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Emmanuel Profile picture
@ejustin46
Jul 20 • 6 tweets • 3 min read • Read on X
Scrolly
WHAT a STRANGE IDEA to think that immunity against SARS-CoV-2, would solely rely on a single protein, known as the Spike, and only be dependent on the functionality of neutralizing antibodies ! 🤔

Throughout the course of the pandemic, the Spike protein has dominated ... Image
2) ... the spotlight, whether it be in the context of vaccination or its mutations that enable the virus and its variants to evade the effects of antibodies.

Cursed are those who had the audacity to mention the complexity of the immune response against SARS-CoV-2 ... Image
3) ..with a virus which has 29 proteins, with an immune system which, recognizes over 1400 epitopes, including those found on various proteins, and responds also through the activation of interferons, cytokines, T cells, and other immune cells such as macrophages. Image
4) At the onset of each wave, the "experts" inform us that a single protein, the Spike, along with sometimes just one mutation, that evaded antibodies, could be sufficient to initiate a new wave.

Those who questioned this official stance of the "expert community" ...
5) ... faced criticism, obstruction, or chose to depart from X, much like many of my friends.
I will persist in my fight and will continue to share studies that highlight the intricate nature of the immune system, its vulnerabilities over time ... Image
6) ... and above all, the significant influence of individual behavior in the onset of waves.

Thanks for reading 🙏
FYI @DavidJoffe64 @jlerollblues @michael_hoerger @C_A_G0101

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More from @ejustin46

Emmanuel Profile picture
Jul 21
STROKE(S) and COVID-19
(mega-thread)
Image
Image
2)
3)
Read 6 tweets
Emmanuel Profile picture
Jul 21
WHY in the latest @zalaly study the figures for long COVID (7.8% for the unvaccinated and 3.5% for vaccinated) SEEM SO LOW?

In all the research conducted on long COVID, it is important to consider three key factors:
▶️ 1. The definition of long COVID being used. Image
2) ▶️ 2. The duration of the study period.
▶️ 3. The characteristics of the reference sample.

If we have correctly understood the key points of this study (Ziyad will correct us if necessary), they are as follows.
3) DEFINITION of long COVID :
"An incident health outcome that first occurred between 30 days and 1 year after TO and had not been present before TO."
In most definitions, they use the value of 3 months after infection. Why here the value is from 1 month and stops at one year?🤔 Image
Read 7 tweets
Emmanuel Profile picture
Jul 21
SARS-COV-2, The CELLS KILLER
(apoptosis, necroptosis, pyroptosis, ferroptosis, and NETosis)
🧵 mega-thread

Picture : Apoptotic cell (pink) heavily infected with SARS-COV-2 virus particles (green), isolated from a patient sample. Image
2)
3)
Read 9 tweets
Emmanuel Profile picture
Jul 20
KILLING ME SOFTLY WITH
... the SARS-CoV-2 virus
(2nd part/study)

"A confusion of pathways: Discerning cell death mechanisms in SARS-CoV-2 infection"
science.org/doi/10.1126/sc…
Image
2) SARS-CoV-2 infection causes a confusing array of cell death pathways. Infected cells undergo necroptosis, a form of inflammatory cell death. Meanwhile, nearby uninfected cells also die through apoptosis and pyroptosis, other types of cell death.
3)This widespread cell death in both infected and uninfected cells helps explain the severe tissue damage seen in COVID-19. The virus's ability to trigger multiple cell death mechanisms, even in cells it doesn't directly infect, is a key factor in the disease's devastating impact
Read 4 tweets
Emmanuel Profile picture
Jul 20
WEEKEND FIGURES

The T cell immune response against SARS-CoV-2.

Image
Image
Image
2) Early and strong immune responses, including interferon and adaptive immunity, are crucial for controlling primary SARS-CoV-2 infection. Delayed or weak responses lead to elevated cellular activation, inflammation, and poor clinical outcomes. Image
3) Memory T cell responses are maintained for up to 12 months after infection clearance. CD4+ and CD8+ T cells, representing a small fraction of the immune repertoire, target numerous epitopes. CD4+ T cells recognize at least 19 epitopes, while CD8+ T cells target 17 epitopes. Image
Read 5 tweets
Emmanuel Profile picture
Jul 19
Soon a TREATMENT for LONG COVID ?

One of the most important studies on this subject 💯💥
🙏 @DavidJoffe64

(AI generated image resized) science.org/doi/10.1126/sc…
Image
2) Allow me first of all, to quickly introduce what IFN-γ is.

IFN-γ is a key protein involved in the immune response against SARS-CoV-2. During the initial infection, IFN-γ helps activate immune cells like T cells and macrophages to fight the virus and clear the infection. Image
3) However, in some people, the body continues to produce high levels of IFN-γ even after the virus has been cleared. This persistent IFN-γ signaling is problematic, causes inflammation leading to long-term breathing difficulties and other respiratory symptoms. Image
Read 8 tweets

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