Thread by @_HeartofGrace_

1/ 💉🚨 Hypothetical: Rapid Onset of Paralysis after COVID 19 Vaccination: potential cause: cGAS-STING "hyper" Activation a WITH INCREASED activation due to physioolgical differences in teenager compared to adult.
This thread will discuss upsetting scenario.
(Heavy science)

2/ Emerging role of STING signalling in CNS injury: inflammation, autophagy, necroptosis, ferroptosis and pyroptosis

jneuroinflammation.biomedcentral.com/articles/10.11…

3/ Scenario: teen is given covid vaccine mRNA based, may or may not have NDA plasmid contamination, or other contamination.

DNA plasmid, spike protein, and bacteria are all known to activate cGAs STING pathway.

This pathway can be hyperactivated

4/ of in one or more areas it is bombarded repeatedly with virus (spike), dsDNA (double stranded DNA, like DNA Plasmid), bacteria, and can also become dysregulated if STING 3 variant is there, a mutation, other TMEM173 variant, etc. nature.com/articles/s4143…

5/ Scenario: young teen, gets covid vaccine. spike protein (and or DNA plasmid or other contaminant) bombards cGAs STING pathway (STING variant may be present/and or mutation in STING):
Mechanism of cGAS-STING Activation and Hyperactivation
1. cGAS-STING Pathway:

6/ cGAS: Detects plasmid DNA/spike and produces cyclic GMP-AMP (cGAMP).

STING (Stimulator of Interferon Genes): Activated by cGAMP, leading to the production of type I interferons and other pro-inflammatory cytokines.

7/ This will lead to chronic activation and positive forward/Feedback loop and hyperactivation of this pathway.

Continuous presence of DNA plasmid pieces in the cytosol due to their repeated introduction or inefficient clearance/with spike protein.

8/ this results in sustained activation of the cGAS-STING pathway, resulting in a chronic inflammatory state.

This generates more cells that are nearby to become involved due to paracrine diffusion. ncbi.nlm.nih.gov/pmc/articles/P…

9/ Persistent inflammation causes continuous tissue damage, releasing more cellular debris and DNA, further activating the cGAS-STING pathway. The cells that are getting attacked by the body's own immune system release their OWN DNA , and this activates cGAS again, and the

10/ body comes back in and attacks a second time, and begins a LOOP of attack, a cycle, and it continues (many other threads on this starting back in October).

11/ then the neuroinflammation begins of the brain and central nervous system.

High levels of inflammatory cytokines can cross the blood-brain barrier (BBB), leading to inflammation in the central nervous system (CNS).

12/ Chronic inflammation can activate microglia (the brain's resident immune cells), causing them to release neurotoxic substances.
This is all a cascade occurring from the cGAS STING pathway being activated, and becoming dysregulated as it is activated.

13/ cGAS is supposed to protect us.

Demyelination and neuronal damage now starts to occur. Nerves are now being damaged, and neurons in the brain are being attacked by the body's immune system.

14/ Chronic inflammation might trigger an autoimmune response against neural tissues, leading to demyelination (loss of the protective myelin sheath around nerves) and neuronal damage.

15/ this prolonged inflammation and immune attack can result in axonal injury, disrupting neural communication--the communication with the brain to other parts of the body--like the arms and legs.
Inflammatory myelopathy might begin.

16/ : Inflammation of the spinal cord (myelitis) can cause damage to the neural pathways responsible for motor control--this is muscle control.

Them in the case of paralysis. severe inflammation can lead to swelling or compression of the spinal cord,

17/ impairing neural transmission.
Inflammatory damage to peripheral nerves can result in neuropathy, affecting muscle function and leading to weakness or paralysis.

I am so sorry.

18/ If occurring over a couple of weeks:
Early Symptoms:
Weakness including Initial weakness in limbs, difficulty walking, or muscle fatigue.
Numbness, tingling, or pain in affected areas.

19/ Progressive loss of motor control, leading to difficulty with movement and coordination.
Complete loss of voluntary muscle function in affected regions, potentially leading to paraplegia or quadriplegia depending on the extent of spinal cord or nerve involvement.

20/ reason for teens to suffer from stronger damage is stronger immune response due to age. Adolescents may have a more robust immune response, which could result in an exaggerated reaction to the presence of DNA plasmid and spike protein with contaminants and/or sting variant

21/ younger nervous system. Puberty involves significant hormonal changes, which could modulate immune responses and contribute to a more intense inflammatory reaction.

22/ What happened:
The persistent presence of DNA plasmids and or spike with STING variation maintains the activation of the cGAS-STING pathway, causing a cytokine storm with high levels of inflammatory mediators in the bloodstream.

23/ Pro-inflammatory cytokines cross the blood-brain barrier, leading to inflammation within the central nervous system (CNS). Microglia (resident immune cells in the brain and spinal cord) become activated and start releasing neurotoxic substances.

24/ Inflammation spreads to the spinal cord (myelitis), causing swelling, edema, and damage to neural tissues, attack the myelin sheath, leading to demyelination, disrupting neural signal transmission.

And then, axonal damage and permanent damage to the central nervous system

25/ paralysis