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Ziyad Al-Aly, MD Profile picture
@zalaly
Sep 1 • 6 tweets • 3 min read • Read on X
400 million reasons to care about #LongCovid

ICYMI: our review on #LongCovid in @NatureMedicine

Long Covid has affected at least 400 million people worldwide at a cost of $1 trillion per year.

#LongCovid is a defining health crisis of our time!

nature.com/articles/s4159…Image
We review the mechanisms of Long Covid including viral persistence, immune dysfunction, thrombo-inflammation, neuronal inflammation, and microbiome dysbiosis.
nature.com/articles/s4159…
Image
We review the devastating impacts of Long Covid on individuals and communities, health systems, economies, and global health metrics.

nature.com/articles/s4159…
We provide a comprehensive roadmap for research. Details in link (free/open access).

A robust and visionary interdisciplinary research strategy is needed to address the challenge of #LongCovid. We CAN and MUST crack the code on Long Covid.

nature.com/articles/s4159…
Image
And a comprehensive roadmap for policy.
We must not ignore the lessons learned from the COVID-19 pandemic. Details in link (free/open access)

nature.com/articles/s4159…
Image
400 million reasons to care about #LongCovid !!!!

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More from @zalaly

Ziyad Al-Aly, MD Profile picture
Aug 26
🧵1/ A Significant surge in the number of people with a disability in the U.S.

The @stlouisfed just released an analysis using data from the Current Population Survey (CPS), revealing some concerning trends. Here’s what they found:

#Disability #DisabilityJustice #LongCovid Image
2/ Above Trend Increase in Disability
Since 2019, the number of disabled individuals has surged beyond the expected trend by nearly 2 million. This isn't just a statistical anomaly—it's a huge indicator of a deeper, underlying health crisis.Image
3/ Cognitive Disabilities Skyrocket
Most alarming is the rise in cognitive disabilities. The population reporting only a cognitive disability has grown by nearly 1 million—a 43% increase since 2019.
Read 8 tweets
Ziyad Al-Aly, MD Profile picture
Aug 22
ICYMI #LongCovid is a defining crisis of our time

Long Covid affects at least 400 million people globally with an economic cost of $1 trillion/yr

Addressing Long Covid requires a coordinated—but so far absent—response strategy

Our review @NatureMedicine
nature.com/articles/s4159…
ロングコビッドは、私たちの時代を決定づける危機です。

ロングコビッドは、世界中で少なくとも 4 億人に影響を与え、年間 1 兆ドルの経済的損失を招いています。

@NatureMedicine での私たちのレビュー

nature.com/articles/s4159…
La COVID prolongada es una crisis que define nuestro tiempo.

La COVID prolongada afecta al menos a 400 millones de personas en todo el mundo y tiene un coste económico de un billón de dólares al año.

Nuestra reseña en @NatureMedicine
nature.com/articles/s4159…
Read 6 tweets
Ziyad Al-Aly, MD Profile picture
Aug 9
📢Our review "Long COVID science, research and policy" is out in @NatureMedicine

By @zalaly @ahandvanish @LisaAMcCorkell @leticiasaurus @swulfie @VirusesImmunity @EricTopol

A thread
nature.com/articles/s4159…
In this review, we provide (1) a synthesis of the state of science on Long COVID; (2) assess the impacts of Long COVID on individuals, health systems, the economy & global health metrics; and (3) provide a forward-looking research & policy roadmaps nature.com/articles/s4159…
Image
We begin with a timeline of the history of #LongCovid. We recognize the prescience of the #MECFS community that warned us about what’s to come, the op-ed by @fi_lowenstein in @NYTimes, the first mainstream media piece by @edyong209 in @TheAtlantic & more
nature.com/articles/s4159…
Image
Read 19 tweets
Ziyad Al-Aly, MD Profile picture
Aug 2
My Statement on the introduction of the Long COVID Research Moonshot Act #LongCovidMoonshot

I fully support this bill and urge the U.S. Congress and our community to support it.

Short thread: Image
Today U.S. Senator Bernie Sanders @SenSanders formally introduced the Long COVID Research Moonshot Act. This marks a historic moment, the culmination of relentless effort and dedication from countless individuals. #LongCovidMoonshot
The bill calls for the establishment of a Long Covid program at NIH with research funding of $1 billion per year for 10 years, and additional funding to other federal agencies for clinician education, public awareness, and more. #LongCovidMoonshot
Read 9 tweets
Ziyad Al-Aly, MD Profile picture
Jul 23
COVID increases risk of diabetes.

This has now been demonstrated in many studies including the largest (more than 16 million) in @TheLancetEndo

Paper

My comment here
doi.org/10.1016/S2213-…
doi.org/10.1016/S2213-…
Perhaps most alarmingly, the authors report that the
risk of type 2 diabetes remained high beyond the first
year after SARS-CoV-2 infection.

This is yet another study showing the long risk horizon of COVID-19

doi.org/10.1016/S2213-…
It is very clear that SARS-CoV-2 can cause new health problems years after the initial infection

doi.org/10.1016/S2213-…
Read 7 tweets
Ziyad Al-Aly, MD Profile picture
Jul 17
📣 Our new paper in @NEJM

Has the risk of #LongCovid changed over the course of the pandemic?

By @Biostayan, Taeyoung Choi and me

A 🧵
nejm.org/doi/full/10.10…
We enrolled people who had SARS-CoV-2 infection in the pre-delta, delta and omicron eras (441,583 people) and built 3 era-specific controls

We assessed the cumulative incidence of #LongCovid at 1 year after infection by pandemic era & vaccination status

nejm.org/doi/full/10.10…
Image
Among unvaccinated people, the cumulative incidence of #LongCovid declined over the course of the pandemic from a high of 10.4 per 100 adults infected in the pre-delta era to 7.7 per 100 adults infected in the omicron era

nejm.org/doi/full/10.10…
Image
Read 19 tweets

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