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Apr 23 7 tweets 3 min read Read on X
𝙄𝙣𝙩𝙚𝙧𝙚𝙨𝙩𝙞𝙣𝙜 𝙨𝙩𝙪𝙙𝙮 : 𝘽𝙚𝙝𝙖𝙫𝙞𝙤𝙧-𝙙𝙧𝙞𝙫𝙚𝙣 𝙛𝙤𝙧𝙚𝙘𝙖𝙨𝙩𝙨 𝙤𝙛 𝙣𝙚𝙞𝙜𝙝𝙗𝙤𝙧𝙝𝙤𝙤𝙙-𝙡𝙚𝙫𝙚𝙡 𝘾𝙊𝙑𝙄𝘿-19 𝙨𝙥𝙧𝙚𝙖𝙙 𝙞𝙣 𝙉𝙚𝙬 𝙔𝙤𝙧𝙠 𝘾𝙞𝙩𝙮

@C_A_G0101
medrxiv.org/content/10.110…
Image
2) The paper analyzes aggregated foot traffic data from mobile devices to measure mobility and contact patterns across different place categories (restaurants, retail, etc.) in New York City neighborhoods during the COVID-19 pandemic in 2020. Image
3) It finds distinct mobility networks and indoor contact patterns (crowdedness, dwell time) vary across place categories and neighborhoods, driven by the local distribution of points of interest and human activities. Image
4) A behavior-driven epidemic model is developed that incorporates these place-category specific mobility networks and links the force of infection to crowdedness and dwell time using power-law functions. Image
5) Model fitting suggests force of infection increases sublinearly with crowdedness and dwell time, showing a diminishing returns effect.
When coupled with data assimilation, the model can accurately reproduce neighborhood-level COVID-19 case trends in NYC in 2020 and ... Image
6) ...generate improved short-term forecasts compared to a baseline model without place-category distinction.
The behavior-driven model captures how social drivers of contagion shaped transmission and ... Image
7) ...can potentially support outbreak response if adapted for other respiratory diseases spread through similar routes.

Thanks for reading 🙏

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More from @ejustin46

Apr 25
𝙎𝙥𝙖𝙩𝙞𝙤𝙩𝙚𝙢𝙥𝙤𝙧𝙖𝙡 𝙩𝙧𝙖𝙣𝙨𝙢𝙞𝙨𝙨𝙞𝙤𝙣 𝙤𝙛 𝙎𝘼𝙍𝙎-𝘾𝙤𝙑-2 𝙞𝙣 𝙋𝙚𝙧𝙣𝙖𝙢𝙗𝙪𝙘𝙤—𝘽𝙧𝙖𝙯𝙞𝙡


𝘦𝘷𝘦𝘯 𝘪𝘯 𝘱𝘢𝘳𝘢𝘥𝘪𝘴𝘦, 𝘵𝘩𝘦𝘳𝘦 𝘪𝘴 𝘵𝘩𝘦 𝘷𝘪𝘳𝘶𝘴 🤦‍♂️ journals.asm.org/doi/10.1128/sp…
Image
2) The study analyzed 1,389 SARS-CoV-2 genomes sequenced from samples collected in Pernambuco state, Brazil between June 2020 and August 2021.
Multiple lineages of SARS-CoV-2 circulated in Pernambuco, including B.1.1, B.1.1.28, B.1.1.33, P.2, P.1 (Gamma), and B.1.617.2 (Delta) Image
3) There were three main transmission waves - the first in mid-2020 dominated by B.1.1, the second in late 2020 associated with emergence of P.2, and the third large wave in early 2021 driven by the rapid spread of the highly transmissible P.1 Gamma variant. Image
Read 7 tweets
Apr 25
𝗕𝗟𝗢𝗖𝗞𝗜𝗡𝗚 𝗦𝗔𝗥𝗦-𝗖𝗼𝗩-2 𝗥𝗘𝗣𝗟𝗜𝗖𝗔𝗧𝗜𝗢𝗡 ?

nature.com/articles/s4200…
Image
2) PAV-104 is a small molecule that was previously shown to inhibit the assembly of influenza and Nipah viruses. This study investigated its effects on SARS-CoV-2.
In cell culture experiments using Calu-3 lung epithelial cells and primary human airway epithelial cells ... Image
3) ...PAV-104 potently inhibited the replication of several SARS-CoV-2 variants, including Omicron, Delta, and Gamma. It inhibited replication by over 99%.
PAV-104 was shown to act at a post-entry stage of the SARS-CoV-2 life cycle. It did not affect viral entry ... Image
Read 6 tweets
Apr 25
𝗦𝗽𝗲𝗲𝗱 ​​𝗼𝗳 𝘁𝗿𝗮𝗻𝘀𝗺𝗶𝘀𝘀𝗶𝗼𝗻 𝗼𝗳 𝘇𝗼𝗼𝗻𝗼𝘀𝗲𝘀 : 𝗛5𝗡1 𝗰𝗹𝗮𝗱𝗲 2.3.4.4𝗯

