2:Image This study showed that Vitamin K2 could treat depression.

K2 (as MK-7) improved depression at just 90 ug/day, a pretty puny dose, in 8 weeks.

K2 fulfills multiple roles in the body that gives it this effect.

The effect is very noticeable in my experience, it's an instant mood lifter.Image
Jun 8 ā€¢ 10 tweets ā€¢ 4 min read
Magnesium is often a missing link in tinnitus - and supplementing it can alleviate the ringing sensation. (šŸ§µ1/8)Image A short report in 2016 showed that serum magnesium levels were lower in people with tinnitus.

Keep in mind this was serum levels, typically the last place for magnesium to become depleted in.

But is this correlation or something real? Image
Jun 7 ā€¢ 10 tweets ā€¢ 4 min read
A captivating study showed that zinc carnosine is protective for leaky gut and stimulates repair of the gut lining. (šŸ§µ1/7)Image This was published in 2007 in the BMJ's GUT journal.

They actually ran multiple studies and published it in this one paper:

āžœ A human study on leaky gut (intestinal permeability)
āžœ Studies on repair and cell migration
āžœ Analysis of gut damage and structure Image
Jun 7 ā€¢ 9 tweets ā€¢ 6 min read
If you want to live longer, read this.

These are the 7 KEYS TO EXTENDING LIFESPAN in research (šŸ§µ1/8):Image The Basic Principle of Longevity

We can think of life fundamentally as growth + repair phases.

Growth phase: muscle building, tissue regeneration, immune cell proliferation, injury repair, and more. Very important.

Clean up phase: breakdown of damaged components, fat loss, fine-tuning immune cells

We need both, but in research it's typically thought of as:

Aging: excessive growth + damage accumulation

Lifespan promoting: growth restriction + damage removal

Most research focuses on the clean up phase for lifespan extension, and that's likely because we live in a time where signals for the growth phase tend to be abundant.

This is true, even in experimental animals - even "normal" animals are typically overfed.

We also need the growth phase for health, it coincides with having high thyroid, high T, low cortisol and more.

So keep that in mind as we go through the below - this is not to say that these always perfectly mimic real world conditions, but we will be going through what experimentally drives the aging process and what extends lifespan.

True health is unlocked when your body can go deep into the growth phase and deep into the cleanup phase, not being "stuck" in either phase, which leads to problems.Image
Jun 6 ā€¢ 9 tweets ā€¢ 4 min read
Wrinkles and other signs of skin aging can be reversed with an oral supplement of astaxanthin, a critical study concludes.

(šŸ§µ1/8)Image Astaxanthin is a powerful antioxidant found in red seafood like salmon and shrimp.

If you're unfamiliar, I've written more about what it is below.

This study pooled together all of the human studies done on astaxanthin.

Let's go through them.

(2/8) Image
Jun 5 ā€¢ 9 tweets ā€¢ 4 min read
N-acetylcysteine (NAC) was shown to reverse brain damage from aluminum in a critical study.

(šŸ§µ1/8)Image Animals were put into 6 groups - either getting aluminum or NAC or both.

The aluminum was administered as aluminum chloride, and it was done so orally.

This is important because roughly only 0.5% of oral aluminum chloride is absorbed, so the real effective doses the animals received were far less than than the 100 mg / kg.

This is still a high dose, but aluminum is known to accumulate in tissues.Image
Jun 4 ā€¢ 10 tweets ā€¢ 4 min read
Thiamine (vitamin B1) megadosing improved survival by over 8X in sepsis, a condition that kills ~20% of all people, in a recent study.

(šŸ§µ1/7)Image This study came out in 2024, looking at 2 different randomized clinical trials of thiamine (B1) usage in sepsis.

Sepsis is when there is bacterial leakage into the bloodstream in large amounts.

This causes massive inflammation that ultimately causes organ failure and often death.Image
May 31 ā€¢ 9 tweets ā€¢ 5 min read
Magnesium has the ability to shrink arterial plaques, demonstrated by some incredible clinical trials.

(šŸ§µ1/8)Image This first study came out in 2008.

They gave people magnesium citrate, just under 100 mg elemental magnesium per day.

This is a puny dose, magnesium RDA is 4X that and people often supplement even more than that.

These studies are all in hemodialysis patients, and that's mainly because these people develop heart disease at a much quicker rate due to toxin accumulation and altered mineral balance.Image
May 30 ā€¢ 11 tweets ā€¢ 6 min read
ANOTHER one of the most impressive studies in recent memory found that the combination of NAC + Glycine has remarkable anti-aging effects in nearly every metric.

(šŸ§µ1/8)Image
Image This study came out in 2021.

Both older (71-80 years old) and young (21-30 y/o) people were enrolled.

The older folks got a large dose:

ā—‡ Glycine: ~7 g/day
ā—‡ NAC: ~9 g/day (ā‰ˆ 6.9 g cysteine equivalent)

for 24 weeks.

