Chris Ponting Profile picture
Disease genomics & molecular mechanisms; ME/cfs: https://t.co/jtrsmeVEuN @ Edinburgh University. Views - my own. He/him.
Aug 28 4 tweets 2 min read
📢#ME is clear to see in the blood of 1,455 #pwME
<New Preprint, not peer reviewed>
116 blood molecules or cells are significantly different between #pwME and population controls
& in both females & males
& these differences are NOT due to inactivity

1/4 medrxiv.org/content/10.110…
Image Only for a handful of 3,237 blood traits was ME’s effect explained partially by inactivity.
By contrast, ME had a significant direct effect - not due to inactivity - on 290 traits.
Note: no single trait/molecule can cleanly distinguish #pwME from controls
2/4 Image
Apr 13, 2022 7 tweets 2 min read
*New review on lncRNAs* intended to provoke scepticism where warranted,
with @WHaerty annualreviews.org/doi/abs/10.114… We highlight logical fallacies in the lncRNA literature, such as “because one lncRNA (e.g. Xist) is functional, all must be” Image