GABA can suppress cortisol by its action in the brain.
The hypothalamus produces CRH ➞ pituitary to produce ACTH ➞ adrenals to produce cortisol.
GABA input to the hypothalamus calms these neurons, preventing CRH release and cortisol production.
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Sep 13 • 9 tweets • 5 min read
Ivermectin has some striking anti-cancer properties.
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A study came out earlier this year in Nature, one of the biggest biology journals on the planet.
The big finding was that Ivermectin turned "cold tumors" into "hot tumors" - essentially meaning they were more likely to be seen and destroyed by the immune system.
Thus, it induced immunogenic cancer cell death (ICD).
CD4 + CD8 are markers for immune cells called T cells - as you can see they were in greater amounts around the tumor with ivermectin.
This shrank breast tumors.
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Sep 11 • 8 tweets • 5 min read
Bluetooth headphones might cause serious damage, new research has shown.
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This study was published last year in Nature.
While it is an epidemiological study, the researchers implemented several techniques to minimize confounding variables.
They did this by "matching" people with Propensity Score Matching (PSM).
That means they found a "twin" for each person (similar in all measured aspects like age, sex, obesity, smoking etc.) - one using and one not using bluetooth headphones.
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Sep 11 • 10 tweets • 4 min read
Aspirin is as effective as Cialis for erectile dysfunction - an unexpected finding from a recent study shows.
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This study was published in 2019, investigating men with vascular ED.
Aspirin was compared to tadalafil (Cialis) head to head.
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Sep 10 • 7 tweets • 3 min read
Apple cider vinegar can shed ~7 pounds a month and reduce insulin resistance, a new study demonstrates.
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This study was published last year in the prestigious British Medical Journal.
Magnesium rapidly (15 mins) and completely stops headaches, including migraines, in the vast majority of people.
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We have three oldish studies on this protocol, which is 1 gram of magnesium sulfate administered intravenously.
That's around 200 mg of elemental magnesium.
In this first paper, 40 people came to the clinic with various forms of headache, including chronic migraines.
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Sep 9 • 9 tweets • 4 min read
Collagen can reverse aging in the brain, even in small amounts, according to a recent study.
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This study was published in 2019 in the Journal of Nutrients.
Healthy patients age 49-63 received just 5g of collagen a day, a bit over a teaspoon.
They got imaging on their brains to see the structural impacts collagen would have, along with tests on memory and learning.
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Sep 8 • 9 tweets • 5 min read
Fatty liver was completely reversed using one simple, cheap supplement, in a fascinating study.
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This was a small experiment done in the late 90s, and somehow it's never been investigated since clinically.
They gave children 2-6g of taurine per day for several months, in some cases over a year.
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Sep 7 • 26 tweets • 10 min read
This is the MOST important thing to understand about health.
The antioxidant system protects you from every disease + aging.
But antioxidants aren't just about berries and chocolate.
Here's what you need to know to make yours in the top 1%
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Why do we need antioxidants?
Every moment we are exposed to what are called reactive oxygen species (ROS).
These are molecules related to oxygen that are highly reactive, and:
◈ Damage every structural component of the cell (proteins, lipids, DNA)
◈ Dysregulates cell signaling
◈ Turns on inflammation
◈ Shuts down energy production
Literally every single disease is driven by these processes - collectively known as oxidative stress.
I can't stress enough how important it is.
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Sep 7 • 11 tweets • 4 min read
Vitamin C can reduce cortisol by ~40%, according to a critical new study.
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This study was published last year, examining the effects of 1g of vitamin C per day in people with high stress hormones.
Vitamin C is known to be stored in the adrenal glands and released in times of stress.
A few previous studies suggested adding vitamin C could lower cortisol.
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Sep 5 • 8 tweets • 4 min read
Want to live longer? Here are 7 tools shown to extend lifespan in research (🧵1/7):
#1 Glycine + NAC
The combination increases lifespan by ~25%.
