Characteristics and Determinants of Pulmonary Long COVID
🤔Interesting USA study in preprint!
➡️This single-center retrospective study included 1,097 patients with clinically defined LongCOVID characterized by persistent pulmonary symptoms (dyspnea, cough, and chest discomfort) lasting for ≥1 month after resolution of primary COVID infection( Alpha, Delta and Omicron period).
➡️Longitudinal pulmonary function testing (PFTs) and CT imaging as investigational techniques
➡️Half(51%) of all pulmonary LC patients had impaired diffusion capacity for carbon monoxide (DLCO)/ total lung capacity(TLC)( 56y +/-13y’s)
➡️Invasive mechanical ventilation during primary infection conferred the greatest increased odds, followed by O2 therapy and even NO O2 treatment.
➡️Your culprit: post-C19 Interstitial Lung Fibrosis!
➡️Longitudinal PFTs revealed PERSISTENT diffusion impaired restriction as a key feature of pulmonary Long COVID.
➡️These results emphasize the importance of incorporating PFTs into routine clinical practice for evaluation of Long COVID patients with prolonged pulmonary symptoms.
➡️Subsequent clinical trials should leverage combined symptomatic and quantitative PFT measurements for more targeted enrollment of pulmonary Long COVID patients
❗Of course a preprint with remarks and noted limitations, but I posted this because of its importance that we shouldn’t forget the many pulmonary LC patients…….for whom scaling a flight of stairs is often a near impossibility......., most probably are sadly set for life!😢
❗Furthermore, an Important findings for us clinicians: Study suggests symptoms alone do not provide sufficient granularity to identify distinct endotypes of pulmonary Long COVID, thereby highlighting the importance of incorporating routine PFTs /CT scans in the diagnostic evaluation of this patient population!!
insight.jci.org/articles/view/…
🤔Interesting USA study in preprint!
➡️This single-center retrospective study included 1,097 patients with clinically defined LongCOVID characterized by persistent pulmonary symptoms (dyspnea, cough, and chest discomfort) lasting for ≥1 month after resolution of primary COVID infection( Alpha, Delta and Omicron period).
➡️Longitudinal pulmonary function testing (PFTs) and CT imaging as investigational techniques
➡️Half(51%) of all pulmonary LC patients had impaired diffusion capacity for carbon monoxide (DLCO)/ total lung capacity(TLC)( 56y +/-13y’s)
➡️Invasive mechanical ventilation during primary infection conferred the greatest increased odds, followed by O2 therapy and even NO O2 treatment.
➡️Your culprit: post-C19 Interstitial Lung Fibrosis!
➡️Longitudinal PFTs revealed PERSISTENT diffusion impaired restriction as a key feature of pulmonary Long COVID.
➡️These results emphasize the importance of incorporating PFTs into routine clinical practice for evaluation of Long COVID patients with prolonged pulmonary symptoms.
➡️Subsequent clinical trials should leverage combined symptomatic and quantitative PFT measurements for more targeted enrollment of pulmonary Long COVID patients
❗Of course a preprint with remarks and noted limitations, but I posted this because of its importance that we shouldn’t forget the many pulmonary LC patients…….for whom scaling a flight of stairs is often a near impossibility......., most probably are sadly set for life!😢
❗Furthermore, an Important findings for us clinicians: Study suggests symptoms alone do not provide sufficient granularity to identify distinct endotypes of pulmonary Long COVID, thereby highlighting the importance of incorporating routine PFTs /CT scans in the diagnostic evaluation of this patient population!!
insight.jci.org/articles/view/…
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