This doesn't necessarily mean that one has to take this much, since this was measuring a relatively short period of time on the elderly, so they were trying to up their stores rapidly.

Typically, a maintenance dose of NAC is 1.2-2.4g, and glycine 3-6g.Image
May 27 ā€¢ 7 tweets ā€¢ 4 min read
Vitamin C is a powerful blood pressure reducer - dropping blood pressure by up to 20 points, shown in a meta analysis.

(šŸ§µ1/7)Image This review paper was released in 2020, examining the available human randomized clinical trials on vitamin C and blood pressure.

They ended up gathering 8 studies in total, and they paint a clear picture. Image
May 24 ā€¢ 22 tweets ā€¢ 11 min read
If you CAN'T SLEEP well - read this.

This is the ULTIMATE GUIDE to optimizing sleep: to fall asleep and stay asleep effortlessly by addressing the root causes (šŸ§µ1/15):Image First and foremost we must discuss the circadian rhythm.

This is the primary governor of your sleep. If your body doesn't even know what time it is, how can you expect it to be ready to fall asleep?

Of course, the main focus here is going to be melatonin, a central circadian regulating molecule that signals darkness and sleepiness.

Melatonin is formed from the amino acid tryptophan, which we get in the diet from protein.

In order to get from tryptophan to melatonin, the body requires:

ā—‡ Iron
ā—‡ Vitamin C
ā—‡ Vitamin B5
ā—‡ Vitamin B6
ā—‡ Healthy methylation
ā—‡ Good mitochondrial function

In fact, melatonin is actually synthesized within the mitochondria.Image
May 21 ā€¢ 7 tweets ā€¢ 3 min read
5 WARNING SIGNS that are "normal," that are really your body crying for help.

#1 Waking up to pee at night

Your body has hormonal / metabolic signals to ensure you don't wake up to pee.

Not enough:

ā—‡ Vitamin C
ā—‡ Zinc
ā—‡ Salt
ā—‡ Potassium

Can cause this.Image I did a full thread on the exact mechanisms behind how this happens, so be sure to check that out for more.
May 13 ā€¢ 9 tweets ā€¢ 5 min read
Red light can literally reduce fat in the belly / waist area via spot reduction, some fascinating research shows. (šŸ§µ1/8)Image This first study examined the effects of a red laser on waist reduction (DOI 10.1007/s11695-010-0126-y)

They gave subjects a red laser at 635-680 nm, 1.2 to 3.6 J/cmĀ².

30 min twice a week for 4 weeks.

After every session, there was a measurable reduction in waistline.

After the 8th session, this amounted to a >2cm reduction.

When people were asked to rate how much their appearance improved around the waist - they answered a 1.2 on a scale up to 3.

Placebo? 0/3.Image
Image
May 12 ā€¢ 10 tweets ā€¢ 5 min read
Magnesium + potassium combination lowered cortisol by ~45% and completely eliminated severe insomnia in a recent clinical trial.

(šŸ§µ1/7)Image They gave type 2 diabetics with sleep disorders one of four treatments:

ā—‡ Placebo (T1)
ā—‡ Magnesium (Mg, T2)
ā—‡ Potassium (K, T3)
ā—‡ A combination of Mg and K (T4)

each at 250 mg - for 2 months. Keep in mind this is a puny amount of potassium.

The results were astonishing. Image
May 10 ā€¢ 4 tweets ā€¢ 1 min read
if people actually knew how much of hair loss is dictated by mitochondrial function we wouldn't have brothers losing their manhood to DHT inhibition Image
May 6 ā€¢ 10 tweets ā€¢ 5 min read
N-Acetylcysteine (NAC) has the ability to substantially improve ADHD - shown in a number of different studies.

(šŸ§µ1/7)Image This first study was done in people with the autoimmune condition Lupus.

While they may seem unrelated, they found that ADHD scores are elevated in these patients.

They also knew that levels of glutathione, which NAC repletes, are low in immune cells of Lupus patients, which contributes to abnormal immune activation.Image
May 4 ā€¢ 9 tweets ā€¢ 4 min read
Calorie restriction can increase lifespan by ~40% - but a stunning study showed that it's NOT because of fat loss or insulin sensitivity.

In fact, the animals who were the fattest actually lived the longest! (šŸ§µ1/8):Image This was a landmark study in 2024 that examined genetically diverse animals.

They also looked at nearly 1,000 mice in total.

This gave them a ton of certainty in the measurements since you can't just chalk it up to one type of mouse having the effect.

Groups were either 1 day of fasting, 2 days, control, 20% calorie restriction or 40%.
Apr 24 ā€¢ 9 tweets ā€¢ 4 min read
Zinc can rapidly and potently reduce cortisol - shown in an astonishing clinical trial.

(šŸ§µ1/8)Image This study was a small one published in 1990.

Despite that, it gives us key insight into the role of zinc and how it regulates stress. Image
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