Vipin M. Vashishtha Profile picture
Sep 26, 2024 8 tweets 3 min read Read on X
A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is >99.9% effective & contains no drugs 1/ Image
The FDA approved substance in the spray is known as the Pathogen Capture and Neutralizing Spray (PCANS), & contains no drugs of any kind.
Instead, the spray forms a gel that lines the inside of the nose. 2/ Image
While this gel doesn't affect the user's breathing, it does trap any viruses or bacteria that are subsequently inhaled into the nose, immobilizing them until they die. 3/ Image
In lab tests, the spray protected mice from a mouse-adapted form of the H1N1 influenza virus, even when that virus was administered at 25 times the lethal dose. 4/ Image
What's more, virus levels in the animals' lungs were reduced by over 99.99% as compared to an untreated control group of mice. The spray was retained in the rodents' noses for up to eight hours, and was effective at blocking infection for at least four hours. 5/
Although PCANS has yet to be tested on humans, it has been used in a 3D-printed model of a human nose, where it captured twice as many microbe-containing droplets as mucus alone. 6/ Image
It blocked and neutralized almost 100% of all viruses and bacteria we tested, including influenza, SARS-CoV-2, RSV, adenovirus, K Pneumonia and more. 7/
And if you suffer from allergies, take note – the researchers believe the spray could one day also be used on a daily basis to trap and neutralize allergens. 8/8

onlinelibrary.wiley.com/doi/10.1002/ad…

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More from @vipintukur

Jan 3
Rogue antibodies might cause #LongCOVID!

When antibodies from people w/ longCOVID were injected into healthy mice, the animals appeared to experience pain & fatigue — two of the hallmarks of long COVID. 1/ Image
The finding — now from two studies — suggests that the antibodies are the cause of the long COVID symptoms.

Antibodies isolated from people with long COVID increase pain sensitivity and reduce movement in mice when transferred to the animals, research shows. 2/ Image
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The findings suggest that antibodies might drive some symptoms of longCOVID — although how that process works is unclear, and the results will need to be replicated in larger studies. 3/ Image
Read 4 tweets
Jan 2
Wow!

Pupil size in sleep reveals how memories are processed!

Researchers have found that the pupil is key to understanding how, and when, the brain forms strong, long-lasting memories. 1/ Image
By studying mice equipped w/ brain electrodes & tiny eye-tracking cameras, researchers find that new memories are being replayed & consolidated when pupil is contracted during a substage of non-REM sleep. When the pupil is dilated, the process repeats for older memories. 2/ Image
The brain's ability to separate these two substages of sleep with a previously unknown micro-structure is what prevents "catastrophic forgetting" in which the consolidation of one memory wipes out another one. 3/ Image
Read 11 tweets
Dec 29, 2024
Impact of COVID-19 on accelerating of immunosenescence & brain aging

The pandemic has highlighted a complex interplay between viral infection, immune aging & brain health, that can potentially accelerate neuroimmune aging & contribute to persistence of long COVID condition 1/ Image
By inducing chronic inflammation, immunosenescence, and neuroinflammation, COVID-19 may exacerbate the processes of neuroimmune aging, leading to increased risks of cognitive decline, neurodegenerative diseases, and impaired immune function. 2/ Image
Both aging & COVID-19 can induce neuroinflammation through the accumulation of senescent cells, persistent microglia and astrocytes’ activation, and increased pro-inflammatory cytokine production, such as IL-1β, IL-6, and TNF-α. 3/ Image
Read 6 tweets
Dec 27, 2024
COVID pregnancies may have boosted autism risk!

A NEW study shows the onset of autism in COVID exposed babies at 28 months. Researchers found 23 of 211 children (11%), screened positive for autism spectrum disorder, compared with an expected prevalence of 1-2% at that age 1/ Image
When researchers analyzed videos of children lying on their backs in what’s called General Movement Assessment, 14% of infants showed signs of developmental problems. The test evaluates early motor functions & is often used to assess the risk of neurodevelopmental disorders 2/ Image
Later, the findings proved equally troubling. At 6-8 months old, 13 of 109 infants born to infected mothers — almost 12% — had failed to reach developmental milestones. In stark contrast, all infants in a control group born before the pandemic showed normal development. 3/
Read 10 tweets
Dec 27, 2024
Researchers have identified interleukin-23 receptor (IL-23R) as a significant biomarker of cellular senescence and aging. Experiments show that IL-23R levels in the bloodstream increase with age and can decrease, reflecting senescent cell clearing, with senolytic therapies. 1/ Image
Cellular senescence occurs when cells stop dividing but do not trigger apoptosis mechanisms that would allow them to die naturally. 2/ Image
Instead, they are stuck in a zombie-like state, where they still have the urge to feed and carry out metabolic activities, but with increasingly incoherent cell signaling and increased pro-inflammatory cytokine secretions. 3/ Image
Read 12 tweets
Dec 26, 2024
Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses!

A novel vaccine platform that improved protection against diverse influenza subtypes when tested in animal models and human organoids. 1/ Image
The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined.

However, most individuals exhibit a more robust response to one of these strains and thus are vulnerable to infection by others. 2/ Image
By studying a monozygotic twin cohort, the researchers found that although prior exposure was a factor, host genetics were a stronger driver of subtype bias to influenza viral strains. 3/ Image
Read 5 tweets

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