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Jun 5 โ€ข 10 tweets โ€ข 2 min read โ€ข Read on X
๐™’๐™–๐™จ๐™ฉ๐™š๐™ฌ๐™–๐™ฉ๐™š๐™ง ๐™จ๐™ช๐™ง๐™ซ๐™š๐™ž๐™ก๐™ก๐™–๐™ฃ๐™˜๐™š ๐™›๐™ค๐™ง ๐™—๐™ž๐™ง๐™™ ๐™›๐™ก๐™ช (๐˜ผ/๐™ƒ5๐™‰1)

๐˜ž๐˜ฉ๐˜ฆ๐˜ณ๐˜ฆ ๐˜ข๐˜ณ๐˜ฆ ๐˜ธ๐˜ฆ ๐˜ธ๐˜ช๐˜ต๐˜ฉ ๐˜ต๐˜ฉ๐˜ฆ ๐˜ด๐˜ถ๐˜ณ๐˜ท๐˜ฆ๐˜ช๐˜ญ๐˜ญ๐˜ข๐˜ฏ๐˜ค๐˜ฆ?
(๐˜Œ๐˜œ ๐˜ณ๐˜ฆ๐˜ฑ๐˜ฐ๐˜ณ๐˜ต 27๐˜ต๐˜ฉ ๐˜”๐˜ข๐˜บ)
โ€ฆstewater-observatory.jrc.ec.europa.eu/#/bulletin
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2) Wastewater surveillance for bird flu is supported by 13 EU countries and 7 non-EU countries. The HPAI A(HSN1) virus was detected in US dairy herds, acquired from an infected mammal. The EU Wastewater Observatory and Global Consortium contribute to pandemic preparedness efforts
3) The report highlights the threat of highly pathogenic avian influenza viruses H5N1 and HSN1. The viruses have been detected in multiple countries, with some cases of zoonotic transmission. Water can serve as a transmission pathway for the virus, particularly for waterfowl. Image
4) Biosecurity measures are crucial in preventing its spread.
For wastewater surveillance for avian influenza in Europe, Austria and Denmark are in the initial stages, while Belgium and Greece have already started surveillance. Czechia focuses on early detection, and France ...
5) ...has implemented specific tests. The overall objective is to detect and prevent the spread of avian influenza through monitoring wastewater for early warning signs.
Greece, Hungary, Italy, Lithuania, the Netherlands, Slovakia, and Slovenia are all involved ...
6) ... in various surveillance activities related to avian influenza in wastewater. These activities include pilot exercises, testing wastewater samples, and monitoring for early detection of H5N1. Collaboration with international partners is also emphasized.
7) Efforts include also a project in Slovenia, interest expressed by Spain and Sweden, successful detection in wastewater samples in Sweden, clinical and bio-surveillance in South Africa, a proof-of-concept study in Japan, ongoing trials in New Zealand, and ...
8) ...research projects in the UK and Northern Ireland. These initiatives aim to monitor and detect avian flu in wastewater for early detection and prevention.

In 2023, South Africa faced an avian influenza outbreak, leading to the culling of millions of chickens and ...
9) ... a shortage of eggs and chicken in retail outlets. The UAE and UK have wastewater surveillance programs to monitor the spread of bird flu, while Northern Ireland and the US have developed testing methods for influenza A viruses in wastewater samples.
10) The detection of H5 avian influenza in select areas in Texas has prompted further research. The University of Missouri has also developed a probe to detect H5 avian influenza genetic material in wastewater.

