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Emmanuel

@ejustin46

May 1

𝘿𝙮𝙣𝙖𝙢𝙞𝙘 𝙙𝙞𝙫𝙚𝙧𝙨𝙞𝙩𝙮 𝙤𝙛 𝙎𝘼𝙍𝙎-𝘾𝙤𝙑-2 𝙜𝙚𝙣𝙚𝙩𝙞𝙘 𝙢𝙪𝙩𝙖𝙩𝙞𝙤𝙣𝙨 𝙞𝙣 𝙖 𝙡𝙪𝙣𝙜 𝙩𝙧𝙖𝙣𝙨𝙥𝙡𝙖𝙣𝙩𝙖𝙩𝙞𝙤𝙣 𝙥𝙖𝙩𝙞𝙚𝙣𝙩 𝙬𝙞𝙩𝙝 𝙥𝙚𝙧𝙨𝙞𝙨𝙩𝙚𝙣𝙩 𝘾𝙊𝙑𝙄𝘿-19

nature.com/articles/s4146…

2) This study reports a case of a lung transplant patient who developed a chronic persistent SARS-CoV-2 infection despite remdesivir (RDV) treatment.
Whole genome sequencing revealed the virus accumulated diverse mutations over time, particularly in the spike protein ...

3) ...and RNA-dependent RNA polymerase (RdRp).
Several mutations in RdRp (V792I, M794I, C799F) emerged after RDV treatment and were associated with increased RDV resistance. In particular, the C799F mutation conferred the highest level of resistance.

Read 7 tweets

Emmanuel

@ejustin46

Apr 30

𝙃5𝙉1 𝘼𝙑𝙄𝘼𝙉 𝙄𝙉𝙁𝙇𝙐𝙀𝙉𝙕𝘼 :
𝙃𝙤𝙬 𝙃5𝙉1 𝙞𝙨 𝙏𝙍𝘼𝙉𝙎𝙈𝙄𝙏𝙏𝙀𝘿 ?
𝙒𝙝𝙖𝙩 𝙖𝙧𝙚 𝙩𝙝𝙚 𝙍𝙄𝙎𝙆 𝙛𝙤𝙧 𝙃𝙐𝙈𝘼𝙉𝙎 ?
(2𝘯𝘥 𝘱𝘢𝘳𝘵)
▶️ Underestimation of cases
▶️ Overestimation of fatality rate

2) 𝙐𝙣𝙙𝙚𝙧𝙚𝙨𝙩𝙞𝙢𝙖𝙩𝙞𝙤𝙣 𝙤𝙛 𝙘𝙖𝙨𝙚𝙨 :
"We are underestimating, again, the true burden of H5N1 in humans"

Clade 2.3.4.4b H5N1 avian influenza viruses have spread globally since 2020, causing major outbreaks in poultry and ...ncbi.nlm.nih.gov/pmc/articles/P…

3) ...infecting a wide range of mammal species.
The true number of human H5N1 infections from this strain is unknown but likely significantly underestimated, especially as the viruses can infect mammals. Only 12 cases have been reported to WHO since 2020.

Read 11 tweets

Emmanuel

@ejustin46

Apr 30

𝙃5𝙉1 𝘼𝙑𝙄𝘼𝙉 𝙄𝙉𝙁𝙇𝙐𝙀𝙉𝙕𝘼 :
𝙃𝙤𝙬 𝙃5𝙉1 𝙞𝙨 𝙏𝙍𝘼𝙉𝙎𝙈𝙄𝙏𝙏𝙀𝘿 ?
𝙒𝙝𝙖𝙩 𝙖𝙧𝙚 𝙩𝙝𝙚 𝙍𝙄𝙎𝙆 𝙛𝙤𝙧 𝙃𝙐𝙈𝘼𝙉𝙎 ?
(1𝘴𝘵 𝘱𝘢𝘳𝘵)
... qnd why the nb of humans cases are underestimated, and consequently the fatality rate overestimated ?

2) We would first like to take a step back, and remember that the circulation of H*N* is an ancient story :

Fig. Possible origins of pandemic influenza viruses. Phylogenetic studies suggest that an avian influenza virus was transmitted to humans, leading to the 1918 pandemic

3) For the H5N1 that we have been following for a long time, the clade we are currently talking about emerged in 2021 !

