Emmanuel Profile picture
Apr 23, 2024 โ€ข 7 tweets โ€ข 3 min read โ€ข Read on X
๐™„๐™ฃ๐™ฉ๐™š๐™ง๐™š๐™จ๐™ฉ๐™ž๐™ฃ๐™œ ๐™จ๐™ฉ๐™ช๐™™๐™ฎ : ๐˜ฝ๐™š๐™๐™–๐™ซ๐™ž๐™ค๐™ง-๐™™๐™ง๐™ž๐™ซ๐™š๐™ฃ ๐™›๐™ค๐™ง๐™š๐™˜๐™–๐™จ๐™ฉ๐™จ ๐™ค๐™› ๐™ฃ๐™š๐™ž๐™œ๐™๐™—๐™ค๐™ง๐™๐™ค๐™ค๐™™-๐™ก๐™š๐™ซ๐™š๐™ก ๐˜พ๐™Š๐™‘๐™„๐˜ฟ-19 ๐™จ๐™ฅ๐™ง๐™š๐™–๐™™ ๐™ž๐™ฃ ๐™‰๐™š๐™ฌ ๐™”๐™ค๐™ง๐™  ๐˜พ๐™ž๐™ฉ๐™ฎ

@C_A_G0101
medrxiv.org/content/10.110โ€ฆ
Image
2) The paper analyzes aggregated foot traffic data from mobile devices to measure mobility and contact patterns across different place categories (restaurants, retail, etc.) in New York City neighborhoods during the COVID-19 pandemic in 2020. Image
3) It finds distinct mobility networks and indoor contact patterns (crowdedness, dwell time) vary across place categories and neighborhoods, driven by the local distribution of points of interest and human activities. Image
4) A behavior-driven epidemic model is developed that incorporates these place-category specific mobility networks and links the force of infection to crowdedness and dwell time using power-law functions. Image
5) Model fitting suggests force of infection increases sublinearly with crowdedness and dwell time, showing a diminishing returns effect.
When coupled with data assimilation, the model can accurately reproduce neighborhood-level COVID-19 case trends in NYC in 2020 and ... Image
6) ...generate improved short-term forecasts compared to a baseline model without place-category distinction.
The behavior-driven model captures how social drivers of contagion shaped transmission and ... Image
7) ...can potentially support outbreak response if adapted for other respiratory diseases spread through similar routes.

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More from @ejustin46

Apr 18
"Now this is not the end. It is not even the beginning of the end" (Winston Churchill)

This study shows that the Sarbecoviruses have the capacity to generate new variants rapidly, with RBD of two novel viral groups exhibiting high similarity to SARS-CoV-2
biorxiv.org/content/10.110โ€ฆImage
2) Over 3 years, researchers sampled 1,462 bats in Cambodia Steung Treng province, identifying extensive and diverse coronaviruses co-circulation. Using metatranscriptomic and amplicon sequencing, they generated 33 complete sarbecovirus genomes. Image
4) This study suggests that the viral family of Sarbecoviruses can reserve some unpleasant surprises, and quite rapidly:

โ–ถ๏ธ They emphasize the "significant pandemic threat" posed by the genetic diversity and evolutionary dynamics of circulating bat coronaviruses.
Read 7 tweets
Apr 18
Doctor, I'm confused ๐Ÿค”
I have a high level of antibodies, yet I'm still experiencing long COVID. Why is that?

"The ANTIBODIES PARADOX in LONG COVID Condition: Unraveling the Disconnect Between Humoral Immunity and Chronic Illness"
nature.com/articles/s4146โ€ฆImage
2) The finding in this study of persistently higher anti-N antibody levels in people with Post-Covid Condition (PCC) compared to those with acute infection only, does seem paradoxical at first glance. Image
3) A few points on this:

โ–ถ๏ธ The study suggests this may indicate "altered immune activation or viral persistence" in people with PCC, rather than just a stronger antibody response per se. Image
Read 8 tweets
Apr 17
The incredible world of T-CELLS and why are they exhausted fighting the SARS-COV-2 virus ?

(An explanation๐Ÿงต for kids based on an astonish study Thanks to @DavidJoffe64)
sciencedirect.com/science/articlโ€ฆImage
2) T-cells are like the superheroes of our immune system - they work hard to protect us from germs and viruses.

When a virus like SARS-COV-2 gets into our body, the T cells spring into action. There are different types of T cells, each with a special job to do. Image
3) - Some T cells are like the fighters, killing off the virus-infected cells.
- Other T cells are the coordinators, telling the other immune cells what to do.
- There are also T cells that act like the police, making sure the immune response doesn't go overboard.
Read 11 tweets
Apr 16
"COVID-19 CRUSADERS:
The TRIO of NASAL IMMUNE CELLS That BATTLE the VIRUS"

A masterpiece study in Nature ๐Ÿ’ฏ๐Ÿ’ฅ
nature.com/articles/s4159โ€ฆImage
2) The most important immune components in the nasal tissue for fighting COVID-19 are:

โ–ถ๏ธ Monocytes and neutrophils
- These immune cells moved into the area under the nose lining during active COVID-19 infection and helped protect the underlying lymphoid tissue. Image
3)โ–ถ๏ธ Macrophages
- As people recovered from COVID-19, macrophages started to help repair the nasal tissue.
โ–ถ๏ธ Germinal centers and B cells
- The specialized germinal center structures in the nose contained active B cells that were producing antibodies against the COVID-19 virus Image
Read 6 tweets
Apr 16
How SARS-COV-2 spreads (Re) and why there are differences between countries ?

An explanation for kids based on the astonishing new study of @firefoxx66 @richardneher and colleagues
pubmed.ncbi.nlm.nih.gov/40233303/Image
2) With a really fast-spreading virus going around, like the one that causes COVID-19, when someone gets sick, they can pass the virus to other people. But some sick people end up spreading it to a lot more people than others. Image
2) The scientists in this study wanted to figure out how the virus is spreading and how much it's spreading from person to person. To do this, they looked at the genetic code, or the "DNA", of the virus.

Whenever the virus infects someone new, it can change a little bit.
Read 7 tweets
Apr 12
STRUCTURAL BRAIN CHANGE with LONG COVID ๐Ÿ˜ฐ

Brain scans of Long COVID patients showed reduced volumes in critical brainstem regions like superior and middle cerebellar peduncles, along with decreased connectivity.
These structural and functional changes were linked to motor ... Image
2) ... sensory, and autonomic dysfunction in patients. Researchers propose a "Broken Bridge Syndrome" where COVID-19 disrupts the vital connection between the brainstem and cerebellum, contributing to the diverse neurological symptoms of Long COVID. Image
3) Figure 4 clearly shows the structural dissolution and volume reduction of the 4th ventricle in the superior cerebellar peduncle in one and the same COVID-19 patient. Image
Read 4 tweets

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