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Emmanuel Profile picture
@ejustin46
May 30 • 4 tweets • 2 min read • Read on X
𝗞𝗶𝗻𝗲𝘁𝗶𝗰𝘀 𝗼𝗳 𝗦𝗔𝗥𝗦-𝗖𝗼𝗩-2 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻 𝗯𝗶𝗼𝗺𝗮𝗿𝗸𝗲𝗿𝘀 𝗶𝗻 𝗮 𝗵𝗼𝘂𝘀𝗲𝗵𝗼𝗹𝗱 𝘁𝗿𝗮𝗻𝘀𝗺𝗶𝘀𝘀𝗶𝗼𝗻 𝘀𝘁𝘂𝗱𝘆

nature.com/articles/s4159…
Image
2) This field study followed 30 households with COVID-19 index cases and contacts. 9 contacts became infected. kinetics of viral RNA, antigen, infectious virus in nasal/saliva samples and antibodies were measured. Image
3) RNA detected earlier in saliva than nasal samples in 6/9 infected contacts. Antigen correlated better with infectious virus. Antibodies rose by week 3. Higher RNA levels in samples yielding infectious virus. Image
4) This provides data on biomarker dynamics and performance of different diagnostic tests over the course of SARS-CoV-2 infection.

Thanks for reading 🙏 Image

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More from @ejustin46

Emmanuel Profile picture
Jun 1
𝙇𝙊𝙉𝙂-𝙏𝙀𝙍𝙈 𝙄𝙈𝙈𝙐𝙉𝙄𝙏𝙔,
𝙬𝙝𝙖𝙩 𝙡𝙚𝙫𝙚𝙡 𝙖𝙣𝙙 𝙛𝙤𝙧 𝙝𝙤𝙬 𝙡𝙤𝙣𝙜 ?

𝘛𝘩𝘦 𝘮𝘢𝘫𝘰𝘳 𝘙𝘖𝘓𝘌 𝘰𝘧 𝘐𝘨𝘎 𝘈𝘕𝘛𝘐𝘉𝘖𝘋𝘐𝘌𝘚
Thanks to @DrDenDunnen @siamosolocani Image
2) IgG antibodies play a crucial role in the immune response to the infection. These antibodies are produced by B cells in response to exposure to the virus.
The main role of IgG antibodies against SARS-CoV-2 is to neutralize the virus. They bind to specific proteins ...
3) ...on the virus surface, such as the spike protein, preventing the virus from entering and infecting human cells. This neutralization can help in reducing the severity of the infection and preventing the virus from spreading further within the body. Image
Read 7 tweets
Emmanuel Profile picture
Jun 1
𝗩𝗮𝗿𝗶𝗮𝗯𝗹𝗲 𝗿𝗮𝘁𝗲𝘀 𝗼𝗳 𝗦𝗔𝗥𝗦-𝗖𝗼𝗩-2 𝗲𝘃𝗼𝗹𝘂𝘁𝗶𝗼𝗻 𝗶𝗻 𝗰𝗵𝗿𝗼𝗻𝗶𝗰 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻𝘀

biorxiv.org/content/10.110…
Image
2) This study examines patterns of within-host evolution of SARS-CoV-2 by analyzing viral genomic sequence data from 9 cases of prolonged/chronic infection.
A novel statistical method is developed to infer the number and evolutionary rates of distinct viral subpopulations. Image
3) Analysis of the data finds evidence of non-trivial population structure in 4 out of the 9 cases.
Rates of evolution inferred for some subpopulations were significantly faster or slower than estimates for the global SARS-CoV-2 population Image
Read 7 tweets
Emmanuel Profile picture
Jun 1
𝗧 𝗖𝗘𝗟𝗟𝗦, 𝘁𝗵𝗲 𝗱𝗶𝗳𝗳𝗶𝗰𝘂𝗹𝘁 𝗯𝗮𝘁𝘁𝗹𝗲 𝗼𝗳 𝗦𝗔𝗥𝗦-𝗖𝗢𝗩-2 𝗜𝗡𝗙𝗘𝗖𝗧𝗜𝗢𝗡 𝗪𝗔𝗥𝗥𝗜𝗢𝗥𝗦
(5th 𝘱𝘢𝘳𝘵)

