Emmanuel Profile picture
Apr 22, 2024 10 tweets 4 min read Read on X
𝗧𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰 𝘁𝗮𝗿𝗴𝗲𝘁𝘀 𝗳𝗼𝗿 𝗖𝗢𝗩𝗜𝗗-19

2 𝘸𝘰𝘯𝘥𝘦𝘳𝘧𝘶𝘭 𝘴𝘵𝘶𝘥𝘪𝘦𝘴 𝘸𝘪𝘵𝘩 𝘨𝘳𝘦𝘢𝘵 𝘷𝘪𝘴𝘶𝘢𝘭𝘪𝘴𝘢𝘵𝘪𝘰𝘯𝘴, 𝘧𝘰𝘳 𝘢 𝘱𝘰𝘴𝘪𝘵𝘪𝘷𝘦 𝘰𝘶𝘵𝘭𝘰𝘰𝘬 🤗 Image
2)"Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies"

Current treatment strategies for COVID-19 can be classified into "target virus" and "target host" categories. Repurposing existing drugs, emerging drugs .. nature.com/articles/s4139…
Image
3) ...and promising potential targets fall under these categories.
For the host, ACE2 receptor, TMPRSS2 protease, inflammatory cytokines and their pathways, CD147, and HMGB1 are potential therapeutic targets based on their roles in viral entry/pathogenesis/excessive inflammation. Image
4) Future directions include focusing on more promising targets, strengthening multi-disciplinary cooperation, addressing gaps between preclinical/clinical research, and monitoring viral mutations. A combination of antiviral and immunomodulatory therapies may be most effective. Image
5) For vaccines ... Image
6) "Therapeutic strategies for COVID-19: progress and lessons learned"
nature.com/articles/s4157…
Image
7) Potential therapeutic targets include viral proteins like spike, protease, RNA polymerase, and host proteins involved in viral entry/ immunopathology. Various agents have shown anti-SARS-CoV-2 activity in preclinical/clinical studies, but most require further development. Image
8) Treatment strategies aim to administer antiviral drugs early to outpatients, while immunomodulators may benefit severely ill inpatients. Treating long COVID remains challenging due to its unclear mechanisms. Development of pan-coronavirus therapies is another priority area. Image
9) Overall, while progress has been made, more convenient and broadly effective antiviral therapies are still needed to effectively tackle COVID-19 and future coronavirus outbreaks, including those targeting key viral proteins and able to counter emerging variants. Image
10) Thanks for reading 🙏 and have a wonderful sunday 🤗 Image

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Emmanuel

Emmanuel Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @ejustin46

Apr 29
Why is Identifying "Non-Trivial SARS-CoV-2 Population Structure within Hosts" Important for Understanding SARS-COV-2 Evolution and the Emergence of New Variants?

journals.plos.org/plospathogens/…Image
2) The "non-trivial population structure" refers to the viral population within a host consisting of two or more distinct, independently evolving subpopulations, rather than a single, homogeneous population. Image
3) The key points about non-trivial population structure are:
▶️ It was relatively common, found in 5 out of the 9 chronic SARS-CoV-2 infection cases examined.
▶️ It was more prevalent in severely immunocompromised individuals compared to those not significantly immunocompromised Image
Read 7 tweets
Apr 26
No, Omicron is not the "humanized" SARS-COV-2 !

(Explanation in simple terms)
biorxiv.org/content/10.110…Image
2) Viruses are not living things. They are tiny particles that can only make copies of themselves inside the cells of living things, like humans. When a virus makes copies of itself, it doesn't always make perfect copies.
3) Sometimes, little mistakes happen, and the new virus has a small change, or mutation, in its genes.

Most of the time, these mutations don't do anything useful for the virus. But every now and then, a mutation might happen that makes the virus better at infecting people. Image
Read 7 tweets
Apr 26
"What if humans had sent SARS-COV-2 into space, or even brought COVID-19 along for astronauts?"

biorxiv.org/content/10.110…Image
2) This study looks at the risks of COVID-19 for people traveling to space.

Space travel is becoming more common, with over 600 people having gone to space. But COVID-19 could be a big problem for astronauts in the unique environment of space. Image
3) The study aims to understand how COVID-19 might behave differently in space compared to on Earth.

The researchers reviewed studies on other airborne diseases in space. They found that some diseases, like Epstein-Barr virus and Serratia bacteria ... Image
Read 6 tweets
Apr 24
From Lung Damage to Gut Dysbiosis:
The Lasting Implications of SARS-CoV-2 Variant-Specific Microbiome Changes (From Wuhan strain to Omicron)
labanimres.biomedcentral.com/articles/10.11…Image
2) The Wuhan strain of SARS-CoV-2 caused serious damage to the lungs of infected mice. The mice had a very high chance of dying from this strain. The researchers also looked at the bacteria in the lungs and guts of the infected mice. Image
3) The Wuhan strain increased harmful bacteria like E. coli in the lungs. This can make the lungs more prone to other infections.

The Omicron variant caused different changes in the gut bacteria of the mice. It increased certain bacteria linked to inflammation in the gut. Image
Read 5 tweets
Apr 23
What are GAMMA CORONAVIRUSES ?
And why did we decide to talk about it? Image
Image
2) A brief reminder :

▶️ SARS-CoV-2 belongs to the family Coronaviridae, is classified as a coronavirus and is responsible for COVID-19
▶️ Bird Flu refers to various strains of the influenza virus, particularly those in the Orthomyxoviridae family including H5N1 and H7N9. Image
3) ▶️ Gammacoronavirus belongs to the family Coronaviridae like SARS-COV-2.

Some notable gammacoronaviruses include:
- Infectious Bronchitis Virus (IBV): A major pathogen in poultry responsible for respiratory disease and reduced egg production. Image
Read 10 tweets
Apr 21
A TREATMENT that Could Finally END Long COVID Suffering ?

This isn't the first time a treatment has been announced, and as millions continue to struggle with long Covid, we need to remain both cautious and hopeful 🤗 Image
2) Researchers at WEHI announced that they discovered a new drug that can stop long COVID symptoms in mice. This drug is more effective than the current top treatment, Paxlovid, for both long COVID and acute COVID cases. Image
3) They focused on a specific protein called PLpro that other treatments haven't targeted well. This breakthrough could lead to new medicines for long COVID, a condition where people continue to feel sick long after their COVID-19 infection. Image
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(