Increased LP-PLA2 is strongly associated with increased cardiovascular disease (PMIDs: 22499993, 17431184) and cleaves oxidized phospholipids in LDL.
3/8
Seed oils increase linoleic acid derived oxylipins which are pro-inflammatory, such as 9/13 HODE and many others (PMID: 3292391).
Lower intake of seed oils decreases linoleic acid derived oxylipins 9/13 HODE and 9/13 oxoODE (PMID: 2295994).
Centenarians have lower levels of linoleic acid derived oxylipins (23483888).
5/11 HETEs (Arachidonic acid derived oxylipins) are also associated with obesity (PMID: 28403941)
Increased HODEs associated with increased rates of Alzheimer's dementia (PMID: 17688973)
4/8
Seed oils increase DNA adducts of malonaldehyde (PMID: 8640909), a known carcinogen in animal models and putative carcinogen in humans.
5/8
Cooking foods like french fries in seed oils leads to high levels of 4HNE (DOI 10.1007/s11746-015-2699-z)
4HNE is a toxic aldehyde found in increased levels in the brains of humans with cognitive impairment/dementia precursors (PMID:16413966, 18325775).
6/8
In summary, choosing to eat refined, bleached and deodorized oils like soybean, sunflower, safflower, corn, peanut, or even canola oil can lead to increased pro inflammatory molecules like oxidized LDL, Lp(a), LP-LPA2, and oxylipins derived from linoleic including 9/13 HODE etc....
But we are told by Harvard, and other institutions they are healthy and not inflammatory? Hogwash.
7/8
Humans have never had access to these industrially processed, highly refined, fragile and easily damaged oils outside of the seeds they occur in within the natural world.
Eliminating seed oils from your diet will radically improve your health.
Working on some formal, respectful debates with those who disagree.
8/8
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Believe it or not, the mitochondria in every cell in your body make the MAJORITY of your melatonin. (>95%) in response to infrared light (PMID 36671781, 29164625)
And almost NONE of us are getting enough of it.
We spend >97% of our lives indoors, where there is very little IR light.
If you live 86 years, you will spend 83 of them indoors.
Most of us spend less than 30 minutes per day truly outside. No bueno.
I am not a fan of methylene blue. The data clearly shows that unless you have a block in your electron transport chain, it LOWERS ATP production in your mitochondria.
I think most people are conflating MAO-A inhibition and serotonergic effects with mitochondrial benefit.
Yes, metabolic dysfunction is common but methylene blue is not the way to address this.
The easy root cause solution is to cut out seed oils and processed sugars rather than turning your tongue (and brain) blue.
Sugar is bad for you, but not for the reason you think.
Sugar is NOT bad for you because it raises your blood sugar.
Sugar is bad for you because it causes dysbiosis in your gut => increases endotoxin =>inflammation/metabolic dysfunction.
A thread... 🧵
From the outset, it's important to point out that "naked sugar" (think table sugar= sucrose and high fructose corn syrup) has different effects in the body than sugar consumed as a part of fruits/fruit juice/honey etc.. we'll get to this eventually...
Most believe that "naked sugar" is bad for you because if raises your blood glucose, but there is a dearth of evidence to actually suggest that raising your blood sugar is harmful for humans at all independent of pre-existing diabetes (PMID: 30249012).
Fasting insulin is a SINGLE, CHEAP, EASY BLOOD TEST that could change the health landscape in the United States over night.
If every doctor ordered a fasting insulin ($30) on their patients -and knew how to interpret it**- we would immediately understand how great the burden of metabolic dysfunction in our country is and we could begin targeting it effectively.
The problem here is doctors are NOT taught that:
a) metabolic dysfunction (aka insulin resistance) lies at the root of the MAJORITY of chronic illness in our country...