𝘓𝘖𝘕𝘎 𝘊𝘖𝘝𝘐𝘋 𝘢𝘯𝘥 𝘵𝘩𝘦 𝘛 𝘊𝘌𝘓𝘓𝘚 𝘋𝘠𝘚𝘙𝘌𝘎𝘜𝘓𝘈𝘛𝘐𝘖𝘕 Image
2) This study, that we posted in 2023, was finally published in 2024.
Researchers studied 43 individuals who had cleared SARS-CoV-2 infection (recovered, R group) and individuals experiencing persistent symptoms at least 8 months after infection (long COVID, LC group). Image
3) Multi-omics analyses including CyTOF, flow cytometry, RNA-seq, single-cell RNA-seq and serology were performed on blood samples from these individuals. 
The LC group showed systemic inflammation and immune dysregulation. T cell subset distribution was perturbed ... Image
Read 8 tweets
Emmanuel Profile picture
Jun 1
𝗚𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗮 𝗹𝗲𝘁𝗵𝗮𝗹 𝗺𝗼𝘂𝘀𝗲 𝗺𝗼𝗱𝗲𝗹 𝗲𝘅𝗽𝗿𝗲𝘀𝘀𝗶𝗻𝗴 𝗵𝘂𝗺𝗮𝗻 𝗔𝗖𝗘2 𝗮𝗻𝗱 𝗧𝗠𝗣𝗥𝗦𝗦2 𝗳𝗼𝗿 𝗦𝗔𝗥𝗦-𝗖𝗼𝗩-2 𝗶𝗻𝗳𝗲𝗰𝘁𝗶𝗼𝗻 𝗮𝗻𝗱 𝗽𝗮𝘁𝗵𝗼𝗴𝗲𝗻𝗲𝘀𝗶𝘀 🤔

nature.com/articles/s1227…
Image
2) Researchers generated double-transgenic mice expressing both human angiotensin-converting enzyme 2 (hACE2) and human transmembrane protease serine 2 (hTMPRSS2) to increase their susceptibility to SARS-CoV-2 infection. Image
3) In vitro and in vivo experiments showed that co-expression of hACE2 and hTMPRSS2 enhanced SARS-CoV-2 infectivity and entry.
The double-transgenic mice exhibited significant weight loss, clinical symptoms, lung injury, inflammation and lethality when infected with SARS-CoV-2. Image
Read 6 tweets
Emmanuel Profile picture
Jun 1
"𝙊𝙍𝙂𝘼𝙉𝙀𝙇𝙇𝙀𝙎" 𝙖𝙧𝙚 𝙤𝙣 𝙩𝙧𝙚𝙣𝙙 !
𝘔𝘦𝘨𝘢-𝘵𝘩𝘳𝘦𝘢𝘥

Organelles are small, specialized structures in cells which operate like organs by carrying out specific tasks. They appear in many studies recently. Image
2) A good article in layman terms, on Organelles
news-medical.net/life-sciences/…
Image
3)
Read 8 tweets
Emmanuel Profile picture
Jun 1
𝗧𝗵𝗲 𝗺𝗼𝘀𝘁 𝗖𝗥𝗜𝗦𝗣 𝗜𝗠𝗔𝗚𝗘𝗦 𝗮𝘃𝗮𝗶𝗹𝗮𝗯𝗹𝗲 𝗼𝗳 𝘁𝗵𝗲 𝘃𝗶𝗿𝘂𝘀’𝘀 𝗥𝗡𝗔 𝗮𝗻𝗱 𝗥𝗘𝗣𝗟𝗜𝗖𝗔𝗧𝗜𝗢𝗡 𝗦𝗧𝗥𝗨𝗖𝗧𝗨𝗥𝗘𝗦 👍

SARS-CoV-2 vgRNA accumulates in infected cells into CLUSTERS that grow, from small clusters at 6 hours to larger clusters by 24 hours Image
2) It is a complete new way to see viruses in action !!!

Using super-resolution microscopy, researchers revealed details of SARS-CoV-2 replication in host cells. They labeled viral RNA and proteins with fluorescent probes and suppressed fluorescence ...news.stanford.edu/stories/2024/0…
3) ...to image individual molecules blinking on and off, achieving 10nm resolution. Images showed RNA accumulating over 6-24 hours into growing clusters around the nucleus that contain replication machinery. Image
Read 7 tweets

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