Sleep loss is a metabolic disorder.

🧵1/8 These findings are from a paper in @scisignal which describes how sleep deprivation increases resting energy expenditure, leading to the development of a negative energy balance in highly active cells like neurons. 2/8 science.org/doi/10.1126/sc…

A history of heavy cannabis use is associated with lower brain activation during a working memory task.

🧵1/9 These findings are from a study in @JAMANetworkOpen which examined the association of lifetime history of heavy cannabis use and recent cannabis use with brain activation across a range of brain functions in a large sample of young adults in the US. 2/9 jamanetwork.com/journals/jaman…

Being a father rewires the brain.

🧵1/12 These findings are from a paper in @JAMAPsych which described how the paternal brain is wired by pregnancy. 2/12 jamanetwork.com/journals/jamap…

Our paper was just published in The Lancet Psychiatry.

🧵1/11 Recently, INTEGRATE, the international guidelines for the algorithmic treatment of schizophrenia were released, and we commend the authors for their focus on “metabolic health from treatment initiation”. 2/11 thelancet.com/journals/lanps…

This is the inflammatory subtype of depression.

🧵1/10 These findings are from a paper in @APAPubJournals which discussed the importance of refining our diagnostic nosology of depression through the lens of inflammation. 2/10 psychiatryonline.org/doi/10.1176/ap…

Coffee enhances neurocognitive function by reorganizing brain functional connectivity.

🧵1/8 These findings are from a study in @SciReports which investigated functional connectivity before and after drinking coffee using graph-theoretic analysis of electroencephalography (EEG). 2/8 nature.com/articles/s4159…

Caffeine hinders the brain’s recovery following sleep deprivation by suppressing cerebral grey matter response.

🧵1/9 These findings are from a study in @SciReports which explored whether daily use of caffeine could prevent or exacerbate the grey matter alterations induced by 5-day sleep restriction. 2/9 nature.com/articles/s4159…

Healthier diets & lower waist-to-hip ratio are associated with better cognition & brain connectivity.

🧵1/7 These findings are from a study in @JAMANetworkOpen which aimed to ascertain how longitudinal changes in diet quality and waist to hip ratio (WHR) during midlife are associated with hippocampal connectivity and cognitive function in later life. 2/7 jamanetwork.com/journals/jaman…

This is a neuroscientific model of a near-death experience.

🧵1/11 These findings are from a paper in @NatRevNeurol which discussed processes that underlie the rich conscious experience in near-death experiences (NDEs), addressing both the potential psychological mechanisms and neurophysiological changes. 2/11 nature.com/articles/s4158…

Citrus fruit intake is associated with a lower risk of depression.

🧵1/9 These findings are from a study in @MicrobiomeJ which aimed to determine if citrus intake protected against depression via the gut microbiome. 2/9 microbiomejournal.biomedcentral.com/articles/10.11…

The gut-brain axis may be an evolutionary advance of the root-leaf axis in plants.

🧵1/9 These findings are from a paper in @jineuroscience which proposed morphological and functional similarities between (i) plant leaves and the human brain and (ii) plant roots and the human gastro-intestinal tract. 2/9 imrpress.com/journal/JIN/17…

"95% of serotonin is in the gut"

Many state that it's not relevant since it doesn't cross the blood-brain barrier

A new study found that deleting the serotonin reuptake transporter in the gut of mice produced significant antidepressant effects

We are still learning so much Source: gastrojournal.org/article/S0016-…

Red light increases energy (ATP) production & reduces blood glucose levels.

🧵1/10 These findings are from a study in @jbiophotonics which aimed to test the hypothesis that increased ATP production due to photobiomodulation (PBM) will demand increased glucose consumption, and change plasma glucose levels. 2/10 onlinelibrary.wiley.com/doi/10.1002/jb…

The first trial of creatine in Alzheimer's dementia was just published.

Brain creatine levels & cognition significantly increased.

🧵1/8 These findings are from a study in @alzassociation which investigated the feasibility of 20 g/day creatine for 8 weeks in 20 people with Alzheimer's disease (AD). 2/8 alz-journals.onlinelibrary.wiley.com/doi/10.1002/tr…

Our paper was just published in Brain Medicine.

🧵1/11 Ultra-processed foods now dominate the food supplies of high-income countries, with over 50% of energy intake coming from ultra-processed foods in the United States. 2/11

People with depression have an expanded brain network which predates symptom onset.

🧵1/13 Despite depression being the leading cause of health-related disability, the neurobiological mechanisms underlying this disorder remain poorly understood from the perspective of neural network systems. 2/13

Depression may rewire the gut-brain axis towards craving carbohydrates & disliking protein.

🧵1/9 These findings are from a study in @CambUP_Psych which analyzed how depression affects food preferences in a sample of 117 people (54 with depression & 63 healthy controls) via cue reactivity tasks. 2/9 cambridge.org/core/journals/…

Cannabis smoking is linked with epigenome-wide disruptions which persist despite quitting.

🧵1/8 These findings are from a study in @BMC_series which conducted an epigenome-wide DNA methylation analysis that identified differential methylated positions (DMPs) associated with cannabis smoking. 2/8 bmcpulmmed.biomedcentral.com/articles/10.11…

Adjunctive vitamin D preserves brain structural & functional connectivity in depression.

🧵1/9 These findings are from a study in @CambUP_Psych which investigated the effects of vitamin D supplementation on the brains of people with depression. 2/9 cambridge.org/core/journals/…

The largest summary of supplements for depression.

Saffron had the largest decrease in depressive symptoms. Source: cambridge.org/core/journals/…

The geometry of the brain shapes its function more than connectivity.

🧵1/11 These findings are from a study in @Nature which aimed to determine a unified framework for how brain function emerges from a relatively stable anatomical scaffold. 2/11 nature.com/articles/s4158…