How the stressed-out brain can weaken the immune system
Stress leads to disarray of the gut microbiome, which in turn causes inflammation and a drop in the body’s ability to fend off infection. #MECFS #LongCovid
nature.com/articles/d4158…
Stress leads to disarray of the gut microbiome, which in turn causes inflammation and a drop in the body’s ability to fend off infection. #MECFS #LongCovid
nature.com/articles/d4158…
"Closer analysis showed that removing the Brunner’s glands from mice eliminates bacteria in the Lactobacillus genus, which live in the small intestine."nature.com/articles/d4158…
"In a healthy gastrointestinal tract, Lactobacilli stimulate production of proteins that act as grout between the cells lining the gut, keeping most of the gut’s contents inside while allowing certain nutrients to enter the bloodstream."nature.com/articles/d4158…
"But when Lactobacilli are gone, the gut becomes ‘leaky’ and “things that shouldn’t cross into the blood do so”, de Araujo says."nature.com/articles/d4158…
"The immune system attacks these foreign molecules, causing the inflammation and illness seen in mice without Brunner’s glands."
"The researchers then examined the glands’ neurons."nature.com/articles/d4158…
"They found that the neurons connect to fibres in the vagus nerve, a communications pathway between the gut and the brain."
"These fibres run directly to the brain’s amygdala, which is involved in emotion and stress response."nature.com/articles/d4158…
"Placing mice with intact Brunner’s glands under chronic stress had the same effect as removing the glands: Lactobacillus levels fell, and inflammation increased."
"This suggested that stress had shut down the Brunner’s glands."nature.com/articles/d4158…
Stress-sensitive neural circuits change the gut microbiome via duodenal glands
cell.com/cell/fulltext/…
cell.com/cell/fulltext/…
"- Secretion of mucin from the glands of Brunner promotes gut Lactobacilli proliferation
- Central amygdala neurons stimulate Brunner’s glands via vagal nerves"cell.com/cell/fulltext/…
"- Stress inhibits the central amygdala, thereby suppressing Brunner’s glands activity
- Impaired gland activity compromises Lactobacilli populations and host immunity"cell.com/cell/fulltext/…
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