If you CAN'T SLEEP, read this. Here are 6 KEYS to focus on you've been ignoring (🧵1/6):

#1 Glycine

Glycine has been shown to:

◇ Help stop nighttime urination
◇ Improve sleep satisfaction
◇ Improve daytime alertness

It acts as a neurotransmitter to promote sleep (NMDA).

https://x.com/Outdoctrination/status/1923353390672966063

#2 Undereating

Not saying to stuff your face, but if you undereat on total calories and especially on carbs - this can ruin your sleep by:

➜ Lowering leptin / raising orexin (prevents sleep)
➜ Increasing cortisol and other stress hormones

Ensure you're getting enough.

A groundbreaking new study shows that a mineral deficiency can drive Alzheimer's, and consuming it can reverse it.

(🧵1/10) The study was published last year in Nature.

While lithium is used as a drug in high doses for things like bipolar disorder, it is a naturally occurring mineral in some foods and water supplies.

Unexpectedly, it seems to play a major role in Alzheimer's.

(2/10)

Hair loss / male pattern baldness is an inflammatory condition often driven by excess histamine - and antihistamines can regrow hair.

(🧵1/8)

https://x.com/Outdoctrination/status/1867925050768105492

This first study that looked at the antihistamine cetirizine for regrowing hair.

This is the same ingredient as Zyrtec allergy pills - just applied topically on the scalp.

They did this for 6 months.

A recent study showed that patients with a highly lethal cancer had their tumors shrink, with a 100% disease control rate when given a simple mineral.

(🧵1/7) Advanced non-small cell lung cancer is a brutal condition.

Only ~10% of people with it survive past 5 years.

This study sought to uncover the role of selenium in this cancer, and wanted to see if using it as a therapy could help.

If you want to live longer, read this.

Here are 6 underrated tools that EXTEND LIFESPAN in research (🧵1/8):

#1 Glycine

Glycine increases lifespan by up to ~28% across different organisms.

https://x.com/Outdoctrination/status/1963941283434553483

Glycine counteracts the pro-aging effects of excess methionine, a major component of muscle meat.

It's able to do this through the GNMT enzyme - which absorbs extra methyl groups from methionine.

Those extra methyl groups otherwise alter global gene expression, disrupting several health promoting processes.

CAVITIES - A sign your internal health is deteriorating.

This is how they happen step by step and how to prevent them (🧵1/14): UNDERSTANDING THE TOOTH.

Teeth have multiple layers, with these top 2 being most relevant for cavities.

While we often think of teeth as just these rocks that are in our mouths, they're highly structured living tissues.

1. Enamel

This is the outermost layer of the tooth, where cavities most often hit.

It's made primarily of a mineral known as hydroxyapatite - a complex of calcium, phosphate and some other elements.

We have cells called ameloblasts which regenerate the enamel, but these only present during youth.

BUT this layer can remineralize passively, meaning it can without the need for these cells to a certain degree (more on that later).
2. Dentin
This is the layer right below the enamel, and unlike the enamel this can actively regenerate via cells called the odontoblasts.

However these cells can die off if you aren't careful, especially from bacterial antigens like endotoxin.

3. Pulp

This is the soft tissue containing nerves. If your cavity reaches here, you'll need a root canal or even get a tooth yanked.

The deeper a cavity goes into the tooth, the more it will hurt.

The key to understand here is that remineralization only really happens at the very early stages of the cavity. Once it gets deep enough, you're essentially screwed.

So DON'T WAIT. You want to act preventatively.

Vitamin C can powerfully reduce fatigue, even improving energy levels within hours in studies.

(🧵1/8)

https://x.com/Outdoctrination/status/1964678029747073264

This first study came out in 2008.

They were looking at people exhausted from work, and initiated 6 grams of vitamin C daily, for 2 weeks, as therapy.

They also measured other biomarkers to see if vitamin C improved anything else.

The results were amazing.

Autism is a mitochondrial disorder - and restoring their function can improve it, demonstrated beautifully in a recent trial.

(🧵1/8)

https://x.com/Outdoctrination/status/2027753174434529669

Mitochondrial dysfunction is any abnormality in this organelle's ability to generate energy or other substrates.

Depending on the criteria, anywhere from 5% up to 90% (in this study) of people with autism spectrum disorders suffer from some form of mitochondrial dysfunction.

Thus, the goal in this study was to identify that subset and treat accordingly.

DANDRUFF - An inflammatory / fungal sign your underlying health is deteriorating.

Let's go through exactly how it develops, what it means for your health, and some ways to help. (🧵1/13) The skin has multiple components.

The two we'll focus on here:

1. The epidermis. This is where the flakes are formed and where everything goes wrong.

2. The sebaceous gland. This is what produces sebum, an oil of the skin absolutely vital for this process.

BAKING SODA is strikingly helpful for improving sleep, according to a recent intriguing study.

(🧵1/7) This study was published in 2023, examining the effects of a baking soda bath versus normal showering or tap water baths.

They used ~1 cup of baking soda in the bath (1000 ppm).

This was done in a randomized fashion for 1 week.

10 mins per day before bed.

An intriguing study showed that vinegar reduces kidney stone incidence, and mapped out exactly how it does it.

(🧵1/8)

https://x.com/Outdoctrination/status/2005299119959499128

This study was published in 2019.

