Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Dalton (Analyze & Optimize) Profile picture
Dalton (Analyze & Optimize)
@Outdoctrination
Biomolecular Engineer. Helping people virtually worldwide with a personalized approach. Book a free call here to work with us: https://t.co/zanpmphTQB
Jun 6 ā€¢ 9 tweets ā€¢ 4 min read
Wrinkles and other signs of skin aging can be reversed with an oral supplement of astaxanthin, a critical study concludes.

(šŸ§µ1/8)Image Astaxanthin is a powerful antioxidant found in red seafood like salmon and shrimp.

If you're unfamiliar, I've written more about what it is below.

This study pooled together all of the human studies done on astaxanthin.

Let's go through them.

(2/8) Image
Jun 5 ā€¢ 9 tweets ā€¢ 4 min read
N-acetylcysteine (NAC) was shown to reverse brain damage from aluminum in a critical study.

(šŸ§µ1/8)Image Animals were put into 6 groups - either getting aluminum or NAC or both.

The aluminum was administered as aluminum chloride, and it was done so orally.

This is important because roughly only 0.5% of oral aluminum chloride is absorbed, so the real effective doses the animals received were far less than than the 100 mg / kg.

This is still a high dose, but aluminum is known to accumulate in tissues.Image
Jun 4 ā€¢ 10 tweets ā€¢ 4 min read
Thiamine (vitamin B1) megadosing improved survival by over 8X in sepsis, a condition that kills ~20% of all people, in a recent study.

(šŸ§µ1/7)Image This study came out in 2024, looking at 2 different randomized clinical trials of thiamine (B1) usage in sepsis.

Sepsis is when there is bacterial leakage into the bloodstream in large amounts.

This causes massive inflammation that ultimately causes organ failure and often death.Image
May 31 ā€¢ 9 tweets ā€¢ 5 min read
Magnesium has the ability to shrink arterial plaques, demonstrated by some incredible clinical trials.

(šŸ§µ1/8)Image This first study came out in 2008.

They gave people magnesium citrate, just under 100 mg elemental magnesium per day.

This is a puny dose, magnesium RDA is 4X that and people often supplement even more than that.

These studies are all in hemodialysis patients, and that's mainly because these people develop heart disease at a much quicker rate due to toxin accumulation and altered mineral balance.Image
May 30 ā€¢ 11 tweets ā€¢ 6 min read
ANOTHER one of the most impressive studies in recent memory found that the combination of NAC + Glycine has remarkable anti-aging effects in nearly every metric.

(šŸ§µ1/8)Image
Image This study came out in 2021.

Both older (71-80 years old) and young (21-30 y/o) people were enrolled.

The older folks got a large dose:

ā—‡ Glycine: ~7 g/day
ā—‡ NAC: ~9 g/day (ā‰ˆ 6.9 g cysteine equivalent)

for 24 weeks.

This doesn't necessarily mean that one has to take this much, since this was measuring a relatively short period of time on the elderly, so they were trying to up their stores rapidly.

Typically, a maintenance dose of NAC is 1.2-2.4g, and glycine 3-6g.Image
May 27 ā€¢ 7 tweets ā€¢ 4 min read
Vitamin C is a powerful blood pressure reducer - dropping blood pressure by up to 20 points, shown in a meta analysis.

(šŸ§µ1/7)Image This review paper was released in 2020, examining the available human randomized clinical trials on vitamin C and blood pressure.

They ended up gathering 8 studies in total, and they paint a clear picture. Image
May 24 ā€¢ 22 tweets ā€¢ 11 min read
If you CAN'T SLEEP well - read this.

This is the ULTIMATE GUIDE to optimizing sleep: to fall asleep and stay asleep effortlessly by addressing the root causes (šŸ§µ1/15):Image First and foremost we must discuss the circadian rhythm.

This is the primary governor of your sleep. If your body doesn't even know what time it is, how can you expect it to be ready to fall asleep?

