John P. Moore is one of the coauthors of the article in the @Nation claiming that the publication in the @nytimes of @Ayjchan's well-documented brief for the lab leak origin of #Covid_19 was "shoddy" and "an example of science opinion run amok." He took the letter to 1/5
The Nation's editor by me and @fcabello1 mentioning that both targets of his and Gregg Gonsalves's piece were women scholars as an accusation of sexism. He wrote to me in response, claiming that "several female academics who support the natural origins hypothesis have been 2/5
subjected to unambiguously sexist and personal attacks from Lab Leak supporters." This is incorrect. The women scientists criticized by lab leak supporters repeatedly called the latter "conspiracy theorists," and in some cases wrote to their employers requesting that they be 3/5
sanctioned. The pushback to this has been justified, having nothing to do with gender. This was entirely different from Moore's and Gonsalves's failure to address the evidence Dr. Chan adduced, accusing her of a "science-be-damned" attitude, and questioning her right to a 4/5
platform in a widely read medium. Dr. Moore has no account on this site, but perhaps one of his allies (@DrPaulOffit?) can explain the use of these tactics in this important debate. 5/5
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1/2 For decades biologists have accepted the idea that cell differentiation is due to the multistable dynamical attractors of gene regulatory networks, representable by ordinary differential equations or Boolean networks. It was even in my 2005 textbook: amazon.com/gp/product/052…
2/2 But this model is incorrect. We now know switching between discrete functionally specialized cell states is due to phase-transition-like reorganization of liquid-like chromatin hubs, in which thousands of enhancers are recruited from linearly distant sites across the nucleus.
3/N The cell functions expressed the differentiated cell types are not defined by the attractors of dynamical systems, but are exaggerations of activities of the single cell life forms from which multicellular organisms evolved. The physics of phase transitions in the sui generis
1/N I've never used Twitter to present a new scientific view. But these ideas span evolutionary & developmental biology and philosophy, so it won't be published in any widely read journal, and even if it is, it will take several years to happen, and few will see it. So here goes.
2/N 1. Cells are autonomous agents. They strive to maintain their lives and have dynamical and conditional interactions with their environments, from which they draw nutrition and energy. They reproduce and flourish in niches that are constructed in part by their own activities.
3/N 2. Although it seems that there are no processes inside cells that violate laws of chemistry and physics, their internal organization is not understood in conventional terms. The evolutionary steps that led to their emergence as autonomous agents are thus very obscure.
1/N After looking at the demographics, virology, public health dimensions, and earlier parallels (e.g., the 1918 flu epidemic), it seems to me that this whole episode is being handled incorrectly. This is partly due to @realDonaldTrump's self-serving blunders, but not entirely.
2/N This will be a longish thread, which few will see initially. If anyone, particularly with a large following, finds it persuasive, please retweet
3/N Coronavirus #COVID19 is essentially innocuous in anyone under 50, but becomes extremely damaging for those over 60, and particularly over 70. Old people must avoid being infected. But this is not because their immune systems are "weak" or because they are more likely...
The Mueller investigation was totally worth it, despite its conclusions. In early 2017, with a clearly corrupt president in place, but both houses of Congress dominated by Republicans, there would have been no way to launch a legislative branch investigation of his misdeeds. 1/N
Even though it was implausible from the start that collusion with Russia by Trump and his team swung the election, there were enough signs of deals with Russian eleites and operatives to justify a probe. the appointment of a DOJ Special Prosecutor was a gift to the Dems. 2/N
During a 2-year period, though the Dems were out of power, Trump was under a cloud. The SP probe was not based on a phony pretext - Russians had been involved and the Trumpers had encouraged them, though it turned out not to be criminal. 3/N