This research group previously uncovered that vinegar consumption was associated with >60% reduced odds of kidney stones.

They decided to test it themselves.

Coenzyme Q10 is a key factor aging - and supplementing it extends lifespan in multiple studies.

(🧵1/7)

https://x.com/Outdoctrination/status/1972277835591999550

I stumbled across this study a few months ago.

They gave animals on a "high PUFA diet" coenzyme q10 at 0.7 mg / kg bodyweight.

This dose is puny (7-8 mg human equivalent), and the "high PUFA diet" was under 5% PUFA, still way less than what the average person gets nowadays due to seed oils being in everything.

An incredible study showed major reductions in arterial plaques simply by shining a form of red light onto the body, more so than even statins.

(🧵1/7)

https://x.com/Outdoctrination/status/1762946202889490517

This was an animal study done in a classic model of heart disease, the high cholesterol diet in rabbits.

This diet causes them to rapidly develop atherosclerosis since they naturally consume none of it.

They also compared light therapy to statin.

Nicotine has some powerful anti-inflammatory effects, even improving things like autoimmunity and allergies in experiments.

(🧵1/8) More than a few studies have shown that nicotine consumers have lower rates of inflammatory conditions.

For instance, this study showed that the more snuff one consumed, the less MS they developed.

In some studies, even smoking is inversely associated with these conditions.

But is it just a statistical anomaly or a real effect?

I used to have DEBILITATING allergies every year.

Couldn't even go outside without breaking out into tears and itches.

Now I forget that they even exist.

This is what I learned about allergies - the 8 KEY ROOT CAUSES behind them (🧵1/12): There are a few chemical mediators that induce the symptoms of allergies:

- Histamine
- Serotonin
- Prostaglandins
- Leukotrienes
- Type 2 cytokines (IL-3, IL-4, IL-5, IL-9 IL-13)

These drive excess mucus production, itch, airway thickening / constriction, redness… everything.

The primary cells involved in releasing them are:

- Mast cells
- Eosinophils
- Basophils
- Neutrophils
- T Cells

This system is in place to protect us against things like parasites and foreign toxins. It helps us eliminate them effectively before they cause even more damage.

The question is, what causes the increased production of these chemicals from these cells unnecessarily?

Why do some people’s immune cells release more of these mediators in response to things that are harmless like pollen?

Taurine is one of the most important nutrients for the brain, serving a number of protective roles in cognitive aging and stroke.

(🧵1/7)
I was surprised to find out that taurine is actually the second most abundant amino acid in the central nervous system, behind glutamate.

Taurine levels in both the cerebrospinal fluid and certain brain regions are lower in people with Alzheimer's disease.

This has important consequences.

Autism was substantially improved with just a few 5 minute red light sessions, reducing behavioral symptoms by over 50% in a fascinating study.

(🧵1/8) This study was published in 2018.

Children with autism were given a 635 nm (red) light therapy, administered as either a laser or LED (placebo) light.

While the lights were the same wavelength, the laser is more effective because of its superior:

◇ Spot area
◇ Coherence
◇ Power / intensity

compared to the LED.

They gave the children just twice weekly 5 min sessions at the base of the skull and temporal areas of the skull, for 4 weeks total.

The results were stunning.

Your gut is crying for help - here are 5 signs it's giving you that you've been ignoring (🧵1/10):

#1 Coated tongue

This is SO common, yet people just brush their tongue and forget about it.

This coating is literally intestinal bacteria or fungi accumulating on your tongue. Your gut is connected directly to your mouth.

If you have:

➜ Bacterial overgrowth (SIBIO)
➜ Candida
➜ Poor gut motility

these microbes will be abundant and move UP the gut, eventually on to your tongue.

See this all the time with our clients.

Combining L-Theanine with caffeine can produce some therapeutic effects in ADHD by modulating brain activity networks.

(🧵1/7)

https://x.com/Outdoctrination/status/1877384078619554207

The inability to pay attention in ADHD is not just a feeling, it's a well characterized system in the brain.

There is a brain network known as the default mode network.

This network is several brain regions coordinating together in processes like daydreaming, and can be seen on fMRI scans.

Children with ADHD have higher reactivity of the posterior DMN (precuneus region) during tasks.

ANOTHER one of the most impressive studies in recent memory found that the combination of NAC + Glycine has remarkable anti-aging effects in nearly every metric.

(🧵1/8)

https://x.com/Outdoctrination/status/1952777425932148765

This study came out in 2021.

Both older (71-80 years old) and young (21-30 y/o) people were enrolled.

The older folks got a large dose:

◇ Glycine: ~7 g/day
◇ NAC: ~9 g/day (≈ 6.9 g cysteine equivalent)

for 24 weeks.

This doesn't necessarily mean that one has to take this much, since this was measuring a relatively short period of time on the elderly, so they were trying to up their stores rapidly.

Typically, a maintenance dose of NAC is 1.2-2.4g, and glycine 3-6g.

A fascinating study showed that saffron reversed clinical depression in 96% of postpartum mothers.

(🧵1/8)

https://x.com/Outdoctrination/status/1924465072598061407

This study was published in 2017, and I don't have the official PDF just the raw manuscript here so bare with me if it doesn't look super pretty.

Postpartum depression is a huge and often overlooked condition where, after pregnancy, women become depressed.