Naomi Harvey PhD #WearAMask Profile picture
Jun 4 15 tweets 4 min read Read on X
Grape seed extract 🍇

Seriously, get it in your cupboard and if it’s ok for you to take (I haven’t found any proven interactions though), use it for Covid prevention or when infected

200-400mg of 95% OPC extract reduces viral load & stops the virus from replicating by 50%
It’s a tricky one to shop for as some are just ‘grape seed’ & provide 2-3grams of grape seed powder. But what is needed is 200-400mg of OPC extract.

The study wasn’t done by any company trying to sell it (so there’s no conflict of interest) so there’s no ‘gold standard’ brand.
Solaray do a good 100mg one but you’d need 2 a day to get the minimum dose.

solaray.com/products/grape…
Pureclinica in the UK do one that process 270mg of OPC’s in a 300mg tablet. I don’t know a lot about the company but I know people who’ve benefited from this during acute covid infection.

pureclinica.com/products/grape…
Important caveat:

This is *not* the same as grapefruit seed extract!

That is a citrus 🍊 fruit and is dangerous to take with certain medications so please do not confused them.
And don’t get tannin free extract as it’s the tannins that are the anti virals!
I am not a medical doctor so this cannot be taken as medical advice, but I want people to know what options they have.

The science is quite clear here that grape seed extract has potent antiviral effects on SARS-CoV-2 (COVID19) when taken in supplement form.
@PutAimovigOnNHS @maddyoby In terms of BP I personally usually opt to just keep an eye on my BP with my own machine and see how it goes but the potential for additional blood thinning isn’t one you can monitor. I felt the risk was very low though given no case reports or study evidence.
The potential interactions/effects are:

> it could lower blood pressure so be aware if that’s an issue for you or you’re on BP lowering meds

> it may have a slight blood thinning effect as many polyphenols do so be aware if you’re on blood thinners already
This is where I’m meant to say “speak to your doctor before starting a new supplement”

Please do so if you have a good doctor, that’s great.

But I won’t patronise anyone by saying they should, as I know many don’t even have a doctor they can speak with 😔
@Anonym5x5 I think this is what my Mum took as she struggles to swallow capsules, but it made her feel sick though :(
@Z3R0Gravitas He’s taking 200mg daily as prevention from infection since he’s the one who leaves the house to shop & work etc. He also uses nasal spray & a mask, so it’s part of his Swiss cheese 🧀 protocol.

But I’ve chosen to take them only around exposure risks, since I take so much else.
One other possible side effect: may cause low blood sugar but this case study doesn’t say what dose they took.

So be aware if your blood sugar is already low.
@Velma25803515 Since Covid causes blood clots, I would take both during an active infection as NK can help reduce the clot risk and may help degrease spike protein. But if taking as a prevention, it’s only something you could decide. Signs of over thin blood are here healthdirect.gov.au/amp/article/th…
@Velma25803515 *decrease

I seem to be able to take Nattokinase (15,000fu so a large dose), serrapeptase, aspirin, omega 3, and Sulodexide all at once and still my blood clots fine and seems normal.

Others bruise from one capsule of 2,000fu Nattokinase so it depends on the individual really.

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More from @Naomi_D_Harvey

May 31
People like the presenter at @ACSMNews hold false beliefs about exercise and illness like ME/CFS and Long Covid.

One of them is they believe the disease is caused by bed rest - but the reality is, 80% never did any bed rest at all at the onset of illness
Other very strict laboratory studies of extreme bed rest (beyond what most people ever experience) show that the metabolic consequences of it do not trigger anything like the diseased state we see in ME or Long Covid.

The presenters are, I’m afraid, showing their ignorance.
They also failed to read or acknowledge the actual exercise science on people with ME & Long Covid that shows a distinct abnormal pathology in response to exercise in these patients. A pathology not seen in any other disease. Again, highlighting their lack of expertise @ACSMNews
Read 7 tweets
May 30
Ellagic acid [EA] “supplementation (30 mg EA/kg BW) for 14 wk attenuated oxidative stress–induced endothelial dysfunction” [in mice 🐁]

“EA reduces gene expression levels of TNFα, IL-6, and chemokine C-C motif ligand-2 secretion in LPS-stimulated macrophages and adipocytes”
Urolithin A: important for vascular health & mitochondria

It’s made from Ellagic acid by gut microbiota

BUT - not everyone can make it

60% of the USA cannot make it at all, none, zip, zero.

Most UA supplements provide Ellagic acid, but if you can’t make UA that won’t help.
Read 6 tweets
Apr 15
📢 “irisin protects against neuroinflammation by acting directly on glial cells in the brain”

Irisin is a peptide released by muscles after exercise.

It’s been identified as one of the reasons exercise helps cognition & works directly on microglia

hsci.harvard.edu/news/hormone-i…
Given it’s released after exercise, people with #MyalgicEncephalomyelitis and #LongCovid with PEM may surely be considered to be low in circulating Irisin.

Importantly: “soluble irisin…is sufficient to confer the benefits of exercise on cognitive function”
“Since irisin does not specifically target amyloid plaques, but rather neuroinflammation directly, we’re optimistic it could have beneficial effects on neurodegenerative diseases beyond just Alzheimer’s,” added Wrann.
Read 6 tweets
Apr 10
There’s a *very* pragmatic and important reason why ME/CFS must be included in this.

At least 50% of pwLC meet the diagnostic criteria for ME. We know that.

With the end of funded covid testing, Long Covid as a diagnosis will dwindle. Ppl are already not getting LC diagnosed.
Moving forwards, more of those with covid induced-ME/CFS will either have no diagnosis or will be diagnosed with ME/CFS just as anyone else who develops it from an unknown cause.

Mixed in with them will be those with non-covid-ME/CFS from EBV etc that’s still happening.
If ME/CFS is left out (original and Covid induced), then those who have Long Covid moving forwards will be left out also, as the diagnosis will not last in the numbers it has achieved with copious testing available. It’s already happening and has been for 1-2 years now.
Read 10 tweets
Apr 8
This looks MUCH better than the usual very limited scales.

I’m glad the Moderate group isn’t quite so wide and I like the expansion of the Very Severe into sub categories.
Oh and no wonder it’s good, co authors include Janet Dafoe, Whitney Dafoe and Ron Davis 😊

This is a marked improvement on previous severity groupings for #MEcfs
*correction: expansion of extremely severe into subcategories
Read 9 tweets
Mar 25
Check your choline intake: are you getting enough? #MEcfs #LongCovid

In people who have a variation of the PEMT -744 gene with one change from G-->C (rs12325817) 78% developed organ dysfunction when fed a low choline diet

pubmed.ncbi.nlm.nih.gov/16816108/
Choline deficiency is more likely in those with folate or B12 deficiency since choline is utilised more for methylation in the absence of those B vits.

Lack of choline leads the body to cannibalise it’s own cell membranes to keep blood levels above 50% ods.od.nih.gov/factsheets/Cho…
Choline levels have been found to be depleted in #pwME
Read 7 tweets

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