Emmanuel Profile picture
Sep 26 6 tweets 3 min read Read on X
ALTERATIONS in the PLASMA PROTEOME (proteins in the blood) PERSIST TEN MONTHS after RECOVERY from MILD to MODERATE SARS-CoV-2 INFECTION !

frontiersin.org/journals/immun…
Image
2) This study examined how the plasma proteome (proteins in the blood) changes in vaccinated and unvaccinated SARS-CoV-2 patients over 10 months.

During acute infection, unvaccinated patients showed strong inflammatory and immune responses while ... Image
3) ...vaccinated patients had adaptive immune responses with less inflammation.

Even months later, unvaccinated patients still had some ongoing inflammation and immune activation, while both groups had reduced levels of proteins involved in normal cell functions and signaling. Image
4) The researchers also found that factors beyond just vaccination, like age and disease severity, influenced the protein patterns in patients' blood. Image
5) They identified specific proteins linked to persistent symptoms and lung abnormalities months after infection which could be useful for understanding long-term effects of COVID-19. Image
6) Overall, the results show vaccination helps reduce the acute inflammatory response, but changes in the blood proteome can persist in both vaccinated and unvaccinated individuals, with potential implications for long-term health.

Thanks for reading 🙏 Image

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More from @ejustin46

Sep 28
If we were to examine OTHER PROTEINS of SARS-CoV-2 BESIDES the SPIKE protein,
we could look into nsp14 and nsp10 for instance 🧐

Replication is the key word !
biorxiv.org/content/10.110…
Image
2) The coronavirus contains a key protein called nsp14 that acts as an exoribonuclease, proofreading the viral genome during replication. Nsp14's activity is boosted by interacting with another protein, nsp10. Image
3) The researchers modified nsp14 in a mouse coronavirus model, making specific changes to the interface where nsp14 binds to nsp10. This impaired the virus's ability to replicate and reduced nsp14's exonuclease activity in lab tests. Image
Read 6 tweets
Sep 28
PULMONARY LONG COVID (PLC) = PERSISTENT INFLAMMATION

"Single cell sequencing reveals cellular landscape alterations in the airway mucosa of patients with pulmonary long COVID"
erj.ersjournals.com/content/early/…
Image
2) This study used advanced genetic analysis techniques to examine the cells lining the airways of patients with long-lasting COVID-19 symptoms, called "pulmonary long COVID" (PLC). Image
3) The key findings were:

- More neutrophils, a type of immune cell, were present in the airways of PLC patients compared to healthy controls. This was confirmed through direct microscopic examination of the airway samples. Image
Read 6 tweets
Sep 28
PROTECT the CHILDREN in SCHOOL !!!

This study is two years old. What have we accomplished since then? Why have we done nothing?
elifesciences.org/articles/75593…
Image
2) The study investigates the impact of different COVID-19 testing strategies on SARS-CoV-2 transmission dynamics in primary schools.

Three strategies are evaluated:
- Symptomatic isolation - Testing and isolating only symptomatic individuals. Image
3)- Reactive screening - Testing an entire class when a symptomatic case is identified.
- Repetitive screening - Regular testing of the entire school population.
To balance control and minimizing disruption, the authors suggest using repetitive testing ... Image
Read 5 tweets
Sep 28
SARS-COV-2 is really UNIQUE !

Its SPIKE protein's unique fluid, widely spaced STRUCTURE, PREVENTS full IMMUNE RECOGNITION, making it DIFFICULT for VACCINES to generate LONG-LASTING ANTIBODIES 😨
(Thanks to @inkblue01)
nature.com/articles/s4159…
Image
2) The unique structure of the SARS-CoV-2 spike protein, which lacks a rigid pattern and is embedded in a fluid membrane, may hinder the immune system's ability to produce durable antibodies.

This study analyzing bone marrow samples from 19 vaccinated adults revealed ... Image
3) ... that SARS-CoV-2-specific antibody-secreting cells (ASCs) are mostly absent from the long-lived plasma cell (LLPC) compartment, unlike robust responses seen with Flu and Tetanus vaccines. Image
Read 4 tweets
Sep 27
CANCER and COVID-19 ! 😨

"Oncogenic potential of SARS-CoV-2—targeting hallmarks of cancer pathways"
biosignaling.biomedcentral.com/articles/10.11…
Image
2) The COVID-19 pandemic may be linked to an increased risk of cancer. The virus appears to interact with and alter various cellular processes that are also involved in the development and progression of cancer. Image
3) Computational studies have shown that SARS-CoV-2 proteins can target and disrupt the normal function of key genes and signaling pathways that are crucial for preventing cancer, such as tumor suppressor genes. This can lead to uncontrolled cell growth and division ... Image
Read 7 tweets

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