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Apr 18 โ€ข 7 tweets โ€ข 3 min read โ€ข Read on X
๐™๐™๐™š ๐™ข๐™ž๐™จ๐™ฉ๐™–๐™ ๐™š ๐™ค๐™› ๐™—๐™š๐™ก๐™ž๐™š๐™ซ๐™ž๐™ฃ๐™œ ๐™ž๐™ฃ "๐™๐™ฎ๐™™๐™ง๐™ž๐™™ ๐™ž๐™ข๐™ข๐™ช๐™ฃ๐™ž๐™ฉ๐™ฎ"

"๐˜๐˜บ๐˜ฃ๐˜ณ๐˜ช๐˜ฅ ๐˜ช๐˜ฎ๐˜ฎ๐˜ถ๐˜ฏ๐˜ช๐˜ต๐˜บ ๐˜ฉ๐˜ข๐˜ด ๐˜ญ๐˜ช๐˜ฎ๐˜ช๐˜ต๐˜ฆ๐˜ฅ ๐˜ช๐˜ฎ๐˜ฑ๐˜ข๐˜ค๐˜ต ๐˜ฐ๐˜ฏ ๐˜ง๐˜ถ๐˜ต๐˜ถ๐˜ณ๐˜ฆ ๐˜Š๐˜–๐˜๐˜๐˜‹-19 ๐˜ธ๐˜ข๐˜ท๐˜ฆ๐˜ด ๐˜ธ๐˜ช๐˜ต๐˜ฉ ๐˜ช๐˜ฎ๐˜ฎ๐˜ถ๐˜ฏ๐˜ฆ-๐˜ฆ๐˜ด๐˜ค๐˜ข๐˜ฑ๐˜ฆ ๐˜ท๐˜ข๐˜ณ๐˜ช๐˜ข๐˜ฏ๐˜ต๐˜ด"
bmcinfectdis.biomedcentral.com/articles/10.11โ€ฆ
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2) The study uses an agent-based model to simulate COVID-19 transmission and evaluate the impact of hybrid immunity on future epidemic waves. Hybrid immunity refers to immunity from both past infection and vaccination. Image
3) It considers scenarios with different population age structures ("older" vs "younger"), vaccination coverage levels (20%, 50%, 80%), and timeline of vaccination rollout and infection waves.
For a second wave caused by the same Omicron variant, high vaccination coverage (>50%) Image
4) ...can delay and suppress future waves compared to low (20%) coverage, especially if past infection rates were also high (>50%).
Older populations consistently experience worse clinical outcomes like deaths than younger populations, even with the same attack rates. Image
5) Higher vaccination is more important in older populations to protect high-risk groups.
If the second wave is caused by an Omicron immune escape variant, previously observed protective effects of vaccination are reduced. Past and future attack rates show a linear relationship Image
6) ...and future rates can exceed past rates.
The benefits of vaccination and hybrid immunity depend on many factors like demography, vaccine efficacy, and variants. Hybrid immunity landscapes will become more complex over time with multiple exposures and variants. Image
7) In summary, the study shows how vaccination can help mitigate future COVID-19 waves, but its impact depends strongly on population characteristics, variants, and waning immunity over time.

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More from @ejustin46

Apr 20
๐—›5๐—ก1 ๐—ฐ๐—น๐—ฎ๐—ฑ๐—ฒ 2.3.4.4๐—ฏ ๐—ณ๐—ถ๐—ฟ๐˜€๐˜ ๐˜๐—ถ๐—บ๐—ฒ ๐—ฑ๐—ฒ๐˜๐—ฒ๐—ฐ๐˜๐—ฒ๐—ฑ ๐—ถ๐—ป ๐——๐—ข๐—Ÿ๐—ฃ๐—›๐—œ๐—ก๐—ฆ, ๐˜„๐—ต๐—ถ๐—ฐ๐—ต ๐—ฎ๐—ฟ๐—ฒ ๐— ๐—”๐— ๐— ๐—”๐—Ÿ๐—ฆ, ๐—ก๐—ข๐—ง ๐—™๐—œ๐—ฆ๐—› !

