π₯πΌπΉπ² πΌπ³ ππ‘ππππ π ππ§ππ’π‘ πΆπ» ππ΅π² πππ©πππ’π£π ππ‘π§ πΌπ³ ππ’π©ππ-19 ππΌ π£ππ₯πππ‘π¦π’π‘ βπ πππ¦πππ¦π
ππ¦π’πππΊ π’ π¬π¦πΊ π΄π΅πΆπ₯πΊ !
dovepress.com/role-of-inflamβ¦
ππ¦π’πππΊ π’ π¬π¦πΊ π΄π΅πΆπ₯πΊ !
dovepress.com/role-of-inflamβ¦
2) COVID-19 and Parkinson's disease (PD) may be linked through shared mechanisms like neuroinflammation, oxidative stress, autophagy dysregulation, and ACE2 downregulation. SARS-CoV-2 infection could trigger pathways involved in PD development.
3) Analysis of gene expression data identified differentially expressed genes (DEGs) between PD/COVID-19 and controls. Pathway analysis showed genes were involved in processes like inflammation and immune response.
4) Ibuprofen may help alleviate PD and COVID-19 by inhibiting the NF-ΞΊB signaling pathway through DEGs like RELA. This pathway is activated in both diseases and involved in inflammation.
5) ACE2 plays a role in PD pathology based on a mouse model with ACE2 knockout. These mice showed worse PD symptoms, more neuronal loss, and increased inflammation markers. ACE2 is expressed in brain areas implicated in PD.
6) SARS-CoV-2 entry involves binding to ACE2 receptor. Downregulating ACE2 during COVID-19 could impact pathways involved in both diseases and exacerbate symptoms
7) Inflammation, oxidative stress, autophagy and mitochondrial dysfunction are shared mechanisms that may amplify adverse effects when PD and COVID-19 interact. Further research is needed to validate models of this interaction.
8) In summary, the paper investigates potential links between COVID-19 infection and increased PD risk or severity based on overlapping molecular pathways, and identifies ACE2 and NF-ΞΊB inhibition as potential targets for further study.
Thanks for reading π
Thanks for reading π
β’ β’ β’
Missing some Tweet in this thread? You can try to
force a refresh
γ
