Nicholas Fabiano, MD Profile picture
Apr 10, 2024 10 tweets 3 min read Read on X
This is a map of repetition among all symptoms in the DSM-5.

🧵1/10 Image
These findings are from a descriptive study published in Psychological Medicine which mapped the repetition among the 1419 symptoms described in 202 diagnoses of adult psychopathology in section II of the DSM-5. 2/10 cambridge.org/core/journals/…
Image
The first stage of coding aimed to distil the constituent symptoms of the diagnoses in chapters 1–19 of section II of the DSM-5. The resulting list of symptoms was then coded for content overlap using both qualitative content coding and natural language processing. 3/10
In total, 202 diagnoses were represented, including 135 primary disorders and 76 specifiers or other specified disorders with additional symptoms. While repetition appeared to be pervasive, the majority (63.2%) of the 628 distinct symptoms were unique to a single diagnosis. 4/10 Image
Overall, of the 202 diagnoses represented, 140 (69.3%) had at least one symptom that repeated in another diagnosis – 118 (58.4%) in a diagnosis in another chapter. 5/10 Image
A noteworthy finding was that the symptoms in the DSM-5 that repeat most frequently, and that repeat across most chapters, are dominated by symptoms of major depressive disorder (MDD). 6/10 Image
Specifically, 10 of the top 15 most non-specific symptoms in the DSM-5 appeared in the diagnostic criteria for MDD. 7/10 Image
Perhaps MDD symptoms are psychological responses to stress, similar to how fever – a symptom that also cuts across numerous diagnostic categories – reflects an inflammatory response to cell damage or stress. 8/10
The pervasiveness of MDD symptoms throughout the DSM-5 likely hampers diagnostic accuracy through misattribution of symptoms in other diagnoses to MDD, and inflation of the rates of comorbidity due to symptom overlap with other diagnoses. 9/10
Ultimately, more empirical work on fine-grained clinical phenomena promises to improve on the reliability and validity of the DSM-5 constructs that frame much research and practice. 10/10

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Nicholas Fabiano, MD

Nicholas Fabiano, MD Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @NTFabiano

Jul 3
Screen time is associated with depressive symptoms - likely mediated by shorter sleep & worse white matter organization.

🧵1/8 Image
These findings are from a study in @JAMAPsych which aimed to identify the association between screen time during late childhood and depressive symptoms in early adolescence. 2/8 jamanetwork.com/journals/jamap…Image
During adolescence, major sleep-circadian changes contribute to a delayed sleep phase; this makes adolescents vulnerable to external influences, such as screen time, which can result in insufficient sleep and poor sleep quality. 3/8
Read 8 tweets
Jul 1
Depression may be contagious through a dysfunctional mirror neuron system.

🧵1/11 Image
This discussion is from a review article in @ElsevierConnect which describes the theory of ‘contagious depression’, whereby depression can be induced or triggered by our social environment. 2/11 sciencedirect.com/science/articl…Image
Emotions can spread like an infectious disease across social networks in a phenomenon called emotional contagion, which can be defined as a tendency to acquire affective states from our social contacts. 3/11
Read 11 tweets
Jun 30
Light can travel through the head, guided by cerebrospinal fluid & tissue geometry.

🧵1/10 Image
These findings are from a study in @spietweets which explored the physical limits of photon transport in the head in the extreme case wherein the source and detector were diametrically opposite. 2/10 spiedigitallibrary.org/journals/neuro…Image
Optical modalities for noninvasive imaging of the human brain hold promise to fill the technology gap between cheap and portable devices such as electroencephalography (EEG) and expensive high-resolution instruments such as functional magnetic resonance imaging (fMRI). 3/10
Read 10 tweets
Jun 29
Quantum entanglement may generate consciousness.

🧵1/13 Image
These findings are from a study in @PhysRevE which employs cavity quantum electrodynamics to explore entangled biphoton generation through cascade emission as a potential source for the synchronized activity of neurons. 2/13 journals.aps.org/pre/abstract/1…Image
Quantum entanglement is the phenomenon of a group of particles being generated, interacting, or sharing spatial proximity in such a way that the quantum state of each particle of the group cannot be described independently of the state of the others. 3/13
Read 13 tweets
Jun 19
Sleep loss is a metabolic disorder.

🧵1/8 Image
These findings are from a paper in @scisignal which describes how sleep deprivation increases resting energy expenditure, leading to the development of a negative energy balance in highly active cells like neurons. 2/8 science.org/doi/10.1126/sc…Image
Sleep loss dysregulates cellular metabolism and energy homeostasis. 3/8 Image
Read 8 tweets
Jun 17
A history of heavy cannabis use is associated with lower brain activation during a working memory task.

🧵1/9 Image
These findings are from a study in @JAMANetworkOpen which examined the association of lifetime history of heavy cannabis use and recent cannabis use with brain activation across a range of brain functions in a large sample of young adults in the US. 2/9 jamanetwork.com/journals/jaman…Image
Given the cognitive effects of cannabis and the disruption of the endogenous cannabinoid system by tetrahydrocannabinol (THC), it may be that brain regions with high cannabinoid 1 (CB1) receptor density might be altered by cannabis. 3/9
Read 9 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(