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Apr 20 โ€ข 5 tweets โ€ข 2 min read โ€ข Read on X
๐—ฃ๐—ฆ๐—œ๐—ง๐—ง๐—”๐—–๐—ข๐—ฆ๐—œ๐—ฆ ๐Ÿคฌ
๐™Ž๐™ฉ๐™ช๐™™๐™ž๐™š๐™จ ๐™ฉ๐™๐™–๐™ฉ ๐™จ๐™ค๐™ช๐™ฃ๐™™๐™š๐™™ ๐™ฉ๐™๐™š ๐™–๐™ก๐™–๐™ง๐™ข :
โ–ถ๏ธ 2016, "an important zoonotic pathogen"
โ–ถ๏ธ 2020, "can cause potentially fatal disease in birds and humans"
โ–ถ๏ธ 2023, "an underappreciated and undiagnosed disease"
โ–ถ๏ธ 2024, ๐˜ฝ๐™„๐™‰๐™‚๐™Š ! Image
2) ๐™๐™š๐™›๐™š๐™ง๐™š๐™ฃ๐™˜๐™š๐™จ
"Australian human and parrot Chlamydia psittaci strains cluster within the highly virulent 6BC clade of this important zoonotic pathogen"
nature.com/articles/srep3โ€ฆ
3) "Species, sex and geographic variation in chlamydial prevalence in abundant wild Australian parrots"
nature.com/articles/s4159โ€ฆ
4) "Psittacosis: An Underappreciated and Often Undiagnosed Disease"
ncbi.nlm.nih.gov/pmc/articles/Pโ€ฆ
5) "Psittacosis โ€“ European region"
who.int/emergencies/diโ€ฆ

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More from @ejustin46

Apr 22
๐—ง๐—ต๐—ฒ๐—ฟ๐—ฎ๐—ฝ๐—ฒ๐˜‚๐˜๐—ถ๐—ฐ ๐˜๐—ฎ๐—ฟ๐—ด๐—ฒ๐˜๐˜€ ๐—ณ๐—ผ๐—ฟ ๐—–๐—ข๐—ฉ๐—œ๐——-19

2 ๐˜ธ๐˜ฐ๐˜ฏ๐˜ฅ๐˜ฆ๐˜ณ๐˜ง๐˜ถ๐˜ญ ๐˜ด๐˜ต๐˜ถ๐˜ฅ๐˜ช๐˜ฆ๐˜ด ๐˜ธ๐˜ช๐˜ต๐˜ฉ ๐˜จ๐˜ณ๐˜ฆ๐˜ข๐˜ต ๐˜ท๐˜ช๐˜ด๐˜ถ๐˜ข๐˜ญ๐˜ช๐˜ด๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ๐˜ด, ๐˜ง๐˜ฐ๐˜ณ ๐˜ข ๐˜ฑ๐˜ฐ๐˜ด๐˜ช๐˜ต๐˜ช๐˜ท๐˜ฆ ๐˜ฐ๐˜ถ๐˜ต๐˜ญ๐˜ฐ๐˜ฐ๐˜ฌ ๐Ÿค— Image
2)"Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies"

Current treatment strategies for COVID-19 can be classified into "target virus" and "target host" categories. Repurposing existing drugs, emerging drugs .. nature.com/articles/s4139โ€ฆ
Image
3) ...and promising potential targets fall under these categories.
For the host, ACE2 receptor, TMPRSS2 protease, inflammatory cytokines and their pathways, CD147, and HMGB1 are potential therapeutic targets based on their roles in viral entry/pathogenesis/excessive inflammation. Image
Read 10 tweets
Apr 21
๐—–๐—ข๐—ฉ๐—œ๐—— ๐—œ๐—ก๐—™๐—˜๐—–๐—ง๐—œ๐—ข๐—ก & ๐—Ÿ๐—ข๐—ก๐—š ๐—–๐—ข๐—ฉ๐—œ๐——
๐—ช๐—ต๐—ถ๐—ฐ๐—ต ๐—ผ๐—ฟ๐—ด๐—ฎ๐—ป๐˜€, ๐˜€๐˜†๐˜€๐˜๐—ฒ๐—บ๐˜€ ๐—ฎ๐—ฟ๐—ฒ ๐—ถ๐—บ๐—ฝ๐—ฎ๐—ฐ๐˜๐—ฒ๐—ฑ ? ๐—ช๐—ต๐—ถ๐—ฐ๐—ต ๐˜€๐˜†๐—บ๐—ฝ๐˜๐—ผ๐—บ๐˜€ ?

