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Emmanuel Profile picture
@ejustin46
Aug 12 • 9 tweets • 3 min read • Read on X
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The risk of COGNITIVE DECLINE and DEMENTIA in OLDER ADULTS DIAGNOSED with COVID-19

A systematic review and meta-analysis + mega-thread 🧵
Thanks to @DavidJoffe64
sciencedirect.com/science/articl…
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2) This meta-analysis (18 studies, 412,957 patients) found that older adults (aged ≥65 years) diagnosed with COVID-19 are at significant risk of developing cognitive impairment. The overall mean MoCA score for COVID patients was 23.34 out of 30, indicating cognitive impairment. Image
3) 65% of COVID-19 patients were identified as having new-onset cognitive impairment based on MoCA scores.

Importantly, the study found that time since COVID-19 infection impacts cognitive outcomes. Patients assessed within 3 months of infection had lower MoCA scores and ... Image
4) ... a higher proportion of cognitive impairment compared to those assessed 3 months or more after infection. This suggests some cognitive recovery over time.

The review also examined the link between COVID-19 and dementia. Image
5) Several studies reported an increased risk of new-onset dementia in COVID-19 patients compared to controls, as well as accelerated cognitive decline in those with pre-existing dementia. Image
6) Overall, the findings indicate that cognitive impairment is an important sequela of COVID-19, especially in older adults. The authors call for further research to fully understand the long-term cognitive impacts of COVID-19.

Thanks for reading 🙏
7) Others threads 👇
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More from @ejustin46

Emmanuel Profile picture
Aug 14
The VARIANT-AGNOSTIC MANNER !

Amazing Study 💯👍 Reveals RBD-62 as Master Key Against SARS-CoV-2 Variants
nature.com/articles/s4146…
Image
2) The term "variant-agnostic" refers to the ability of a therapeutic agent to be effective against multiple variants of a virus, regardless of the specific mutations present in those variants. Image
3) This study describes the development and in vivo evaluation of RBD-62, a therapeutic agent designed to bind to the SARS-CoV-2 receptor ACE2 with high affinity. This approach aims to prevent virus entry and replication in a variant-agnostic manner, avoiding the issues ... Image
Read 7 tweets
Emmanuel Profile picture
Aug 14
ARBITRARY DENIAL of the OBVIOUS !

A great article in Greek that explains the denial surrounding the pandemic 🤬
H/t @reverseyourmind
neostrategy.gr/i-stratigiki-e…
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2) The concept of "Arbitrary Denial of the Obvious" is a prevalent communication strategy often employed in both political discourse and psychological operations by secret services. This tactic involves denying or challenging widely accepted facts to create confusion and ...
3) ...maintain power over critical populations.

This denial can lead to public skepticism towards reliable information, affecting responses to crucial matters like public health and economic stability.
Read 6 tweets
Emmanuel Profile picture
Aug 13
CROSS-REACTIVE IMMUNITY:
the LATEST BUZZWORDS among those DOWNPLAYING COVID-19 🤬
(1st part)

Imagine trying to persuade people that the pandemic is over and that COVID-19 is merely a severe flu. First, you could conduct a series of studies ... Image
2) ...demonstrating that infections with common coronaviruses offer some protection against COVID-19. This strategy has a dual advantage: it equates SARS-CoV-2 with other coronaviruses, thereby downplaying its severity ... Image
3) ...and it suggests that the population—whether vaccinated or not—benefits from natural immunity.

Next, you would emphasize that there is an immune memory established from the initial SARS-CoV-2 infections. This means the population enjoys a form of double protection ... Image
Read 5 tweets
Emmanuel Profile picture
Aug 13
The PROFOUND PERTURBATION of BOTH INNATE and ADAPTIVE IMMUNITY in COVID-19

Important study 💯👍
frontiersin.org/journals/immun…
Image
2) This study provides a comprehensive analysis of the immune system's response to COVID-19. It found that severe cases are marked by:

- Fewer "precursor" NK cells, which are important for an early immune response
- Impaired function of monocytes, a type of immune cell Image
3) - Increased levels of "effector memory" CD8+ T cells, which can indicate an overly aggressive immune response

The study also showed that severe COVID-19 patients have a dysfunctional antibody response, with more SARS-CoV-2-specific IgA than protective IgG antibodies. Image
Read 5 tweets
Emmanuel Profile picture
Aug 13
HOW the IMMUNE SYSTEM RESPONDS to the SARS-COV-2 INFECTION (in 1 graph) ?

A. INFECTION TIMELINE :
After a person is exposed to the virus, the amount of virus in the body (viral load) starts to increase. Image
2) B. IMMUNE RESPONSE:
The body's first line of defense (innate immune response) kicks in soon after exposure, marked by a sharp reaction called a cytokine storm. This happens quickly (shown by the purple line) Image
3) C. ADAPTIVE IMMUNITY:
About a week after infection the body starts to develop a stronger immune response (adaptive immunity). This includes specific types of antibodies, like IgM and IgG, and T cells that help fight the virus. Image
Read 5 tweets
Emmanuel Profile picture
Aug 12
Why do they PREFER US to USE "ENDEMIC" instead of "PANDEMIC"?

After an interesting discussion with @brownecfm and @DavidJoffe64 considering the term "endemic" as a linguistic code, I wanted to respond for once, in a lighter way with some cartoons. Image
2) From the start of the pandemic, governments did not want that 👇 Image
3) Vaccines were initially introduced as the key solution to transition, from an uncontrollable "pandemic" to a more manageable "endemic" and localized situation. Image
Read 10 tweets

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