As precursors to the master antioxidant glutathione, this combination:
✓ Reduces organ damage
✓ Preserves mitochondrial function
at 1.6 g / kg of food (human equivalent) for each.
#2 Aspirin (males only)
Aspirin has multiple actions that prevent the core processes of aging:
◇ Inflammation
◇ Oxidative stress
and has shown benefit in reducing cancer and heart disease in humans.
Carbs are super fuel for testosterone - here is every reason why.
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#1 The leydig cells (in the testicles) rely heavily on glucose.
Steroids are actually made in the mitochondria.
When LH acts on the leydig cells to produce testosterone - the mitochondria need energy production from glucose (glycolysis) to synthesize testosterone.
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Sep 4 • 9 tweets • 4 min read
One nutrient can powerfully reduce Candida, even in small amounts.
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One recent study investigated the effects of just 300 IU of vitamin D (vs placebo) in children.
Candida is very common after broad spectrum antibiotics or during immunosuppression - and these kids were very susceptible.
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Sep 3 • 10 tweets • 4 min read
Cancer starts in the mitochondria, & fixing them might treat it - a groundbreaking study shows it more clearly than ever.
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The metabolic origins of cancer have been known for about a century.
Nobel prize winner Otto Warburg noted that cancer cells had inefficient metabolism - they turned glucose into lactic acid preferentially, instead of into CO2.
Why this helps cancer grow has been revealed more recently.
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Sep 2 • 6 tweets • 3 min read
5 signs your health is deteriorating (that you've been ignoring):
(🧵1/5)
#1 Tinnitus (ringing in the ears)
Underlying causes:
◈ High glutamate
◈ Low GABA (both in the nerves of the ear)
◈ Nerve inflammation
Hiccups are triggered by contractions of the diaphragm, which is controlled by the brain / nervous system.
Hiccups are "always" cured with carbon dioxide.
Exposing people to high levels of CO2 stops hiccups within 5-7 minutes.
High levels of CO2 signal the diaphragm to stop.
Can increase CO2 with diaphragmatic or bag breathing, but low CO2 is caused by low metabolism.
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Sep 2 • 10 tweets • 4 min read
Niacinamide (vitamin B3) reduces dandruff by over 75%, a remarkable study shows.
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This study investigated the impact of a topical (4%) niacinamide cream on seborrheic dermatitis.
This is the condition that causes flaking of the skin and inflammation, including dandruff.
The cream (or placebo) was applied once per day.
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Sep 1 • 9 tweets • 3 min read
Creatine might raise IQ.
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The first study investigating this topic was in 2003.
They took vegetarians in their mid 20s and gave them 5g of (or placebo) for 6 weeks, then no creatine for 6 weeks, and then switched groups for another 6 weeks.
The break was done to see if any benefit went away without creatine.
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Aug 31 • 7 tweets • 3 min read
A new study has shown that grounding boosts metabolism & reduces free radical production in the mitochondria.
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This study was published in June.
Grounding has shown multiple benefits, including:
- Reduction of inflammation
- Normalization of cortisol
- Decreased fatigue
- Lower blood sugar
So the goal here was to get a deeper understanding of how.
Bone broth can drastically lower inflammation in the gut, as shown by a recent study.
(🧵1/7)
The broth in this study was prepared by:
✧ Bone source & prep → Bovine femur bones (100–130 g), cut crosswise, commercially obtained
✧ Cleaning → Washed 3× in distilled water at 50 °C for 15 min to remove meat/fat/blood
✧ Cooking setup → Slow cooker, bone-to-water ratio 1:4
✧ Acidified water → 20 mL white vinegar per 1 L distilled water, boiled before adding bones
✧ Cooking process → Simmered 8 h at 100°C, volume maintained with acidified water
✧ Post-cooking → Cooled 3 h at room temp, refrigerated 6 h at 4 °C
✧ Filtering → Bones and fat removed via funnel with cotton gauze
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Aug 29 • 12 tweets • 4 min read
Hair growth can be powerfully stimulated with the right nutrients, as shown by a recent study.