Read 16 tweets

Emmanuel

@ejustin46

Apr 30

𝙋𝙤𝙨𝙩-𝘾𝙊𝙑𝙄𝘿-19 𝙨𝙮𝙣𝙙𝙧𝙤𝙢𝙚, 𝙬𝙝𝙤 𝙖𝙩 𝙧𝙞𝙨𝙠 𝙖𝙣𝙙 𝙬𝙝𝙮: 𝙖𝙣 𝙞𝙣𝙨𝙞𝙜𝙝𝙩 𝙛𝙧𝙤𝙢 𝙌𝙖𝙩𝙖𝙧 2022

"Out of 368, the prevalence of post-COVID-19 syndrome was 43.2% (n = 159)"
frontiersin.org/journals/publi…

2) A cross-sectional study was conducted involving 368 adults who had tested positive for COVID-19 between January-July 2022 in Qatar.
The prevalence of PCS was found to be 43.2%, with the most common persistent symptoms being fatigue (75.5%), anxiety (49.1%) ...

3) forgetfulness (46.5%) and mood alterations (45.3%).
PCS was more prevalent among females (67.9%) compared to males. The median age of PCS patients was 37 years. Most had a university education and were employed.

Read 4 tweets

Emmanuel

@ejustin46

Apr 30

𝘑𝘰𝘩𝘯𝘴 𝘏𝘰𝘱𝘬𝘪𝘯𝘴 𝘊𝘖𝘝𝘐𝘋 𝘓𝘖𝘕𝘎 𝘚𝘵𝘶𝘥𝘺, 16 000 𝘸𝘪𝘵𝘩 𝘢 𝘩𝘪𝘴𝘵𝘰𝘳𝘺 𝘰𝘧 𝘪𝘯𝘧𝘦𝘤𝘵𝘪𝘰𝘯. 6,000 𝘦𝘯𝘳𝘰𝘭𝘭𝘦𝘥 𝘪𝘯 𝘭𝘰𝘯𝘨𝘪𝘵𝘶𝘥𝘪𝘯𝘢𝘭 𝘧𝘰𝘭𝘭𝘰𝘸-𝘶𝘱.
63% 𝘮𝘦𝘵 𝘵𝘩𝘦 𝘤𝘳𝘪𝘵𝘦𝘳𝘪𝘢 𝘧𝘰𝘳 𝘭𝘰𝘯𝘨 𝘊𝘖𝘝𝘐𝘋 !
medrxiv.org/content/10.110…

2) The Johns Hopkins COVID Long Study (JHCLS) is a prospective cohort study examining the short and long-term consequences of COVID-19 infection. It includes participants both with and without a history of SARS-CoV-2 infection.

3) As of February 2023, over 16,000 participants with a history of infection and nearly 800 without a history completed the baseline survey. Over 6,000 participants with infection and around 300 without have enrolled in longitudinal follow-up.

Read 9 tweets

Emmanuel

@ejustin46

Apr 29

𝙎𝘼𝙍𝙎-𝘾𝙤𝙑-2 𝙩𝙧𝙤𝙥𝙞𝙨𝙢 𝙩𝙤 𝙞𝙣𝙩𝙚𝙨𝙩𝙞𝙣𝙖𝙡 𝙗𝙪𝙩 𝙣𝙤𝙩 𝙜𝙖𝙨𝙩𝙧𝙞𝙘 𝙚𝙥𝙞𝙩𝙝𝙚𝙡𝙞𝙖𝙡 𝙘𝙚𝙡𝙡𝙨 𝙞𝙨 𝙙𝙚𝙛𝙞𝙣𝙚𝙙 𝙗𝙮 𝙡𝙞𝙢𝙞𝙩𝙚𝙙 𝘼𝘾𝙀2 𝙚𝙭𝙥𝙧𝙚𝙨𝙨𝙞𝙤𝙣

cell.com/stem-cell-repo…

2) SARS-CoV-2, the virus that causes COVID-19, can infect cells in the gastrointestinal (GI) tract in addition to the lungs. However, it was unclear if infection varies across different regions of the GI tract.

3) The study directly compared SARS-CoV-2 infection of organoid-derived monolayers from the stomach (corpus), small intestine (jejunum), and colon. Jejunal and colonic monolayers were susceptible to SARS-CoV-2 infection, showing viral RNA, proteins ...

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