Of course, the main focus here is going to be melatonin, a central circadian regulating molecule that signals darkness and sleepiness.

Melatonin is formed from the amino acid tryptophan, which we get in the diet from protein.

In order to get from tryptophan to melatonin, the body requires:

ā—‡ Iron
ā—‡ Vitamin C
ā—‡ Vitamin B5
ā—‡ Vitamin B6
ā—‡ Healthy methylation
ā—‡ Good mitochondrial function

In fact, melatonin is actually synthesized within the mitochondria.Image
May 21 ā€¢ 7 tweets ā€¢ 3 min read
5 WARNING SIGNS that are "normal," that are really your body crying for help.

#1 Waking up to pee at night

Your body has hormonal / metabolic signals to ensure you don't wake up to pee.

Not enough:

ā—‡ Vitamin C
ā—‡ Zinc
ā—‡ Salt
ā—‡ Potassium

Can cause this.Image I did a full thread on the exact mechanisms behind how this happens, so be sure to check that out for more.
May 13 ā€¢ 9 tweets ā€¢ 5 min read
Red light can literally reduce fat in the belly / waist area via spot reduction, some fascinating research shows. (šŸ§µ1/8)Image This first study examined the effects of a red laser on waist reduction (DOI 10.1007/s11695-010-0126-y)

They gave subjects a red laser at 635-680 nm, 1.2 to 3.6 J/cmĀ².

30 min twice a week for 4 weeks.

After every session, there was a measurable reduction in waistline.

After the 8th session, this amounted to a >2cm reduction.

When people were asked to rate how much their appearance improved around the waist - they answered a 1.2 on a scale up to 3.

Placebo? 0/3.Image
Image
May 12 ā€¢ 10 tweets ā€¢ 5 min read
Magnesium + potassium combination lowered cortisol by ~45% and completely eliminated severe insomnia in a recent clinical trial.

(šŸ§µ1/7)Image They gave type 2 diabetics with sleep disorders one of four treatments:

ā—‡ Placebo (T1)
ā—‡ Magnesium (Mg, T2)
ā—‡ Potassium (K, T3)
ā—‡ A combination of Mg and K (T4)

each at 250 mg - for 2 months. Keep in mind this is a puny amount of potassium.

The results were astonishing. Image
May 10 ā€¢ 4 tweets ā€¢ 1 min read
if people actually knew how much of hair loss is dictated by mitochondrial function we wouldn't have brothers losing their manhood to DHT inhibition Image
May 4 ā€¢ 9 tweets ā€¢ 4 min read
Calorie restriction can increase lifespan by ~40% - but a stunning study showed that it's NOT because of fat loss or insulin sensitivity.

In fact, the animals who were the fattest actually lived the longest! (šŸ§µ1/8):Image This was a landmark study in 2024 that examined genetically diverse animals.

They also looked at nearly 1,000 mice in total.

This gave them a ton of certainty in the measurements since you can't just chalk it up to one type of mouse having the effect.

Groups were either 1 day of fasting, 2 days, control, 20% calorie restriction or 40%.
Apr 24 ā€¢ 9 tweets ā€¢ 4 min read
Zinc can rapidly and potently reduce cortisol - shown in an astonishing clinical trial.

(šŸ§µ1/8)Image This study was a small one published in 1990.

Despite that, it gives us key insight into the role of zinc and how it regulates stress. Image
Image
Apr 22 ā€¢ 32 tweets ā€¢ 11 min read
40% of people have this, and most don't even know it.

This is a fatty liver, and you can have it even if you're skinny.

If you do nothing about it, it can kill you.

Here's how it happens, and what to do to fix it:Image The liver is the body's central hub for metabolism, including that of fat.

The problems arise when the liver has more fat than it can deal with.