It has been more than 1 year, since we sounded the alarm about the transmission of avian influenza to mammals.
The almost total indifference gave way to general excitement. Image
2) But, from one extreme to the other, there is a transmission timing. A tik tock 🍭 as says my friend David @DavidJoffe64

From this study from 2023 ! we will just explain one figure.
pubmed.ncbi.nlm.nih.gov/37650905/
Image
3) On April 17, 2023, increased mortality was observed in a backyard poultry farm in Brescia, northern Italy. The farm was quarantined and samples were taken to test for avian influenza. Out of the 22 poultry on the farm, only the hens showed mortality ... Image
Read 8 tweets
Apr 25
▶️ 𝐊𝐄𝐘 𝐒𝐓𝐔𝐃𝐘 : 👍
▶️ 𝐊𝐄𝐘 𝐌𝐔𝐓𝐀𝐓𝐈𝐎𝐍 : 𝐄𝐓9𝐈
▶️ 𝐊𝐄𝐘 𝐒𝐀𝐑𝐒-𝐂𝐎𝐕-2 𝐏𝐑𝐎𝐓𝐄𝐈𝐍 : 𝐄𝐍𝐕𝐄𝐋𝐎𝐏𝐄

Being one of the most important studies we have read, we will take the time to explain all the concepts, one by one. Image
2) 𝙒𝙝𝙖𝙩 𝙖𝙧𝙚 𝘼𝙪𝙩𝙤𝙥𝙝𝙖𝙜𝙤𝙨𝙤𝙢𝙚𝙨 ?
Autophagosomes are double-membrane vesicles formed during autophagy, that sequester cytoplasmic cargo like proteins, organelles and pathogens targeted for degradation.
Upon SARS-CoV-2 invasion, host cells induce autophagy ... Image
3) ...as an intrinsic antiviral defense mechanism. Autophagosomes capture invading viral particles and components.
Cargo-loaded autophagosomes then fuse with lysosomes. This degrades intact virions and disrupts infection. Image
Read 16 tweets
Apr 24
𝗔 𝗞𝗘𝗬 𝗶𝗻𝘁𝗲𝗿𝗳𝗲𝗿𝗼𝗻-𝗶𝗻𝗱𝘂𝗰𝗲𝗱 𝗔𝗡𝗧𝗜𝗩𝗜𝗥𝗔𝗟 𝗙𝗔𝗖𝗧𝗢𝗥 : 𝗜𝗙𝗜𝗧𝗠3 ?

▶️ SARS-COV-2 variants have independently adapted spike to escape IFITM3
▶️ IFITM3 deficiency facilitated infection of AVIAN INFLUENZA in multiple human cell types Image
2) Even if there is no a priori direct link between the adaptation of SARS-COV-2 to IFITM3 and the risk of IFITM3 deficiency for avian influenza, it seemed interesting to us to return to IFITM3.

1𝘴𝘵 𝘴𝘵𝘶𝘥𝘺 𝘱𝘰𝘴𝘵𝘦𝘥 1 𝘺𝘦𝘢𝘳 𝘢𝘨𝘰
pnas.org/doi/10.1073/pn…
Image
2) GBP2 and GBP5 were found to inhibit infection of early SARS-CoV-2 isolates Wuhan-Hu-1 and VIC by blocking furin cleavage of spike and reducing spike processing/glycosylation. This decreased particle infectivity. Image
Read 13 tweets
Apr 24
"𝙁𝙖𝙘𝙩𝙤𝙧𝙨 𝙇𝙞𝙢𝙞𝙩𝙞𝙣𝙜 𝙩𝙝𝙚 𝙎𝙪𝙘𝙘𝙚𝙨𝙨 𝙤𝙛 𝙖𝙣 𝘼𝙡𝙡-𝙑𝙖𝙧𝙞𝙖𝙣𝙩 𝘾𝙊𝙑𝙄𝘿-19 𝙑𝙖𝙘𝙘𝙞𝙣𝙚"

Maintaining non-pharmaceutical interventions like masking is essential to vaccination success, not a replacement.
@C_A_G0101
medrxiv.org/content/10.110…
Image
2) The study used a compartmental SEIIS model to simulate the course of a COVID epidemic both without and with vaccination interventions. Variables like vaccine hesitancy, vaccination speed, duration of immunity, and variants were tested. Image
3) Even a perfect vaccine that always provides sterilizing immunity can still allow high disease rates depending on factors like hesitation, slow rollout, dropping measures, and variants. Image
Read 5 tweets

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