📢#ME is clear to see in the blood of 1,455 #pwME
<New Preprint, not peer reviewed>
116 blood molecules or cells are significantly different between #pwME and population controls
& in both females & males
& these differences are NOT due to inactivity
Only for a handful of 3,237 blood traits was ME’s effect explained partially by inactivity.
By contrast, ME had a significant direct effect - not due to inactivity - on 290 traits.
Note: no single trait/molecule can cleanly distinguish #pwME from controls 2/4
For this we used up to 1,455 #pwME in UK Biobank and 131,303 controls – the largest ME blood ‘omics study to date.
Results were highly reproducible between females and males indicating that female and male ME are similar 3/4
Such a large number of replicated and diverse blood biomarkers that differentiate ME cases from controls should now dispel any lingering perception that ME is psychosomatic
This was a fab collaboration including @AvaKhamseh, @nshejazi and Sjoerd Beentjes. 4/4
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We highlight logical fallacies in the lncRNA literature, such as “because one lncRNA (e.g. Xist) is functional, all must be”
A functionally important few lncRNA tend to be spliced & better conserved but lack a simple syntax relating sequence to structure & mechanism, & so resist simple categorization. True mechanisms likely v diverse, involving multiple protein/RNA factors, enhancers & chromatin states