๐ฃ๐ฆ๐๐ง๐ง๐๐๐ข๐ฆ๐๐ฆ ๐คฌ
๐๐ฉ๐ช๐๐๐๐จ ๐ฉ๐๐๐ฉ ๐จ๐ค๐ช๐ฃ๐๐๐ ๐ฉ๐๐ ๐๐ก๐๐ง๐ข :
โถ๏ธ 2016, "an important zoonotic pathogen"
โถ๏ธ 2020, "can cause potentially fatal disease in birds and humans"
โถ๏ธ 2023, "an underappreciated and undiagnosed disease"
โถ๏ธ 2024, ๐ฝ๐๐๐๐ !
2) ๐๐๐๐๐ง๐๐ฃ๐๐๐จ
"Australian human and parrot Chlamydia psittaci strains cluster within the highly virulent 6BC clade of this important zoonotic pathogen" nature.com/articles/srep3โฆ
3) "Species, sex and geographic variation in chlamydial prevalence in abundant wild Australian parrots" nature.com/articles/s4159โฆ
2)"Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies"
Current treatment strategies for COVID-19 can be classified into "target virus" and "target host" categories. Repurposing existing drugs, emerging drugs .. nature.com/articles/s4139โฆ
3) ...and promising potential targets fall under these categories.
For the host, ACE2 receptor, TMPRSS2 protease, inflammatory cytokines and their pathways, CD147, and HMGB1 are potential therapeutic targets based on their roles in viral entry/pathogenesis/excessive inflammation.
The pathophysiology of infection and PASC is complex and multifactorial, involving direct organ damage from virus infection ..
2) ...immune system dysregulation, autoimmune responses, microthrombosis, and persistent viral proteins/inflammation.
Multiple functions and organs are commonly impacted include lungs (pulmonary fibrosis, vascular dysfunction), heart (myocarditis, microvascular damage),
3) ...brain (neuroinflammation, autonomic dysfunction), gut (microbiome changes), kidneys, blood (hypercoagulability), and skin.
In these tables, there are the systems affected, the number of patients, their characteristics, symptoms and so many reference studies.
2) Ferroptosis, an iron-dependent form of regulated cell death, has been proposed as a potential driver of organ damage in COVID-19 and the post-COVID trajectory of aging and neurodegeneration.
3) COVID-19 infection promotes several events that can lead to ferroptosis, including neuroinflammation, iron dysregulation, oxidative stress, ACE2 receptor disruption, and clock gene alteration.
2) This study describes a mathematical model developed by the Public Health Agency of Canada to estimate COVID-19 importation risk (number of infected travelers arriving) at Canadian airports from international travel between July-November 2021.
3) The model incorporates detailed travel volume data, global COVID epidemiological data, vaccination/ immunity levels, and pre-departure testing requirements for travelers.
Model results estimate a total of 7,863 infected travelers entered Canada during this period.
2) Long COVID or post-acute sequelae of SARS-CoV-2 infection can involve persistent fatigue, cognitive impairment, and cardiac/autonomic issues lasting months to years. The underlying mechanisms are unclear.
3) Essential fatty acids (EFAs) like linoleic acid, alpha-linolenic acid, and their metabolites (AA, EPA, DHA) play important roles in inflammation, immune function, serotonin synthesis, and more.
2) Nisin A is a bacteriocin produced by certain strains of Lactococcus lactis. It is commonly used as a natural food preservative due to its antimicrobial properties against various microorganisms. Nisin A has also shown potential in human and veterinary medicine ...
3) with studies demonstrating its effectiveness in treating conditions such as bovine mastitis, dental caries, cancer, and skin infections. Recently, it has been discovered that nisin A has an affinity for the receptor used by SARS-CoV-2
and has been proposed as ...