Crémieux Profile picture
Sep 16, 2024 14 tweets 4 min read Read on X
I have a pretty major update for one of my articles.

It has to do with Justice Jackson's comment that when Black newborns are delivered by Black doctors, they're much more likely to survive, justifying racially discriminatory admissions.

We now know she was wrong🧵 Image
So if you don't recall, here's how Justice Jackson described the original study's findings.

She was wrong to describe it this way, because she mixed up percentage points with percentages, and she's referring to the uncontrolled rather than the fully-controlled effect. Image
After I saw her mention this, I looked into the study and found that its results all seemed to have p-values between 0.10 and 0.01.

Or in other words, the study was p-hacked. Image
If you look across all of the paper's models, you see that all the results are borderline significant at best, and usually just-nonsignificant, which is a sign of methodological tomfoolery and results that are likely fragile.

With all that said, I recommended ignoring the paper. Image
Today, a reanalysis has come out, and it doesn't tell us why the coefficients are all at best marginally significant, but instead, why they're all in the same direction.

The reason has to do with baby birthweights.
So, first thing:

(A) At very low birthweights, babies have higher mortality rates, and they're similar across baby races;

(B) At very low birthweights, babies have higher mortality rates, and they're similar across physician races. Image
Second thing: Black infants tend to have lower birthweights.

MIxed infants tend to birthweights in-between Blacks and Whites, and there's a mother effect, such that Black mothers have smaller mixed babies than White mothers (selection is still possible)

Third thing:

(A) Black babies with high birthweights disproportionately go to Black doctors;

(B) The Black babies sent to White doctors disproportionately have very low birthweights. Image
If you control for birthweight when running the original authors' models, two things happen.

For one, they fit a lot better.

For two, the apparently beneficial effect of patient-doctor racial concordance for Black babies disappears:Image
At this point, we have to ask ourselves why the original study didn't control for birthweight. One sentence in the original paper suggests the authors knew it was a potential issue, but they still failed to control for it.Image
PNAS also played an important role in keeping the public misinformed because they didn't mandate that the paper include its specification, so no one could see if birthweight was controlled. If we had known the full model details, surely someone would have called this out earlier.
Ultimately, we have ourselves yet another case of PNAS publishing highly popular rubbish and it taking far too long to get it corrected.

Let me preregister something else:

The original paper will continue to be cited more than the correction with the birthweight control.
The public will continue to be misled by the original, bad result. PNAS should probably retract it for the good of the public, but if I had to bet, they won't.

So people like Justice Jackson will continue to cite it to support their case for racial discrimination.
They'll continue doing that even though they're wrong.

To learn more and to find the article linked, check out my post on this: cremieux.xyz/p/missing-fixe…

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More from @cremieuxrecueil

Nov 20
Why?

I doubt the answer is weight loss. Consider 2 other drugs for diabetes: DPP-4 and SGLT-2 inhibitors

GLP-1RAs are associated with less Alzheimer's vs. DPP-4is:

But not SGLT-2is:

Neither generates much weight loss, but SGLT-2is match GLP-1RAs on glycemic benefitsImage
Image
So, at least in this propensity score- or age-matched data, there's no reason to chalk the benefit up to the weight loss effects.

This is a hint though, not definitive. Another hint is that benefits were observed in short trials, meaning likely before significant weight loss.
We can be doubly certain about that last hint because diabetics tend to lose less weight than non-diabetics, and all of the observed benefit has so far been observed in diabetic cohorts, not non-diabetic ones (though those directionally show benefits).

Anyway, trials needed!
Read 4 tweets
Nov 18
Diets that restrict carbohydrate consumption lead to improved blood sugar and insulin levels, as well as reduced insulin resistance.

Additionally, they're good or neutral for the liver and kidneys, and they don't affect the metabolic rate. Image
Carbohydrate isn't the only thing that affects glycemic parameters.

So does fat!

So, for example, if you replace 5% of dietary calories from saturated fat with PUFA, that somewhat improves fasting glucose levels (shown), and directionally improves fasting insulin: Image
Dietary composition may not be useful for improving the rate of weight loss ceteris paribus, but it can definitely make it easier given what else it changes.

Those non-metabolism details may be why so many people find low-carb diets so easy!

Read 4 tweets
Nov 18
Property taxes should, in theory, make it so buying a home is more affordable and young people will have increased access to home ownership.

Let's look through the literature to see what really happens🧵

Firstly, higher property taxes get older people to move. Image
Higher property taxes act as leverage since they're capitalized into house prices.

This reduces the number of people who own multiple homes, increases general ownership, and increases young ownership even more. Image
Property tax exemptions are popular because the old feel like they shouldn't have to pay anything to live in their homes.

Exemptions shift homeownership to older ages and make America less mobile because people live in their homes for longer. Image
Read 11 tweets
Nov 18
There's a popular belief that family wealth is gone in three generations.

The first earns it, the second stewards it, and the third spends it away: from shirtsleeves to shirtsleeves in three generations!

But how true is this belief?

Gregory Clark has new evidence🧵 Image
The first thing to note is that family wealth is correlated across many generations. For example, in medieval England, this is how wealth at death correlates across six generations.

It correlates substantially enough to persist for twelve generations at observed rates of decay: Image
But why?

The dominant theory among laypeople is social: that the wealth is directly transmitted.

This is testable, and the Malthusian era provides us with lots of data for testing. Image
Read 19 tweets
Nov 18
The Catholic Church helped to modernize the West due to its ban on cousin marriage and its disdain for adoption, but also by way of its opposition to polygyny.

The origin of this disdain arguably lies with Church Fathers like Justin Martyr, Irenaeus, and Tertullian🧵 Image
Justin Martyr, in his Dialogue with Trypho argues with a Jew that Christians are the ones living in continuity with God's true intentions.

Justin sees Genesis 2 ("the two shall become one flesh") as normative.

In his apologetic world, Christians are supposed to transcend lust.Image
Irenaeus, in Against Heresies, is attacking Gnostics (Basilides, Carpocrates), whose sexual practices he finds scandalous.

To him, "temperance dwells, self-restraint is practiced, monogamy is observed"—polygyny is a doctrinal and moral deviation from creation affirmation.Image
Read 16 tweets
Nov 17
The effects of charter schools on student test scores are meta-analytically estimated to be small.

In this study, the largest estimated effect was estimated to be equivalent to ~1.35 IQ points, for mathematics scores, which consistently showed larger effects than reading scores. Image
Similarly, the estimated effect of parents' preferred schools and of elite public secondary schools on test scores is around zero. Image
More interestingly, it seems charter school openings lead to competition that marginally boosts non-charter student performance and reduces absenteeism by very small degrees:
Read 12 tweets

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