๐ฆ๐๐ฅ๐ฆ-๐๐ข๐ฉ-2 ๐ฅ๐๐ฃ๐๐๐๐๐ง๐๐ข๐ก ๐ถ๐ป ๐๐ต๐ฒ ๐ต๐ฒ๐ฎ๐ฟ๐ ๐ผ๐ณ ๐๐ต๐ฒ ๐๐๐๐๐ฆ : ๐๐ข๐๐๐ ๐๐ฃ๐ฃ๐๐ฅ๐๐ง๐จ๐ฆ/๐๐ข๐ ๐ฃ๐๐ฅ๐ง๐ ๐๐ก๐ง
(๐งต ๐๐ฆ๐จ๐ข-๐ต๐ฉ๐ณ๐ฆ๐ข๐ฅ ๐ธ๐ช๐ต๐ฉ 4 ๐ด๐ต๐ถ๐ฅ๐ช๐ฆ๐ด)
During viral replication, SARS-CoV-2 enters host cells through binding with ...
(๐งต ๐๐ฆ๐จ๐ข-๐ต๐ฉ๐ณ๐ฆ๐ข๐ฅ ๐ธ๐ช๐ต๐ฉ 4 ๐ด๐ต๐ถ๐ฅ๐ช๐ฆ๐ด)
During viral replication, SARS-CoV-2 enters host cells through binding with ...
2) ...receptors on the cell surface. Once inside the cell, the virus releases its genetic material, which is in the form of RNA. The viral RNA then hijacks the host cell's machinery to replicate itself.
Within the Golgi apparatus, the viral RNA is translated into viral proteins..
Within the Golgi apparatus, the viral RNA is translated into viral proteins..
3) ... by the host cell's ribosomes. These viral proteins undergo post-translational modifications and are processed within the Golgi apparatus. The Golgi apparatus also plays a role in assembling new viral particles.
After replication and assembly, the newly formed SARS-CoV-2 ..
After replication and assembly, the newly formed SARS-CoV-2 ..
4) ...particles are transported from the Golgi apparatus to the cell surface. From there, they can be released to infect other cells or be transmitted to other individuals.
5) 1๐๐ ๐๐๐๐ฑ๐
A brief reminder
โถ๏ธ The ERGIC (ER-Golgi intermediate compartment) is located at the interface between the endoplasmic reticulum (ER) and Golgi apparatus. It acts as a sorting station between these two organelles.
โถ๏ธ The Golgi apparatus is located in the cell
A brief reminder
โถ๏ธ The ERGIC (ER-Golgi intermediate compartment) is located at the interface between the endoplasmic reticulum (ER) and Golgi apparatus. It acts as a sorting station between these two organelles.
โถ๏ธ The Golgi apparatus is located in the cell
6) ... cytoplasm near the nucleus. It consists of stacks of flattened membrane sacs called cisternae.
In this study,
Virion-transporting vesicles and pits at the plasma membrane were found to be coated with proteins. biorxiv.org/content/10.110โฆ
In this study,
Virion-transporting vesicles and pits at the plasma membrane were found to be coated with proteins. biorxiv.org/content/10.110โฆ
7) Immunofluorescence and electron microscopy showed the coat protein was coatomer complex I (COPI).
The results identify COPI as critical for facilitating transport of virions from the ERGIC, revealing a novel role for COPI in the SARS-CoV-2 life cycle.
The results identify COPI as critical for facilitating transport of virions from the ERGIC, revealing a novel role for COPI in the SARS-CoV-2 life cycle.
8) ๐'๐ฎ ๐ด๐ฐ๐ณ๐ณ๐บ ๐ฃ๐ฆ๐ค๐ข๐ถ๐ด๐ฆ ๐/๐๐ธ๐ช๐ต๐ต๐ฆ๐ณ ๐ค๐ณ๐ข๐ด๐ฉ๐ฆ๐ด ๐ด๐ฆ๐ท๐ฆ๐ณ๐ข๐ญ ๐ต๐ช๐ฎ๐ฆ๐ด ๐ค๐ข๐ถ๐ด๐ช๐ฏ๐จ ๐ฎ๐ฆ ๐ต๐ฐ ๐ญ๐ฐ๐ด๐ฆ ๐ด๐ฆ๐ท๐ฆ๐ณ๐ข๐ญ ๐ฉ๐ฐ๐ถ๐ณ๐ด ๐ฐ๐ง ๐ธ๐ฐ๐ณ๐ฌ. ๐ ๐ธ๐ช๐ญ๐ญ ๐ฑ๐ฐ๐ด๐ต ๐ต๐ฉ๐ฆ ๐ณ๐ฆ๐ด๐ต ๐ธ๐ฉ๐ฆ๐ฏ ๐ต๐ฉ๐ฆ ๐ด๐บ๐ด๐ต๐ฆ๐ฎ ๐ช๐ด ๐ด๐ต๐ข๐ฃ๐ญ๐ฆ ๐ข๐จ๐ข๐ช๐ฏ. ๐คทโโ๏ธ
9) 2๐ป๐ฑ ๐๐๐๐ฑ๐ with one of the most fascinating videos I have seen which describes the observation of complex interconnected membrane structures that are visibly connected to a membrane derived from the endoplasmic reticulum (ER).
10) The 3D rendering demonstrates the accumulation of mitochondria at the outer edges of the replication complex.
ncbi.nlm.nih.gov/pmc/articles/Pโฆ
ncbi.nlm.nih.gov/pmc/articles/Pโฆ
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