Paul Saladino, MD Profile picture
Aug 25, 2024 8 tweets 2 min read Read on X
Seed oils ARE inflammatory. Full stop.

They increase oxidized LDL (PMIDs: 2008870, 14739118, 8432867, 28503188, 9488997).

Oxidized LDL is known to worsen atherosclerosis (PMID 24222937) and to bind C-reactive protein (CRP) (12244213) a marker of inflammation.

(All studies cited are in humans)

1/8Image
Seed oils increase Lp(a) (PMIDs: 21466598, 14739118).

Lp(a) is known to be pro-atherogenic, pro-thrombotic and pro-inflammatory (32453609)

2/8
Seed oils increase Lp-PLA2 (Lipoprotein-associated phosholipase A2) (PMID: 28503188).

Increased LP-PLA2 is strongly associated with increased cardiovascular disease (PMIDs: 22499993, 17431184) and cleaves oxidized phospholipids in LDL.

3/8
Seed oils increase linoleic acid derived oxylipins which are pro-inflammatory, such as 9/13 HODE and many others (PMID: 3292391).

Lower intake of seed oils decreases linoleic acid derived oxylipins 9/13 HODE and 9/13 oxoODE (PMID: 2295994).

Centenarians have lower levels of linoleic acid derived oxylipins (23483888).

5/11 HETEs (Arachidonic acid derived oxylipins) are also associated with obesity (PMID: 28403941)

Increased HODEs associated with increased rates of Alzheimer's dementia (PMID: 17688973)

4/8
Seed oils increase DNA adducts of malonaldehyde (PMID: 8640909), a known carcinogen in animal models and putative carcinogen in humans.

5/8
Cooking foods like french fries in seed oils leads to high levels of 4HNE (DOI 10.1007/s11746-015-2699-z)

4HNE is a toxic aldehyde found in increased levels in the brains of humans with cognitive impairment/dementia precursors (PMID:16413966, 18325775).

6/8
In summary, choosing to eat refined, bleached and deodorized oils like soybean, sunflower, safflower, corn, peanut, or even canola oil can lead to increased pro inflammatory molecules like oxidized LDL, Lp(a), LP-LPA2, and oxylipins derived from linoleic including 9/13 HODE etc....

But we are told by Harvard, and other institutions they are healthy and not inflammatory? Hogwash.

7/8
Humans have never had access to these industrially processed, highly refined, fragile and easily damaged oils outside of the seeds they occur in within the natural world.

Eliminating seed oils from your diet will radically improve your health.

Working on some formal, respectful debates with those who disagree.

8/8

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Paul Saladino, MD

Paul Saladino, MD Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @paulsaladinomd

Dec 5, 2025
I cleaned 48 years of toxins from my blood…

I analyzed what came out and what I found blew my mind (results at the end of this post)… Image
In this bag is the “eluate” from a “blood cleaning” procedure called Inuspheresis.

At the bottom, you can see all of the brown material, which is 48 years of accumulated toxins.

Pesticides, plastic residues, forever chemicals, heavy metals, microplastics, etc. Image
These things are VERY difficult to remove from our bodies without some sort of serious detoxification.

I have not always been as intentional about my diet and lifestyle, and I wondered about what sort of toxins were in my body.

I generally prefer to eat clean and spend time in nature.

But this “biohack” was interesting to me. Let me explain further.Image
Read 11 tweets
Sep 15, 2025
Taurine is the next creatine.

Hear me out...

RCTs in humans show clear benefits from taurine (1-6g per day) in both disease states and for exercise performance.

Taurine is powerful stuff. 🧵 Image
Blood pressure reduction (PMID: 26781281), both SBP (systolic) and DBP (diastolic)

Improved vascular function in Type 2 DM (40546935)

Improved markers of metabolic syndrome including SBP/DBP, decreased triglycerides, decreased fasting glucose (38755142)
Decreased HgbA1c, fasting glucose, HOMA-IR, fasting insulin in type II DM and obesity cohorts (35769396, 39796489)
Read 16 tweets
Sep 15, 2025
Biggest nutrient deficiency in the US?

Potassium? Choline? Vitamin D?

Nope, it’s infrared light (760-1000nm). 🧵 Image
Believe it or not, the mitochondria in every cell in your body make the MAJORITY of your melatonin. (>95%) in response to infrared light (PMID 36671781, 29164625)

And almost NONE of us are getting enough of it.
We spend >97% of our lives indoors, where there is very little IR light.

If you live 86 years, you will spend 83 of them indoors.

Most of us spend less than 30 minutes per day truly outside. No bueno.
Read 8 tweets
Apr 2, 2025
I am not a fan of methylene blue. The data clearly shows that unless you have a block in your electron transport chain, it LOWERS ATP production in your mitochondria.

I think most people are conflating MAO-A inhibition and serotonergic effects with mitochondrial benefit.
Yes, metabolic dysfunction is common but methylene blue is not the way to address this.

The easy root cause solution is to cut out seed oils and processed sugars rather than turning your tongue (and brain) blue.
PMID: 21454572, 25277417, 35777722
Read 4 tweets
Mar 9, 2025
Sugar is bad for you, but not for the reason you think.

Sugar is NOT bad for you because it raises your blood sugar.

Sugar is bad for you because it causes dysbiosis in your gut => increases endotoxin =>inflammation/metabolic dysfunction.

A thread... 🧵 Image
From the outset, it's important to point out that "naked sugar" (think table sugar= sucrose and high fructose corn syrup) has different effects in the body than sugar consumed as a part of fruits/fruit juice/honey etc.. we'll get to this eventually...
Most believe that "naked sugar" is bad for you because if raises your blood glucose, but there is a dearth of evidence to actually suggest that raising your blood sugar is harmful for humans at all independent of pre-existing diabetes (PMID: 30249012). Image
Read 25 tweets
Jan 1, 2025
Fasting insulin is a SINGLE, CHEAP, EASY BLOOD TEST that could change the health landscape in the United States over night. Image
If every doctor ordered a fasting insulin ($30) on their patients -and knew how to interpret it**- we would immediately understand how great the burden of metabolic dysfunction in our country is and we could begin targeting it effectively.
The problem here is doctors are NOT taught that:

a) metabolic dysfunction (aka insulin resistance) lies at the root of the MAJORITY of chronic illness in our country...

b) metabolic dysfunction is EASILY diagnosable...

c) metabolic dysfunction is EASILY reversible.
Read 16 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

:(