Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Katelyn Jetelina Profile picture
@dr_kkjetelina
Apr 29 • 4 tweets • 1 min read • Read on X
Interesting #H5N1 preprint on wastewater just dropped.


Three take-homes:

1. Can H5 be detected in wastewater? Yes, one company (@Verily) now has an assay. It's 100% specific. Huge first step.medrxiv.org/content/10.110…
2. Have these assays detected increases this Spring? Yes. @WastewaterSCAN looked at 54 wastewater plants. Data, for example, Dallas is below. H5 started spiking in mid-April. Image
3. Still unanswered questions? A ton.

Animal vs. human? How do we differentiate quickly? This study is watersheds, what about lower-resolution sampling (sewer) to understand spread? What about reporting requirements for select agents (like H5)? What are the genomic sequences?
Preparing means working towards answers *now* (rather than falling reactive) *if* this jumps to human-to-human transmission. H5N1 is the perfect case study for quickly translating the massive wastewater system we built during Covid-19 to other threats. Time to get at it.

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Katelyn Jetelina

Katelyn Jetelina Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @dr_kkjetelina

Katelyn Jetelina Profile picture
Apr 30
Will 50% of people die if #H5N1 jumps? Very unlikely.

Yes, this is @WHO's stat BUT three important points...

1. H5N1 deaths are among a small pool of known cases. Past antibody studies of H5 suggest we are missing many infections.
science.org/doi/10.1126/sc…
2. Viruses have to make trade-offs when they mutate for human-to-human spread. Usually, this is in the form of trading disease severity for transmissibility. Studies in 2015 showed when you give H5 the mutations needed to spread effectively between ferrets, it loses its severity
3. We may have some cross-protection with regular flu strains, too. We've all seen N1 (second part of H5N1) a bunch of times through vaccines or infection. Also H5 and H1 are both “group 1” hemagglutinins, which may provide protection too.
Read 5 tweets
Katelyn Jetelina Profile picture
Feb 1
How well have the fall 2023 Covid-19 vaccines worked against infection? New data out today.

54% additional protection compared to people that didn’t have the fall vaccine.

A few thoughts:
1. This about the same as flu and honestly better than expected with these types of vaccines and virus mutating so fast (good news!)

2. As expected it works against the newest, highly mutated variants (good news!)

3. It has min. waning (surprising but good news)
4. Compliments Netherlands hospitalization data showing protection. and complements lab data showing *removing* the original formula from the vaccine was likely the driver to broadened b-cells. (good news!)
Read 6 tweets
Katelyn Jetelina Profile picture
Nov 28, 2023
Anddddd the @CDCgov finally has a useful wastewater dashboard. Now we are talking! And just in time for exponential growth in Covid-19 🫤

Link:

National and regional trends. cdc.gov/nwss/rv/COVID1…
Image
State-level trends Image
Current state levels Image
Read 4 tweets
Katelyn Jetelina Profile picture
Feb 23, 2023
@FLSurgeonGen there's this thing called "behavior". And it impacts passive surveillance. Don't trust the COVID-19 data? Then let's look at another vaccine...
HPV. In 2008, we had ~6000 reports to VAERS for adverse events following HPV vaccination. In 2013, we had ~50 reports. This means reports decreased by 12x.
Why you may ask? Did it get safer in 5 years? No. We didn't change the vaccine formula.

cdc.gov/mmwr/preview/m…
Maybe fewer people got the vaccine so less people reported adverse events? No. In 2008 <10% of teens had the HPV vaccine. In 2013, 40% had been vaccinated. ...
Read 5 tweets
Katelyn Jetelina Profile picture
Jun 18, 2022
1/n Estimating death rankings from a novel virus is incredibly challenging. We don't have a "counter-factual"-- A 12-month period with no restrictions and stable virus-- to know the "true" toll. These ACIP numbers came from a preprint with an important nuance.
2/n Authors ranked C19 based on 23-month cumulative deaths. They did this to account for restrictions. They also ranked based on annualized deaths (not on ACIP slide). Using annual, the ranks are as follows:

<1 year: 9
1-4 years: 8
5-9 years: 7
10-14 years: 7
15-19 years: 6
3/n Annual rankings are also not perfect. 2020 was a very restrictive year. Many parents changed "normal" behaviors in 2021 and 2022, too.

Which ranking is "true"? We don't know. My guess is somewhere in the middle. Deaths among kids have been increasing as restrictions lifted
Read 6 tweets
Katelyn Jetelina Profile picture
Nov 28, 2021
i hope people recognize how privileged it is to say “don’t panic” to the public. we’re asking people to understand the second most complex system in the human body while navigating a sea of misinformation while coping with significant exhaustion and mental health problems 1/4
all while receiving little-to-no communication from CDC/FDA/WH or even scientists in “English”. SO i humbly suggest an alternative to “don’t panic”… we take the public along for the ride. we communicate the science and how it’s changing. if ive learned anything with my 2/4
newsletter it’s that the average person wants to know! not just “go get your vaccine still” but WHY. not just “we’re waiting for studies” but WHAT science we’re waiting for. not just “there were 61 pos people on a plane” but WHAT we’re looking for if they are positive. 3/4
Read 4 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(