A Simplified Explanation of Fibrin's Role in COVID-19
The Problem:
* COVID-19 can cause blood clots and brain issues.
* These problems can continue even after the infection is gone.
* Scientists don't fully understand how these clots form or what they do to the body.
The Discovery:
* Scientists found that a protein called fibrin plays a big role in these problems.
* Fibrin helps form blood clots.
* In COVID-19, fibrin can bind to the virus and cause more inflammation.
How Fibrin Works:
* Clot Formation: Fibrin helps create blood clots, which can be harmful if they form in the wrong places.
* Inflammation: Fibrin can also trigger inflammation, which can damage tissues.
* Brain Problems: Fibrin can lead to problems in the brain, including inflammation and damage to brain cells.
Potential Solution:
* The scientists found that a special antibody might be able to stop fibrin from causing these problems.
* This antibody could be a possible treatment for COVID-19, especially for people with severe symptoms or long-lasting effects.
In Conclusion:
This research shows that fibrin is a key player in the problems caused by COVID-19. Understanding fibrin's role could lead to new treatments for this disease.
• • •
Missing some Tweet in this thread? You can try to
force a refresh
Everyone keeps talking about developing an app for #LongCovid & I would hate for anyone to recreate the wheel. Are you looking to track symptoms, recovery, treatment, exercise, vitals, pacing, sleep (or lack of), diet and/or sleep? Maybe a few of these designers could collaborate. 🤷♀️
I currently track my data/stats with 𝙐𝙣𝙝𝙞𝙙𝙚, 𝙈𝙮𝘿𝙖𝙩𝙖𝙃𝙚𝙡𝙥𝙨, 𝙎𝙘𝙧𝙞𝙥𝙥𝙨, CDC Surveys (and bloodwork) & don 2 wearable devices. I love contributing to Science. 😃
I've compiled a list of the top 20 apps used by #LongCovid patients in hopes we might encourage collaboration or select all of the best features and/or formats to create THE all-encompassing interactive app/database for our community, our caregivers & doctors in realtime.
Which apps do you find helpful?
1/
• Visible: A pacing and symptom-tracking app tailored for Long COVID and ME/CFS (chronic fatigue syndrome). It uses smartphone camera-based heart rate variability (HRV) measurements, symptom logging, and activity data to help users avoid overexertion (post-exertional malaise). Features include daily “pace scores,” trend analysis, breathing exercises, and optional integration with wearables for all-day monitoring. It emphasizes rest over fitness, with reports for sharing with doctors. Available on iOS and Android; free basic version, premium subscription for advanced features.
2/
• Long COVID Companion: A voice-based app from the Luxembourg Institute of Health for people with Long COVID. It acts as a daily companion to track symptoms, treatments, progress, quality of life, & health metrics over time. Users can log data verbally for ease, with features for pattern recognition and sharing with clinicians. Free on iOS & Android.
3/
**COVID-19 can induce lupus**
🔬🩺🧬🩸🧪🩹💉🩻🦠💊🌡
(systemic lupus erythematosus, SLE) through several immune system mechanisms, especially in genetically predisposed individuals:
**Immune System Hyperactivation:**
COVID-19 triggers a strong immune response. The virus can cause excessive activation of B-cells (antibody-producing cells) and promote overproduction of interferons, both of which are implicated in lupus pathogenesis. This abnormal activation may lead to the immune system mistakenly attacking healthy body tissues—a hallmark of lupus.
1/
**Production of Autoantibodies:**
COVID-19 has been found to stimulate the immune system in a way that leads to the formation of autoantibodies (antibodies that target the body’s own proteins. Autoantibodies such as antinuclear antibodies & lupus anticoagulant are commonly associated with lupus & have been detected in some COVID-19 patients.
2/
**Triggering Disease in Susceptible Hosts:**
Environmental factors like viral infections—including SARS-CoV-2—have long been recognized as possible triggers for new-onset lupus & lupus flare-ups, particularly in people with a genetic predisposition. Wooohoo 😣
3/
For ongoing long COVID patients, the top three reasons to consider a PET scan are:
1.Detecting Hidden Inflammation and Organ Damage
PET scans, especially when combined with MRI (PET/MRI), can reveal persistent inflammation in the heart, lungs, and other organs—even when standard tests appear normal. This helps identify patients at risk for future cardiopulmonary complications such as heart failure, pulmonary hypertension, or valvular disease.
Identifying Brain and Nervous System Involvement
PET scans (such as brain FDG-PET) can uncover hypometabolism or inflammation in the brain, which may explain cognitive, neurological, or autonomic symptoms in long COVID patients. This is particularly valuable for distinguishing long COVID from other neurological or psychiatric disorders.
Tracking Viral Persistence and Immune Activation
Specialized PET imaging agents can help detect viral reservoirs and ongoing immune activation in deep tissues, such as the gut or brainstem. This approach may clarify the underlying cause of persistent symptoms and guide personalized treatment strategies.
These reasons highlight how PET imaging can provide objective evidence of ongoing disease processes, support early intervention, and help tailor management for long COVID patients.
It does sound ‘over the top’ & who wants to believe we are letting our kids get repeated Cov infections potentially destroying their organs.
The tragedy of it all- we knew in 2020. Ask teachers if they see a difference in behavior, mood, memory recall, a dramatic increase in ADHD, and most importantly, look at the test scores and how they have plummeted long after a 3 month lockdown 6 yrs ago.
COVID-19 has been linked to potential dementia risk in young people through mechanisms involving direct neurological damage, vascular changes, and systemic inflammation. Below are key studies and findings that explore this connection:
1. Systemic Vascular and Neurological Pathways**
A 2021 review highlighted COVID-19’s ability to trigger systemic vascular alterations and neuroinflammation, potentially accelerating neurodegenerative processes. Cognitive decline pathways include blood-brain barrier disruption and hypoxic brain injury, which may exacerbate pre-existing dementia or initiate early-onset cases[1].
2. Long COVID and Neurological Symptoms**
A Northwestern Medicine study (2024) found that 10 months post-infection, young adults (18–44) exhibited worsened neurologic symptoms, including cognitive dysfunction, insomnia, and memory deficits. These effects occurred regardless of initial infection severity[2].
My Dear Friends and Fellow Advocates,
With a heart full of passion and gratitude, I write to you today. For five long years, we have fought tirelessly for a cause that too often felt invisible to the world. We’ve faced indifference, we’ve battled through personal struggles—4 to 5 infections, no less—and yet, we refused to succumb to the illness that sought to break us. Yes, I am tired. Yes, I have felt frustrated, defeated even. But here we are. WE MADE IT.
1🧵
Through every obstacle, every moment of doubt, we stood firm—not just for ourselves but for humanity. For our love of people. For the belief that no one should ever endure what we have endured. And let me tell you this: after this past week, I am more inspired than ever. My conviction has been reignited, my spirit rekindled. I come back to our mission with new fervor and light, and I know—deep in my soul—that together we can achieve even more. 2🧵
This is not just my success or yours; this is our collective success. Each and every one of you has played an integral role in bringing Long Covid Awareness Month to life. You gave it your all—your time, your energy, your heart—and it shows. The world is beginning to hear us because of YOU. 3 🧵