If seven year olds are already being seen with problems like this, and it's due to their SARS-COV-2 infections, what hope will so many kids have, reinfected again & again, at least once a year?
Ok hopefully it will only be a subset
But we don't know how big a subset yet
And no, it's not even ok for there to be one kid left avoidably harmed by COVID
But we know it's not just one. It's not just hundreds. Not even thousands. Already millions worldwide 😔
Neurological symptoms are common due to COVID. It was clear early on that SARS-COV-2 infection was systemic, had tropism for many tissues in the body. Right from Jan/Feb/Mar 2020 people should have kept doing everything they could to avoid it
Yet governments often made it harder
By the end of 2020 I was seeing very concerning reports about early onset of serious neurological disease in some middle aged patients who had had COVID
It's vital that governments act now to put in place clean air requirements in workplaces, mandate respirators in healthcare settings, recommend use of well fitting respirators to avoid SARS-COV-2 infections, & inform people should still isolate when sick
“Our findings reveal that a substantial proportion of pediatric COVID-19 patients with neurological symptoms exhibit abnormal neuroimaging findings, with 43.74 percent of children in the included studies demonstrating such abnormalities” iflscience.com/abnormal-brain…
It's not too late. Avoidable harms (health & economic) continue to accumulate
As I've been saying for years, the best time to act is now.
Severe acute respiratory syndrome coronavirus 2 infection is linked to significant liver injury, emerging from the facilitated entry of the virus into liver cells, including cholangiocytes and endothelial cells, due to increased receptor expression🧵
This invasion triggers critical cellular alterations such as mitochondrial swelling, endoplasmic reticulum dilation, and hepatocyte apoptosis.
2/x
Confirmed by biopsy or autopsy, the presence of viral particles in liver tissues correlates with extensive histological damage, characterized by necrosis, steatosis, cholestasis, and inflammation.
3/x
"hyperglycemic conditions enhanced the viral entry receptor expression, infectivity, & susceptibility of SARS-CoV-2-induced cell death in the blood retinal barrier cells confirming reported heightened pathology in comorbid populations" journals.plos.org/plospathogens/…
"...intranasal exposure (to SARS-COV-2 virus, ie simulating inhalation) not only resulted in SARS-CoV-2 spike (S) protein presence in different ocular tissues but also induces a hyperinflammatory immune response in the retina..."
"... Additionally, the long-term exposure to viral S-protein caused microaneurysm, retinal pigmented epithelium (RPE) mottling, retinal atrophy, & vein occlusion in mouse eyes..."
"duck & human IAV receptors were widely expressed in the bovine mammary gland, whereas the chicken receptor dominated the respiratory tract. In general, only a low expression of IAV receptors was observed in the neurons of the cerebrum"
@CCSDMaskUp @RickABright @GISAID @USDA "apparently healthy" raccoons (Japan though here, not current)
"1,088 serum samples collected from animals captured in ... eradication program over 3 periods in Japan ... during 2005–2009 for a serologic survey of avian influenza virus (H5N1) infection" ncbi.nlm.nih.gov/pmc/articles/P…
@CCSDMaskUp @RickABright @GISAID @USDA "Bird flu detected in two dead mountain lions"
March 30, 2023
.benitolink.com/bird-flu-detec…
"reviewed studies generally indicate that human norovirus (NoV), Hep A (HAV) and Hep E (HEV) possess a high heat stability. Heating at 70-72 °C for 2 min significantly reduces infectious titers, but often does not result in a >4 log10 decrease"
.pubmed.ncbi.nlm.nih.gov/38290272/#:~:t…
"Resistant fractions of viruses may remain infectious in thermal inactivation processes and inactivation of newly discovered or enveloped viruses in thermal food preparation processes should not be assumed without further testing"
"Viruses do not follow log‐linear thermal inactivation kinetics and the thermostability of parechovirus and influenza virus is similar to that of proven foodborne viruses"
"viral RNA was detected in few cases in the aquatic fauna and flora, especially in bivalves and labyrinth fish, although these organisms seemed to be mostly passive carriers of the virus rather than host allowing virus replication"
"virus persisted, & remained infective in aquatic environments, for 12 days at 22-35C & up to 20 days at 4C, irrespective of the type of water...significant decrease for AIV persistence models was recorded for sea water, after 12 days, at 35C" pubmed.ncbi.nlm.nih.gov/22106514/#:~:t…