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Emmanuel Profile picture
@ejustin46
Sep 11 β€’ 8 tweets β€’ 3 min read β€’ Read on X
During the acute phase of a COVID-19 INFECTION, individuals EXPERIENCE significant AGE ACCELERATION of up to 24.47 YEARS due to disrupted homeostasis 😨😨😨

... and some still failing to take necessary protective measures πŸ€¦β€β™‚οΈπŸ€¦β€β™‚οΈπŸ€¦β€β™‚οΈ
biorxiv.org/content/10.110…
Image
2) The study developed a highly accurate transcriptomic clock to predict chronological age using 47 genes primarily involved in lymphoid immune function. This clock was validated across multiple healthy cohorts. Image
3) Remarkably, the transcriptomic age of COVID-19 patients showed dramatic acceleration of up to 24.47 years during acute infection. This age acceleration correlated with markers of inflammation, such as C-reactive protein and immune cell counts. Image
4) The findings demonstrate the power of the transcriptomic clock to track reversible changes in biological age in real-time, highlighting its potential utility for monitoring the effects of physiological perturbations and evaluating anti-aging interventions.
5) COMMENT:
In the abstract of this study, there is an inaccuracy or error.
They say that the biological age reverted to the baseline upon recovery.
But in the study, the text states that the transcriptomic age acceleration in COVID-19 patients declined over the course...
6) ...of the illness but does not definitively say it returned to completely normal levels:
"This declined to 11.63 years (95% CI: 4.03 to 19.23, FDR = 0.02) and 5.05 years (95% CI: 0.77 to 9.32, FDR = 0.06) in the mid and late phases, respectively."
7) Results that are similar to other recent studies.
8) Thanks for reading πŸ™

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More from @ejustin46

Emmanuel Profile picture
Sep 13
THERE IS NO IMMUNITY DEBT !
When the results of a study show the opposite of what they speculate !

link.springer.com/article/10.100…
Image
2) In this study, they briefly mention the concept of an "immunity deficit/debt" in relation to the observed changes in RSV infections during the pandemic.
But after re-reviewing the key results presented in the study the findings seem to contradict the speculation about ... Image
3) ...an "immunity debt" or deficit leading to increased RSV severity.
The main results show:
- Shorter hospital stays during the pandemic period compared to pre-pandemic
- Consistent ICU admission rates, with shorter ICU stays during the pandemic. Image
Read 4 tweets
Emmanuel Profile picture
Sep 13
MASKS PROTECT !
A COVID-19 SUPERSPREADING EVENT at a choir rehearsal in Finland. It found that AIRBORNE TRANSMISSION of the virus likely caused the MASS INFECTION, as the singers were quickly exposed to infectious levels of viral aerosols in the room.
journals.plos.org/plosone/articl…
Image
2) This study looked at a COVID-19 outbreak that happened during a choir rehearsal in Finland. It found that the virus likely spread through the air, as the simulations showed the viral particles quickly filling the room and exposing all the singers. Image
3) Using high-quality respirators could have stopped many from getting infected, while regular masks were not enough to protect people during the long rehearsal.
The key takeaways are that airborne transmission is a major risk in indoor settings, and ... Image
Read 4 tweets
Emmanuel Profile picture
Sep 12
SARS-CoV-2 ENVELOPE PROTEIN DISRUPT the CALCIUM TRANSPORT SYSTEM

The envelope protein is a key protein (and the one I studied the most).
By causing calcium imbalances, it can disrupt neurological, cardiovascular, metabolic, immune, and ...
nature.com/articles/s4159…
Image
2) ...musculoskeletal functions, leading to diseases like Alzheimer's, heart failure, diabetes, and osteoporosis.

This study found that the E protein can interact with and disrupt the SERCA calcium transport system, which is important for regulating cellular calcium levels. Image
3) The E protein was shown to associate with SERCA and regulatory proteins like phospholamban in the cell's endoplasmic reticulum. Computer simulations suggested the E protein binds to the same sites on SERCA as the regulatory proteins, potentially interfering with ... Image
Read 6 tweets
Emmanuel Profile picture
Sep 12
EVOLUTION of SARS-COV-2 :
STOCHASTIC processes or IMMUNE evasion ?
(3rd part)

"Puzzles, challenges, and information reservoir of SARS-CoV-2 quasispecies"
journals.asm.org/doi/10.1128/jv…
Image
2) The study suggests that the mutations in SARS-CoV-2 mutant spectra arise through a stochastic process, rather than being primarily driven by immune pressure.
3) A few key points from the text:
- The text states that "Random events with biological consequences abound at all stages of the infectious cycle of viruses." This indicates that the mutations arise stochastically, rather than being directed by ...
Read 8 tweets
Emmanuel Profile picture
Sep 12
EVOLUTION of SARS-COV-2 :
STOCHASTIC processes or IMMUNE evasion ?
(2nd part)

Before delving deeper into the stochastic evolution of the virus, a study to highlight the role of immune evasion in the variants evolutionary process. Image
2) "Evolution of new variants of SARS-COV-2 during the pandemic: mutation limited or selection limited?"


The paper examines how new variants of SARS-CoV-2 emerged during the COVID-19 pandemic. biorxiv.org/content/10.110…
Image
3) It looks at whether the rise of new variants was limited by the ability to mutate (mutation-limited) or by the conditions that allow them to spread (selection-limited).

The analysis shows the rise of new variants was selection-limited, not mutation-limited. Image
Read 6 tweets
Emmanuel Profile picture
Sep 11
How does our BODY MANAGE CO-INFECTIONS with SARS-COV-2 and SEASONAL CORONAVIRUSES or RHINOVIRUS ?

A very interesting study πŸ’―πŸ‘
medrxiv.org/content/10.110…
Image
2) The study found that 11% of SARS-CoV-2 positive participants had a co-infection, primarily with rhinovirus, seasonal coronaviruses, or adenovirus. Image
3) This co-infection rate was higher than previous estimates, likely due to the high circulation of respiratory viruses during the study period.

While SARS-CoV-2 co-infections with common cold viruses like rhinovirus and seasonal coronaviruses were quite common ... Image
Read 7 tweets

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