nature.com/articles/s4200โ€ฆ
Image
2) Researchers detected and isolated highly pathogenic avian influenza A(H5N1) virus from a deceased common bottlenose dolphin in Florida, USA. This represents the first known detection of influenza virus in this dolphin species. Image
3) Upon necropsy and microscopic examination, the dolphin was found to have meningoencephalitis (inflammation of the brain and meninges). The highest viral load was detected in the brain tissues. Image
Read 8 tweets
Apr 19
๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™Š๐™‘-2 ๐™˜๐™–๐™ช๐™จ๐™ž๐™ฃ๐™œ ๐™–๐™ฃ ๐™–๐™™๐™™๐™ž๐™ฉ๐™ž๐™ค๐™ฃ๐™–๐™ก ๐™—๐™ช๐™ง๐™™๐™š๐™ฃ ๐™ค๐™› ๐™–๐™˜๐™ช๐™ฉ๐™š ๐™ง๐™š๐™จ๐™ฅ๐™ž๐™ง๐™–๐™ฉ๐™ค๐™ง๐™ฎ ๐™ž๐™ฃ๐™›๐™š๐™˜๐™ฉ๐™ž๐™ค๐™ฃ๐™จ (๐˜ผ๐™๐™„) ๐™ฌ๐™ž๐™ฉ๐™ ๐™ž๐™ข๐™ฅ๐™ก๐™ž๐™˜๐™–๐™ฉ๐™ž๐™ค๐™ฃ๐™จ ๐™›๐™ค๐™ง ๐™ฉ๐™๐™š ๐™ฌ๐™ค๐™ง๐™  ๐™›๐™ค๐™ง๐™˜๐™š.

ijidonline.com/article/S1201-โ€ฆ
Image
2) The study investigated the contribution of SARS-CoV-2 to the burden of acute respiratory infections (ARI) in Germany during the 2022/2023 winter season.
Over 37,000 participants from the DigiHero cohort reported on ARI episodes from September 2022 to March 2023. Image
3) They provided information on SARS-CoV-2 test results and symptom duration.
A total of 54,813 ARI episodes were reported, including 9,358 that were positive for SARS-CoV-2.
The cumulative incidence of all ARI was 145 per 100 people. For non-SARS ARI it was 120, and ... Image
Read 6 tweets
Apr 19
๐—–๐—ข๐—ฉ๐—œ๐——-19 ๐—ฎ๐—ป๐—ฑ ๐—ฐ๐—ผ๐—ด๐—ป๐—ถ๐˜๐—ถ๐˜ƒ๐—ฒ ๐—ถ๐—บ๐—ฝ๐—ฎ๐—ถ๐—ฟ๐—บ๐—ฒ๐—ป๐˜: ๐—™๐—ฟ๐—ผ๐—บ ๐—ฒ๐˜ƒ๐—ถ๐—ฑ๐—ฒ๐—ป๐—ฐ๐—ฒ ๐˜๐—ผ ๐—ฆ๐—”๐—ฅ๐—ฆ-๐—–๐—ผ๐—ฉ-2 ๐—บ๐—ฒ๐—ฐ๐—ต๐—ฎ๐—ป๐—ถ๐˜€๐—บ

onlinelibrary.wiley.com/doi/10.1002/brโ€ฆ
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2) COVID-19 can cause cognitive impairment (CI) affecting domains like memory, attention, and executive function. Around 30-80% of patients experience some form of CI.
SARS-CoV-2 is thought to cause CI through both direct neural invasion and neuroinflammatory mechanisms. Image
3) Clinical evidence shows impaired performance on cognitive tests like MMSE and MoCA in COVID-19 patients. Neuroimaging shows changes in white matter integrity and hypometabolism in brain regions.
Read 7 tweets
Apr 18
๐——๐—ฎ๐—ฟ๐—ธ ๐—ฆ๐—ถ๐—ฑ๐—ฒ ๐—ผ๐—ณ ๐˜๐—ต๐—ฒ ๐—–๐—ข๐—ฉ๐—œ๐——-19 ๐—ฃ๐—ฎ๐—ป๐—ฑ๐—ฒ๐—บ๐—ถ๐—ฐ :
'๐™‡๐™ค๐™ฃ๐™œ ๐˜พ๐™Š๐™‘๐™„๐˜ฟ'


