Coenzyme Q10 is a key factor aging - and supplementing it extends lifespan in multiple studies.

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https://x.com/Outdoctrination/status/1972277835591999550

I stumbled across this study a few months ago.

They gave animals on a "high PUFA diet" coenzyme q10 at 0.7 mg / kg bodyweight.

This dose is puny (7-8 mg human equivalent), and the "high PUFA diet" was under 5% PUFA, still way less than what the average person gets nowadays due to seed oils being in everything.

An incredible study showed major reductions in arterial plaques simply by shining a form of red light onto the body, more so than even statins.

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https://x.com/Outdoctrination/status/1762946202889490517

This was an animal study done in a classic model of heart disease, the high cholesterol diet in rabbits.

This diet causes them to rapidly develop atherosclerosis since they naturally consume none of it.

They also compared light therapy to statin.

Nicotine has some powerful anti-inflammatory effects, even improving things like autoimmunity and allergies in experiments.

(🧵1/8) More than a few studies have shown that nicotine consumers have lower rates of inflammatory conditions.

For instance, this study showed that the more snuff one consumed, the less MS they developed.

In some studies, even smoking is inversely associated with these conditions.

But is it just a statistical anomaly or a real effect?

I used to have DEBILITATING allergies every year.

Couldn't even go outside without breaking out into tears and itches.

Now I forget that they even exist.

This is what I learned about allergies - the 8 KEY ROOT CAUSES behind them (🧵1/12): There are a few chemical mediators that induce the symptoms of allergies:

- Histamine
- Serotonin
- Prostaglandins
- Leukotrienes
- Type 2 cytokines (IL-3, IL-4, IL-5, IL-9 IL-13)

These drive excess mucus production, itch, airway thickening / constriction, redness… everything.

The primary cells involved in releasing them are:

- Mast cells
- Eosinophils
- Basophils
- Neutrophils
- T Cells

This system is in place to protect us against things like parasites and foreign toxins. It helps us eliminate them effectively before they cause even more damage.

The question is, what causes the increased production of these chemicals from these cells unnecessarily?

Why do some people’s immune cells release more of these mediators in response to things that are harmless like pollen?

Taurine is one of the most important nutrients for the brain, serving a number of protective roles in cognitive aging and stroke.

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I was surprised to find out that taurine is actually the second most abundant amino acid in the central nervous system, behind glutamate.

Taurine levels in both the cerebrospinal fluid and certain brain regions are lower in people with Alzheimer's disease.

This has important consequences.

Autism was substantially improved with just a few 5 minute red light sessions, reducing behavioral symptoms by over 50% in a fascinating study.

(🧵1/8) This study was published in 2018.

Children with autism were given a 635 nm (red) light therapy, administered as either a laser or LED (placebo) light.

While the lights were the same wavelength, the laser is more effective because of its superior:

◇ Spot area
◇ Coherence
◇ Power / intensity

compared to the LED.

They gave the children just twice weekly 5 min sessions at the base of the skull and temporal areas of the skull, for 4 weeks total.

The results were stunning.

Your gut is crying for help - here are 5 signs it's giving you that you've been ignoring (🧵1/10):

#1 Coated tongue

This is SO common, yet people just brush their tongue and forget about it.

This coating is literally intestinal bacteria or fungi accumulating on your tongue. Your gut is connected directly to your mouth.

If you have:

➜ Bacterial overgrowth (SIBIO)
➜ Candida
➜ Poor gut motility

these microbes will be abundant and move UP the gut, eventually on to your tongue.

See this all the time with our clients.

Combining L-Theanine with caffeine can produce some therapeutic effects in ADHD by modulating brain activity networks.

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https://x.com/Outdoctrination/status/1877384078619554207

The inability to pay attention in ADHD is not just a feeling, it's a well characterized system in the brain.

There is a brain network known as the default mode network.

This network is several brain regions coordinating together in processes like daydreaming, and can be seen on fMRI scans.

Children with ADHD have higher reactivity of the posterior DMN (precuneus region) during tasks.

ANOTHER one of the most impressive studies in recent memory found that the combination of NAC + Glycine has remarkable anti-aging effects in nearly every metric.

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https://x.com/Outdoctrination/status/1952777425932148765

This study came out in 2021.

Both older (71-80 years old) and young (21-30 y/o) people were enrolled.

The older folks got a large dose:

◇ Glycine: ~7 g/day
◇ NAC: ~9 g/day (≈ 6.9 g cysteine equivalent)

for 24 weeks.

This doesn't necessarily mean that one has to take this much, since this was measuring a relatively short period of time on the elderly, so they were trying to up their stores rapidly.

Typically, a maintenance dose of NAC is 1.2-2.4g, and glycine 3-6g.

Magnesium has the ability to shrink arterial plaques, demonstrated by some incredible clinical trials.

(🧵1/8) This first study came out in 2008.

