2) The paper analyzes aggregated foot traffic data from mobile devices to measure mobility and contact patterns across different place categories (restaurants, retail, etc.) in New York City neighborhoods during the COVID-19 pandemic in 2020.
3) It finds distinct mobility networks and indoor contact patterns (crowdedness, dwell time) vary across place categories and neighborhoods, driven by the local distribution of points of interest and human activities.
4) A behavior-driven epidemic model is developed that incorporates these place-category specific mobility networks and links the force of infection to crowdedness and dwell time using power-law functions.
5) Model fitting suggests force of infection increases sublinearly with crowdedness and dwell time, showing a diminishing returns effect.
When coupled with data assimilation, the model can accurately reproduce neighborhood-level COVID-19 case trends in NYC in 2020 and ...
6) ...generate improved short-term forecasts compared to a baseline model without place-category distinction.
The behavior-driven model captures how social drivers of contagion shaped transmission and ...
7) ...can potentially support outbreak response if adapted for other respiratory diseases spread through similar routes.
Thanks for reading 🙏
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2) The study analyzed 1,389 SARS-CoV-2 genomes sequenced from samples collected in Pernambuco state, Brazil between June 2020 and August 2021.
Multiple lineages of SARS-CoV-2 circulated in Pernambuco, including B.1.1, B.1.1.28, B.1.1.33, P.2, P.1 (Gamma), and B.1.617.2 (Delta)
3) There were three main transmission waves - the first in mid-2020 dominated by B.1.1, the second in late 2020 associated with emergence of P.2, and the third large wave in early 2021 driven by the rapid spread of the highly transmissible P.1 Gamma variant.
2) PAV-104 is a small molecule that was previously shown to inhibit the assembly of influenza and Nipah viruses. This study investigated its effects on SARS-CoV-2.
In cell culture experiments using Calu-3 lung epithelial cells and primary human airway epithelial cells ...
3) ...PAV-104 potently inhibited the replication of several SARS-CoV-2 variants, including Omicron, Delta, and Gamma. It inhibited replication by over 99%.
PAV-104 was shown to act at a post-entry stage of the SARS-CoV-2 life cycle. It did not affect viral entry ...
It has been more than 1 year, since we sounded the alarm about the transmission of avian influenza to mammals.
The almost total indifference gave way to general excitement.
2) But, from one extreme to the other, there is a transmission timing. A tik tock 🍭 as says my friend David @DavidJoffe64
3) On April 17, 2023, increased mortality was observed in a backyard poultry farm in Brescia, northern Italy. The farm was quarantined and samples were taken to test for avian influenza. Out of the 22 poultry on the farm, only the hens showed mortality ...
Being one of the most important studies we have read, we will take the time to explain all the concepts, one by one.
2) 𝙒𝙝𝙖𝙩 𝙖𝙧𝙚 𝘼𝙪𝙩𝙤𝙥𝙝𝙖𝙜𝙤𝙨𝙤𝙢𝙚𝙨 ?
Autophagosomes are double-membrane vesicles formed during autophagy, that sequester cytoplasmic cargo like proteins, organelles and pathogens targeted for degradation.
Upon SARS-CoV-2 invasion, host cells induce autophagy ...
3) ...as an intrinsic antiviral defense mechanism. Autophagosomes capture invading viral particles and components.
Cargo-loaded autophagosomes then fuse with lysosomes. This degrades intact virions and disrupts infection.
▶️ SARS-COV-2 variants have independently adapted spike to escape IFITM3
▶️ IFITM3 deficiency facilitated infection of AVIAN INFLUENZA in multiple human cell types
2) Even if there is no a priori direct link between the adaptation of SARS-COV-2 to IFITM3 and the risk of IFITM3 deficiency for avian influenza, it seemed interesting to us to return to IFITM3.
2) GBP2 and GBP5 were found to inhibit infection of early SARS-CoV-2 isolates Wuhan-Hu-1 and VIC by blocking furin cleavage of spike and reducing spike processing/glycosylation. This decreased particle infectivity.
Maintaining non-pharmaceutical interventions like masking is essential to vaccination success, not a replacement.
@C_A_G0101 medrxiv.org/content/10.110…
2) The study used a compartmental SEIIS model to simulate the course of a COVID epidemic both without and with vaccination interventions. Variables like vaccine hesitancy, vaccination speed, duration of immunity, and variants were tested.
3) Even a perfect vaccine that always provides sterilizing immunity can still allow high disease rates depending on factors like hesitation, slow rollout, dropping measures, and variants.