Expect 2 more weeks of very high and stable transmission before the summer wave accelerates.
Currently at an estimated 850,000 daily infections, 1 in 56 Americans contagious, 43,000 resulting Long COVID cases/day.
Deep Dive:
Over the next two weeks, we should see very high and stable transmission, before transmission increases rapidly. Note that transmission estimates are down marginally – of no practical impact – relative to last week. One might be tempted to consider that the summer wave is subsiding. That might be a 5-10% probability.
This is where the model gets interesting. The forecasts are derived from a combination of recent patterns in transmission (levels, change, rate of change, rate of rate of change) as well as historical medians for that date. If only using the recent patterns, a decline in the wave would be reasonable.
However, the historic data capture all of that useful information on variation in human behavior (back to school, end of summer vacations, flights, Labor Day) that focusing only on recent patterns would miss. Because behavioral patterns also fuel viral evolution, these historical data also get, to some extent, at the idea of viral evolution of new variants, which we do not track directly in the model.
When considering the forecast, view it two ways. One, based on current trends and historic data, this is what we would expect. Two, if human behavior defied historic trends, we could see something much different, such as a wave subsiding if everyone were more cautious than average this year, or unfortunately something slightly worse than predicted due to the decline in public health guidance on mitigation.
According to the composite forecasting model, that means hovering between 700,000 to 1,050,000 infections/day over the next month. Transmission is very high, and we may reach a later-summer peak of 1.1-1.3 daily infections around September 11.
Although the forecast is for steady transmission over the next two weeks, the forecast is volatile due to quality issues with incoming data.
Schools, medical facilities, and businesses should now escalate precautions and prepare for the disruption of a high percentage of the population getting sick through the remainder of 2024.
You can find the full PMC COVID-19 dashboard and weekly report for Aug 2, 2024 online.
In the report, I have included a link to the PPT slides from yesterday's Space on the new JAMA-NO #KeepMasksInHealthcare article.
The relative "lull" in SARS-CoV-2 transmission is unlikely to go much lower.
✨1 in 209 people are estimated actively infectious, likely the lowest levels of 2025 nationwide.
Get boosted. Stock up on masks, tests, & filters.
PMC COVlD Update, Nov 3, 2025 (U.S.)
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No data presently suggest the rise of a winter wave any earlier than "usual."
If following historical trends, transmission will pick up Nov 15-29. Last year's rise was atypically late.
PMC COVlD Update, Nov 3, 2025 (U.S.)
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Expect rising misinformation/disinformation as transmission heats up:
🔹Abuse of community notes, particularly surrounding wastewater methodology
🔹Paid bot army attacks, especially about boosters & masks
Transmission typically accelerates in mid-November.
We are currently in a relative 'lull.' We estimate about a quarter-million new daily infections with 1 in 185 people actively infectious. Still bad, likely to get worse.
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PMC COVlD Update, Oct 27, 2025 (US)
Our forecast through November 8 calls for flat transmission.
Nothing yet indicates the onset of a winter wave, but it would also be atypical for the lull to last much longer than another 2-3 weeks.
2/9 🧵
PMC COVlD Update, Oct 27, 2025 (US)
We estimate 264,000 new daily infections during this 'lull' period.
Biobot data have returned. Our substitute data from WWS last week correlated r=.97 (near perfect) with that, but Biobot did retroactively increase recent estimates.
SARS-CoV-2 transmission has fallen.
🔹1 in 191 (0.5%) actively infectious
🔹"Lull" levels at 20% of the summer peak
🔹255,000 new daily infections (still concerning)
Many will knock out higher-risk activities the next 2-4 weeks.
🧵1/11
PMC COVlD Update, Oct 20, 2025 (U.S.)
"Lull" transmission remains dangerous:
🔹1.8 million estimated new weekly infections
🔹>90,000 estimated new #LongCOVID conditions from this week's infections
🔹>500 excess deaths to result from this week's infections
🧵2/11
PMC COVlD Update, Oct 20, 2025 (U.S.)
Exposure risk during "lull" transmission remains high when engaging in many social interactions.
Interacting with 25 people yields a 12% chance of exposure. 100 people? 41% chance of exposure, assuming no testing/isolation.
The PMC website includes an international directory of websites with COVlD wastewater monitoring. It is more up to date than the directories of the EU and WHO.
Let's review what's happening in Europe...
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Data in #Austria show a rising COVlD wave. The x axis (bottom) has infrequent labels, but the data shown go through October 8th.
An estimated 1 in 81 people are actively infectious during the ongoing 11th wave.
The "shutdown" has created a blackout at the state level.
Transmission is half that of the peak one month ago, and we anticipate a relative national "lull" in early-to-mid November, albeit still at dangerous levels.
Our model uses a combination of CDC and Biobot data, so we are able to estimate national statistics despite the CDC data going offline. On the map, note that Puerto Rico continues to update; they use a CDC-style system but were dropped by the CDC long ago. For full methodology, review the technical appendix on the website.
PMC COVlD Update, Week of Oct 6, 2025 (U.S.)
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#DuringCOVID is today. We estimate >600,000 new daily infections. This is about half the peak on September 6.
Notice current levels are similar to the estimated peaks of the first 3 waves.
PMC COVlD Update, Week of Oct 6, 2025 (U.S.)
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Weekly estimates:
🔹4.5 million infections
🔹>200,000 resulting long-term health conditions
🔹>1,300 resulting excess deaths
Key points in my letter to the pharmacy boards. 🧵1/7
Georgia law indicates that the pharmacy board is to follow ACIP. They do not dictate further nuance. Georgia continues to require prescriptions, going against the spirit of the law, ACIP, and 47 other states.
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Louisiana law tells the pharmacy board to follow ACIP. ACIP says do not require a prescription, and 47 other states agree.
The Louisiana pharmacy board continues to require a prescription.