Vipin M. Vashishtha Profile picture
Sep 26, 2024 8 tweets 3 min read Read on X
A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is >99.9% effective & contains no drugs 1/ Image
The FDA approved substance in the spray is known as the Pathogen Capture and Neutralizing Spray (PCANS), & contains no drugs of any kind.
Instead, the spray forms a gel that lines the inside of the nose. 2/ Image
While this gel doesn't affect the user's breathing, it does trap any viruses or bacteria that are subsequently inhaled into the nose, immobilizing them until they die. 3/ Image
In lab tests, the spray protected mice from a mouse-adapted form of the H1N1 influenza virus, even when that virus was administered at 25 times the lethal dose. 4/ Image
What's more, virus levels in the animals' lungs were reduced by over 99.99% as compared to an untreated control group of mice. The spray was retained in the rodents' noses for up to eight hours, and was effective at blocking infection for at least four hours. 5/
Although PCANS has yet to be tested on humans, it has been used in a 3D-printed model of a human nose, where it captured twice as many microbe-containing droplets as mucus alone. 6/ Image
It blocked and neutralized almost 100% of all viruses and bacteria we tested, including influenza, SARS-CoV-2, RSV, adenovirus, K Pneumonia and more. 7/
And if you suffer from allergies, take note – the researchers believe the spray could one day also be used on a daily basis to trap and neutralize allergens. 8/8

onlinelibrary.wiley.com/doi/10.1002/ad…

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More from @vipintukur

Feb 24
Oral Cavity Serves as Long-Term COVID-19 Reservoir with Increased Periodontal and Viral Disease Risk:

-COVID-19 history significantly correlates with severe oral health complications while vaccination reduced but did not eliminate these issues. 1/ Image
A NEW study identified oral associated #LonhCovid primarily manifested as periodontal (gum) disease (COVID +ve: 73.1±18.9% vs COVID -ve: 33.1±14.3%)
Covid19 positive cases correlated w/ higher rates of dry mouth (57.5%), taste disturbance (47%) & smell loss (20%). 2/ Image
Vaccination reduced oral LongCovid (PASC) in COVID-19 positive subjects; however, periodontal disease indicators persisted compared to the COVID-19 negative group. 3/ Image
Read 6 tweets
Feb 24
SARS-CoV-2 triggers the production of the antiviral protein IFN-γ, which is associated with fatigue, muscle ache & depression. Recent study shows that in #LongCOVID, IFN-y production persists until symptoms improve, highlighting a potential biomarker & a target for therapies 1/ Image
The study shows that initial infection with SARS-CoV-2 triggers production of the antiviral protein IFN-γ, which is a normal reaction from the immune system. 2/ Image
For most people, when their infection clears, COVID-19 symptoms cease and production of this protein stops, but the researchers found that high levels of IFN-γpersisted in some Long COVID patients for up to 31 months. 3/ Image
Read 10 tweets
Feb 21
A ray of hope for millions of Down syndrome patients!

Gene editing may eventually allow #Trisomy21 to be treated at the cellular level.

Researchers used the CRISPR-Cas9 gene editing system to cleave the 3rd chromosome in previously generated trisomy 21 cell lines 1/ Image
Down syndrome is caused by the presence of a third copy of the 21st chromosome. The condition occurs in approximately 1 in 700 live births and is relatively easy to diagnose at early stages of development. However, there are no treatments. 2/ Image
The researchers used the CRISPR-Cas9 gene editing system to cleave the third chromosome in previously generated trisomy 21 cell linesderived from both pluripotent cells and skin fibroblasts. 3/ Image
Read 7 tweets
Feb 15
According to a NEW study, maternal #Acetaminophen (Paracetamol) exposure during pregnancy may alter placental gene expression leading to a higher likelihood of childhood attention deficit hyperactivity disorder (ADHD) 1/ Image
Researchers analyzed plasma biomarkers of acetaminophen (APAP) exposure in a cohort of 307 African American mother-child pairs. Detection of APAP in second-trimester maternal blood samples correlated with increased odds of ADHD diagnosis in children by age 8–10. 2/
Acetaminophen (also called paracetamol) is widely used during pregnancy, with an estimated 41–70% of pregnant individuals in the United States, Europe, and Asia reporting its use. 3/ Image
Read 11 tweets
Feb 13
An exciting new oral antiviral for SARS-CoV-2!

A NEW study presents the systematic design of quinoline-containing SARS-CoV-2 papain-like protease (#PLpro) inhibitors as potential oral antiviral drug candidates to treat Covid-19 patients 1/ Image
SARS-CoV-2 main protease (Mpro) inhibitor nirmatrelvir has broad-spectrum antiviral activity against SARS-CoV, MERS-CoV, SARS-CoV-2, and common human coronaviruses HCoV-OC43, 229E, NL63, and HKU1. 2/ Image
Several additional Mpro inhibitors are at different stages of clinical trials, including Pfizer’s second-generation inhibitor PF-07817883 (Ibuzatrelvir) and Merck’s MK-7845 3/
Read 12 tweets
Feb 12
A recent study provides direct evidence for the role of the vagus nerve in gut microbiome-brain communication, addressing a critical gap in the field.
The research demonstrates a clear causal relationship between gut microbiota and vagal nerve activity. 1/ Image
While the vagus nerve has long been thought to facilitate communication between the gut microbiome—the community of microorganisms living in the intestines—and the brain, direct evidence for this process has been limited. 2/ Image
Researchers observed that mice raised without any gut bacteria, known as germ-free mice, exhibited significantly lower activity in their vagus nerve compared to mice with a normal gut microbiome. 3/ Image
Read 10 tweets

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