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Paul Saladino, MD

Aug 25 • 8 tweets • 2 min read • Read on X

Seed oils ARE inflammatory. Full stop.

They increase oxidized LDL (PMIDs: 2008870, 14739118, 8432867, 28503188, 9488997).

Oxidized LDL is known to worsen atherosclerosis (PMID 24222937) and to bind C-reactive protein (CRP) (12244213) a marker of inflammation.

(All studies cited are in humans)

1/8

Seed oils increase Lp(a) (PMIDs: 21466598, 14739118).

Lp(a) is known to be pro-atherogenic, pro-thrombotic and pro-inflammatory (32453609)

2/8

Seed oils increase Lp-PLA2 (Lipoprotein-associated phosholipase A2) (PMID: 28503188).

Increased LP-PLA2 is strongly associated with increased cardiovascular disease (PMIDs: 22499993, 17431184) and cleaves oxidized phospholipids in LDL.

3/8

Seed oils increase linoleic acid derived oxylipins which are pro-inflammatory, such as 9/13 HODE and many others (PMID: 3292391).

Lower intake of seed oils decreases linoleic acid derived oxylipins 9/13 HODE and 9/13 oxoODE (PMID: 2295994).

Centenarians have lower levels of linoleic acid derived oxylipins (23483888).

5/11 HETEs (Arachidonic acid derived oxylipins) are also associated with obesity (PMID: 28403941)

Increased HODEs associated with increased rates of Alzheimer's dementia (PMID: 17688973)

4/8

Seed oils increase DNA adducts of malonaldehyde (PMID: 8640909), a known carcinogen in animal models and putative carcinogen in humans.

5/8

Cooking foods like french fries in seed oils leads to high levels of 4HNE (DOI 10.1007/s11746-015-2699-z)

4HNE is a toxic aldehyde found in increased levels in the brains of humans with cognitive impairment/dementia precursors (PMID:16413966, 18325775).

6/8

In summary, choosing to eat refined, bleached and deodorized oils like soybean, sunflower, safflower, corn, peanut, or even canola oil can lead to increased pro inflammatory molecules like oxidized LDL, Lp(a), LP-LPA2, and oxylipins derived from linoleic including 9/13 HODE etc....

But we are told by Harvard, and other institutions they are healthy and not inflammatory? Hogwash.

7/8

Humans have never had access to these industrially processed, highly refined, fragile and easily damaged oils outside of the seeds they occur in within the natural world.

Eliminating seed oils from your diet will radically improve your health.

Working on some formal, respectful debates with those who disagree.

8/8

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More from @paulsaladinomd

Paul Saladino, MD

@paulsaladinomd

Feb 13

You're not fat because you eat too much, you're fat because you eat the wrong foods...

(1/12)

Yes, eating too much of the wrong foods (ultra-processed foods) is doubly bad...

But it's the wrong foods that are CAUSING you to overeat, and therein lies the problem for many people.

(2/12)

Calorie counting/restriction may work in the short term but it almost always FAILS long term. (PMID 28657838)

Clearly, "eat less, move more" is horrible weight loss advice...

(3/12)

Read 12 tweets

Paul Saladino, MD

@paulsaladinomd

Nov 28, 2023

What do the randomized controlled trials with seed oils in humans REALLY show when we look at them in detail?

Let’s briefly look at ALL eleven of them and see where this leaves us…

Thread ⬇️

𝐑𝐨𝐬𝐞 𝐂𝐨𝐫𝐧 𝐎𝐢𝐥 𝐓𝐫𝐢𝐚𝐥 (𝐑𝐂𝐎𝐓) (𝐏𝐌𝐈𝐃:𝟏𝟒𝟐𝟖𝟖𝟏𝟎𝟓): 1965 - 2y follow up. 80 patients with ischaemic heart disease. 80g olive oil vs 80g corn oil per day vs control (diet as normal) .

Result: At two years, the proportion of patients remaining free of major cardiac events is greater for the control group (75%) than for the two oil groups (olive oil 57%, corn oil 52%).

Potential flaws: only the experimental group was instructed to avoid trans fats (TF), while the controlled group was believed to consume trans fat since it was given no advice on dietary fat. In spite of this, the group eating saturated fat had better cardiac outcomes than the experimental group.

