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Nicholas Fabiano, MD Profile picture
Nicholas Fabiano, MD
@NTFabiano
Writing about science
22 subscribers
Apr 3 • 10 tweets • 3 min read
Your environment predicts aging and mortality more than genetics.

🧵1/10 Image These findings are from a study in @NatureMedicine which aimed to quantify the relative contributions of environment (referred to as the exposome) and genetics to aging and premature mortality. 2/10 nature.com/articles/s4159…Image
Apr 2 • 13 tweets • 3 min read
This is the most comprehensive review of the neuroprotective mechanisms of exercise.

TL;DR: You only need ~30 min/week of high intensity exercise to substantially reduce risk of dementia or premature death.

🧵1/13 Image These findings are from a review in @TheLancet which explored the neuroprotective mechanisms of endurance exercise and highlighted the importance of cardiorespiratory fitness (CRF) in promoting healthy brain aging. 2/13 thelancet.com/journals/lance…Image
Apr 1 • 8 tweets • 2 min read
Bright light therapy is an effective adjunctive treatment for nonseasonal depressive disorders.

🧵1/8 Image These findings are from a study in @JAMAPsych which aimed to assess bright light therapy (BLT) effectiveness as an adjunctive treatment for nonseasonal depressive disorders. 2/8 jamanetwork.com/journals/jamap…Image
Mar 31 • 12 tweets • 3 min read
This is the first map of human brain mitochondria.

🧵1/11 Image These findings are from a study in @Nature which created a map of mitochondria throughout the entire brain to bridge the scale gap between cognitive neuroscience and cell biology. 2/11 nature.com/articles/s4158…Image
Mar 23 • 8 tweets • 2 min read
Daytime napping is associated with a larger total brain volume.

🧵1/8 Image These findings are from a study in @SleepHealthEiC which studied the relationship between habitual daytime napping and cognition and brain structure, using Mendelian randomization. 2/8 sleephealthjournal.org/article/S2352-…Image
Mar 22 • 9 tweets • 2 min read
Higher muscle mitochondrial oxidative capacity is associated with >10 years of preserved brain structure.

🧵1/9 Image These findings are from a study in @NatureComms which examined the association of muscle mitochondrial oxidative capacity with up to over a decade-long changes in brain atrophy and microstructure. 2/9 nature.com/articles/s4146…Image
Mar 21 • 9 tweets • 3 min read
Creatine upregulates the mRNA content of genes and protein content of kinases in muscle - independent of exercise intervention.

🧵1/9 Image These findings are from a study in @PhysiologicalG which investigated the effect of short-term creatine supplementation on global and targeted mRNA expression and protein content in human skeletal muscle. 2/9 journals.physiology.org/doi/full/10.11…Image
Mar 20 • 9 tweets • 2 min read
Ketones exhibit robust effects in restabilizing brain networks.

🧵1/9 Image These findings are from a study in @PNASNews which integrated human brain and physiological data to investigate underlying mechanisms. 2/9 pnas.org/doi/10.1073/pn…Image
Mar 19 • 9 tweets • 3 min read
There are two subtypes of autism: brain hypoconnectivity & hyperconnectivity.

🧵1/9 Image These findings are from a study in @biorxivpreprint which leveraged cross-species functional neuroimaging to examine whether variability in brain functional connectivity reflects distinct biological mechanisms. 2/9 biorxiv.org/content/10.110…Image
Mar 18 • 9 tweets • 2 min read
Reducing sugar intake in the first 1000 days of life is associated with a reduced risk of chronic diseases in adulthood.

🧵1/8 Image These findings are from a study in @ScienceMagazine which examined the impact of exposure to sugar restrictions within 1000 days after conception on type 2 diabetes and hypertension. 2/8 science.org/doi/10.1126/sc…Image
Mar 17 • 10 tweets • 2 min read
Greater daylight exposure is associated with a reduced risk of mental disorders.

🧵1/10 Image These findings are from a study in @natmenthealth which performed the largest to-date (n=86,772 adults) cross-sectional analysis of light, sleep, and mental health. 2/10 nature.com/articles/s4422…Image
Mar 16 • 11 tweets • 2 min read
Asthma is associated with an increased risk for schizophrenia.

🧵1/11 Image These findings are from a study in @PLOSONE which investigated the association between asthma, corticosteroid use, and schizophrenia. 2/11 journals.plos.org/plosone/articl…Image
Mar 16 • 12 tweets • 3 min read
There is a high degree of genetic correlation across psychiatric disorders - it’s time to refine the DSM.

🧵1/12 Image These findings are from a study in @ScienceMagazine which used genome-wide association data for 265,218 patients and 784,643 control participants to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. 2/12 science.org/doi/abs/10.112…Image
Mar 15 • 10 tweets • 3 min read
Schizophrenia may be on the autism spectrum.

🧵1/10 White matter tracts with greater mean diffusivity in schizophrenia compared to controls (top row in blue) and compared to individuals with autism (bottom row in red). These findings are from a review in @ElsevierConnect which investigated the phenomenological overlap between autism and schizophrenia. 2/10 sciencedirect.com/science/articl…Image
Mar 14 • 4 tweets • 1 min read
Relative reproductive success (RLRS) is highest for ADHD. Image Source: link.springer.com/article/10.100…
Mar 14 • 9 tweets • 2 min read
Coffee preserves the main biological mechanisms of aging.

🧵1/9 Image These findings are from a review in @ElsevierConnect which explored evidence from studies in humans supporting an ability of coffee and of its main components (caffeine and chlorogenic acids) to preserve the main biological aging mechanisms. 2/9 sciencedirect.com/science/articl…Image
Mar 13 • 10 tweets • 3 min read
There is an inverse, stepwise association between dietary creatine intake and depression.

🧵1/10 Image These findings are from a study in @transl_psych which examined the association between dietary creatine and depression in U.S. adults. 2/10 nature.com/articles/s4139…Image
Mar 12 • 9 tweets • 2 min read
Psilocybin decreases cerebral blood flow to the amygdala - a brain area that controls fear.

🧵1/9 Image These findings are from a study in @SciReports which used functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin for treatment-resistant depression. 2/9 nature.com/articles/s4159…Image
Mar 11 • 8 tweets • 2 min read
Brain volume overgrowth is linked to the emergence and severity of autistic social deficits.

🧵1/8 Image These findings are from a study in @Nature which conducted neuroimaging on 106 infants at high familial risk of autism spectrum disorder (ASD) and 42 low-risk infants. 2/8 nature.com/articles/natur…Image
Mar 10 • 11 tweets • 3 min read
Our paper was just published in European Neuropsychopharmacology.

🧵1/10 Image Creatine is an extensively studied, safe and relatively inexpensive nutraceutical commonly used to improve muscle performance which can reach the central nervous system. 2/10
Mar 9 • 12 tweets • 3 min read
Time perception is slowed down in depression, but sped up in mania.

🧵1/12 Image These findings are from a study in @scnpjournal which explored the existing literature encompassing experimental studies on time perception in patients with bipolar disorder (BD). 2/12 cambridge.org/core/journals/…Image