The pathophysiology of infection and PASC is complex and multifactorial, involving direct organ damage from virus infection .. Image
2) ...immune system dysregulation, autoimmune responses, microthrombosis, and persistent viral proteins/inflammation.
Multiple functions and organs are commonly impacted include lungs (pulmonary fibrosis, vascular dysfunction), heart (myocarditis, microvascular damage), Image
3) ...brain (neuroinflammation, autonomic dysfunction), gut (microbiome changes), kidneys, blood (hypercoagulability), and skin.
In these tables, there are the systems affected, the number of patients, their characteristics, symptoms and so many reference studies. Image
Read 11 tweets
Apr 21
๐™ˆ๐™š๐™ก๐™–๐™ฉ๐™ค๐™ฃ๐™ž๐™ฃ: ๐™– ๐™›๐™š๐™ง๐™ง๐™ค๐™ฅ๐™ฉ๐™ค๐™จ๐™ž๐™จ ๐™ž๐™ฃ๐™๐™ž๐™—๐™ž๐™ฉ๐™ค๐™ง ๐™ฌ๐™ž๐™ฉ๐™ ๐™ฅ๐™ค๐™ฉ๐™š๐™ฃ๐™ฉ๐™ž๐™–๐™ก ๐™ฉ๐™๐™š๐™ง๐™–๐™ฅ๐™š๐™ช๐™ฉ๐™ž๐™˜ ๐™š๐™›๐™›๐™ž๐™˜๐™–๐™˜๐™ฎ ๐™›๐™ค๐™ง ๐™–๐™˜๐™˜๐™š๐™ก๐™š๐™ง๐™–๐™ฉ๐™š๐™™ ๐™—๐™ง๐™–๐™ž๐™ฃ ๐™–๐™œ๐™ž๐™ฃ๐™œ ๐™–๐™ฃ๐™™ ๐™ฃ๐™š๐™ช๐™ง๐™ค๐™™๐™š๐™œ๐™š๐™ฃ๐™š๐™ง๐™–๐™ฉ๐™ž๐™ค๐™ฃ.
#LongCovid

โ€ฆarneurodegeneration.biomedcentral.com/articles/10.11โ€ฆ
Image
2) Ferroptosis, an iron-dependent form of regulated cell death, has been proposed as a potential driver of organ damage in COVID-19 and the post-COVID trajectory of aging and neurodegeneration. Image
3) COVID-19 infection promotes several events that can lead to ferroptosis, including neuroinflammation, iron dysregulation, oxidative stress, ACE2 receptor disruption, and clock gene alteration. Image
Read 7 tweets
Apr 21
๐—ฆ๐—”๐—ฅ๐—ฆ-๐—–๐—ผ๐—ฉ-2 ๐—ถ๐—บ๐—ฝ๐—ผ๐—ฟ๐˜๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ฟ๐—ถ๐˜€๐—ธ ๐—ฏ๐˜† ๐—ฎ๐—ถ๐—ฟ ๐˜๐—ฟ๐—ฎ๐˜ƒ๐—ฒ๐—น ๐—ถ๐—ป๐˜๐—ผ ๐—–๐—ฎ๐—ป๐—ฎ๐—ฑ๐—ฎ

bmcpublichealth.biomedcentral.com/articles/10.11โ€ฆ
Image
2) This study describes a mathematical model developed by the Public Health Agency of Canada to estimate COVID-19 importation risk (number of infected travelers arriving) at Canadian airports from international travel between July-November 2021. Image
3) The model incorporates detailed travel volume data, global COVID epidemiological data, vaccination/ immunity levels, and pre-departure testing requirements for travelers.
Model results estimate a total of 7,863 infected travelers entered Canada during this period.
Read 6 tweets
Apr 21
๐—Ÿ๐—ผ๐—ป๐—ด ๐—–๐—ข๐—ฉ๐—œ๐—— ๐—ฎ๐—ป๐—ฑ ๐—ณ๐—ฎ๐˜๐˜๐˜† ๐—ฎ๐—ฐ๐—ถ๐—ฑ๐˜€ (๐—˜๐—™๐—”๐˜€)

lipidworld.biomedcentral.com/articles/10.11โ€ฆ
Image
2) Long COVID or post-acute sequelae of SARS-CoV-2 infection can involve persistent fatigue, cognitive impairment, and cardiac/autonomic issues lasting months to years. The underlying mechanisms are unclear.
3) Essential fatty acids (EFAs) like linoleic acid, alpha-linolenic acid, and their metabolites (AA, EPA, DHA) play important roles in inflammation, immune function, serotonin synthesis, and more. Image
Read 10 tweets
Apr 20
๐™‰๐™„๐™Ž๐™„๐™‰ ๐™ซ๐™–๐™ง๐™ž๐™–๐™ฃ๐™ฉ๐™จ: ๐™ฌ๐™๐™–๐™ฉ ๐™ข๐™–๐™ ๐™š๐™จ ๐™ฉ๐™๐™š๐™ข ๐™™๐™ž๐™›๐™›๐™š๐™ง๐™š๐™ฃ๐™ฉ ๐™–๐™ฃ๐™™ ๐™ช๐™ฃ๐™ž๐™ฆ๐™ช๐™š? ๐Ÿค”

"Nisin has an affinity for the same receptor used by SARS-CoV-2 to enter human cells"
sciencedirect.com/science/articlโ€ฆ
Image
2) Nisin A is a bacteriocin produced by certain strains of Lactococcus lactis. It is commonly used as a natural food preservative due to its antimicrobial properties against various microorganisms. Nisin A has also shown potential in human and veterinary medicine ... Image
3) with studies demonstrating its effectiveness in treating conditions such as bovine mastitis, dental caries, cancer, and skin infections. Recently, it has been discovered that nisin A has an affinity for the receptor used by SARS-CoV-2
and has been proposed as ... Image
Read 5 tweets

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