๐ง๐ต๐ฒ๐ฟ๐ฎ๐ฝ๐ฒ๐๐๐ถ๐ฐ ๐๐ฎ๐ฟ๐ด๐ฒ๐๐ ๐ณ๐ผ๐ฟ ๐๐ข๐ฉ๐๐-19
2 ๐ธ๐ฐ๐ฏ๐ฅ๐ฆ๐ณ๐ง๐ถ๐ญ ๐ด๐ต๐ถ๐ฅ๐ช๐ฆ๐ด ๐ธ๐ช๐ต๐ฉ ๐จ๐ณ๐ฆ๐ข๐ต ๐ท๐ช๐ด๐ถ๐ข๐ญ๐ช๐ด๐ข๐ต๐ช๐ฐ๐ฏ๐ด, ๐ง๐ฐ๐ณ ๐ข ๐ฑ๐ฐ๐ด๐ช๐ต๐ช๐ท๐ฆ ๐ฐ๐ถ๐ต๐ญ๐ฐ๐ฐ๐ฌ ๐ค
2 ๐ธ๐ฐ๐ฏ๐ฅ๐ฆ๐ณ๐ง๐ถ๐ญ ๐ด๐ต๐ถ๐ฅ๐ช๐ฆ๐ด ๐ธ๐ช๐ต๐ฉ ๐จ๐ณ๐ฆ๐ข๐ต ๐ท๐ช๐ด๐ถ๐ข๐ญ๐ช๐ด๐ข๐ต๐ช๐ฐ๐ฏ๐ด, ๐ง๐ฐ๐ณ ๐ข ๐ฑ๐ฐ๐ด๐ช๐ต๐ช๐ท๐ฆ ๐ฐ๐ถ๐ต๐ญ๐ฐ๐ฐ๐ฌ ๐ค
2)"Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies"
Current treatment strategies for COVID-19 can be classified into "target virus" and "target host" categories. Repurposing existing drugs, emerging drugs .. nature.com/articles/s4139โฆ
Current treatment strategies for COVID-19 can be classified into "target virus" and "target host" categories. Repurposing existing drugs, emerging drugs .. nature.com/articles/s4139โฆ
3) ...and promising potential targets fall under these categories.
For the host, ACE2 receptor, TMPRSS2 protease, inflammatory cytokines and their pathways, CD147, and HMGB1 are potential therapeutic targets based on their roles in viral entry/pathogenesis/excessive inflammation.
For the host, ACE2 receptor, TMPRSS2 protease, inflammatory cytokines and their pathways, CD147, and HMGB1 are potential therapeutic targets based on their roles in viral entry/pathogenesis/excessive inflammation.
4) Future directions include focusing on more promising targets, strengthening multi-disciplinary cooperation, addressing gaps between preclinical/clinical research, and monitoring viral mutations. A combination of antiviral and immunomodulatory therapies may be most effective.
5) For vaccines ...
7) Potential therapeutic targets include viral proteins like spike, protease, RNA polymerase, and host proteins involved in viral entry/ immunopathology. Various agents have shown anti-SARS-CoV-2 activity in preclinical/clinical studies, but most require further development.
8) Treatment strategies aim to administer antiviral drugs early to outpatients, while immunomodulators may benefit severely ill inpatients. Treating long COVID remains challenging due to its unclear mechanisms. Development of pan-coronavirus therapies is another priority area.
9) Overall, while progress has been made, more convenient and broadly effective antiviral therapies are still needed to effectively tackle COVID-19 and future coronavirus outbreaks, including those targeting key viral proteins and able to counter emerging variants.
10) Thanks for reading ๐ and have a wonderful sunday ๐ค
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