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Roland Baker Profile picture
@RolandBakerIII
May 16 • 10 tweets • 3 min read • Read on X
Influenza A H5N1 Puzzle. What do you think?

Left: Influenza A in waste water as of 5/4/2024

Right: Large slaughterhouses and meat processing plants that discharge directly to waterways
Image
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@LongDesertTrain But then I found the original source is in the EPA document on pages 3-3 & 3-4 (PDF pages 51 & 52) And they make mention of various datasets which I'm trying to track down.
epa.gov/system/files/d…
@LongDesertTrain Then mention several datasets:

Hydrologic and Water Quality System (HAWQS)
epa.gov/waterdata/hawq…
@LongDesertTrain EPA’s Enforcement and Compliance History Online (ECHO) database
echo.epa.gov
@LongDesertTrain National Hydrography Dataset Plus (NHDPlus)
epa.gov/waterdata/get-…
@LongDesertTrain Publicly owned treatment works (POTW)

Note sure which one yet:
search.epa.gov/epasearch/?que…
@LongDesertTrain I'm still trying to figure this out (not my area of expertise!) because @CCSDMaskUp and I would like to make a map out of these data.
@LongDesertTrain @CCSDMaskUp This is the list of the direct dischargers.
@LongDesertTrain @CCSDMaskUp @DPersists Can you help Ryan find the list of indirect discharges?

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More from @RolandBakerIII

Roland Baker Profile picture
May 16
(1/n) Highly pathogenic avian influenza viruses of the H5N1 clade 2.3.4.4b in the urban environment in New York City positive:

* Red-tailed hawk 1/81
* Canada goose 3/222
* Peregrine falcon 1/12
* Chicken 1/302
* Total 6+ out of 1798 sampled

Next Symptoms =>

H/T @bollyweed
Image
Red tailed hawk
* Neurologic symptoms
* loss of leg function
* torticollis
* glottis wide open.
Canada goose 1
* Oculi uterque
* eyes cloudy and occluded
* head tremors, ataxia
* unable to stand.
Read 6 tweets
Roland Baker Profile picture
May 13
(1/n) Marked endotheliotropism of highly pathogenic avian influenza virus H5N1 following intestinal inoculation in cats:
pubmed.ncbi.nlm.nih.gov/22090101/
Image
* Spread of HPAIV H5N1 from the lumen of the intestine to other organs took place via the blood and lymphatic vascular systems but not via neuronal transmission
* Massive infection of endothelial and lymphendothelial cells
Read 15 tweets
Roland Baker Profile picture
Feb 22
/1 MRI reveals blood–brain barrier disruption of the temporal lobes and frontal lobes with enhanced BBB permeability unique to Long COVID cases with brain fog caused by sustained systemic inflammation. H/T @StevenMathern
nature.com/articles/s4159…

Image
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/2 BBB disruption in the temporal lobes was associated with anosmia. BBB disfunction & sustained systemic inflammation was associated with increased astrocytic protein S100β, IL-6, bFGF and IL-13.
/3 Patients with long COVID had elevated levels of IL-8, GFAP and TGFβ, with TGFβ specifically increased in the cohort with brain fog.
Read 7 tweets
Roland Baker Profile picture
Jan 30
Nature: Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans: 2 weeks of a a ketogenic diet was associated with a significant upregulation of pathways and enrichment in cells associated with the adaptive immune system. In contrast, a vegan diet had a significant impact on the innate immune system, including upregulation of pathways associated with antiviral immunity. Both diets significantly and differentially impacted the microbiome and host-associated amino acid metabolism, with a strong downregulation of most microbial pathways following ketogenic diet compared with baseline and vegan diet. Despite the diversity of participants, we also observed a tightly connected network between datasets driven by compounds associated with amino acids, lipids and the immune system.
nature.com/articles/s4159…
These findings are aligned with the previously reported role of ketogenic diet in increasing γδ T cell responses in mice.
On the other hand, we observed a previously unreported upregulation of innate immunity following vegan diet. Our findings also highlight a significant upregulation of erythropoiesis and heme metabolism following vegan diet.
Read 9 tweets
Roland Baker Profile picture
Jan 22
(1/3) Three immunizations with Novavax’s protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2: Two long threads on this paper linked below (H/T @StevenMathern)
nature.com/articles/s4154…
(2/3) Link to thread 1 of 2
(3/3) Link to thread 2 of 2
Read 7 tweets
Roland Baker Profile picture
Jan 11
Nature: The selection landscape and genetic legacy of ancient Eurasians: 1,600 imputed ancient genomes beginning around 12,000 years ago indicate rapid evolution far earlier than thought involving diet & selective pressure in FADS, LCT & HLA...
nature.com/articles/s4158…
Using ancient individuals to infer local ancestry tracts in over 400,000 samples from the UK Biobank, the authors identify widespread differences in the distribution of Mesolithic, Neolithic and Bronze Age ancestries across Eurasia.
By calculating ancestry-specific polygenic risk scores, they show that height differences between Northern and Southern Europe are associated with differential Steppe ancestry, rather than selection.
Read 11 tweets

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