Zinc can rapidly and potently reduce cortisol - shown in an astonishing clinical trial.

(🧵1/8) This study was a small one published in 1990.

Despite that, it gives us key insight into the role of zinc and how it regulates stress.

40% of people have this, and most don't even know it.

This is a fatty liver, and you can have it even if you're skinny.

If you do nothing about it, it can kill you.

Here's how it happens, and what to do to fix it: The liver is the body's central hub for metabolism, including that of fat.

The problems arise when the liver has more fat than it can deal with.

There are 3 sources of fat the liver deals with:

1. Fat from the diet
2. Fat it makes from carbs
3. Free fatty acids from the fat tissue

There are 2 ways the liver can get rid of fat:

1. Burn it for energy
2. Send it back into the blood for other organs

If you have more of the first 3 than the second 2, you get a fatty liver. Pretty simple - it's an imbalance of fat metabolism in the liver.

But what actually causes this imbalance?

Baking soda was shown to prevent death by 50-65% in sepsis - an incredibly common and lethal condition that kills 1/5 of all people.

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https://x.com/Outdoctrination/status/1773095227642802669

This paper was published in Frontiers in Pharmacology in 2023.

They investigated people who had gotten baking soda (sodium bicarbonate) IV treatment in sepsis with lactic acidosis.

The impact of sepsis is hard to overstate - up to 35% of people with it die, and it's responsible for roughly 20% of all deaths worldwide.

Sepsis is when bacteria leak into the bloodstream and cause body-wide mayhem.

Aspirin was recently shown to reduce liver fat by nearly 40% in a landmark study.

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https://x.com/Outdoctrination/status/1771573742331691290

This study was published early last year in JAMA.

They examined the response of people with fatty liver disease (now called "metabolic dysfunction-associated steatohepatitis") to aspirin.

They took a baby aspirin (81 mg) daily.

Nattokinase has some powerful heart disease protective properties - a research review has concluded.

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https://x.com/Outdoctrination/status/1988009439228502109

This review came out in 2023 in Reviews in Cardiovascular Medicine.

They looked at the eligible human studies examining nattokinase's impact on heart disease risk factors.

Here's what they found.

Isn't it crazy that the WHO literally admits that working the night shift causes cancer?

This is why - and how to make sure you're fully protected (🧵1/7): The conclusion was built off of multiple lines of evidence.

Studies like the two below showed 2-3X risk of cancers in people who work the night shift.

While not all studies showed the association, there is more than enough reason biologically to believe that this is one of the worst things you can do for your health.

The mitochondria is the powerhouse of the cell. That makes them the powerhouse of YOU and your entire life.

Here are 5 slept on tools to help you support them (🧵1/6):

#1 MitoQ

MitoQ is a modified form of coenzyme Q10 - designed to help it reach the mitochondria more efficiently. This gives it some amazing properties.

https://x.com/Outdoctrination/status/1963941283434553483

MitoQ works mainly as a mitochondrial targeted antioxidant.

A deficiency of antioxidants relative to reactive oxygen species within the mitochondria can both damage the structure of the mitochondria and reduce its energy generation capacity.

Most antioxidants work throughout the cell - mitoQ has the unique ability to target the mitochondria specifically.

Typically dosed at 10-20 mg.

You can reduce stress, inflammation and pain - no supplements, for free, using the power of PRESSURE POINTS.

Here are some of the key regions to hit (🧵1/6):

#1 EX-HN3

Known as the third eye - this point has been studied to reduce anxiety, blood pressure, breathing rate, and heart rate. The way this one works is by hitting the ophthalmic branch of the trigeminal nerve.

This nerve inputs to nucleus tractus solitarius - which is in the brainstem.

This region outputs to the vagus nerve, our primary calming / parasympathetic nerve.

Glycine, even in small amounts, can reduce blood sugar with a meal by >50% and improve insulin resistance, demonstrated in a striking study.

(🧵1/7)

https://x.com/Outdoctrination/status/2017229815116444114

This study was posted in the American Journal of Clinical Nutrition in 2002.

They thought that since gelatin, rich in glycine, is able to stimulate insulin secretion more than other proteins, that it might have an effect on blood sugar with a meal.

L-Theanine was shown to improve sleep and cognitive function, while reducing anxiety and depression in an intriguing clinical trial.

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https://x.com/Outdoctrination/status/1961398623905706264

This study was published in 2019 in Nutrients.

Participants were middle aged and were generally healthy.

They took 200 mg of L-Theanine per day for 4 weeks.

Prior to this, theanine's anti-stress properties were mainly noticed after a single dose, so they set out to see its effects over a more extended dosing period.

Zinc carnosine rapidly and powerfully reduces gut inflammation + heals digestion, even in severe cases.

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https://x.com/Outdoctrination/status/1886067127586820548

Zinc is known to be depleted in inflammatory bowel conditions,

and its levels directly are correlated with the severity and stage of the disease.

Worse inflammation = lower zinc, universally.

Zinc carnosine is a special form of zinc used overseas for various digestive ailments.

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You can literally clean out your brain doing this.

