Vipin M. Vashishtha Profile picture
Sep 26 8 tweets 3 min read Read on X
A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is >99.9% effective & contains no drugs 1/ Image
The FDA approved substance in the spray is known as the Pathogen Capture and Neutralizing Spray (PCANS), & contains no drugs of any kind.
Instead, the spray forms a gel that lines the inside of the nose. 2/ Image
While this gel doesn't affect the user's breathing, it does trap any viruses or bacteria that are subsequently inhaled into the nose, immobilizing them until they die. 3/ Image
In lab tests, the spray protected mice from a mouse-adapted form of the H1N1 influenza virus, even when that virus was administered at 25 times the lethal dose. 4/ Image
What's more, virus levels in the animals' lungs were reduced by over 99.99% as compared to an untreated control group of mice. The spray was retained in the rodents' noses for up to eight hours, and was effective at blocking infection for at least four hours. 5/
Although PCANS has yet to be tested on humans, it has been used in a 3D-printed model of a human nose, where it captured twice as many microbe-containing droplets as mucus alone. 6/ Image
It blocked and neutralized almost 100% of all viruses and bacteria we tested, including influenza, SARS-CoV-2, RSV, adenovirus, K Pneumonia and more. 7/
And if you suffer from allergies, take note – the researchers believe the spray could one day also be used on a daily basis to trap and neutralize allergens. 8/8

onlinelibrary.wiley.com/doi/10.1002/ad…

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More from @vipintukur

Oct 4
A new analysis from Imperial's human challenge study of COVID-19 has revealed subtle differences in the memory and cognition scores of healthy volunteers infected with SARS-CoV-2, which lasted up to a year after infection. 1/ Image
The findings show a small but measurable difference following highly intensive cognitive testing of 18 healthy young people with infection compared to those who did not become infected, monitored under controlled clinical conditions. 2/ Image
We know COVID can have lasting impacts on our memory & ability to carry out common cognitive tasks. However, much of scientific evidence we have comes from large studies based on self-testing & reporting, or where there's a range of variables that could affect these effects 3/ Image
Read 15 tweets
Oct 3
We have long known that children who become seriously ill with certain respiratory viruses such as respiratory syncytial virus (RSV) are at elevated risk of developing asthma later in life. What we haven't known is why. 1/ Image
🔥 A NEW study may have solved the mystery. It shows respiratory viruses can hide out in immune cells in the lungs long after the initial symptoms of an infection have resolved, creating a persistently inflammatory environment that promotes development of lung disease. 2/ Image
Further, they showed that eliminating the infected cells (Dendritic cells and Macrophages) reduces signs of chronic lung damage before they progress to a full-blown chronic respiratory illness. 3/ Image
Read 21 tweets
Oct 2
A peptide synthesized by researchers in Brazil protected human lung cells against infection by SARS-CoV-2 in the laboratory and eliminated the inflammation caused by the virus in mice susceptible to COVID-19. 1/ Image
Development of the peptide was inspired by the protein ACE2, the human cell’s natural receptor for SARS-CoV-2.

The results point to a possible route to the creation of antiviral blocker drugs that are more effective against the disease. 2/ Image
SARS-CoV-2 invades host cells by binding to the ACE receptor on their surface via its spike protein (S). The infection process is like a key fitting into a lock. 3/ Image
Read 12 tweets
Oct 1
Researchers evaluated the brain changes in structure and function that were observed in 53 #LongCovid participants who had cognitive complaints almost 2 years after they were infected with SARS-CoV-2. 1/ Image
The study revealed that the participants experienced a wide range of physical and cognitive symptoms, with weakness, discomfort, and fatigue being the most prevalent. 2/ Image
Researchers observed that increased radial diffusivity in different white matter tracts was negatively correlated with the memory domain.

The higher resting state activity in the fronto-parietal network was associated with lower memory performance. 3/ Image
Read 7 tweets
Sep 30
The molecular origins of neuro-COVID, and how it contributes to #LongCovid (PASC) are unknown, however a growing body of research highlights that the self-assembly of protein fragments from SARS-CoV-2 into amyloid nanofibrils may play a causative role. 1/ Image
Earlier, researchers identified two fragments from the SARS-CoV-2 proteins, ORF 6 & ORF10, that self-assemble into neurotoxic amyloid assemblies.

Here they show the self-assembly mechanisms & nano-architectures formed by these fragments and their biological responses. 2/ Image
By solubilising the peptides in a fluorinated solvent, they eliminated insoluble aggregates in the starting materials (seeds) that change the polymorphic landscape of the assemblies. 3/
Read 6 tweets
Sep 28
Covid-19 mRNA vaccines fail to generate long-lived plasma cells (LLPCs) in the bone marrow ( BM). This phenomenon may be responsible for the faster waning of immunity against SARS-CoV-2 virus following mRNA vaccines 1/ Image
The ‘holy grail of Vaccinology’ is the generation of long-lived plasma cells (LLPCs). A new study demonstrates the exclusion of SARS-CoV-2 specificity in the BM LLPCs and the need to improve durability of the mRNA vaccines. 2/

nature.com/articles/s4159…

Image
Researchers enrolled 19 healthy adults at 2.5–33 months after receipt of a SARS-CoV-2 mRNA vaccine & measured influenza-, tetanus- or SARS-CoV-2-specific antibody-secreting cells (ASCs) in long-lived plasma cell (LLPC) and non-LLPC subsets within the bone marrow (BM) 3/ Image
Read 9 tweets

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