Glycine, even in small amounts, can reduce blood sugar with a meal by >50% and improve insulin resistance, demonstrated in a striking study.

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https://x.com/Outdoctrination/status/2017229815116444114

This study was posted in the American Journal of Clinical Nutrition in 2002.

They thought that since gelatin, rich in glycine, is able to stimulate insulin secretion more than other proteins, that it might have an effect on blood sugar with a meal.

L-Theanine was shown to improve sleep and cognitive function, while reducing anxiety and depression in an intriguing clinical trial.

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https://x.com/Outdoctrination/status/1961398623905706264

This study was published in 2019 in Nutrients.

Participants were middle aged and were generally healthy.

They took 200 mg of L-Theanine per day for 4 weeks.

Prior to this, theanine's anti-stress properties were mainly noticed after a single dose, so they set out to see its effects over a more extended dosing period.

Zinc carnosine rapidly and powerfully reduces gut inflammation + heals digestion, even in severe cases.

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https://x.com/Outdoctrination/status/1886067127586820548

Zinc is known to be depleted in inflammatory bowel conditions,

and its levels directly are correlated with the severity and stage of the disease.

Worse inflammation = lower zinc, universally.

Zinc carnosine is a special form of zinc used overseas for various digestive ailments.

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You can literally clean out your brain doing this.

The GLYMPHATIC SYSTEM in the brain helps flush out various toxins from the cerebrospinal & interstitial fluids of the brain.

It might just be your behind fatigue, cognitive decline and even depression.

Here's how (🧵1/8): The brain produces cerebrospinal fluid from blood for a multitude of reasons.

Your neurons need it to fire properly, and it also physically protects your brain from damage and from being too heavy.

But perhaps the most important role of CSF is to enable glymphatic clearance.

If you CAN'T SLEEP, read this. Here are 6 KEYS to focus on you've been ignoring (🧵1/6):

#1 Glycine

Glycine has been shown to:

◇ Help stop nighttime urination
◇ Improve sleep satisfaction
◇ Improve daytime alertness

It acts as a neurotransmitter to promote sleep (NMDA).

https://x.com/Outdoctrination/status/1923353390672966063

#2 Undereating

Not saying to stuff your face, but if you undereat on total calories and especially on carbs - this can ruin your sleep by:

➜ Lowering leptin / raising orexin (prevents sleep)
➜ Increasing cortisol and other stress hormones

Ensure you're getting enough.

A groundbreaking new study shows that a mineral deficiency can drive Alzheimer's, and consuming it can reverse it.

(🧵1/10) The study was published last year in Nature.

While lithium is used as a drug in high doses for things like bipolar disorder, it is a naturally occurring mineral in some foods and water supplies.

Unexpectedly, it seems to play a major role in Alzheimer's.

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Hair loss / male pattern baldness is an inflammatory condition often driven by excess histamine - and antihistamines can regrow hair.

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https://x.com/Outdoctrination/status/1867925050768105492

This first study that looked at the antihistamine cetirizine for regrowing hair.

This is the same ingredient as Zyrtec allergy pills - just applied topically on the scalp.

They did this for 6 months.

A recent study showed that patients with a highly lethal cancer had their tumors shrink, with a 100% disease control rate when given a simple mineral.

(🧵1/7) Advanced non-small cell lung cancer is a brutal condition.

Only ~10% of people with it survive past 5 years.

This study sought to uncover the role of selenium in this cancer, and wanted to see if using it as a therapy could help.

Insane studies showed that polyester underwear destroys sperm and makes men infertile, and wrecks hormones while preventing pregnancy in women.

(🧵1/7) The most insane study of the bunch was in men, studying the effect of polyester underwear on fertility.

These men were well within reproductive age, and had all given birth to multiple children already.

I'll spare you the actual picture but they wore polyester slings around the scrotum like this (direct contact).

They had to wear these slings constantly for a year.

If you want to live longer, read this.

Here are 6 underrated tools that EXTEND LIFESPAN in research (🧵1/8):

#1 Glycine

Glycine increases lifespan by up to ~28% across different organisms.

https://x.com/Outdoctrination/status/1963941283434553483

Glycine counteracts the pro-aging effects of excess methionine, a major component of muscle meat.

It's able to do this through the GNMT enzyme - which absorbs extra methyl groups from methionine.

Those extra methyl groups otherwise alter global gene expression, disrupting several health promoting processes.

CAVITIES - A sign your internal health is deteriorating.

This is how they happen step by step and how to prevent them (🧵1/14): UNDERSTANDING THE TOOTH.

Teeth have multiple layers, with these top 2 being most relevant for cavities.

While we often think of teeth as just these rocks that are in our mouths, they're highly structured living tissues.

1. Enamel

This is the outermost layer of the tooth, where cavities most often hit.

It's made primarily of a mineral known as hydroxyapatite - a complex of calcium, phosphate and some other elements.

We have cells called ameloblasts which regenerate the enamel, but these only present during youth.

