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Apr 19 โ€ข 6 tweets โ€ข 3 min read โ€ข Read on X
๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™Š๐™‘-2 ๐™˜๐™–๐™ช๐™จ๐™ž๐™ฃ๐™œ ๐™–๐™ฃ ๐™–๐™™๐™™๐™ž๐™ฉ๐™ž๐™ค๐™ฃ๐™–๐™ก ๐™—๐™ช๐™ง๐™™๐™š๐™ฃ ๐™ค๐™› ๐™–๐™˜๐™ช๐™ฉ๐™š ๐™ง๐™š๐™จ๐™ฅ๐™ž๐™ง๐™–๐™ฉ๐™ค๐™ง๐™ฎ ๐™ž๐™ฃ๐™›๐™š๐™˜๐™ฉ๐™ž๐™ค๐™ฃ๐™จ (๐˜ผ๐™๐™„) ๐™ฌ๐™ž๐™ฉ๐™ ๐™ž๐™ข๐™ฅ๐™ก๐™ž๐™˜๐™–๐™ฉ๐™ž๐™ค๐™ฃ๐™จ ๐™›๐™ค๐™ง ๐™ฉ๐™๐™š ๐™ฌ๐™ค๐™ง๐™  ๐™›๐™ค๐™ง๐™˜๐™š.

ijidonline.com/article/S1201-โ€ฆ
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2) The study investigated the contribution of SARS-CoV-2 to the burden of acute respiratory infections (ARI) in Germany during the 2022/2023 winter season.
Over 37,000 participants from the DigiHero cohort reported on ARI episodes from September 2022 to March 2023. Image
3) They provided information on SARS-CoV-2 test results and symptom duration.
A total of 54,813 ARI episodes were reported, including 9,358 that were positive for SARS-CoV-2.
The cumulative incidence of all ARI was 145 per 100 people. For non-SARS ARI it was 120, and ... Image
4) ...for SARS ARI it was 25, indicating a 21% excess of ARI due to SARS-CoV-2.
SARS ARI caused symptoms for longer (9.7 days vs 8.8 days) and more days spent in bed (3.0 days vs 2.0 days) compared to non-SARS ARI.
Extrapolating to the German population the ... Image
5)...estimated number of SARS ARI was at least 17 million, exceeding official registered cases by 2-fold due to underreporting.
Risk factors for higher ARI incidence included younger age, larger household size, and lower social class. Males and older individuals had lower risk. Image
6) The study estimates are consistent with higher reported ARI incidence compared to pre-pandemic winters, suggesting an additional ARI burden due to SARS-CoV-2.

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More from @ejustin46

Apr 21
๐™ˆ๐™š๐™ก๐™–๐™ฉ๐™ค๐™ฃ๐™ž๐™ฃ: ๐™– ๐™›๐™š๐™ง๐™ง๐™ค๐™ฅ๐™ฉ๐™ค๐™จ๐™ž๐™จ ๐™ž๐™ฃ๐™๐™ž๐™—๐™ž๐™ฉ๐™ค๐™ง ๐™ฌ๐™ž๐™ฉ๐™ ๐™ฅ๐™ค๐™ฉ๐™š๐™ฃ๐™ฉ๐™ž๐™–๐™ก ๐™ฉ๐™๐™š๐™ง๐™–๐™ฅ๐™š๐™ช๐™ฉ๐™ž๐™˜ ๐™š๐™›๐™›๐™ž๐™˜๐™–๐™˜๐™ฎ ๐™›๐™ค๐™ง ๐™–๐™˜๐™˜๐™š๐™ก๐™š๐™ง๐™–๐™ฉ๐™š๐™™ ๐™—๐™ง๐™–๐™ž๐™ฃ ๐™–๐™œ๐™ž๐™ฃ๐™œ ๐™–๐™ฃ๐™™ ๐™ฃ๐™š๐™ช๐™ง๐™ค๐™™๐™š๐™œ๐™š๐™ฃ๐™š๐™ง๐™–๐™ฉ๐™ž๐™ค๐™ฃ.
#LongCovid

โ€ฆarneurodegeneration.biomedcentral.com/articles/10.11โ€ฆ
Image
2) Ferroptosis, an iron-dependent form of regulated cell death, has been proposed as a potential driver of organ damage in COVID-19 and the post-COVID trajectory of aging and neurodegeneration. Image
3) COVID-19 infection promotes several events that can lead to ferroptosis, including neuroinflammation, iron dysregulation, oxidative stress, ACE2 receptor disruption, and clock gene alteration. Image
Read 7 tweets
Apr 21
๐—ฆ๐—”๐—ฅ๐—ฆ-๐—–๐—ผ๐—ฉ-2 ๐—ถ๐—บ๐—ฝ๐—ผ๐—ฟ๐˜๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ฟ๐—ถ๐˜€๐—ธ ๐—ฏ๐˜† ๐—ฎ๐—ถ๐—ฟ ๐˜๐—ฟ๐—ฎ๐˜ƒ๐—ฒ๐—น ๐—ถ๐—ป๐˜๐—ผ ๐—–๐—ฎ๐—ป๐—ฎ๐—ฑ๐—ฎ

