Mastic gum has the power to improve cavities, gingivitis, reduce dental plaques and has even been called a "potent antitumor agent" for oral cancer.

(🧵1/7) Mastic gum is made from the resin of the tree Pistacia lentiscus.

It's been used for over 2,000 years medicinally for various reasons,

but notably, it has some key antibacterial and anti-cancer properties, especially in the mouth.

A quick and easy way to lower stress and inflammation: HUMMING.

Humming is one of many ways that you can activate your parasympathetic nervous system through the VAGUS NERVE, completely for free.

Here are some other ways, and how they can benefit your health (🧵1/6):

https://x.com/Outdoctrination/status/2043712196132446395

Method #2: Diaphragmatic Breathing

This type of deep breathing results in structural changes throughout the abdominal cavity, diaphragm and esophagus.

This ends up directly stimulating the vagus nerve.

BPC-157 is one of the most famous peptides out there - with claims it's a borderline miracle cure for anything you can name.

Here's everything we know (& more importantly, don't know) about how it works (🧵1/10): BPC-157 is called such because it is literally known as "Body Protection Compound."

It's a string of 15 amino acids. It's also known as "stable gastric pentadecapeptide" because it doesn't break down much in stomach acid.

It is a synthetic peptide, but its structure is derived from a protein found naturally in the stomach.

Zinc has been called "The Wonder Drug for the Treatment of Cancers (Carcinomas)" by some researchers - and this is why: (🧵1/8)

https://x.com/Outdoctrination/status/1969795169529495952

What stands out first is that it's extremely common for zinc levels to be lower in cancerous tissue than in healthy tissue.

This is most exemplified in prostate cancer - across these studies an average decrease of over 60% in zinc levels.

Coconut oil has surprisingly potent antifungal properties, even against Candida.

(🧵1/8)

https://x.com/Outdoctrination/status/1912147168322109742

Coconut oil is a powerful antifungal, more than the leading drug fluconazole, in vitro.

Yep.

In cultured cells, coconut oil outperformed the standard antifungal prescription medication.

Autism is a mitochondrial disorder - and restoring their function can improve it, demonstrated beautifully in a recent trial.

(🧵1/8)
Mitochondrial dysfunction is any abnormality in this organelle's ability to generate energy or other substrates.

Depending on the criteria, anywhere from 5% up to 90% (in this study) of people with autism spectrum disorders suffer from some form of mitochondrial dysfunction.

Thus, the goal in this study was to identify that subset and treat accordingly.

You can literally clean out your brain by doing this.

It accumulates waste that makes you tired and ends up giving you dementia.

Luckily, these 7 techniques enhance its clearance to help keep your mind sharp.

#1 Sleeping on your side Side sleeping helps by:

◇ Allowing gravity to help move cerebrospinal fluid
◇ Reducing intracranial pressure
◇ Improving blood flow through the neck and head

This stimulates the clearance of the glymphatic system

Lactoferrin has "potent anti-obesity" effects, reducing visceral fat substantially within a few weeks, according to a remarkable study.

(🧵1/7)

https://x.com/Outdoctrination/status/2002518879386390678

This study came out in 2010 in the British Journal of Nutrition.

People were enrolled who had:

◈ BMI >25 kg/m2
◈ Visceral fat area >100 cm²

So they were "considered to be visceral fat-type obese, but had not been treated at an out-patient department and had no serious disease."

For those of you who don't know, visceral fat is the type of fat that accumulates around the organs and is much more inflammatory and metabolically dangerous.

They were given 300 mg of enteric coated lactoferrin per day for 8 weeks (or placebo).

A fascinating study showed that Vitamin E nearly doubles testosterone in response to stimulation, and by over 100 points at baseline.

(🧵1/8) Subjects were restricted to eating the diet the hospital put them on, with a consistent amount of vitamin (3-5 mg).

They were then put on 483 mg (724.5 IU) of vitamin E for 8 weeks.

This is a huge dose - over 30X the "recommended" daily amount.

It was also vitamin E acetate - a relatively poorly absorbed form of the vitamin.

(2/8)

Zinc can help shed body fat - independently of calories, multiple clinical trials have shown.

(🧵1/7) This study put people on weight loss diets of roughly ~300 calories fewer than baseline.

They were all overweight / obese measured by BMI.

30 mg of zinc as zinc sulfate or placebo was given in either group. This was done because zinc is a common deficiency in obesity.

15 weeks later, they found some astounding results.

Taurine is one of the most important nutrients for the brain, serving a number of protective roles in cognitive aging and stroke.

(🧵1/7)
I was surprised to find out that taurine is actually the second most abundant amino acid in the central nervous system, behind glutamate.

Taurine levels in both the cerebrospinal fluid and certain brain regions are lower in people with Alzheimer's disease.

This has important consequences.

