Chris Ponting Profile picture
Aug 28 4 tweets 2 min read Read on X
📢#ME is clear to see in the blood of 1,455 #pwME
<New Preprint, not peer reviewed>
116 blood molecules or cells are significantly different between #pwME and population controls
& in both females & males
& these differences are NOT due to inactivity

1/4 medrxiv.org/content/10.110…
Image
Only for a handful of 3,237 blood traits was ME’s effect explained partially by inactivity.
By contrast, ME had a significant direct effect - not due to inactivity - on 290 traits.
Note: no single trait/molecule can cleanly distinguish #pwME from controls
2/4 Image
For this we used up to 1,455 #pwME in UK Biobank and 131,303 controls – the largest ME blood ‘omics study to date.
Results were highly reproducible between females and males indicating that female and male ME are similar 3/4 Image
Such a large number of replicated and diverse blood biomarkers that differentiate ME cases from controls should now dispel any lingering perception that ME is psychosomatic
This was a fab collaboration including @AvaKhamseh, @nshejazi and Sjoerd Beentjes. 4/4 Image

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More from @CGATist

Apr 13, 2022
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