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Ziyad Al-Aly, MD Profile picture
@zalaly
May 15 • 5 tweets • 2 min read • Read on X
Is Covid still deadlier than the flu in 2024?

The short answer is yes!

In 2024, Covid remains deadlier than flu.

New research from my team in @JAMA_current

By @Biostayan Taeyoung Choi and @zalaly

A thread with the correct links🧵

jamanetwork.com/journals/jama/…
In this study of 11,272 people

8625 hospitalized for COVID-19
2647 hospitalized for flu

jamanetwork.com/journals/jama/…
5.7% died in the COVID-19 group

3.04% died in the flu group

That is a difference of 2.66% deaths

This translates into 35% higher

jamanetwork.com/journals/jama/…
The 35% higher risk of death in people hospitalized for COVID vs flu should be interpreted in the context of 2 times more hospitalization for covid than hospitalization for flu

This compounds the rates of death due to COVID vs flu

jamanetwork.com/journals/jama/…
Image
Trivializing Covid as an inconsequential “cold” is not based on fact.

Here are the facts:

1. Covid leads to more hospitalizations than flu
2. Covid leads to more deaths than flu

jamanetwork.com/journals/jama/…

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More from @zalaly

Ziyad Al-Aly, MD Profile picture
May 15
Is Covid still deadlier than the flu in 2024?

The short answer is yes!

In 2024, Covid remains deadlier than flu.

New research from my team in @JAMA_current

By @Biostayan Taeyoung Choi and @zalaly

A thread 🧵

jamanetwork.com/journals/jama/…
In this study of 11,272 people

8625 hospitalized for COVID-19

2647 hospitalized for flu

jamanetwork.com/journals/jama/…
5.7% died in the COVID-19 group

3.04% died in the flu group

That is a difference of 2.66% deaths

This translates into 35% higher risk of death in COVID-19 vs flu in 2024

jamanetwork.com/journals/jama/…
Read 6 tweets
Ziyad Al-Aly, MD Profile picture
Feb 22
📣 New in @ScienceMagazine

I teamed up with @EricTopol to write this #SciencePerspective on Long Covid

Solving the puzzle of #LongCovid

A long 🧵

science.org/doi/10.1126/sc…
First, what is Long Covid?

It is a complex nonmonolithic multisystemic disease with sequelae across almost all organ systems

It can manifest across the life span (from children to older adults) and across race & ethnicity, sex, & baseline health status

science.org/doi/10.1126/sc…
Long Covid is likely a disease with many subtypes that may have different risk factors (genetic, environmental, etc.) and distinct biologic mechanisms that may respond differently to treatments.

science.org/doi/10.1126/sc…
Read 19 tweets
Ziyad Al-Aly, MD Profile picture
Dec 24, 2023
3 key messages from our recent paper in @TheLancetInfDis

1. Covid is worse than flu

Covid remains a much more serious threat to human health than the flu

thelancet.com/journals/lanin…
2. Comparing the two:

COVID is more multisystemic
Flu is more respiratory

thelancet.com/journals/lanin…
3. Both covid and flu cause more health loss in the long-term than what is evident around the time of the infection

Trivializing these illnesses as inconsequential ignores the large burden of health loss that occurs in the post-acute/chronic/long phase

thelancet.com/journals/lanin…
Read 4 tweets
Ziyad Al-Aly, MD Profile picture
Dec 16, 2023
Some people objected to use of the term “long flu”

Let me explain

A thread

thelancet.com/journals/lanin…
Lets start with the evidence about health loss

higher in post-acute flu than acute flu

higher in post-acute covid (long covid) than acute covid

In both acute and post-acute phases, burden of health loss was higher in covid than flu

thelancet.com/journals/lanin…
For me, a big revelation from the study was:

the realization that when you measure it, the burden of health loss is higher in post-acute (long) phase of illness than acute phase of illness

I knew this about covid
I did not know this about flu
Read 10 tweets
Ziyad Al-Aly, MD Profile picture
Dec 14, 2023
📣 New from my team in @TheLancetInfDis

Long-term outcomes of people hospitalized for COVID-19 vs seasonal influenza

A 🧵

thelancet.com/journals/lanin…
The study included:

81,280 individuals hospitalized for SARS-CoV-2
&
10,985 individuals hospitalized for seasonal influenza

We followed them for 1.5 years to characterize the risks of death, health care utilization & 94 health outcomes

thelancet.com/journals/lanin…
Covid had higher risk of death, healthcare utilization and sequelae in most organ systems than flu

This was evident in pre-delta, delta, and omicron; and also evident in vaccinated and unvaccinated individuals.

thelancet.com/journals/lanin…

Image
Image
Read 9 tweets
Ziyad Al-Aly, MD Profile picture
Aug 21, 2023
1/ 📣 New from my team in @NatureMedicine

In a study of 6 million people, we examined risk trajectories of 80 components of Long Covid over 2 years post-infection

📌 Risks remained elevated for many Long Covid conditions even 2 years infection

A 🧵

nature.com/articles/s4159…
2/ The study included:

138,818 individuals with SARS-CoV-2
&
5,985,227 non-infected controls

We followed them for 2 years to characterize the risk trajectories of death, hospitalization and 80 components of Long Covid

nature.com/articles/s4159…
3/ In people who were not hospitalized during the acute phase of COVID (the majority)

risk of death remained elevated up to 6 months

risk of hospitalization remained elevated up to 19 months

risks remained elevated for 31% of sequelae during the 2-year

nature.com/articles/s4159…
Image
Read 22 tweets

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