The GLYMPHATIC SYSTEM in the brain helps flush out various toxins from the cerebrospinal & interstitial fluids of the brain.

It might just be your behind fatigue, cognitive decline and even depression.

Here's how (🧵1/8): The brain produces cerebrospinal fluid from blood for a multitude of reasons.

Your neurons need it to fire properly, and it also physically protects your brain from damage and from being too heavy.

But perhaps the most important role of CSF is to enable glymphatic clearance.

If you CAN'T SLEEP, read this. Here are 6 KEYS to focus on you've been ignoring (🧵1/6):

#1 Glycine

Glycine has been shown to:

◇ Help stop nighttime urination
◇ Improve sleep satisfaction
◇ Improve daytime alertness

It acts as a neurotransmitter to promote sleep (NMDA).

https://x.com/Outdoctrination/status/1923353390672966063

#2 Undereating

Not saying to stuff your face, but if you undereat on total calories and especially on carbs - this can ruin your sleep by:

➜ Lowering leptin / raising orexin (prevents sleep)
➜ Increasing cortisol and other stress hormones

Ensure you're getting enough.

A groundbreaking new study shows that a mineral deficiency can drive Alzheimer's, and consuming it can reverse it.

(🧵1/10) The study was published last year in Nature.

While lithium is used as a drug in high doses for things like bipolar disorder, it is a naturally occurring mineral in some foods and water supplies.

Unexpectedly, it seems to play a major role in Alzheimer's.

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Hair loss / male pattern baldness is an inflammatory condition often driven by excess histamine - and antihistamines can regrow hair.

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https://x.com/Outdoctrination/status/1867925050768105492

This first study that looked at the antihistamine cetirizine for regrowing hair.

This is the same ingredient as Zyrtec allergy pills - just applied topically on the scalp.

They did this for 6 months.

A recent study showed that patients with a highly lethal cancer had their tumors shrink, with a 100% disease control rate when given a simple mineral.

(🧵1/7) Advanced non-small cell lung cancer is a brutal condition.

Only ~10% of people with it survive past 5 years.

This study sought to uncover the role of selenium in this cancer, and wanted to see if using it as a therapy could help.

Insane studies showed that polyester underwear destroys sperm and makes men infertile, and wrecks hormones while preventing pregnancy in women.

(🧵1/7) The most insane study of the bunch was in men, studying the effect of polyester underwear on fertility.

These men were well within reproductive age, and had all given birth to multiple children already.

I'll spare you the actual picture but they wore polyester slings around the scrotum like this (direct contact).

They had to wear these slings constantly for a year.

If you want to live longer, read this.

Here are 6 underrated tools that EXTEND LIFESPAN in research (🧵1/8):

#1 Glycine

Glycine increases lifespan by up to ~28% across different organisms.

https://x.com/Outdoctrination/status/1963941283434553483

Glycine counteracts the pro-aging effects of excess methionine, a major component of muscle meat.

It's able to do this through the GNMT enzyme - which absorbs extra methyl groups from methionine.

Those extra methyl groups otherwise alter global gene expression, disrupting several health promoting processes.

CAVITIES - A sign your internal health is deteriorating.

This is how they happen step by step and how to prevent them (🧵1/14): UNDERSTANDING THE TOOTH.

Teeth have multiple layers, with these top 2 being most relevant for cavities.

While we often think of teeth as just these rocks that are in our mouths, they're highly structured living tissues.

1. Enamel

This is the outermost layer of the tooth, where cavities most often hit.

It's made primarily of a mineral known as hydroxyapatite - a complex of calcium, phosphate and some other elements.

We have cells called ameloblasts which regenerate the enamel, but these only present during youth.

BUT this layer can remineralize passively, meaning it can without the need for these cells to a certain degree (more on that later).
2. Dentin
This is the layer right below the enamel, and unlike the enamel this can actively regenerate via cells called the odontoblasts.

However these cells can die off if you aren't careful, especially from bacterial antigens like endotoxin.

3. Pulp

This is the soft tissue containing nerves. If your cavity reaches here, you'll need a root canal or even get a tooth yanked.

The deeper a cavity goes into the tooth, the more it will hurt.

The key to understand here is that remineralization only really happens at the very early stages of the cavity. Once it gets deep enough, you're essentially screwed.

So DON'T WAIT. You want to act preventatively.

Vitamin C can powerfully reduce fatigue, even improving energy levels within hours in studies.

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https://x.com/Outdoctrination/status/1964678029747073264

This first study came out in 2008.

They were looking at people exhausted from work, and initiated 6 grams of vitamin C daily, for 2 weeks, as therapy.

They also measured other biomarkers to see if vitamin C improved anything else.

The results were amazing.

Autism is a mitochondrial disorder - and restoring their function can improve it, demonstrated beautifully in a recent trial.

(🧵1/8)

https://x.com/Outdoctrination/status/2027753174434529669

Mitochondrial dysfunction is any abnormality in this organelle's ability to generate energy or other substrates.

Depending on the criteria, anywhere from 5% up to 90% (in this study) of people with autism spectrum disorders suffer from some form of mitochondrial dysfunction.

Thus, the goal in this study was to identify that subset and treat accordingly.