Time and the SARS-CoV-2 virus do share some similarities in terms of how they affect our lives. Time, as a concept, cannot be eliminated ...
2) ...or stopped, it continues to pass and settle in our memories. Similarly, the SARS-CoV-2 virus cannot be eliminated from our bodies once we are infected, it can settle in our organs and cause long-lasting effects.
3) In this first study researchers showed that the virus can persist in the body more than a year after Infection. thelancet.com/journals/laninโฆ
4) In another study they showed that the Spike protein is still there more than 1 year after infection academic.oup.com/cid/article/76โฆ
5) Another way to detect the SARS-CoV-2 persistence or the latent virus reactivation, is for example, through processes which involve myeloid inflammation nature.com/articles/s4159โฆ
6) This viral persistence can be found in many organs, tissues, cells as brain, blood, penile tissues or faeces many months after the acute phase. nature.com/articles/s4157โฆ
7) Clearly the virus has taken hold in the human body.
2) This study investigated antigenic relationships between SARS-CoV-2 variants using neutralization titers from human and hamster primary infection sera.
Neutralization titers from hamster primary infection sera correlated well with those from human primary infection sera ...
3) ...and showed similar patterns of specificity against variants.
Antigenic maps created using human or hamster primary infection sera alone resembled each other closely, indicating hamster sera are a suitable surrogate for mapping antigenic variation.
2) The study compared humoral and cellular immunity to SARS-CoV-2 in 28 children and 28 adults approximately 7 months after mild/asymptomatic SARS-CoV-2 infection.
Both children and adults had comparable levels of antibodies targeting the SARS-CoV-2 spike protein and RBD
3) However, children had lower antibody levels against the nucleocapsid protein compared to adults.
Neutralizing antibody titers against ancestral SARS-CoV-2 and Omicron variants were similar between children and adults.
2) The study used data from the 2022 BRFSS survey to examine similarities and differences between cognitive impairment and long COVID. CI was measured as serious difficulty concentrating, remembering or making decisions. Long COVID was defined as COVID symptoms lasting 3+ months
3) Rates of both CI (13.4%) and long COVID (7.4%) were higher among certain demographic groups like women, younger adults, Hispanics, smokers, and those with comorbidities.
Having either CI or long COVID increased the prevalence of the other condition.
2) The study developed a mathematical model combining wastewater surveillance data, seroprevalence surveys, and vaccination/hospitalization data to estimate the impact of vaccination and SARS-CoV-2 variants on disease prevalence and wastewater viral load in Kentucky.
3) Randomized community-wide seroprevalence surveys were done to estimate post-vaccine prevalence, avoiding biases of relying only on clinical testing data. A population-level SVI2RT model tracked prevalence longitudinally based on vaccination and variants.
2) Human Leukocyte Antigens (HLA) system play a crucial role in the immune response against infections, including SARS-CoV-2. HLA molecules are found on the surface of cells and are responsible for presenting fragments of viral proteins to the immune system.
3) This presentation helps to activate and guide the immune response against the virus.
The HLA system is highly diverse, with many different alleles. These alleles can influence the immune response by determining the ability of HLA molecules to present viral antigens effectively
2) The study investigated the dynamics of COVID-19 contacts and subsequent conversion to SARS-CoV-2 infection across three NHS hospital trusts in the UK between September 2020-December 2022. Of the over 5,000 contacts identified, 9.2% (476) tested positive within 14 days.
3) There was no significant difference in overall conversion proportions between Omicron and non-Omicron contacts (9.1% vs 9.4%).
However, Omicron contacts converted faster, with a median of 3 days compared to 4 days for non-Omicron. A higher proportion of Omicron contacts ...