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May 12 โ€ข 7 tweets โ€ข 3 min read โ€ข Read on X
๐—ฆ๐—”๐—ฅ๐—ฆ-๐—–๐—ผ๐—ฉ-2 ๐—ฎ๐—ฏ๐—ฒ๐—ฟ๐—ฟ๐—ฎ๐—ป๐˜๐—น๐˜† ๐—ฒ๐—น๐—ฒ๐˜ƒ๐—ฎ๐˜๐—ฒ๐˜€ ๐—บ๐—ถ๐˜๐—ผ๐—ฐ๐—ต๐—ผ๐—ป๐—ฑ๐—ฟ๐—ถ๐—ฎ๐—น ๐—ฏ๐—ถ๐—ผ๐—ฒ๐—ป๐—ฒ๐—ฟ๐—ด๐—ฒ๐˜๐—ถ๐—ฐ๐˜€ ๐˜๐—ผ ๐—ถ๐—ป๐—ฑ๐˜‚๐—ฐ๐—ฒ ๐—ฟ๐—ผ๐—ฏ๐˜‚๐˜€๐˜ ๐˜ƒ๐—ถ๐—ฟ๐˜‚๐˜€ ๐—ฝ๐—ฟ๐—ผ๐—ฝ๐—ฎ๐—ด๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐Ÿ”ฅ

nature.com/articles/s4139โ€ฆ
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2) SARS-CoV-2 infection aberrantly elevates mitochondrial bioenergetics and induces mitochondrial elongation during the early stages of infection in human cells. This promotes ATP generation to support robust viral replication. Image
3) SARS-CoV-2 increases mitochondrial membrane potential through the interaction of viral RNA and nucleocapsid protein. This leads to elongated mitochondria morphology. Image
4) Infection also enhances oxidative phosphorylation and expression of mitochondrial respiratory chain complexes to increase ATP production.
SARS-CoV-2 activates the EGFR signaling pathway and induces mitochondrial translocation of EGFR. Image
5) This contributes to sustaining the abnormal elevation in mitochondrial bioenergetics.
Treatment with FDA-approved EGFR inhibitors, especially vandetanib, reduces SARS-CoV-2 replication by inhibiting mitochondrial EGFR translocation and restoring mitochondrial function. Image
6) Vandetanib administration to SARS-CoV-2 infected mice alleviates viral load, clinical symptoms, and lung inflammation.
Vandetanib demonstrates potent antiviral activity in vitro against various SARS-CoV-2 variants including Alpha, Beta, Delta and Omicron. Image
7) The findings reveal a physiologically relevant role for SARS-CoV-2-induced changes in mitochondrial dynamics and EGFR signaling in supporting viral persistence. EGFR inhibitors may be promising therapeutic candidates for COVID-19.

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More from @ejustin46

May 14
"๐™ƒ๐™‡๐˜ผ" (๐™ƒ๐™ช๐™ข๐™–๐™ฃ ๐™‡๐™š๐™ช๐™ ๐™ค๐™˜๐™ฎ๐™ฉ๐™š ๐˜ผ๐™ฃ๐™ฉ๐™ž๐™œ๐™š๐™ฃ), ๐™–๐™ฃ ๐™–๐™—๐™—๐™ง๐™š๐™ซ๐™ž๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐™ฌ๐™š ๐™ฌ๐™ž๐™ก๐™ก ๐™ค๐™›๐™ฉ๐™š๐™ฃ ๐™๐™š๐™–๐™ง ๐™–๐™—๐™ค๐™ช๐™ฉ !

nature.com/articles/s4146โ€ฆ
Image
2) The study investigated the genetic factors influencing antibody response to COVID-19 vaccines and clinical outcomes using data from over 350,000 vaccinated individuals in the UK. Image
3) It confirmed previous findings that the HLA-DQB1*06 alleles enhance vaccine-induced antibody responses. However, these alleles alone did not significantly reduce COVID-19 risk at a population level.
Read 8 tweets
May 14
๐—›5๐—ก1, ๐—™๐—จ๐—ง๐—จ๐—ฅ๐—˜ ๐—ฃ๐—”๐—ก๐——๐—˜๐— ๐—œ๐—– ๐—ข๐—ฅ ๐—ก๐—ข๐—ง?

