๐๐ข๐ฉ๐๐ ๐๐ก๐๐๐๐ง๐๐ข๐ก & ๐๐ข๐ก๐ ๐๐ข๐ฉ๐๐
๐ช๐ต๐ถ๐ฐ๐ต ๐ผ๐ฟ๐ด๐ฎ๐ป๐, ๐๐๐๐๐ฒ๐บ๐ ๐ฎ๐ฟ๐ฒ ๐ถ๐บ๐ฝ๐ฎ๐ฐ๐๐ฒ๐ฑ ? ๐ช๐ต๐ถ๐ฐ๐ต ๐๐๐บ๐ฝ๐๐ผ๐บ๐ ?
The pathophysiology of infection and PASC is complex and multifactorial, involving direct organ damage from virus infection ..
๐ช๐ต๐ถ๐ฐ๐ต ๐ผ๐ฟ๐ด๐ฎ๐ป๐, ๐๐๐๐๐ฒ๐บ๐ ๐ฎ๐ฟ๐ฒ ๐ถ๐บ๐ฝ๐ฎ๐ฐ๐๐ฒ๐ฑ ? ๐ช๐ต๐ถ๐ฐ๐ต ๐๐๐บ๐ฝ๐๐ผ๐บ๐ ?
The pathophysiology of infection and PASC is complex and multifactorial, involving direct organ damage from virus infection ..
2) ...immune system dysregulation, autoimmune responses, microthrombosis, and persistent viral proteins/inflammation.
Multiple functions and organs are commonly impacted include lungs (pulmonary fibrosis, vascular dysfunction), heart (myocarditis, microvascular damage),
Multiple functions and organs are commonly impacted include lungs (pulmonary fibrosis, vascular dysfunction), heart (myocarditis, microvascular damage),
3) ...brain (neuroinflammation, autonomic dysfunction), gut (microbiome changes), kidneys, blood (hypercoagulability), and skin.
In these tables, there are the systems affected, the number of patients, their characteristics, symptoms and so many reference studies.
In these tables, there are the systems affected, the number of patients, their characteristics, symptoms and so many reference studies.
4) We have decided in this thread to summarize partially, these 2 tables with affected systems, nb of studies, nb of patients and symptoms, to visualise to what extent COVID-19 can impact our body.
5) ๐๐๐๐๐๐๐ผ๐๐๐๐ ๐๐๐๐๐๐
12 studies, more than 3.000 patients, follow-up 3-12 months, symptoms :
โถ๏ธ 42% of survivors had mild pulmonary function abnormalities
โถ๏ธ 25.4% of the patients, mostly demonstrated diffusion reductions in DLCO
...
12 studies, more than 3.000 patients, follow-up 3-12 months, symptoms :
โถ๏ธ 42% of survivors had mild pulmonary function abnormalities
โถ๏ธ 25.4% of the patients, mostly demonstrated diffusion reductions in DLCO
...
6)
โถ๏ธ Diminished TLC and diffusion capacity in 23 and 36 participants
โถ๏ธ Impaired DLCO in 33 (36%) and VA in 24 (26%) participants
โถ๏ธ Abnormal pulmonary function in 43 (75.4%) patients
โถ๏ธ Pulmonary diffusion abnormality in 22-56% of participants
...
โถ๏ธ Diminished TLC and diffusion capacity in 23 and 36 participants
โถ๏ธ Impaired DLCO in 33 (36%) and VA in 24 (26%) participants
โถ๏ธ Abnormal pulmonary function in 43 (75.4%) patients
โถ๏ธ Pulmonary diffusion abnormality in 22-56% of participants
...
7) ๐พ๐๐๐พ๐๐๐ผ๐๐๐๐ ๐๐๐๐๐๐
7 studies, more than 2.000 patients, follow-up 17-97 days, symptoms :
โถ๏ธ Cardiovascular-related symptoms (70, 13%), resting heart rate increase 60 (11.2%)
โถ๏ธ Chest pain (21.7%)
โถ๏ธ Abnormal CMR (78), including raised myocardial native T1 (73)
7 studies, more than 2.000 patients, follow-up 17-97 days, symptoms :
โถ๏ธ Cardiovascular-related symptoms (70, 13%), resting heart rate increase 60 (11.2%)
โถ๏ธ Chest pain (21.7%)
โถ๏ธ Abnormal CMR (78), including raised myocardial native T1 (73)
8)
โถ๏ธ Abnormal echocardiogram 667 (55%), new myocardial infarction in 36 (3%). โถ๏ธ Abnormal CMR (60.4%). Either pericarditis and/or myocarditis (30.9%): isolated pericarditis (5.8%), myopericarditis (7.9%),
โถ๏ธ Cardiovascular pathology (12%), myocarditis (8%)
...
โถ๏ธ Abnormal echocardiogram 667 (55%), new myocardial infarction in 36 (3%). โถ๏ธ Abnormal CMR (60.4%). Either pericarditis and/or myocarditis (30.9%): isolated pericarditis (5.8%), myopericarditis (7.9%),
โถ๏ธ Cardiovascular pathology (12%), myocarditis (8%)
...
9) ๐๐๐๐๐๐๐ ๐๐๐๐๐๐ ๐๐ฃ๐ ๐๐๐๐พ๐๐๐ผ๐๐๐๐พ ๐ฟ๐๐๐๐๐ฟ๐๐๐
8 studies, more than 100.000 patients, follow-up 15 days-6 months, symptoms :
โถ๏ธ Smell and taste loss was reported in 68% (40/59)
โถ๏ธ Fatigue (40), "brain fog" (29), and changes in cognition (25)
8 studies, more than 100.000 patients, follow-up 15 days-6 months, symptoms :
โถ๏ธ Smell and taste loss was reported in 68% (40/59)
โถ๏ธ Fatigue (40), "brain fog" (29), and changes in cognition (25)
10) โถ๏ธ Headache (97, 74.6%), severe headache (24), anosmia/ageusia (54.6% vs. 18.2% in headache)
โถ๏ธ Late onset of Guillain-Barrรฉ syndrome
โถ๏ธ 28% PTSD, 31% depression, 42% anxiety, 20% OC symptoms, and 40% insomnia
โถ๏ธ Psychiatric illness (18.1%), mood disorder (9.9%)
...
โถ๏ธ Late onset of Guillain-Barrรฉ syndrome
โถ๏ธ 28% PTSD, 31% depression, 42% anxiety, 20% OC symptoms, and 40% insomnia
โถ๏ธ Psychiatric illness (18.1%), mood disorder (9.9%)
...
11) There is of course much more information in this fascinating study that we highly recommend.
H/t @inkblue01
Thanks for reading ๐ nature.com/articles/s4141โฆ
H/t @inkblue01
Thanks for reading ๐ nature.com/articles/s4141โฆ
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