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Nicholas Fabiano, MD Profile picture
Nicholas Fabiano, MD
@NTFabiano
Writing about science
22 subscribers
May 14 • 14 tweets • 3 min read
People with depression have an expanded brain network which predates symptom onset.

🧵1/13 Image Despite depression being the leading cause of health-related disability, the neurobiological mechanisms underlying this disorder remain poorly understood from the perspective of neural network systems. 2/13
May 13 • 9 tweets • 3 min read
Depression may rewire the gut-brain axis towards craving carbohydrates & disliking protein.

🧵1/9 Image These findings are from a study in @CambUP_Psych which analyzed how depression affects food preferences in a sample of 117 people (54 with depression & 63 healthy controls) via cue reactivity tasks. 2/9 cambridge.org/core/journals/…Image
May 11 • 8 tweets • 2 min read
Cannabis smoking is linked with epigenome-wide disruptions which persist despite quitting.

🧵1/8 Image These findings are from a study in @BMC_series which conducted an epigenome-wide DNA methylation analysis that identified differential methylated positions (DMPs) associated with cannabis smoking. 2/8 bmcpulmmed.biomedcentral.com/articles/10.11…Image
May 10 • 9 tweets • 3 min read
Adjunctive vitamin D preserves brain structural & functional connectivity in depression.

🧵1/9 Image These findings are from a study in @CambUP_Psych which investigated the effects of vitamin D supplementation on the brains of people with depression. 2/9 cambridge.org/core/journals/…Image
May 9 • 7 tweets • 1 min read
The largest summary of supplements for depression.

Saffron had the largest decrease in depressive symptoms. Forest plot for change in depressive symptoms. a Denotes significance at p < 0.05. b Abbreviations: ADT: antidepressant; Ca: calcium; CI: confidence interval; CoQ10: co-enzyme Q10; DHA: docosahexaenoic acid; E amoenum: Echium amoenum; EPA: eicosapentaenoic acid; Fe: ferrum; Mg: magnesium; PEA: palmitoylethanolamide; R rosea: Rhodiola rosea; SAMe: S-adenosyl methionine; SMD: standard mean difference; SJW: St. John’s wort; vitamin B1: thiamine; vitamin B6: pyridoxine; vitamin B7: biotin; vitamin B: vitamin B complex; vitamin B12: cobalamin; vitamin C: ascorbic acid; vitamin D: cholecalciferol... Source: cambridge.org/core/journals/…
May 6 • 11 tweets • 3 min read
The geometry of the brain shapes its function more than connectivity.

🧵1/11 Image These findings are from a study in @Nature which aimed to determine a unified framework for how brain function emerges from a relatively stable anatomical scaffold. 2/11 nature.com/articles/s4158…Image
May 4 • 9 tweets • 2 min read
Playing a video game increased brain hippocampal grey matter.

🧵1/9 Image These findings are from a study in @PLOSONE which tested the impact of 3D-platform video game training (i.e., Super Mario 64) on brain grey matter of older adults. 2/9 journals.plos.org/plosone/articl…Image
May 3 • 11 tweets • 3 min read
Higher physical activity is associated with lower brain amyloid burden - a key protein linked to Alzheimer’s dementia.

🧵1/11 Image These findings are from a study in @alzassociation which investigated midlife physical activity changes in relation to Alzheimer's disease (AD)-related pathologies. 2/11 alz-journals.onlinelibrary.wiley.com/doi/full/10.10…Image
May 1 • 8 tweets • 2 min read
72 hours without your phone rewires neural pathways tied to impulse control and reward.

🧵1/8 Image These findings are from a study in @ELSpsychology which used a functional MRI (fMRI) to investigate the effects of smartphone restriction over 72 h in 25 young adult smartphone users. 2/8 sciencedirect.com/science/articl…Image
Apr 29 • 10 tweets • 3 min read
Exercise leads to the release of myokines, increasing neuron growth by 4x.