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More from @ejustin46

Jun 7
๐™ƒ๐™ž๐™œ๐™ ๐™ก๐™š๐™ซ๐™š๐™ก ๐™ค๐™› ๐™ฃ๐™š๐™ช๐™ฉ๐™ง๐™–๐™ก๐™ž๐™ฏ๐™ž๐™ฃ๐™œ ๐™–๐™ฃ๐™ฉ๐™ž๐™—๐™ค๐™™๐™ž๐™š๐™จ = ๐™๐™ž๐™œ๐™ ๐™ก๐™š๐™ซ๐™š๐™ก ๐™ค๐™› ๐™ฅ๐™ง๐™ค๐™ฉ๐™š๐™˜๐™ฉ๐™ž๐™ค๐™ฃ ๐™–๐™œ๐™–๐™ž๐™ฃ๐™จ๐™ฉ ๐™ž๐™ฃ๐™›๐™š๐™˜๐™ฉ๐™ž๐™ค๐™ฃ

๐™’๐™๐™–๐™ฉ, ๐™ž๐™› ๐™ž๐™ฉ ๐™ฌ๐™–๐™จ๐™ฃ'๐™ฉ ๐™ฉ๐™๐™–๐™ฉ ๐™จ๐™ž๐™ข๐™ฅ๐™ก๐™š?
wwwnc.cdc.gov/eid/article/29โ€ฆ
Image
2) Several studies have shown that higher levels of neutralizing antibodies are associated with immune protection from symptomatic SARS-CoV-2 infection. However, the estimated relationship between neutralizing antibody levels and protection has varied between studies.
3) The authors reconciled these differences by normalizing the antibody titers across studies. They found that the study results converge on a consistent relationship between antibody levels and protection from COVID-19. This can be useful for planning future vaccine use ... Image
Read 8 tweets
Jun 6
๐™†๐™€๐™” ๐™Ž๐™๐™๐˜ฟ๐™” :
"๐˜พ๐™ค๐™œ๐™ฃ๐™ž๐™ฉ๐™ž๐™ซ๐™š ๐™ฅ๐™ง๐™ค๐™›๐™ž๐™ก๐™š, ๐™ฃ๐™š๐™ช๐™ง๐™ค๐™ž๐™ข๐™–๐™œ๐™ž๐™ฃ๐™œ ๐™–๐™ฃ๐™™ ๐™›๐™ก๐™ช๐™ž๐™™ ๐™—๐™ž๐™ค๐™ข๐™–๐™ง๐™ ๐™š๐™ง๐™จ ๐™ž๐™ฃ ๐™ฅ๐™ค๐™จ๐™ฉ-๐™–๐™˜๐™ช๐™ฉ๐™š ๐˜พ๐™Š๐™‘๐™„๐˜ฟ-19 ๐™จ๐™ฎ๐™ฃ๐™™๐™ง๐™ค๐™ข๐™š"

nature.com/articles/s4159โ€ฆ
Image
2) The study aimed to characterize the cognitive profile and track the recovery of post-acute COVID-19 syndrome (PACS) patients with cognitive complaints. The researchers conducted comprehensive neuropsychological assessments, collected blood/CSF samples, and performed ... Image
3) ...MRI scans at baseline and 6-month follow-up. Key findings:
- 75.5% of participants showed cognitive impairments, primarily in attention/executive function and verbal memory.
- Mental health issues like apathy (64%), anxiety (57%), and severe fatigue (35%) were prevalent. Image
Read 6 tweets
Jun 6
๐—œ๐˜€ ๐—•๐—”.2.86 (๐—ถ๐—ป๐—ฐ. ๐—๐—ก.1), ๐—ฆ๐—”๐—ฅ๐—ฆ-๐—–๐—ข๐—ฉ-4 ?