Low dose naltrexone is legitimately a life changing drug for many - its anti-inflammatory benefits are able to help in a multitude of conditions. Let's talk about it. (🧵1/8) Naltrexone is classically an opioid antagonist.

At its normal doses (50-100 mg) it's used to block opioid signaling in conditions like addiction, which reduces dopamine output from drugs.

This makes it easier to get off the drugs.

However, when used at lower doses it has some amazing other actions.

Vinegar at ~1 tbsp reduces insulin response by up to 50% across multiple trials, a review article concluded.

(🧵1/8) This first paper is a review article from 2017.

They looked at studies giving people vinegar alongside meals and monitored their blood sugar and insulin responses.

Having high levels of these post meal is highly indicative of insulin resistance and is a risk for heart disease.

Apologies, I do not have the official PDF so I'm working with the raw file here.

The vitamin that NEVER gets talked about has more benefits than you can even count.

Mental health, boosting metabolism, gut health and even increasing testosterone.

Let's talk about the marvelous VITAMIN K2: This study showed that Vitamin K2 could treat depression.

K2 (as MK-7) improved depression at just 90 ug/day, a pretty puny dose, in 8 weeks.

K2 fulfills multiple roles in the body that gives it this effect.

The effect is very noticeable in my experience, it's an instant mood lifter.

Magnesium is often a missing link in tinnitus - and supplementing it can alleviate the ringing sensation. (🧵1/8) A short report in 2016 showed that serum magnesium levels were lower in people with tinnitus.

Keep in mind this was serum levels, typically the last place for magnesium to become depleted in.

But is this correlation or something real?

A captivating study showed that zinc carnosine is protective for leaky gut and stimulates repair of the gut lining. (🧵1/7) This was published in 2007 in the BMJ's GUT journal.

They actually ran multiple studies and published it in this one paper:

➜ A human study on leaky gut (intestinal permeability)
➜ Studies on repair and cell migration
➜ Analysis of gut damage and structure

If you want to live longer, read this.

These are the 7 KEYS TO EXTENDING LIFESPAN in research (🧵1/8):

https://x.com/Outdoctrination/status/2036803401745637824

The Basic Principle of Longevity

We can think of life fundamentally as growth + repair phases.

Growth phase: muscle building, tissue regeneration, immune cell proliferation, injury repair, and more. Very important.

Clean up phase: breakdown of damaged components, fat loss, fine-tuning immune cells

We need both, but in research it's typically thought of as:

Aging: excessive growth + damage accumulation

Lifespan promoting: growth restriction + damage removal

Most research focuses on the clean up phase for lifespan extension, and that's likely because we live in a time where signals for the growth phase tend to be abundant.

This is true, even in experimental animals - even "normal" animals are typically overfed.

We also need the growth phase for health, it coincides with having high thyroid, high T, low cortisol and more.

So keep that in mind as we go through the below - this is not to say that these always perfectly mimic real world conditions, but we will be going through what experimentally drives the aging process and what extends lifespan.

True health is unlocked when your body can go deep into the growth phase and deep into the cleanup phase, not being "stuck" in either phase, which leads to problems.

Wrinkles and other signs of skin aging can be reversed with an oral supplement of astaxanthin, a critical study concludes.

(🧵1/8) Astaxanthin is a powerful antioxidant found in red seafood like salmon and shrimp.

If you're unfamiliar, I've written more about what it is below.

This study pooled together all of the human studies done on astaxanthin.

Let's go through them.

(2/8)

N-acetylcysteine (NAC) was shown to reverse brain damage from aluminum in a critical study.

(🧵1/8) Animals were put into 6 groups - either getting aluminum or NAC or both.

The aluminum was administered as aluminum chloride, and it was done so orally.

This is important because roughly only 0.5% of oral aluminum chloride is absorbed, so the real effective doses the animals received were far less than than the 100 mg / kg.

This is still a high dose, but aluminum is known to accumulate in tissues.

Thiamine (vitamin B1) megadosing improved survival by over 8X in sepsis, a condition that kills ~20% of all people, in a recent study.

(🧵1/7) This study came out in 2024, looking at 2 different randomized clinical trials of thiamine (B1) usage in sepsis.

Sepsis is when there is bacterial leakage into the bloodstream in large amounts.

This causes massive inflammation that ultimately causes organ failure and often death.

Magnesium has the ability to shrink arterial plaques, demonstrated by some incredible clinical trials.

(🧵1/8)

https://x.com/Outdoctrination/status/1977744364244812001

This first study came out in 2008.

They gave people magnesium citrate, just under 100 mg elemental magnesium per day.

This is a puny dose, magnesium RDA is 4X that and people often supplement even more than that.

These studies are all in hemodialysis patients, and that's mainly because these people develop heart disease at a much quicker rate due to toxin accumulation and altered mineral balance.