2) The study looked at what immune responses protect people from getting infected with different variants of the COVID-19 virus. It focused on antibodies that can neutralize the virus (called neutralizing antibodies or nAbs).
3) For the Delta variant, the researchers found that nAbs against the original COVID-19 strain (called D614G) accounted for 37% of the protection people had from prior infection. But this protection decreased over time as the antibodies weakened.
4) For the Omicron variant, nAbs against the Omicron BA.1 subvariant only accounted for 11% of the protection. This is because Omicron is much better at evading antibodies compared to earlier variants.
5) The study shows that the immune responses that protect against different COVID-19 variants can be very different. Boosting antibodies against the current variants may help restore protection that is lost over time or due to immune evasion by new variants.
6) However, antibodies alone don't fully explain the protection people have. Other immune responses, like those from immune cells, are also likely important for preventing COVID-19 infection.
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2) The recovery process for Long COVID is a multifaceted topic. This study I shared in May 2023 was among the initial studies to tackle this subject. More research will continue to emerge to further comprehend and explore this topic.
3) In this study researchers aimed to identify distinct trajectories in the evolution of post-COVID-19 condition over 2 years. They used data from a large prospective cohort of 2,197 patients in France to model symptom trajectories.
2) The study found that while 84% of patients reported Long-COVID symptoms at 1-year, this decreased to 61% at 2-years. Importantly, patients who experienced a second SARS-CoV-2 infection between the 1 / 2years follow-ups were at significantly higher risk of persistent Long-COVID
3)...symptoms. In contrast, patients who remained uninfected after the initial COVID-19 episode and were vaccinated were more likely to recover from Long-COVID over time.
EVEN MILD COVID CAN CAUSE PROLONGED COGNITIVE IMPAIRMENT ! 😨
Cognitive Difficulties in COVID-19 patients with varying levels of disease severity - mild (not hospitalized), moderate (hospitalized), and severe (ICU admission) ? bmcpsychology.biomedcentral.com/articles/10.11…
2) The results showed that cognitive difficulties were present across all three groups, but were more prevalent in the moderate and severe cases.
Specifically:
▶️ 11.7% of the mild group
▶️ 39.2% of the moderate group
▶️ 48.9% of the severe group exhibited cognitive deficits.
3) - Poorer performance was observed in domains like sustained attention, visual memory, and working memory, with the severe group showing the greatest impairments.
- Factors like age, depressive symptoms, and disease severity were predictive of cognitive outcomes.
H5N1 : "DÉJÀ VU ALL OVER AGAIN — REFUSING to LEARN the LESSONS of COVID-19"
H/t @falsel_net
The article warns that the US response to a potential H5N1 pandemic risks repeating the mistakes of COVID-19, with inadequate testing, coordination ...nejm.org/doi/full/10.10…
2) ... and political/legal constraints limiting public health measures.
Despite pandemic preparedness plans, the US struggled with COVID-19 due to overconfidence, fractured jurisdiction, and political polarization.
3) Similar issues now threaten the response to H5N1, as antivaccine sentiment, legal challenges, and congressional unwillingness to invest could impair the ability to rapidly scale countermeasures. The article urges health professionals to advocate for evidence-based policies ...
LESSONS from the COVID-19 PANDEMIC for VENTILATION and INDOOR AIR QUALITY
"With frequent outbreaks in elder care facilities and school classrooms, it became clear that it was a fatal mistake to largely neglect the recommendations of scientists ... science.org/doi/10.1126/sc…
2) ...and engineers regarding minimum standards for ventilation and indoor air quality."
KEY LESSONS include:
▶️ Experts beyond just public health authorities are needed to guide effective policies.
▶️ Simply opening windows is often not enough - mechanical ventilation ...
3) ... is necessary but must be monitored.
▶️ Ventilation is often neglected in building design, so regulations are needed.
▶️ Air filtration and disinfection can supplement but not replace good ventilation
2) The study reports the spillover of a highly pathogenic avian influenza (HPAI) H5N1 virus, clade 2.3.4.4b, into dairy cattle herds across multiple U.S. states. Affected cows displayed clinical signs including decreased feed intake, respiratory distress, and ...
3) ...reduced milk production with abnormal milk.
Infectious virus and viral RNA were consistently detected in milk from affected cows. Histological analysis revealed a distinct tropism of the virus for the epithelial cells lining the mammary gland alveoli.