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Emmanuel Profile picture
@ejustin46
Sep 26, 2024 • 6 tweets • 3 min read • Read on X
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ALTERATIONS in the PLASMA PROTEOME (proteins in the blood) PERSIST TEN MONTHS after RECOVERY from MILD to MODERATE SARS-CoV-2 INFECTION !

frontiersin.org/journals/immun…
Image
2) This study examined how the plasma proteome (proteins in the blood) changes in vaccinated and unvaccinated SARS-CoV-2 patients over 10 months.

During acute infection, unvaccinated patients showed strong inflammatory and immune responses while ... Image
3) ...vaccinated patients had adaptive immune responses with less inflammation.

Even months later, unvaccinated patients still had some ongoing inflammation and immune activation, while both groups had reduced levels of proteins involved in normal cell functions and signaling. Image
4) The researchers also found that factors beyond just vaccination, like age and disease severity, influenced the protein patterns in patients' blood. Image
5) They identified specific proteins linked to persistent symptoms and lung abnormalities months after infection which could be useful for understanding long-term effects of COVID-19. Image
6) Overall, the results show vaccination helps reduce the acute inflammatory response, but changes in the blood proteome can persist in both vaccinated and unvaccinated individuals, with potential implications for long-term health.

Thanks for reading 🙏 Image

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More from @ejustin46

Emmanuel Profile picture
Aug 5
COVID-19 and/or SARS-CoV-2
(opinion)

Patients care most about how COVID-19 affects their health and daily life, including for those with long COVID. Scientists focus on understanding the virus to find better treatments. Both views are important for dealing with the pandemic. Image
2) I'm bringing up this topic because, after talking so much about the disease, its long-term effects, treatments, and vaccines, many people have forgotten that we are dealing with the most dangerous virus humanity has ever faced.
3) What inspired me is this article about chaos theory and quantum mechanics and how it can help us to better understand SARS-CoV-2

A new study found a way to link them by showing that gravity may come from the disorder or "entropy" of matter and energy.
interestingengineering.com/science/quantu…
Read 10 tweets
Emmanuel Profile picture
Aug 1
INSIDE OUR INFECTED CELLS.
How SARS-COV-2 stealthy hijacks our cellular sanctuaries (organelles) ?
🤓 Visual explanations

Organelles provide the possibility for the virus to organize its RNA in PROTECTED structures, concentrate REPLICATION machinery ...
nature.com/articles/s4146…Image
2) ...compartmentalize the replication process, and hide from immune detection.

Figure 1g - The large perinuclear clusters of viral RNA demonstrate how the viral RNA is organized into PROTECTED structures. Image
2) Figure 3d- The nanoscale puncta of the viral RNA-dependent RNA polymerase (nsp12) within and around the viral RNA clusters show the concentration of REPLICATION machinery. Image
Read 5 tweets
Emmanuel Profile picture
Jul 30
SARS-CoV-2: The VIRUS That MASTERFULLY "ADAPTS" to SPREAD FURTHER !

If you were SARS-CoV-2, you could choose to spread in two ways: you could release a lot of tiny particles into the air to infect many people, or you could release just a few super infectious particles ... Image
2) ... that are really good at making someone sick.
This study published in Nature shows that some variants of the virus are especially strong, meaning they can infect with fewer particles, making it easier for them to spread quickly!
nature.com/articles/s4429…Image
3) Researchers found that different variants of SARS-CoV-2, like Alpha, Delta, and Omicron, have unique abilities to spread. For instance, the Delta variant was shown to be more infectious, meaning it could spread more easily and required fewer viral particles to cause illness... Image
Read 7 tweets
Emmanuel Profile picture
Jul 29
WHAT is OMICRON'S CLEVER TRICK ?
An explanation for kids 👫
... from a great study of @StuartTurville and colleagues

Omicron is different and spreads faster between people because Omicron attaches to a special protein in our bodies called ACE2 in a different way. Image
2) There are two types of ACE2 proteins - one that helps control blood pressure, and another that helps other proteins.

Previous COVID viruses could attach to both types of ACE2, with the help of another protein called TMPRSS2. Image
3) But Omicron can only attach to the ACE2 proteins that help other proteins, without needing the TMPRSS2 protein.

This allows Omicron to spread more easily in the nose and throat, but not cause as much damage deep in the lungs. Image
Read 4 tweets
Emmanuel Profile picture
Jul 28
CORONAVIRUSES and the BRAIN:
Exploring Hidden Links to Neurological Diseases

Human coronaviruses (HCoVs) include seven types, with MERS-CoV, SARS-CoV-1, and SARS-CoV-2 being the most contagious and causing severe pandemics. Image
2) These viruses mainly affect the respiratory system, causing symptoms like cough, fever, and breathing difficulties.
Recent evidence suggests a link between HCoVs and brain disorders. Image
3) This study looks at how these viruses may be associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It also examines the long-term effects of HCoV infections and on similarities between HCoV proteins and those related to brain diseases. Image
Read 4 tweets
Emmanuel Profile picture
Jul 28
The SARS-CoV-2 PUZZLE :
How Our Microbes Shape the Disease Picture ?

New technology called next-generation sequencing (NGS) shows that many germs can be present at the same time, affecting how diseases show up in people. Image
2) Instead of thinking one disease is caused by one germ, researchers now consider that multiple active germs can be involved, especially in illnesses like COVID-19.
The germs living in our bodies may play a role in how diseases develop. Image
3) This article looks at how these germs interact with viruses like Influenza and SARS-CoV-2. Changes in the types of germs present can affect the immune response and overall severity of the disease. Image
Read 6 tweets

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