They gave people magnesium citrate, just under 100 mg elemental magnesium per day.

This is a puny dose, magnesium RDA is 4X that and people often supplement even more than that.

These studies are all in hemodialysis patients, and that's mainly because these people develop heart disease at a much quicker rate due to toxin accumulation and altered mineral balance.

Aluminum from vaccines is likely causing neurotoxicity, and we are misled about that fact from public health authorities.

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https://x.com/Outdoctrination/status/2020490038870433827

The narrative that most doctors / public health agencies say around this topic is that:

1. It's a small amount of aluminum, in comparison to how much we are exposed to through diet.

2. It stays at the injection site, never migrating to the brain or other tissues.

3. It gets filtered out by the kidneys nice and easy no problem

Unfortunately, these are all only half true, and experimental evidence shows that injected aluminum in low amounts can indeed cause problems.

Vitamin K2 has some striking anti-cancer properties, massively reducing liver cancer risk in multiple studies.

(🧵1/8) This first study came out in 2004 in JAMA.

Women with viral cirrhosis (liver damage from hepatitis C mainly) came in expecting a supplement that would simply help their bones.

However, something incredible happened.

Those receiving 45 mg K2 per day as MK4 had an 80% reduction in risk of developing liver cancer (HCC).

When adjusting for other factors, that risk reduction jumped to 87%.

Vitamin B1 (thiamine) megadosing can massively reduce fatigue, in many cases reversing it entirely.

(🧵1/20) This first study was a small pilot study conducted about a decade ago.

Anywhere from 600-1500 mg of B1 was used, depending on the weight of the patient.

The results were stunning.

10/12 patients had a complete reversal of fatigue.

The other two saw reductions by 50% and 66%.

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There's a 94% chance you're low on this vitamin.

It impacts nearly every disease and aging process imaginable.

VITAMIN E is one of the most multifaceted tools to maintain your health.

Here's why (🧵1/15): Vitamin E does a few things that make it so powerful:

1. Prevents the destruction of polyunsaturated fats (think seed oil)
2. Lowers inflammation (from these fats)
3. Counteracts estrogen

These 3 processes alone are involved for the vast majority of health issues.

Iron can actually SHORTEN your lifespan and age you on a cellular level.

(🧵1/10) This study was published in 2024, investigating the effects of iron chelation on age related parameters.

They used a common aging animal model - a Klotho knockout animal.

Animals are known to have shorter lifespans without this gene, and longer lifespans with more of it.

They gave them a drug called deferiprone, which binds up free iron and gets rid of it.

Put your finger on your wrist like this right now.

I can tell you more about your health on this alone than with $100s in lab tests.

Ready? This is what it means (🧵1/8): What you are feeling is your radial artery in your wrist area.

This tells you your:

◇ Heart rate (duh)
◇ Pulse amplitude

Both of these give you a ton of information on your health - in real time.

Let's talk about your heart rate first

Aged garlic was shown to shrink arterial plaques in a landmark clinical trial.

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https://x.com/Outdoctrination/status/1988009439228502109

This study was published in 2019, examining people with diabetes with plaque in the coronary artery.

This is the primary place where if plaque forms, you're susceptible to a heart attack.

N-acetylcysteine (NAC) was shown to reverse brain damage from aluminum in a critical study.

(🧵1/8) Animals were put into 6 groups - either getting aluminum or NAC or both.

The aluminum was administered as aluminum chloride, and it was done so orally.

This is important because roughly only 0.5% of oral aluminum chloride is absorbed, so the real effective doses the animals received were far less than than the 100 mg / kg.

This is still a high dose, but aluminum is known to accumulate in tissues.

Vinegar drastically reduces blood sugar and insulin levels, according to multiple clinical trials.

(🧵1/7) This first paper is a review article from 2017.

They looked at studies giving people vinegar alongside meals and monitored their blood sugar and insulin responses.

Having high levels of these post meal is highly indicative of insulin resistance and is a risk for heart disease.

Apologies, I do not have the official PDF so I'm working with the raw file here.

Why you SHOULDN'T be hysterical about vitamin C causing kidney stones, and what to do to prevent them (🧵1/10): The idea that vitamin C supplementation can cause kidney stones is not completely baseless, but it does lack context.

Ascorbic acid, or vitamin C, can get metabolized in our cells to create oxalate.

Oxalate is what binds to calcium to form kidney stones in most people.

Seems pretty straightforward, BUT...

FLUORIDE: The toxin in your water that destroys thyroid function.

Here's how, and what to do about it.

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In 2024 a massive review of studies was done on the effects of fluoride exposure and markers of thyroid health.

The higher the fluoride concentration in:

◈ Drinking water
◈ Urine
◈ Serum

the higher the TSH level was - a marker of primary hypothyroidism.

TSH rises when the thyroid gland does not respond to stimulation.