๐™๐™๐™ง๐™š๐™š, ๐™›๐™ค๐™ช๐™ง ๐™ค๐™ง ๐™›๐™ž๐™ซ๐™š ๐™จ๐™ฉ๐™š๐™ฅ๐™จ ๐™–๐™ง๐™š ๐™ฉ๐™๐™š ๐™˜๐™๐™–๐™ฃ๐™œ๐™š๐™จ, ๐˜5๐˜•1 ๐˜ฏ๐˜ฆ๐˜ฆ๐˜ฅ๐˜ด, ๐˜ต๐˜ฐ ๐˜ฃ๐˜ฆ๐˜ค๐˜ฐ๐˜ฎ๐˜ฆ ๐˜ต๐˜ณ๐˜ข๐˜ฏ๐˜ด๐˜ฎ๐˜ช๐˜ด๐˜ด๐˜ช๐˜ฃ๐˜ญ๐˜ฆ ๐˜ฃ๐˜ฆ๐˜ต๐˜ธ๐˜ฆ๐˜ฆ๐˜ฏ ๐˜ฉ๐˜ถ๐˜ฎ๐˜ข๐˜ฏ๐˜ด
science.org/content/articlโ€ฆ
2) From Kai Kupferschmidt's @kakape remarkable article with interviews with Tom Peacock @PeacockFlu and other experts, for the sake of simplicity, we have extracted these different steps. Image
3) ๐˜๐˜ช๐˜ณ๐˜ด๐˜ต ๐˜ด๐˜ต๐˜ฆ๐˜ฑ : ๐˜”๐˜ถ๐˜ต๐˜ข๐˜ต๐˜ช๐˜ฐ๐˜ฏ ๐˜—๐˜‰2/๐˜Œ627๐˜’ Image
Read 12 tweets
May 14
๐™‹๐™ง๐™š๐™ซ๐™–๐™ก๐™š๐™ฃ๐™˜๐™š ๐™–๐™ฃ๐™™ ๐™˜๐™ค-๐™ค๐™˜๐™˜๐™ช๐™ง๐™ง๐™š๐™ฃ๐™˜๐™š ๐™ค๐™› ๐™˜๐™ค๐™œ๐™ฃ๐™ž๐™ฉ๐™ž๐™ซ๐™š ๐™ž๐™ข๐™ฅ๐™–๐™ž๐™ง๐™ข๐™š๐™ฃ๐™ฉ ๐™ž๐™ฃ ๐™˜๐™๐™ž๐™ก๐™™๐™ง๐™š๐™ฃ ๐™–๐™ฃ๐™™ ๐™ฎ๐™ค๐™ช๐™ฃ๐™œ ๐™ฅ๐™š๐™ค๐™ฅ๐™ก๐™š ๐™ช๐™ฅ ๐™ฉ๐™ค 12-๐™ข๐™ค๐™ฃ๐™ฉ๐™๐™จ ๐™ฅ๐™ค๐™จ๐™ฉ ๐™ž๐™ฃ๐™›๐™š๐™˜๐™ฉ๐™ž๐™ค๐™ฃ ๐™ฌ๐™ž๐™ฉ๐™ ๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™ค๐™‘-2

