Thread by @elisaperego78

A review of 54 cardiac tissue samples showed "SARS-CoV-2 infects cardiomyocytes by the TNF-NF-κB pathway, potentially triggering acute cardiovascular complications and increasing the long-term cardiovascular risk in COVID-19 patients."

#LongCovid

nature.com/articles/s4159…

"SARS-CoV-2 infection induced significant changes in gene expression within cardiomyocytes [in the cardiac tissue samples under study]"

Cardiomyocytes are primary cells in the heart myocardium
.sciencedirect.com/topics/enginee…

"The most notable expression change [in the study] .. was observed in a gene encoding an immune cytokine known to be transcriptionally upregulated during SARS-CoV infection—CXCL2, which recruits immune cells to sites of inflammation."

"Increased levels of inflammatory cytokines [in relation to Covid] may contribute to cardiac dysfunction"

"Additionally, NF-κB plays a key role in regulating inflammation, and its activation has been linked to cardiac inflammation and remodeling in heart failure. The NF-κB pathway plays a central role in the regulation of immune responses, inflammation, cell survival" etc.

Additional evidence of pathology (details in the paper) was identified in the study, which could explain cardiovascular disease triggered by Covid, including heart failure

Complex paper rich of details which can be found in the study. It raises further concerns over the well known effects of SARS-CoV-2 infection on the cardiovascular system. I flag for the community's attention

H/t @LongCovidPapers