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Emmanuel

@ejustin46

Apr 11

𝗧𝗵𝗲 𝗕𝗜𝗚 𝗖𝗛𝗔𝗟𝗟𝗘𝗡𝗚𝗘 𝗼𝗳 "𝗔𝗡𝗧𝗜𝗚𝗘𝗡𝗜𝗖 𝗦𝗜𝗡" !

nature.com/articles/s4146…

2) The study investigated how previous vaccination with mRNA vaccines targeting the original Wuhan strain of SARS-CoV-2 affects the immune response to infection with the Omicron variant.

3) Three groups of individuals were studied: 1) unvaccinated individuals infected with Omicron, 2) individuals vaccinated 3 times who were later infected with Omicron, 3) individuals vaccinated 3 times but uninfected.

Read 8 tweets

Emmanuel

@ejustin46

Apr 11

𝘼𝙉𝙏𝙄𝙂𝙀𝙉𝙄𝘾 𝘾𝘼𝙍𝙏𝙊𝙂𝙍𝘼𝙋𝙃𝙔
𝙪𝙨𝙞𝙣𝙜 𝙝𝙖𝙢𝙨𝙩𝙚𝙧 𝙨𝙚𝙧𝙖 𝙞𝙙𝙚𝙣𝙩𝙞𝙛𝙞𝙚𝙨 𝙎𝘼𝙍𝙎-𝘾𝙤𝙑-2 𝙅𝙉.1 𝙚𝙫𝙖𝙨𝙞𝙤𝙣 𝙨𝙚𝙚𝙣 𝙞𝙣 𝙝𝙪𝙢𝙖𝙣 𝙓𝘽𝘽.1.5 𝙗𝙤𝙤𝙨𝙩𝙚𝙧 𝙨𝙚𝙧𝙖

𝘒𝘦𝘺 𝘴𝘵𝘶𝘥𝘺 👍
biorxiv.org/content/10.110…

2) This study investigated antigenic relationships between SARS-CoV-2 variants using neutralization titers from human and hamster primary infection sera.
Neutralization titers from hamster primary infection sera correlated well with those from human primary infection sera ...

3) ...and showed similar patterns of specificity against variants.
Antigenic maps created using human or hamster primary infection sera alone resembled each other closely, indicating hamster sera are a suitable surrogate for mapping antigenic variation.

Read 8 tweets

Emmanuel

@ejustin46

Apr 11

𝗖𝗛𝗜𝗟𝗗𝗥𝗘𝗡 𝗔𝗧 𝗥𝗜𝗦𝗞 !!!

𝗦𝗔𝗥𝗦-𝗖𝗼𝗩-2 𝗜𝗺𝗺𝘂𝗻𝗲 𝗥𝗲𝘀𝗽𝗼𝗻𝘀𝗲𝘀: 𝗔𝗿𝗲 𝗖𝗵𝗶𝗹𝗱𝗿𝗲𝗻 𝗟𝗲𝘀𝘀 𝗣𝗿𝗼𝘁𝗲𝗰𝘁𝗲𝗱?
medrxiv.org/content/10.110…

2) The study compared humoral and cellular immunity to SARS-CoV-2 in 28 children and 28 adults approximately 7 months after mild/asymptomatic SARS-CoV-2 infection.
Both children and adults had comparable levels of antibodies targeting the SARS-CoV-2 spike protein and RBD

3) However, children had lower antibody levels against the nucleocapsid protein compared to adults.
Neutralizing antibody titers against ancestral SARS-CoV-2 and Omicron variants were similar between children and adults.

Read 6 tweets

Emmanuel

@ejustin46

Apr 11

𝗦𝗶𝗺𝗶𝗹𝗮𝗿𝗶𝘁𝗶𝗲𝘀 𝗮𝗻𝗱 𝗱𝗶𝗳𝗳𝗲𝗿𝗲𝗻𝗰𝗲𝘀 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗰𝗼𝗴𝗻𝗶𝘁𝗶𝘃𝗲 𝗶𝗺𝗽𝗮𝗶𝗿𝗺𝗲𝗻𝘁 (𝗖𝗜) 𝗮𝗻𝗱 𝗹𝗼𝗻𝗴 𝗖𝗢𝗩𝗜𝗗.

medrxiv.org/content/10.110…

2) The study used data from the 2022 BRFSS survey to examine similarities and differences between cognitive impairment and long COVID. CI was measured as serious difficulty concentrating, remembering or making decisions. Long COVID was defined as COVID symptoms lasting 3+ months

3) Rates of both CI (13.4%) and long COVID (7.4%) were higher among certain demographic groups like women, younger adults, Hispanics, smokers, and those with comorbidities.
Having either CI or long COVID increased the prevalence of the other condition.

Read 6 tweets

Emmanuel

@ejustin46

Apr 10

"64% 𝙘𝙤𝙪𝙣𝙩𝙮 𝙫𝙖𝙘𝙘𝙞𝙣𝙖𝙩𝙞𝙤𝙣 𝙧𝙖𝙩𝙚 𝙩𝙧𝙖𝙣𝙨𝙡𝙖𝙩𝙚 𝙞𝙣𝙩𝙤 𝙖𝙗𝙤𝙪𝙩 𝙖 61% 𝙙𝙚𝙘𝙧𝙚𝙖𝙨𝙚 𝙞𝙣 𝙎𝘼𝙍𝙎-𝘾𝙤𝙑-2 𝙞𝙣𝙘𝙞𝙙𝙚𝙣𝙘𝙚"

nature.com/articles/s4385…

2) The study developed a mathematical model combining wastewater surveillance data, seroprevalence surveys, and vaccination/hospitalization data to estimate the impact of vaccination and SARS-CoV-2 variants on disease prevalence and wastewater viral load in Kentucky.

3) Randomized community-wide seroprevalence surveys were done to estimate post-vaccine prevalence, avoiding biases of relying only on clinical testing data. A population-level SVI2RT model tracked prevalence longitudinally based on vaccination and variants.

Read 5 tweets

Emmanuel

@ejustin46

Apr 10

𝙏𝙝𝙚 𝙁𝙄𝙂𝙃𝙏 𝙖𝙜𝙖𝙞𝙣𝙨𝙩 𝙎𝘼𝙍𝙎-𝘾𝙊𝙑-2 𝙞𝙨 𝙐𝙉𝙁𝘼𝙄𝙍!

𝙒𝙚 𝙖𝙧𝙚 𝙉𝙊𝙏 𝙀𝙌𝙐𝘼𝙇 𝙞𝙣 𝙩𝙝𝙚 𝙛𝙖𝙘𝙚 𝙤𝙛 𝙞𝙡𝙡𝙣𝙚𝙨𝙨, 𝙖𝙨 𝙬𝙚 𝙝𝙖𝙫𝙚 𝙙𝙞𝙛𝙛𝙚𝙧𝙚𝙣𝙩 𝙃𝙇𝘼 (𝙃𝙪𝙢𝙖𝙣 𝙇𝙚𝙪𝙠𝙤𝙘𝙮𝙩𝙚 𝘼𝙣𝙩𝙞𝙜𝙚𝙣) 𝙖𝙡𝙡𝙚𝙡𝙚𝙨

2) Human Leukocyte Antigens (HLA) system play a crucial role in the immune response against infections, including SARS-CoV-2. HLA molecules are found on the surface of cells and are responsible for presenting fragments of viral proteins to the immune system.

3) This presentation helps to activate and guide the immune response against the virus.
The HLA system is highly diverse, with many different alleles. These alleles can influence the immune response by determining the ability of HLA molecules to present viral antigens effectively

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