There are 3 sources of fat the liver deals with:

1. Fat from the diet
2. Fat it makes from carbs
3. Free fatty acids from the fat tissue

There are 2 ways the liver can get rid of fat:

1. Burn it for energy
2. Send it back into the blood for other organs

If you have more of the first 3 than the second 2, you get a fatty liver. Pretty simple - it's an imbalance of fat metabolism in the liver.

But what actually causes this imbalance?Image
Apr 21 ā€¢ 8 tweets ā€¢ 4 min read
Baking soda was shown to prevent death by 50-65% in sepsis - an incredibly common and lethal condition that kills 1/5 of all people.

(šŸ§µ1/7)Image This paper was published in Frontiers in Pharmacology in 2023.

They investigated people who had gotten baking soda (sodium bicarbonate) IV treatment in sepsis with lactic acidosis.

The impact of sepsis is hard to overstate - up to 35% of people with it die, and it's responsible for roughly 20% of all deaths worldwide.

Sepsis is when bacteria leak into the bloodstream and cause body-wide mayhem.Image
Apr 20 ā€¢ 9 tweets ā€¢ 4 min read
Aspirin was recently shown to reduce liver fat by nearly 40% in a landmark study.

(šŸ§µ1/7)Image
Image This study was published early last year in JAMA.

They examined the response of people with fatty liver disease (now called "metabolic dysfunction-associated steatohepatitis") to aspirin.

They took a baby aspirin (81 mg) daily. Image
Apr 19 ā€¢ 9 tweets ā€¢ 4 min read
Nattokinase has some powerful heart disease protective properties - a research review has concluded.

(šŸ§µ1/7)Image This review came out in 2023 in Reviews in Cardiovascular Medicine.

They looked at the eligible human studies examining nattokinase's impact on heart disease risk factors.

Here's what they found. Image
Apr 14 ā€¢ 8 tweets ā€¢ 5 min read
Isn't it crazy that the WHO literally admits that working the night shift causes cancer?

This is why - and how to make sure you're fully protected (šŸ§µ1/7):Image The conclusion was built off of multiple lines of evidence.

Studies like the two below showed 2-3X risk of cancers in people who work the night shift.

While not all studies showed the association, there is more than enough reason biologically to believe that this is one of the worst things you can do for your health.Image
Image
Apr 14 ā€¢ 7 tweets ā€¢ 4 min read
The mitochondria is the powerhouse of the cell. That makes them the powerhouse of YOU and your entire life.

Here are 5 slept on tools to help you support them (šŸ§µ1/6):

#1 MitoQ

MitoQ is a modified form of coenzyme Q10 - designed to help it reach the mitochondria more efficiently. This gives it some amazing properties.Image MitoQ works mainly as a mitochondrial targeted antioxidant.

A deficiency of antioxidants relative to reactive oxygen species within the mitochondria can both damage the structure of the mitochondria and reduce its energy generation capacity.

Most antioxidants work throughout the cell - mitoQ has the unique ability to target the mitochondria specifically.

Typically dosed at 10-20 mg.Image
Apr 13 ā€¢ 7 tweets ā€¢ 4 min read
You can reduce stress, inflammation and pain - no supplements, for free, using the power of PRESSURE POINTS.

Here are some of the key regions to hit (šŸ§µ1/6):

#1 EX-HN3

Known as the third eye - this point has been studied to reduce anxiety, blood pressure, breathing rate, and heart rate. The way this one works is by hitting the ophthalmic branch of the trigeminal nerve.

This nerve inputs to nucleus tractus solitarius - which is in the brainstem.

This region outputs to the vagus nerve, our primary calming / parasympathetic nerve. Image
Image
Apr 11 ā€¢ 9 tweets ā€¢ 4 min read
Glycine, even in small amounts, can reduce blood sugar with a meal by >50% and improve insulin resistance, demonstrated in a striking study.

(šŸ§µ1/7)Image This study was posted in the American Journal of Clinical Nutrition in 2002.

They thought that since gelatin, rich in glycine, is able to stimulate insulin secretion more than other proteins, that it might have an effect on blood sugar with a meal. Image