BUT this layer can remineralize passively, meaning it can without the need for these cells to a certain degree (more on that later).
2. Dentin
This is the layer right below the enamel, and unlike the enamel this can actively regenerate via cells called the odontoblasts.

However these cells can die off if you aren't careful, especially from bacterial antigens like endotoxin.

3. Pulp

This is the soft tissue containing nerves. If your cavity reaches here, you'll need a root canal or even get a tooth yanked.

The deeper a cavity goes into the tooth, the more it will hurt.

The key to understand here is that remineralization only really happens at the very early stages of the cavity. Once it gets deep enough, you're essentially screwed.

So DON'T WAIT. You want to act preventatively.

Vitamin C can powerfully reduce fatigue, even improving energy levels within hours in studies.

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https://x.com/Outdoctrination/status/1964678029747073264

This first study came out in 2008.

They were looking at people exhausted from work, and initiated 6 grams of vitamin C daily, for 2 weeks, as therapy.

They also measured other biomarkers to see if vitamin C improved anything else.

The results were amazing.

Autism is a mitochondrial disorder - and restoring their function can improve it, demonstrated beautifully in a recent trial.

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https://x.com/Outdoctrination/status/2027753174434529669

Mitochondrial dysfunction is any abnormality in this organelle's ability to generate energy or other substrates.

Depending on the criteria, anywhere from 5% up to 90% (in this study) of people with autism spectrum disorders suffer from some form of mitochondrial dysfunction.

Thus, the goal in this study was to identify that subset and treat accordingly.

DANDRUFF - An inflammatory / fungal sign your underlying health is deteriorating.

Let's go through exactly how it develops, what it means for your health, and some ways to help. (🧵1/13) The skin has multiple components.

The two we'll focus on here:

1. The epidermis. This is where the flakes are formed and where everything goes wrong.

2. The sebaceous gland. This is what produces sebum, an oil of the skin absolutely vital for this process.

BAKING SODA is strikingly helpful for improving sleep, according to a recent intriguing study.

(🧵1/7) This study was published in 2023, examining the effects of a baking soda bath versus normal showering or tap water baths.

They used ~1 cup of baking soda in the bath (1000 ppm).

This was done in a randomized fashion for 1 week.

10 mins per day before bed.

An intriguing study showed that vinegar reduces kidney stone incidence, and mapped out exactly how it does it.

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https://x.com/Outdoctrination/status/2005299119959499128

This study was published in 2019.

This research group previously uncovered that vinegar consumption was associated with >60% reduced odds of kidney stones.

They decided to test it themselves.

Coenzyme Q10 is a key factor aging - and supplementing it extends lifespan in multiple studies.

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https://x.com/Outdoctrination/status/1972277835591999550

I stumbled across this study a few months ago.

They gave animals on a "high PUFA diet" coenzyme q10 at 0.7 mg / kg bodyweight.

This dose is puny (7-8 mg human equivalent), and the "high PUFA diet" was under 5% PUFA, still way less than what the average person gets nowadays due to seed oils being in everything.

An incredible study showed major reductions in arterial plaques simply by shining a form of red light onto the body, more so than even statins.

(🧵1/7)

https://x.com/Outdoctrination/status/1762946202889490517

This was an animal study done in a classic model of heart disease, the high cholesterol diet in rabbits.

This diet causes them to rapidly develop atherosclerosis since they naturally consume none of it.

They also compared light therapy to statin.

Nicotine has some powerful anti-inflammatory effects, even improving things like autoimmunity and allergies in experiments.

(🧵1/8) More than a few studies have shown that nicotine consumers have lower rates of inflammatory conditions.

For instance, this study showed that the more snuff one consumed, the less MS they developed.

In some studies, even smoking is inversely associated with these conditions.

But is it just a statistical anomaly or a real effect?

I used to have DEBILITATING allergies every year.

Couldn't even go outside without breaking out into tears and itches.

Now I forget that they even exist.

This is what I learned about allergies - the 8 KEY ROOT CAUSES behind them (🧵1/12): There are a few chemical mediators that induce the symptoms of allergies:

- Histamine
- Serotonin
- Prostaglandins
- Leukotrienes
- Type 2 cytokines (IL-3, IL-4, IL-5, IL-9 IL-13)

These drive excess mucus production, itch, airway thickening / constriction, redness… everything.

The primary cells involved in releasing them are:

- Mast cells
- Eosinophils
- Basophils
- Neutrophils
- T Cells

This system is in place to protect us against things like parasites and foreign toxins. It helps us eliminate them effectively before they cause even more damage.

The question is, what causes the increased production of these chemicals from these cells unnecessarily?

Why do some people’s immune cells release more of these mediators in response to things that are harmless like pollen?

Taurine is one of the most important nutrients for the brain, serving a number of protective roles in cognitive aging and stroke.

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I was surprised to find out that taurine is actually the second most abundant amino acid in the central nervous system, behind glutamate.

Taurine levels in both the cerebrospinal fluid and certain brain regions are lower in people with Alzheimer's disease.

This has important consequences.