🧵1/10 Image These findings are from a study in @WileyGlobal which examined the impact of myokines, released during exercise, on neuron growth. 2/10 advanced.onlinelibrary.wiley.com/doi/10.1002/ad…Image
Apr 27 • 9 tweets • 2 min read
Light treatment had the same effect as an antidepressant - with earlier response and less side effects.

🧵1/9 Image These findings are from a study in @APA_Journals which compared the effectiveness of light therapy and an antidepressant for the treatment of seasonal affective disorder. 2/9 psychiatryonline.org/doi/10.1176/aj…Image
Apr 26 • 13 tweets • 3 min read
Severe exercise reversibly reduces brain myelin content.

Myelin lipids may act as glial energy reserves in extreme metabolic conditions.

🧵1/12 Image These findings are from a study in @NatMetabolism which used magnetic resonance imaging to study the impact of marathon running on brain structure in humans. 2/12 nature.com/articles/s4225…Image
Apr 25 • 11 tweets • 3 min read
Psilocybin led to increased brain complexity & spontaneous behaviour in a person with a post-comatose disorder of consciousness.

🧵1/10 Image These findings are from a case report in @ClinicalNeuroph which describe the first-ever administration of psilocybin, a classic psychedelic, to a patient in a minimally conscious state. 2/10 sciencedirect.com/science/articl…Image
Apr 23 • 10 tweets • 3 min read
The amygdala is a brain region involved in stress.

Resting metabolic activity of the amygdala significantly predicts the development of cardiovascular disease.

🧵1/10 Image These findings are from a study in @TheLancet which aimed to determine whether resting metabolic activity of the amygdala predicted risk of subsequent cardiovascular events. 2/10 thelancet.com/journals/lance…Image
Apr 21 • 12 tweets • 3 min read
Why do living organisms need sleep?

A new theory suggests that myelin acts as a proton capacitor, accumulating energy during sleep.

🧵1/12 Image These findings are from a paper in @ElsevierConnect which discussed a novel hypothesis as to why living organisms need sleep. 2/12 sciencedirect.com/science/articl…Image
Apr 20 • 12 tweets • 3 min read
The human brain emits light that reflects changes in cognitive state.

🧵1/12 Image These findings are from a study in @iScience_CP which investigated the role of ultraweak photon emissions (UPEs) in the human brain. 2/12 cell.com/iscience/fullt…Image
Apr 18 • 11 tweets • 4 min read
I just filmed a 1.5 hour podcast on creatine for mental health.

Here are the highlights.

🧵1/10 Image While creatine's role in muscle energetics is well-established, its equally crucial function in brain metabolism has recently gained scientific attention. 2/10
Apr 17 • 20 tweets • 5 min read
Our paper was just published in European Neuropsychopharmacology.

🧵1/18 Image Creatine, a nitrogenous organic composed of the amino acids arginine, glycine and methionine, is a common and well-researched supplement used among athletes and bodybuilders to improve physical performance. 2/18
Apr 15 • 10 tweets • 2 min read
Sleep onset between 10-11 PM is associated with the lowest incidence of cardiovascular disease.

🧵1/10 Image These findings are from a study in @OUPAcademic which examined the association between wrist-worn accelerometer-derived sleep onset timing and cardiovascular disease (CVD). 2/10 academic.oup.com/ehjdh/article/…Image
Apr 13 • 8 tweets • 2 min read
Daily use & high-potency cannabis are strong predictors of developing a psychotic disorder - such as schizophrenia.

🧵1/8 Image These findings are from a study in @thelancet which aimed to identify patterns of cannabis use with the strongest effect on odds of psychotic disorder. 2/8 thelancet.com/article/S2215-…Image
Apr 11 • 11 tweets • 2 min read
Our paper was just published in The European Journal of Psychiatry.

🧵1/10 Image The role of animals has garnered increasing attention within the mental health field due to their potential therapeutic benefits. 2/10