sciencedirect.com/science/articlโ€ฆ
Image
2) This study examines cognitive impairment ('brain fog') in children post-SARS-CoV-2. At 12 months, 7% experienced brain fog, with no difference between first infection and reinfection. Persistent brain fog was reported by 2.4%. Image
3) Brain fog was associated with poorer mental health, fatigue, well-being and sleep. Females and older adolescents reported more brain fog. Consistently over 12 months, brain fog correlated with higher difficulties, fatigue, lower wellbeing and more sleep issues. Image
Read 4 tweets
May 14
๐˜ˆ ๐˜ท๐˜ฆ๐˜ณ๐˜บ ๐˜ช๐˜ฏ๐˜ต๐˜ฆ๐˜ณ๐˜ฆ๐˜ด๐˜ต๐˜ช๐˜ฏ๐˜จ ๐˜ด๐˜ต๐˜ถ๐˜ฅ๐˜บ :
"๐—ฃ๐—ฒ๐—ฟ๐˜€๐—ถ๐˜€๐˜๐—ฒ๐—ป๐˜ ๐—”๐—ฐ๐˜๐—ถ๐˜ƒ๐—ฎ๐˜๐—ถ๐—ผ๐—ป ๐—ผ๐—ณ ๐—–๐—ต๐—ฟ๐—ผ๐—ป๐—ถ๐—ฐ ๐—œ๐—ป๐—ณ๐—น๐—ฎ๐—บ๐—บ๐—ฎ๐˜๐—ผ๐—ฟ๐˜† ๐—ฃ๐—ฎ๐˜๐—ต๐˜„๐—ฎ๐˜†๐˜€ ๐—ถ๐—ป ๐—Ÿ๐—ผ๐—ป๐—ด ๐—–๐—ผ๐˜ƒ๐—ถ๐—ฑ"

biorxiv.org/content/10.110โ€ฆ
Image
2) The study evaluated 142 participants, including uninfected controls, acutely infected individuals, convalescent controls, and long COVID patients. Samples included PBMCs and plasma collected at various time points after infection. Image
3) Comprehensive immunological, virological, transcriptomic and proteomic analyses were performed to characterize the immune profiles in these groups.
Read 9 tweets
May 14
๐™‘๐™„๐™๐™๐™Ž๐™€๐™Ž ๐™‡๐™Š๐™‘๐™€ ๐™๐™Š ๐™๐™๐˜ผ๐™‘๐™€๐™‡ !

In 2 months, 10 SARS-COV-2 variants + 9 others pathogens detected in wastewater from aircraft and airport terminals at Singapore Changi Airport, Jan-Feb 2023
medrxiv.org/content/10.110โ€ฆ

Image
Image
2) The study investigated the feasibility of monitoring SARS-CoV-2 and other pathogens in wastewater from aircraft and airport terminals at Singapore Changi Airport between Jan-Feb 2023.
SARS-CoV-2 and variants were detected in wastewater from both aircraft and airport terminals. Image
3) Several variants of interest were detected in aircraft wastewater 18-31 days before being detected in local wastewater or clinical cases.
Viral load trends from airport terminal wastewater correlated more strongly with local COVID-19 cases rather than global cases ... Image
Read 6 tweets
May 13
๐™‡๐™ค๐™ฃ๐™œ ๐˜พ๐™Š๐™‘๐™„๐˜ฟ ๐™ž๐™ฃ ๐™ƒ๐™€๐˜ผ๐™‡๐™๐™ƒ ๐™’๐™Š๐™๐™†๐™€๐™๐™Ž ๐™›๐™ง๐™ค๐™ข ๐™Ž๐™ค๐™ช๐™ฉ๐™ ๐˜ผ๐™›๐™ง๐™ž๐™˜๐™– !


โ–ถ๏ธ 104 PARTICIPANTS TESTED POSITIVE
โ–ถ๏ธ 36 with NO SYMPTOMS <30 days
โ–ถ๏ธ 68 with SYMPTOMS > 91 DAYS
incl.
โ–ถ๏ธ 60 with SYMPTOMS from 231 to 680 DAYS !!! ๐Ÿ˜ฑ academic.oup.com/ooim/article/5โ€ฆ
Image
2) This study investigates post-acute sequelae of SARS-CoV-2 (PASC) in 68 healthcare workers in South Africa with persistent COVID-19 symptoms beyond 91 days. The most common symptoms were headaches, cough, fatigue, muscle pain and shortness of breath. Image
3) Using the MRC dyspnoea scale, 34% had breathing issues on exertion. Infections occurred mainly in the initial pandemic waves. This highlights prolonged symptoms in healthcare workers, potentially impacting their health, showing a need for improved testing and treatments. Image
Read 4 tweets

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