bmcpublichealth.biomedcentral.com/articles/10.11โ€ฆ
Image
2) This study describes a mathematical model developed by the Public Health Agency of Canada to estimate COVID-19 importation risk (number of infected travelers arriving) at Canadian airports from international travel between July-November 2021. Image
3) The model incorporates detailed travel volume data, global COVID epidemiological data, vaccination/ immunity levels, and pre-departure testing requirements for travelers.
Model results estimate a total of 7,863 infected travelers entered Canada during this period.
Read 6 tweets
Apr 20
๐—ฃ๐—ฆ๐—œ๐—ง๐—ง๐—”๐—–๐—ข๐—ฆ๐—œ๐—ฆ ๐Ÿคฌ
๐™Ž๐™ฉ๐™ช๐™™๐™ž๐™š๐™จ ๐™ฉ๐™๐™–๐™ฉ ๐™จ๐™ค๐™ช๐™ฃ๐™™๐™š๐™™ ๐™ฉ๐™๐™š ๐™–๐™ก๐™–๐™ง๐™ข :
โ–ถ๏ธ 2016, "an important zoonotic pathogen"
โ–ถ๏ธ 2020, "can cause potentially fatal disease in birds and humans"
โ–ถ๏ธ 2023, "an underappreciated and undiagnosed disease"
โ–ถ๏ธ 2024, ๐˜ฝ๐™„๐™‰๐™‚๐™Š ! Image
2) ๐™๐™š๐™›๐™š๐™ง๐™š๐™ฃ๐™˜๐™š๐™จ
"Australian human and parrot Chlamydia psittaci strains cluster within the highly virulent 6BC clade of this important zoonotic pathogen"
nature.com/articles/srep3โ€ฆ
3) "Species, sex and geographic variation in chlamydial prevalence in abundant wild Australian parrots"
nature.com/articles/s4159โ€ฆ
Read 5 tweets
Apr 20
๐™‰๐™„๐™Ž๐™„๐™‰ ๐™ซ๐™–๐™ง๐™ž๐™–๐™ฃ๐™ฉ๐™จ: ๐™ฌ๐™๐™–๐™ฉ ๐™ข๐™–๐™ ๐™š๐™จ ๐™ฉ๐™๐™š๐™ข ๐™™๐™ž๐™›๐™›๐™š๐™ง๐™š๐™ฃ๐™ฉ ๐™–๐™ฃ๐™™ ๐™ช๐™ฃ๐™ž๐™ฆ๐™ช๐™š? ๐Ÿค”

"Nisin has an affinity for the same receptor used by SARS-CoV-2 to enter human cells"
sciencedirect.com/science/articlโ€ฆ
Image
2) Nisin A is a bacteriocin produced by certain strains of Lactococcus lactis. It is commonly used as a natural food preservative due to its antimicrobial properties against various microorganisms. Nisin A has also shown potential in human and veterinary medicine ... Image
3) with studies demonstrating its effectiveness in treating conditions such as bovine mastitis, dental caries, cancer, and skin infections. Recently, it has been discovered that nisin A has an affinity for the receptor used by SARS-CoV-2
and has been proposed as ... Image
Read 5 tweets
Apr 20
๐—›5๐—ก1 ๐—ฐ๐—น๐—ฎ๐—ฑ๐—ฒ 2.3.4.4๐—ฏ ๐—ณ๐—ถ๐—ฟ๐˜€๐˜ ๐˜๐—ถ๐—บ๐—ฒ ๐—ฑ๐—ฒ๐˜๐—ฒ๐—ฐ๐˜๐—ฒ๐—ฑ ๐—ถ๐—ป ๐——๐—ข๐—Ÿ๐—ฃ๐—›๐—œ๐—ก๐—ฆ, ๐˜„๐—ต๐—ถ๐—ฐ๐—ต ๐—ฎ๐—ฟ๐—ฒ ๐— ๐—”๐— ๐— ๐—”๐—Ÿ๐—ฆ, ๐—ก๐—ข๐—ง ๐—™๐—œ๐—ฆ๐—› !

nature.com/articles/s4200โ€ฆ
Image
2) Researchers detected and isolated highly pathogenic avian influenza A(H5N1) virus from a deceased common bottlenose dolphin in Florida, USA. This represents the first known detection of influenza virus in this dolphin species. Image
3) Upon necropsy and microscopic examination, the dolphin was found to have meningoencephalitis (inflammation of the brain and meninges). The highest viral load was detected in the brain tissues. Image
Read 8 tweets
Apr 19
๐—–๐—ข๐—ฉ๐—œ๐——-19 ๐—ฎ๐—ป๐—ฑ ๐—ฐ๐—ผ๐—ด๐—ป๐—ถ๐˜๐—ถ๐˜ƒ๐—ฒ ๐—ถ๐—บ๐—ฝ๐—ฎ๐—ถ๐—ฟ๐—บ๐—ฒ๐—ป๐˜: ๐—™๐—ฟ๐—ผ๐—บ ๐—ฒ๐˜ƒ๐—ถ๐—ฑ๐—ฒ๐—ป๐—ฐ๐—ฒ ๐˜๐—ผ ๐—ฆ๐—”๐—ฅ๐—ฆ-๐—–๐—ผ๐—ฉ-2 ๐—บ๐—ฒ๐—ฐ๐—ต๐—ฎ๐—ป๐—ถ๐˜€๐—บ

onlinelibrary.wiley.com/doi/10.1002/brโ€ฆ
Image
2) COVID-19 can cause cognitive impairment (CI) affecting domains like memory, attention, and executive function. Around 30-80% of patients experience some form of CI.
SARS-CoV-2 is thought to cause CI through both direct neural invasion and neuroinflammatory mechanisms. Image
3) Clinical evidence shows impaired performance on cognitive tests like MMSE and MoCA in COVID-19 patients. Neuroimaging shows changes in white matter integrity and hypometabolism in brain regions.
Read 7 tweets

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