A NEW nasal spray that trap & neutralize not only SARS-CoV-2, Influenza, RSV, Adeno & many other viruses & bacteria that are inhaled into the nose, immobilizing them until they die. The substance is >99.9% effective & contains no drugs 1/
The FDA approved substance in the spray is known as the Pathogen Capture and Neutralizing Spray (PCANS), & contains no drugs of any kind.
Instead, the spray forms a gel that lines the inside of the nose. 2/
While this gel doesn't affect the user's breathing, it does trap any viruses or bacteria that are subsequently inhaled into the nose, immobilizing them until they die. 3/
In lab tests, the spray protected mice from a mouse-adapted form of the H1N1 influenza virus, even when that virus was administered at 25 times the lethal dose. 4/
What's more, virus levels in the animals' lungs were reduced by over 99.99% as compared to an untreated control group of mice. The spray was retained in the rodents' noses for up to eight hours, and was effective at blocking infection for at least four hours. 5/
Although PCANS has yet to be tested on humans, it has been used in a 3D-printed model of a human nose, where it captured twice as many microbe-containing droplets as mucus alone. 6/
It blocked and neutralized almost 100% of all viruses and bacteria we tested, including influenza, SARS-CoV-2, RSV, adenovirus, K Pneumonia and more. 7/
And if you suffer from allergies, take note – the researchers believe the spray could one day also be used on a daily basis to trap and neutralize allergens. 8/8
COVID-19 is not a condition simply of the lung. Often, those who are most severely affected are the ones who have brain complications.
Hospitalisation with COVID-19 can lead to measurable cognitive deficits that can be identified even 12–18 months after hospitalization 1/
A large study shows that 12–18 months after hospitalization due to COVID-19, patients have worse cognitive function than matched control participants. 2/
Importantly, these findings correlate with reduced brain volume in key areas on MRI scans as well as evidence of abnormally high levels of brain injury proteins in the blood. 3/
Previous studies have shown that SARS-CoV-2 infection can induce neurovirulence through microglial activation in the brains of patients and experimentally inoculated animals, which are models representative for moderate to severe respiratory disease. 1/
Researchers in a NEW study investigated the neuroinvasive and neurovirulent potential of SARS-CoV-2 in intranasally inoculated ferrets, a model for subclinical to mild respiratory disease. 2/
Results: Viral RNA was detected in various respiratory tissue samples by qPCR at 7 days post inoculation (dpi). Virus antigen was detected in the nasal turbinates of ferrets sacrificed at 7 days post inoculation and was associated with inflammation. 3/
What triggers neuroinflammation?
Why is our brain so prone to inflammation?
🔥 A recent pathbreaking study explains the molecular mechanisms that trigger neuroinflammation. It shows exactly why neuroinflammation & neurodegeneration are so common. 1/
But before we delve into this new discovery, let’s glance over a new study linking SARS-CoV-2 & later development of neurodegenerative brain disorders by inducing amyloid aggregation of proteins in human CSF & result in soluble protein depletion. 2/
Now coming back to this extraordinary research. We know that all living cells teem with RNA that relay genetic messages to keep cells functioning. But these necessary molecules can also set off cellular alarms. 3/
Conventionally, we believe it helps in clearing the infection & the invading pathogen faster by stepping up the cytokines production by the immune cells. So, it helps our body fighting against infection. 1/
But wait, a NEW research suggests this may not be always true. In some instances, fever—in a particular subset of T cells—cause mitochondrial stress, DNA damage & cell death. So, the fever may favour mutagenesis in some cells!! 2/
The findings offer a mechanistic understanding of how cells respond to heat and could explain how chronic inflammation contributes to the development of cancer. 3/
40 million deaths by 2050: toll of drug-resistant infections to rise by 70%
➡️ More than 39 million people could die from antibiotic-resistant infections between now and 2050, according to a report based on mortality data and hospital records from 204 countries. 1/
Researchers analysed mortality data and hospital records from 204 countries between 1990 and 2021, focusing on 22 pathogens, 84 combinations of bacteria and drugs they are resistant to and 11 diseases, including blood infections and meningitis. 2/
Deaths from infections by Staphylococcus aureus saw the biggest rise, increasing by 90.29%.
Deaths linked to Carbapenem-resistant gram-negative bacteria have risen by 149.51%, from 50,900 cases in 1990 to 127,000 cases in 2021. 3/
A new international study provides a shortlist of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. 1/
Researchers analyze environmental qPCR and sequencing data collected in the Huanan market in early 2020. They demonstrate that market-linked SARS-CoV-2 genetic diversity is consistent with market emergence 2/
They find increased SARS-CoV-2 positivity near & within a wildlife stall. They identify wildlife DNA in all SARS-CoV-2-positive samples from this stall, including species such as civets, bamboo rats, & raccoon dogs, previously identified as possible intermediate hosts. 3/