Interesting study with 1301 patients, employees of one of the biggest national banks in Turkey. idcmjournal.org/long-covid
2) The study examined the prevalence and risk factors for long COVID, defined as persisting symptoms for 3 or more months after acute COVID-19 infection.
A total of 1301 patients were surveyed who had tested positive for COVID-19 between March 2020 to September 2021.
3) All were employees of a large Turkish bank.
19.8% of patients (257 individuals) met the criteria for long COVID, having at least one symptom persisting for 3 or more months.
The most commonly reported long-term symptoms were myalgia (14.3%), arthralgia (14.1%) ...
4) ...and back pain (13.8%). Musculoskeletal and neurological systems were most frequently affected.
Female gender and diabetes mellitus were identified as independent risk factors for long COVID based on multivariate regression analysis.
5) COVID-19 severity did not have a significant association with long COVID risk, suggesting long-term impacts beyond acute disease severity.
The study helps characterize the prevalence and risk factors for long COVID in Turkey.
6) Identifying those at higher risk may aid in management and rehabilitation efforts.
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2) Researchers detected and isolated highly pathogenic avian influenza A(H5N1) virus from a deceased common bottlenose dolphin in Florida, USA. This represents the first known detection of influenza virus in this dolphin species.
3) Upon necropsy and microscopic examination, the dolphin was found to have meningoencephalitis (inflammation of the brain and meninges). The highest viral load was detected in the brain tissues.
2) The study investigated the contribution of SARS-CoV-2 to the burden of acute respiratory infections (ARI) in Germany during the 2022/2023 winter season.
Over 37,000 participants from the DigiHero cohort reported on ARI episodes from September 2022 to March 2023.
3) They provided information on SARS-CoV-2 test results and symptom duration.
A total of 54,813 ARI episodes were reported, including 9,358 that were positive for SARS-CoV-2.
The cumulative incidence of all ARI was 145 per 100 people. For non-SARS ARI it was 120, and ...
2) COVID-19 can cause cognitive impairment (CI) affecting domains like memory, attention, and executive function. Around 30-80% of patients experience some form of CI.
SARS-CoV-2 is thought to cause CI through both direct neural invasion and neuroinflammatory mechanisms.
3) Clinical evidence shows impaired performance on cognitive tests like MMSE and MoCA in COVID-19 patients. Neuroimaging shows changes in white matter integrity and hypometabolism in brain regions.
๐พ๐๐ฃ ๐ฌ๐ ๐๐๐ง๐๐๐ฉ๐ก๐ฎ ๐๐ฉ๐ฉ๐๐๐ ๐ฉ๐๐ ๐๐ผ๐๐-๐พ๐๐-2 ๐ค๐ฃ ๐ ๐๐๐ฃ๐๐ฉ๐๐ ๐ก๐๐ซ๐๐ก ?
Despite deployment of vaccines against SARS-CoV-2, clinically relevant modalities to curb the pandemic by directly attacking the virus on a genetic level remain highly desirable
2) The objective is to act on these RNAi suppressors to create new vaccines.
Some brief explanations and reference studies :
A viral RNAi suppressor is a protein encoded by certain viruses that inhibits or suppresses the host cell's RNA interference (RNAi) pathway.
3) The RNAi pathway is a natural defense mechanism in cells that helps regulate gene expression and protect against viral infections. It involves the production of small RNA molecules, such as small-interfering RNAs (siRNAs), that can specifically target and degrade viral RNA.
2) The role of re-patterning in systems change is to shift the fundamental values, mindsets, behaviors, interactions within a system towards equity. It involves identifying and changing patterns of behavior, relationships, and structures that contribute to inequitable outcomes.
3) By focusing on everyday patterns, such as small shifts in behavior or interactions, it is possible to create meaningful change in people's lived experience of systems.
The article introduces seven patterns that have been identified as ways to actively re-pattern systems
2) The researchers generated a panel of 28 potent monoclonal antibodies from volunteers who were infected with the Omicron BA.4 or BA.5 variants of SARS-CoV-2, despite being vaccinated.
3) They characterized the antibodies functionally and in some cases structurally. The antibodies targeted the spike protein receptor binding domain (RBD) or N-terminal domain (NTD).