ncbi.nlm.nih.gov/books/NBK56451…
Inhibition of mitochondrial function by metformin increases glucose uptake, glycolysis and GDF-15 release from intestinal cells
"Immune-mediated necrotising myopathy (IMNM) is a type of idiopathic inflammatory myopathy (IIM) characterized by subacute, proximal and symmetric muscle weakness,"sciencedirect.com/science/articl…
Jan 29 • 8 tweets • 4 min read
The first major set of genetic associations found in #longCOVID #MECFS
drugtargetreview.com/article/113093…
Genetic risk factors for severe and fatigue dominant #longCOVID and commonalities with #MECFS identified by combinatorial analysis
"Patients with lower levels of taurine had a lot more symptoms, more of them were hospitalized and there was an increased risk for mortality"medicalxpress.com/news/2023-10-a…
Oct 24, 2023 • 12 tweets • 4 min read
Lactate activates the mitochondrial electron transport chain independently of its metabolism #LongCovid #MECFS
"- Lactate is a mitochondrial messenger that shifts ATP production to the mitochondria
- It activates the electron transport chain (ETC) without being metabolized"cell.com/molecular-cell…
Oct 8, 2023 • 17 tweets • 5 min read
Lactate and lactic acidosis #LongCovid #MECFS
"Susceptible patients suffer episodes of D-lactic acidosis usually following ingestion of a high-carbohydrate meal."acutecaretesting.org/en/articles/la…
D-Lactate: Implications for Gastrointestinal Diseases
"They found that the sympathetic nerves were producing noradrenaline, which was binding to killer T cells using a receptor called ADRB1."genengnews.com/topics/cancer/…
Jun 4, 2023 • 9 tweets • 3 min read
VUMC team discovers new genetic disease (neurogenic orthostatic hypotension)
"Researchers at Vanderbilt University Medical Center have discovered a new genetic disease that causes a severe form of neurogenic orthostatic hypotension, a rapid drop in blood pressure upon standing that can cause fainting."
Jun 4, 2023 • 8 tweets • 3 min read
Metformin decreases IFN-α production from plasmacytoid dendritic cells (pDCs) #MECFS#LongCovid
"Though all cells can make IFN-α/β, plasmacytoid DCs are the major producers during chronic infections."
A catatonic woman awakened after 20 years. Her story may change psychiatry.
New research suggests that a subset of patients with psychiatric conditions such as schizophrenia may actually have autoimmune disease that attacks the brain
"Markx and his colleagues discovered that although April’s illness was clinically indistinguishable from schizophrenia, she also had lupus, an underlying and treatable autoimmune condition that was attacking her brain."
Jun 4, 2023 • 17 tweets • 6 min read
CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer
"Metformin blocks complex I of the electron transport chain (ETC), therefore inhibiting OXPHOS and ATP production, leading to AMP-activated protein kinase (AMPK) activation in numerous cell types."
Jun 4, 2023 • 5 tweets • 2 min read
Mitochondria in innate immunity signaling and its therapeutic implications in autoimmune diseases
"metformin has been studied in individuals with mild to moderate systemic lupus erythematosus (SLE), and it has been reported to reduce disease relapse, potentially by reducing NET formation and IFNα production by plasmacytoid dendritic cells."
Jun 4, 2023 • 5 tweets • 2 min read
Inosine-Containing RNA Is a Novel Innate Immune Recognition Element and Reduces RSV Infection
"The cellular enzyme ADAR-1 (adenosine deaminase acting on RNA-1) activation in virally infected cells leads to presence of inosine-containing RNA (Ino-RNA)."
Jun 4, 2023 • 4 tweets • 2 min read
Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity
"Dysautonomia envelops various disorders of the Autonomic Nervous System including Postural Orthostatic Tachycardia Syndrome (POTS), Neurogenic Orthostatic Hypotension (nOH), Postural Orthostatic Intolerance (POI) and many others."
