Ziyad Al-Aly, MD Profile picture
Sep 23 11 tweets 6 min read Read on X
Here are key slides of my talk at the NIH-RECOVER-TLC
#RECOVERTLC
nature.com/articles/s4159…
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The number of people with Long Covid is huge. This demands global attention. nature.com/articles/s4159…
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The economic toll of Long Covid is significant.

nature.com/articles/s4159…
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Multiple mechanisms at play
science.org/doi/10.1126/sc…
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The impacts of Long Covid.
nature.com/articles/s4159…
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Number of approved medications for Long Covid is zero. This MUST change.

nature.com/articles/s4159…
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A policy roadmap.

nature.com/articles/s4159…
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Research roadmap
nature.com/articles/s4159…
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Input from the community


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RECOVER-TLC must succeed.
I end with a quote from @loscharlos "the stakes for RECOVER couldn't be higher"
nature.com/articles/s4159…
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More from @zalaly

Sep 10
Here is the first randomized trial to show that an antiviral can prevent Long Covid.

In the PANORAMIC trial, people randomized to molnupiravir had less risk of Long Covid than people who received no antivirals

My comment in the link below. A short🧵
thelancet.com/journals/lanin…
The study included people with at least one risk factor for progression to severe COVID-19 illness.

People randomized to molnupiravir or usual care (no antivirals) were followed for 6 months

thelancet.com/journals/lanin…
People who were randomly assigned to molnupiravir during the acute phase of COVID-19 had better outcomes at 3 months and 6 months than those randomly assigned to usual care

thelancet.com/journals/lanin…
Read 9 tweets
Sep 1
400 million reasons to care about #LongCovid

ICYMI: our review on #LongCovid in @NatureMedicine

Long Covid has affected at least 400 million people worldwide at a cost of $1 trillion per year.

#LongCovid is a defining health crisis of our time!

nature.com/articles/s4159…Image
We review the mechanisms of Long Covid including viral persistence, immune dysfunction, thrombo-inflammation, neuronal inflammation, and microbiome dysbiosis.
nature.com/articles/s4159…
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We review the devastating impacts of Long Covid on individuals and communities, health systems, economies, and global health metrics.

nature.com/articles/s4159…
Read 6 tweets
Aug 26
🧵1/ A Significant surge in the number of people with a disability in the U.S.

The @stlouisfed just released an analysis using data from the Current Population Survey (CPS), revealing some concerning trends. Here’s what they found:

#Disability #DisabilityJustice #LongCovid Image
2/ Above Trend Increase in Disability
Since 2019, the number of disabled individuals has surged beyond the expected trend by nearly 2 million. This isn't just a statistical anomaly—it's a huge indicator of a deeper, underlying health crisis.Image
3/ Cognitive Disabilities Skyrocket
Most alarming is the rise in cognitive disabilities. The population reporting only a cognitive disability has grown by nearly 1 million—a 43% increase since 2019.
Read 8 tweets
Aug 22
ICYMI #LongCovid is a defining crisis of our time

Long Covid affects at least 400 million people globally with an economic cost of $1 trillion/yr

Addressing Long Covid requires a coordinated—but so far absent—response strategy

Our review @NatureMedicine
nature.com/articles/s4159…
ロングコビッドは、私たちの時代を決定づける危機です。

ロングコビッドは、世界中で少なくとも 4 億人に影響を与え、年間 1 兆ドルの経済的損失を招いています。

@NatureMedicine での私たちのレビュー

nature.com/articles/s4159…
La COVID prolongada es una crisis que define nuestro tiempo.

La COVID prolongada afecta al menos a 400 millones de personas en todo el mundo y tiene un coste económico de un billón de dólares al año.

Nuestra reseña en @NatureMedicine
nature.com/articles/s4159…
Read 6 tweets
Aug 9
📢Our review "Long COVID science, research and policy" is out in @NatureMedicine

By @zalaly @ahandvanish @LisaAMcCorkell @leticiasaurus @swulfie @VirusesImmunity @EricTopol

A thread
nature.com/articles/s4159…
In this review, we provide (1) a synthesis of the state of science on Long COVID; (2) assess the impacts of Long COVID on individuals, health systems, the economy & global health metrics; and (3) provide a forward-looking research & policy roadmaps nature.com/articles/s4159…
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We begin with a timeline of the history of #LongCovid. We recognize the prescience of the #MECFS community that warned us about what’s to come, the op-ed by @fi_lowenstein in @NYTimes, the first mainstream media piece by @edyong209 in @TheAtlantic & more
nature.com/articles/s4159…
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Read 19 tweets
Aug 2
My Statement on the introduction of the Long COVID Research Moonshot Act #LongCovidMoonshot

I fully support this bill and urge the U.S. Congress and our community to support it.

Short thread: Image
Today U.S. Senator Bernie Sanders @SenSanders formally introduced the Long COVID Research Moonshot Act. This marks a historic moment, the culmination of relentless effort and dedication from countless individuals. #LongCovidMoonshot
The bill calls for the establishment of a Long Covid program at NIH with research funding of $1 billion per year for 10 years, and additional funding to other federal agencies for clinician education, public awareness, and more. #LongCovidMoonshot
Read 9 tweets

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