TLDR: 𝐒𝐞𝐞𝐝 𝐨𝐢𝐥𝐬 𝐖𝐎𝐑𝐒𝐄 𝐟𝐨𝐫 𝐜𝐚𝐫𝐝𝐢𝐚𝐜 𝐞𝐯𝐞𝐧𝐭𝐬 despite control group likely consuming more TF.

𝐎𝐬𝐥𝐨 𝐃𝐢𝐞𝐭 𝐇𝐞𝐚𝐫𝐭 𝐒𝐭𝐮𝐝𝐲 (𝐎𝐃𝐇𝐒) (𝐏𝐌𝐈𝐃: 𝟓𝟐𝟐𝟖𝟖𝟐𝟎): 1958-1963 - 5y follow up. 412 participants, control group vs 76% of its calories from soybean oil in the experimental group.

Result: The experimental diet group had a significant reduction in serum cholesterol, which was associated with a reduced CHD relapse rate.

Potential flaws: The control group consumed 9.6% of their calories from trans fat. Experimental group encouraged to eat more nuts, fruits, and vegetables and to restrict their intake of refined grains and sugar.

TLDR: 𝐏𝐨𝐨𝐫𝐥𝐲 𝐜𝐨𝐧𝐬𝐭𝐫𝐮𝐜𝐭𝐞𝐝 𝐭𝐫𝐢𝐚𝐥. Control group consumed FAR more TF than the experimental group and the experimental group received significantly more dietary counseling.

Read 13 tweets

Paul Saladino, MD

@paulsaladinomd

Sep 8, 2023

Spinach
Oats
Almond butter
Seed oils

These “health” foods contain compounds that have been shown to worsen joint pain and arthritis…

See the research below⤵️

Oxalates - deplete sulfate levels in the body. Lower levels of sulfate can lead to weaker cartilaginous tissues, ligaments, tendons and bones.

Phytic acid - Phytate is the primary storage form of both phosphate and inositol in plant seeds. It forms complexes with dietary minerals, especially iron and zinc, and causes mineral-related deficiency in humans. It also negatively impacts protein and lipid utilisation.

Read 4 tweets

Paul Saladino, MD

@paulsaladinomd

Sep 2, 2023

These nutrients hold the KEY to LONGEVITY:

Taurine
Creatine
Anserine
Carnosine
Carnitine
Vitamin B12 and K2

There is only one food that contains all these nutrients.

Which is it?

Taurine, creatine, carnosine, and anserine

Vitamin B12 and K2

Read 4 tweets

Paul Saladino, MD

@paulsaladinomd

Aug 31, 2023

I have a lot of respect for vegans and vegetarians.

Making intentional choices about your diet and removing all processed foods are the first steps to radical health!

And don't forget that MANY essential nutrients for humans are only found in red meat..

[Threads]

Vitamin A, B12, K2
Creatine
Taurine
Carnitine
Carnosine
Anserine
4-hydroxyproline

These nutrients have been shown to prevent cognitive decline, muscle loss and fight against chronic diseases.

These are all major factors that reduce quality of life and shorten life span.

Dietary creatine, taurine, carnosine, anserine and 4-hydroxyproline are beneficial for preventing chronic diseases in humans.

Read 7 tweets

Paul Saladino, MD

@paulsaladinomd

Aug 17, 2023

This is why @kneesovertoesguy and his family choose to eat an animal-based diet of mostly meat, fruit, honey, raw dairy, and organs…

3 quicks steps on how to start an animal-based diet below ⤵️

Meat and organs should be at the center of diet.

How much meat?

1 pound per 100 pounds of goal body weight. So if you you are 150 pounds, you should eat 1.5 pounds of meat per day.

Which organs? Start with liver. The most nutrient dense food on the planet.
0.5 ounce per day is perfect.

FRUIT & HONEY
Add the least toxic forms of carbohydrates, fruit and honey.

Fruits are colorful and sweet. These are the parts of the plant that want to be eaten.

Honey, has been shown to have many metabolic and hormonal benefits. It is highly prized by hunter gathers across the world.

Carbohydrate intake is based on activity level. The more active you are, the more carbohydrates you will need.

Start at 100-150g per day and adjust from there…

Read 4 tweets

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