Interesting study with 1301 patients, employees of one of the biggest national banks in Turkey. idcmjournal.org/long-covid
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2) The study examined the prevalence and risk factors for long COVID, defined as persisting symptoms for 3 or more months after acute COVID-19 infection.
A total of 1301 patients were surveyed who had tested positive for COVID-19 between March 2020 to September 2021. Image
3) All were employees of a large Turkish bank.
19.8% of patients (257 individuals) met the criteria for long COVID, having at least one symptom persisting for 3 or more months.
The most commonly reported long-term symptoms were myalgia (14.3%), arthralgia (14.1%) ... Image
Read 6 tweets
Apr 18
๐˜พ๐™–๐™ฃ ๐™ฌ๐™š ๐™™๐™ž๐™ง๐™š๐™˜๐™ฉ๐™ก๐™ฎ ๐™–๐™ฉ๐™ฉ๐™–๐™˜๐™  ๐™ฉ๐™๐™š ๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™Š๐™‘-2 ๐™ค๐™ฃ ๐™– ๐™œ๐™š๐™ฃ๐™š๐™ฉ๐™ž๐™˜ ๐™ก๐™š๐™ซ๐™š๐™ก ?
Despite deployment of vaccines against SARS-CoV-2, clinically relevant modalities to curb the pandemic by directly attacking the virus on a genetic level remain highly desirable Image
2) The objective is to act on these RNAi suppressors to create new vaccines.

Some brief explanations and reference studies :

A viral RNAi suppressor is a protein encoded by certain viruses that inhibits or suppresses the host cell's RNA interference (RNAi) pathway.
3) The RNAi pathway is a natural defense mechanism in cells that helps regulate gene expression and protect against viral infections. It involves the production of small RNA molecules, such as small-interfering RNAs (siRNAs), that can specifically target and degrade viral RNA.
Read 7 tweets
Apr 18
๐˜๐˜ฏ๐˜ต๐˜ฆ๐˜ณ๐˜ฆ๐˜ด๐˜ต๐˜ช๐˜ฏ๐˜จ ๐˜จ๐˜ฆ๐˜ฏ๐˜ฆ๐˜ณ๐˜ข๐˜ญ ๐˜ข๐˜ณ๐˜ต๐˜ช๐˜ค๐˜ญ๐˜ฆ
๐™๐™๐™š ๐™ง๐™ค๐™ก๐™š ๐™–๐™ฃ๐™™ ๐™ฅ๐™ค๐™ฌ๐™š๐™ง ๐™ค๐™› ๐™ง๐™š-๐™ฅ๐™–๐™ฉ๐™ฉ๐™š๐™ง๐™ฃ๐™ž๐™ฃ๐™œ ๐™ž๐™ฃ ๐™จ๐™ฎ๐™จ๐™ฉ๐™š๐™ข๐™จ ๐™˜๐™๐™–๐™ฃ๐™œ๐™š

Thx to @DrInfoSec
medium.com/good-shift/theโ€ฆ
Image
2) The role of re-patterning in systems change is to shift the fundamental values, mindsets, behaviors, interactions within a system towards equity. It involves identifying and changing patterns of behavior, relationships, and structures that contribute to inequitable outcomes. Image
3) By focusing on everyday patterns, such as small shifts in behavior or interactions, it is possible to create meaningful change in people's lived experience of systems.
The article introduces seven patterns that have been identified as ways to actively re-pattern systems Image
Read 6 tweets

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