The classification of viruses has always evolved, whether for dengue or influenza with H1N1, H5N1, etc.
thelancet.com/journals/lanmiโ€ฆ
Image
2) We have always considered Omicron, because of its antigenic distance from the Wuhan strain, the SARS-COV-3.
Could BA.2.86 and JN.1 be a SARS-COV-4?
3) In this article, they do not answer this question but discusse the emergence of new SARS-CoV-2 subvariants as BA.2.86, and their implications for vaccine development and immunity. The main points are:
1. Researchers have previously classified SARS-CoV-2 into ...
Read 6 tweets
Jun 6
๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™Š๐™‘-2 :
๐™๐™๐™š ๐™œ๐™ง๐™š๐™–๐™ฉ ๐˜พ๐™Š๐™‰๐™๐™๐™Ž๐™„๐™Š๐™‰ ๐™—๐™š๐™ฉ๐™ฌ๐™š๐™š๐™ฃ ๐™Ž๐™€๐˜ผ๐™Ž๐™Š๐™‰๐˜ผ๐™‡, ๐˜พ๐™”๐˜พ๐™‡๐™„๐˜พ ๐™–๐™ฃ๐™™ ๐™ˆ๐™€๐™๐™€๐™Š๐™๐™Š๐™‡๐™Š๐™‚๐™„๐˜พ๐˜ผ๐™‡ ๐™›๐™–๐™˜๐™ฉ๐™ค๐™ง๐™จ
(๐˜ฎ๐˜ฆ๐˜จ๐˜ข-๐˜ต๐˜ฉ๐˜ณ๐˜ฆ๐˜ข๐˜ฅ - 1๐˜ด๐˜ต ๐˜ฑ๐˜ข๐˜ณ๐˜ต)
2) SEASONAL DISEASES refer to illnesses or health conditions (flu, common cold, allergies...) that are more prevalent during SPECIFIC seasons of the year (usually winter or spring).
These diseases are influenced by environmental factors and the presence of seasonal pathogens. Image
4) COVID-19 is a PANDEMIC and CYCLIC disease.
Pandemic, as it has spread globally and continues to affect populations worldwide.
Cyclic, because it appeared on average every 3/4 months which could give the false impression that it followed the seasons. Image
Read 17 tweets
Jun 6
๐™๐™ƒ๐™€ ๐˜ผ๐˜พ๐˜พ๐™€๐™‡๐™€๐™๐˜ผ๐™๐™„๐™Š๐™‰ ๐™ค๐™› ๐™ƒ๐™„๐™Ž๐™๐™Š๐™๐™”

We see very clearly on this graph the incredible acceleration of the substitution rate, with the swarm or cloud JN.1 Image
2) As a reminder, the substitution rates (and not mutation as I had wrongly indicated in my previous post, thx to @AltenbergLee) were:
โ–ถ๏ธ 2020 : 23
โ–ถ๏ธ 2021 : 23.3
โ–ถ๏ธ 2022 : 29
โ–ถ๏ธ 2023 : 29.6
and since the beginning of 2024 : 31.3


Image
Image
Image
Image
3) Also, as very rightly indicated by @_ppmv, it is this level of divergence which is impressive. Image
Read 8 tweets
Jun 5
๐™’๐™๐™ฎ ๐™ฉ๐™๐™š ๐™‰-๐™ฉ๐™š๐™ง๐™ข๐™ž๐™ฃ๐™–๐™ก ๐™™๐™ค๐™ข๐™–๐™ž๐™ฃ ๐™ก๐™ค๐™ค๐™ฅ๐™จ ๐™–๐™ง๐™š ๐™ž๐™ข๐™ฅ๐™ค๐™ง๐™ฉ๐™–๐™ฃ๐™ฉ ๐™›๐™ค๐™ง ๐™ฉ๐™๐™š ๐™Ž๐˜ผ๐™๐™Ž-๐˜พ๐™Š๐™‘-2 ๐™Ž๐™‹๐™„๐™†๐™€ ๐™ฅ๐™ง๐™ค๐™ฉ๐™š๐™ž๐™ฃ ?

N-terminal loops are the regions/segments of amino acids at the end of a protein.
Thanks to @mrmickme pubmed.ncbi.nlm.nih.gov/35999696/
Image
2) The SARS-CoV-2 has evolved multiple variants of concern that pose an ongoing threat during the pandemic. These variants often carry mutations in the spike protein, which mediates viral entry into cells. The N-terminal domain (NTD) of spike is genetically flexible ... Image
3) ...with many variants showing deletions in outward-facing loops like N2 and N3.
Lab experiments found these NTD deletions enhance entry for variants like Alpha. Deletions alone in the ancestral Wuhan strain also increased entry. Image
Read 7 tweets

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